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1. 发明申请

WO2010108154A3 SELECTIVE AND POTENT PEPTIDE INHIBITORS OF KV1.3 审中-公开
标题翻译： KV1.3的选择和磷酸肽抑制剂
公开(公告)号：WO2010108154A3
公开(公告)日：2011-03-03
申请号：PCT/US2010028061
申请日：2010-03-19
申请人： AMGEN INC , SULLIVAN JOHN K , MIRANDA LESLIE P , GEGG COLIN V , HU SHAW-FEN SYLVIA , BELOUSKI EDWARD J , MURRAY JUSTIN K , NGUYEN HUNG , WALKER KENNETH W , ARORA TARUNA , JACOBSEN FREDERICK W , LI YUE-SHENG , BOONE THOMAS C
发明人： SULLIVAN JOHN K , MIRANDA LESLIE P , GEGG COLIN V , HU SHAW-FEN SYLVIA , BELOUSKI EDWARD J , MURRAY JUSTIN K , NGUYEN HUNG , WALKER KENNETH W , ARORA TARUNA , JACOBSEN FREDERICK W , LI YUE-SHENG , BOONE THOMAS C
IPC分类号： A61K38/00
CPC分类号： C07K16/44 , A61K39/39591 , A61K47/6817 , A61K47/6843 , C07K14/43504 , C07K14/575 , C07K14/605 , C07K14/66 , C07K16/00 , C07K16/18 , C07K16/248 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C07K2319/30 , C07K2319/55
摘要： Disclosed are compositions of matter having an amino acid sequence of SEQ ID NO:4, or a pharmaceutically acceptable salt thereof, including embodiments comprising a toxin peptide analog related to ShK, HmK, and AETX-K and pharmaceutical compositions or medicaments containing them along with a pharmaceutically acceptable carrier. Some embodiments include a half-life extending moiety. Also disclosed are a method of preventing or mitigating a relapse of a symptom of multiple sclerosis and a method of treating an autoimmune disorder using the compositions.
摘要翻译：公开了具有SEQ ID NO：4的氨基酸序列或其药学上可接受的盐的物质组合物，包括包含与ShK，HmK和AETX-K相关的毒素肽类似物的实施方案，以及含有它们的药物组合物或药物以及药学上可接受的载体。一些实施方案包括半衰期延长部分。还公开了预防或减轻多发性硬化症状的复发的方法以及使用该组合物治疗自身免疫病症的方法。

2. 发明申请

WO2005042027A3 ANTAGONISTS OF THE BRADYKININ B1 RECEPTOR 审中-公开
标题翻译： BRADYKININ B1受体拮抗剂
公开(公告)号：WO2005042027A3
公开(公告)日：2006-02-09
申请号：PCT/US2004034976
申请日：2004-10-22
申请人： AMGEN INC , NG GORDON , LI YUE-SHENG , GEGG COLIN V , ASKEW JR BENNY C , STORZ THOMAS , LU YUELIE , D AMICO DERIN C
发明人： NG GORDON , LI YUE-SHENG , GEGG COLIN V , ASKEW JR BENNY C , STORZ THOMAS , LU YUELIE , D AMICO DERIN C
IPC分类号： A61K38/08 , A61K38/10 , A61K47/48 , A61P29/00 , C07K7/06 , C07K7/08 , C07K7/18
CPC分类号： A61K38/08 , A61K38/10 , C07K7/06 , C07K7/08 , C07K7/18
摘要： The present invention relates to certain biologically active peptides and conjugated peptides which can be used as therapeutics or prophylactics against diseases or conditions linked to B1 as the causative agent. In a preferred embodiment of the invention biologically active PEG-conjugated peptides are provided. In one aspect of the present invention, pharmacologically active PEG-conjugated peptides of the present invention are useful to treat inflammation or pain.
摘要翻译：本发明涉及某些生物活性肽和缀合肽，其可以用作治疗剂或预防药物，其与作为致病剂的B1连接的疾病或病症。在本发明的优选实施方案中，提供生物活性PEG-缀合的肽。在本发明的一个方面，本发明的药理学活性的PEG-缀合的肽可用于治疗炎症或疼痛。

3. 发明申请

WO0176640A3 CHEMICALLY MODIFIED NOVEL ERYTHROPOIETIN STIMULATING PROTEIN COMPOSITIONS AND METHODS 审中-公开
标题翻译：化学修饰的新型红细胞膜刺激蛋白组合物和方法
公开(公告)号：WO0176640A3
公开(公告)日：2002-06-27
申请号：PCT/US0111346
申请日：2001-04-06
申请人： AMGEN INC
发明人： KINSTLER OLAF BORIS , GEGG COLIN V , FREEMAN AIMEE , BOONE THOMAS CHARLES
IPC分类号： A61K38/00 , A61K47/48 , A61P7/06 , A61K38/18 , C07K14/475
CPC分类号： A61K38/1709 , A61K47/60
摘要： The present invention broadly relates to the field of protein modification, and, more specifically, the attachment of water soluble polymers to novel erythropoietin stimulating protein (NESP).
摘要翻译：本发明广泛涉及蛋白质修饰领域，更具体地说，涉及水溶性聚合物与新型红细胞生成素刺激蛋白（NESP）的连接。

4. 发明公开

EP2432488A4 SELECTIVE AND POTENT PEPTIDE INHIBITORS OF KV1.3 审中-公开
标题翻译：。TIVE。。H ON ON ON ON ON ON ON ON ON。
公开(公告)号：EP2432488A4
公开(公告)日：2014-01-08
申请号：EP10754211
申请日：2010-03-19
申请人： AMGEN INC
发明人： SULLIVAN JOHN K , MIRANDA LESLIE P , GEGG COLIN V , HU SHAW-FEN SYLVIA , BELOUSKI EDWARD J , MURRAY JUSTIN K , NGUYEN HUNG , WALKER KENNETH W , ARORA TARUNA , JACOBSEN FREDERICK W , LI YUE-SHENG , BOONE THOMAS C
IPC分类号： A61K38/16
CPC分类号： C07K16/44 , A61K39/39591 , A61K47/6817 , A61K47/6843 , C07K14/43504 , C07K14/575 , C07K14/605 , C07K14/66 , C07K16/00 , C07K16/18 , C07K16/248 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C07K2319/30 , C07K2319/55

5. 发明公开

EP1567178A4 MODULATORS OF RECEPTORS FOR PARATHYROIS HORMONE AND PARATHYROID HORMONE-RELATED PROTEIN 审中-公开
标题翻译：受体的甲状旁腺和蛋白质NEBENSCHILDSRÜSENHORMONBEZOGENE调节剂
公开(公告)号：EP1567178A4
公开(公告)日：2009-07-15
申请号：EP02793926
申请日：2002-11-01
申请人： AMGEN INC
发明人： KOSTENUIK PAUL , GEGG COLIN V , JAROSINSKI MARK ANTHONY , KINSTLER OLAF BORIS
IPC分类号： A61K38/29 , A61K39/00 , A61K47/48 , C07K14/635 , A61K38/00 , A61K38/24 , A61K38/27 , A61K39/395 , C07K1/00 , C07K14/00 , C07K16/00 , C07K17/00
CPC分类号： C07K14/635 , A61K38/29 , A61K39/00 , A61K47/60

6. 发明专利

NZ592009A FGF21 MUTANTS AND USES THEREOF 未知
公开(公告)号：NZ592009A
公开(公告)日：2012-11-30
申请号：NZ59200909
申请日：2009-10-08
申请人： AMGEN INC
发明人： WALKER KENNETH W , GEGG COLIN V , HECHT RANDY I
IPC分类号： C07K14/50 , A61K38/18
摘要： Disclosed is a mutant FG21 nucleic acid molecule comprising a nucleotide sequence encoding a polypeptide of SEQ ID NO: 4 having a lysine residue at position 36 and at least one amino acid substitution that is: (a) a lysine residue at one or more of positions 72, 77, 126 and 175; (b) a cysteine residue at one or more of positions 37, 38, 46, 91, 69, 77, 79, 87, 91, 112, 113, 120, 121, 125, 126, 175, 170, and 179: (c) an arginine residue at one or more of positions 56, 59, 69, and 122; (d) a glycine residue at position 170; (e) a glycine residue at position 171; and combinations of (a) - (e). Also disclosed is a method for treating metabolic disorders using such nucleic acids. compositions

7. 发明专利

AU2010201800C1 Modified FC Molecules 未知
公开(公告)号：AU2010201800C1
公开(公告)日：2012-11-01
申请号：AU2010201800
申请日：2010-05-05
申请人： AMGEN INC
发明人： GEGG COLIN V , XIONG FEI , WALKER KENNETH WILLIAM , MIRANDA LESLIE P
IPC分类号： A61K47/48
摘要： Disclosed is a process for preparing a pharmacologically active compound, in which at least one internal conjugation sit of an Fc domain sequence is selected that is amenable to conjugation of an additional functional moiety by a defined conjugation chemistry through 5 the side chain of an amino acid residue at the conjugation site. An appropriate amino acid residue for conjugation may be present in a native Fe domain at the conjugation site or may be added by insertion (i.e., between amino acids in the native Fe domain) or by replacement (i.e., removing amino acids and substituting different amino acids). In the latter case, the number of amino acids added need not correspond to the number of amino acids removed 10 from the previously existing Fc domain. This technology may be used to produce useful compositions of matter and pharmaceutical compositions containing them. A DNA encoding the inventive composition of matter, an expression vector containing the DNA, and a host cell containing the expression vector are also disclosed.

8. 发明专利

CA2405716C CHEMICALLY MODIFIED NOVEL ERYTHROPOIETIN STIMULATING PROTEINCOMPOSITIONS AND METHODS 未知
公开(公告)号：CA2405716C
公开(公告)日：2008-09-30
申请号：CA2405716
申请日：2001-04-06
申请人： AMGEN INC
发明人： KINSTLER OLAF BORIS , GEGG COLIN V , FREEMAN AIMEE , BOONE THOMAS CHARLES
IPC分类号： A61K47/48 , A61K38/00 , A61K38/18 , A61P7/06 , C07K14/505
摘要： The present invention broadly relates to the field of protein modification, and, more specifically, the attachment of water soluble polymers to novel erythropoietin stimulating protein (NESP).

9. 发明专利

CA2580796A1 MODIFIED FC MOLECULES 未知
公开(公告)号：CA2580796A1
公开(公告)日：2006-04-06
申请号：CA2580796
申请日：2005-09-23
申请人： AMGEN INC
发明人： XIONG FEI , SITNEY KAREN C , GEGG COLIN V
IPC分类号： C07K19/00 , A61K47/48 , C07K14/475 , C07K14/505 , C07K14/515 , C07K14/52 , C07K16/00 , C12N1/21 , C12N15/62 , C12N15/70
摘要： The present invention concerns compositions of matter, for example, but not limited to, modified antibodies, in which one or more biologically active peptides are incorporated into a loop region of a non-terminal domain of an immunoglobulin Fc domain.

10. 发明专利

CA2405716A1 CHEMICALLY MODIFIED NOVEL ERYTHROPOIETIN STIMULATING PROTEINCOMPOSITIONS AND METHODS 未知
公开(公告)号：CA2405716A1
公开(公告)日：2001-10-18
申请号：CA2405716
申请日：2001-04-06
申请人： AMGEN INC
发明人： BOONE THOMAS CHARLES , FREEMAN AIMEE , KINSTLER OLAF BORIS , GEGG COLIN V
IPC分类号： A61K38/00 , A61K47/48 , A61P7/06 , A61K38/18 , C07K14/475
摘要： The present invention broadly relates to the field of protein modification, and, more specifically, the attachment of water soluble polymers to novel erythropoietin stimulating protein (NESP).

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