会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 4. 发明申请
    • SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE
    • 取代的杂环化合物和使用方法
    • WO2005042518A2
    • 2005-05-12
    • PCT/US2004/034920
    • 2004-10-21
    • AMGEN INC.ELBAUM, DanielMARTIN, Matthew W.NUNES, Joseph J.
    • ELBAUM, DanielMARTIN, Matthew W.NUNES, Joseph J.
    • C07D403/00
    • C07D403/04
    • The present invention relates to hydroxybenzimidazole pyrimidines or pyridines or pharmaceutically-acceptable salts thereof. Also included is a method of treatment of inflammation, inhibition of T cell activation and proliferation, arthritis, rheumatoid arthritis, psoriatic arthritis, osteoarthritis, organ transplant, acute transplant or heterograft or homograft rejection, transplantation tolerance induction, ischemic or reperfusion injury, myocardial infarction, stroke, multiple sclerosis, inflammatory bowel disease, including ulcerative colitis, Crohn's disease, lupus, contact hypersensitivity, delayed-type hypersensitivity, and gluten-sensitive enteropathy, type 1 diabetes, psoriasis, contact dermatitis, Hashimoto's thyroiditis, Sjogren's syndrome, autoimmune hyperthyroidism, Addison's disease, autoimmune polyglandular disease, autoimmune alopecia, pernicious anemia, vitiligo, autoimmune hypopituatarism, Guillain-Barre syndrome, glomerulonephritis, serum sickness, uticaria, allergic diseases, asthma, hayfever, allergic rhinitis, scleracielma, mycosis fungoides, dermatomyositis, alopecia areata, chronic actinic dermatitis, eczema, Behcet's disease, Pustulosis palmoplanteris, Pyoderma gangrenum, Sezary's syndrome, atopic dermatitis, systemic schlerosis, morphea, atopic dermatitis, colon carcinoma or thymoma in a mammal comprising administering a therapeutically-effective amount a compound as described above.
    • 本发明涉及羟基苯并咪唑嘧啶或其吡啶或其药学上可接受的盐。 还包括治疗炎症,抑制T细胞活化和增殖,关节炎,类风湿性关节炎,牛皮癣性关节炎,骨关节炎,器官移植,急性移植或异体移植或同种移植排斥,移植耐受性诱导,局部缺血或再灌注损伤,心肌梗塞 ,中风,多发性硬化症,炎症性肠病,包括溃疡性结肠炎,克罗恩氏病,狼疮,接触性超敏反应,迟发型超敏反应和面筋敏感性肠病,1型糖尿病,牛皮癣,接触性皮炎,桥本氏甲状腺炎,舍格伦综合征,自身免疫性甲状腺机能亢进 ,艾迪生病,自身免疫性多腺疾病,自身免疫性脱发,恶性贫血,白癜风,自身免疫性垂体功能低下,格林巴利综合征,肾小球肾炎,血清病,乌氏病,过敏性疾病,哮喘,干燥症,过敏性鼻炎,巩膜炎,蕈样霉菌病,皮肌炎, ,慢性ac 包括给予治疗有效量的如上所述的化合物,所述化合物包括但不限于:皮质类固醇,皮肤炎, p>