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1. 发明申请

WO2010062383A2 STABILIZED RECEPTOR POLYPEPTIDES AND USES THEREOF 审中-公开
标题翻译：稳定的受体多聚体及其用途
公开(公告)号：WO2010062383A2
公开(公告)日：2010-06-03
申请号：PCT/US2009006252
申请日：2009-11-24
申请人： AMGEN INC , SUN JEONGHOON , TAM LEI-TING TONY , MICHAELS MARK LEO , BOONE THOMAS C , DESHPANDE ROHINI , LI YUE-SHENG , HAN HQ
发明人： SUN JEONGHOON , TAM LEI-TING TONY , MICHAELS MARK LEO , BOONE THOMAS C , DESHPANDE ROHINI , LI YUE-SHENG , HAN HQ
IPC分类号： C07K14/705
CPC分类号： C07K14/71 , A61K38/00 , C07K14/495
摘要： The present invention provides stabilized activin IIB receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the stabilized polypeptides and proteins. Compositions and methods for treating muscle-wasting diseases and metabolic disorders are also provided.
摘要翻译：本发明提供稳定的活化素IIB受体多肽和能够结合并抑制活化素A，肌生成抑制素或GDF-11的活性的蛋白质。本发明还提供能够产生稳定的多肽和蛋白质的多核苷酸，载体和宿主细胞。还提供了治疗肌肉消瘦疾病和代谢紊乱的组合物和方法。

2. 发明专利

CL2020001536A1 Procedimiento de fabricación continuo para productos de anticuerpos biespecíficos. 未知
公开(公告)号：CL2020001536A1
公开(公告)日：2020-09-04
申请号：CL2020001536
申请日：2020-06-09
申请人： AMGEN INC
发明人： BARKHORDARIAN HEDIEH , GOUDAR CHETAN , DESHPANDE ROHINI , GOMEZ NATALIA , WANG YAN
IPC分类号： B01D15/14 , C07K16/24 , C07K16/28 , C12M1/34
摘要： La presente invención proporciona un procedimiento de fabricación anterior continuo para la producción de productos de anticuerpos biespecíficos, que comprenden al menos dos dominios de unión. El procedimiento comprende al menos las etapas de (i) proporcionar en un biorreactor de perfusión al menos un cultivo celular de mamífero, que es capaz de expresar el producto de anticuerpos biespecíficos, (ii) hacer crecer el cultivo celular de mamífero a una primera tasa de perfusión hasta que se alcanza un punto de ajuste de densidad celular viable y (iii) mantener el cultivo de perfusión a una segunda tasa de perfusión, en el que la concentración de producto de anticuerpos biespecíficos en el biorreactor se mantiene por debajo de un valor umbral. El producto de anticuerpos biespecíficos se somete luego a un procesamiento aguas abajo posterior. Además, la invención proporciona un producto de anticuerpos biespecíficos producido mediante el procedimiento de fabricación anterior continuo.

3. 发明专利

CA3082507A1 CONTINUOUS MANUFACTURING PROCESS FOR BISPECIFIC ANTIBODY PRODUCTS 未知
公开(公告)号：CA3082507A1
公开(公告)日：2019-06-20
申请号：CA3082507
申请日：2018-12-11
申请人： AMGEN INC
发明人： GOUDAR CHETAN , DESHPANDE ROHINI , GOMEZ NATALIA , BARKHORDARIAN HEDIEH , WANG YAN
IPC分类号： C07K16/28 , B01D15/14 , C07K16/24 , C12M1/34
摘要： The present invention provides a continuous upstream manufacturing process for the production of bispecific antibody products, which comprise at least two binding domains. The process comprises at least the steps of (i) providing in a perfusion bioreactor at least one mammalian cell culture, which is capable of expressing the bispecific antibody product, (ii) growing the mammalian cell culture at a first perfusion rate until a set point viable cell density is reached, and (iii) maintaining perfusion culture at a second perfusion rate, wherein the bispecific antibody product concentration in the bioreactor is kept below a threshold value. The bispecific antibody product is then subject to subsequent downstream processing. Moreover, the invention provides a bispecific antibody product produced by the continuous upstream manufacturing process.

4. 发明专利

DK2370463T3 STABILISERET VARIANT AF ACTIVIN-IIB-RECEPTOR 未知
公开(公告)号：DK2370463T3
公开(公告)日：2016-11-28
申请号：DK09761055
申请日：2009-11-24
申请人： AMGEN INC
发明人： SUN JEONGHOON , TAM LEI-TING TONY , MICHAELS MARK LEO , BOONE THOMAS C , DESHPANDE ROHINI , LI YUE-SHENG , HAN HQ
IPC分类号： C07K14/495 , C07K14/71

5. 发明专利

PE20150680A1 VARIANTES DE POLIPEPTIDOS RECEPTORES DE ACTIVINA IIB Y APLICACIONES DE ESTOS 未知
公开(公告)号：PE20150680A1
公开(公告)日：2015-05-16
申请号：PE2015000401
申请日：2009-11-24
申请人： AMGEN INC
发明人： SUN JEONGHOON , TAM LEI-TING TONY , MICHAELS MARK LEO , BOONE THOMAS C , DESHPANDE ROHINI , LI YUE-SHENG , HAN HQ
IPC分类号： C07K14/705
摘要： La invencion proporciona polipeptidos y proteinas del receptor de activina IIB estabilizado capaz de unirse e inhibir las actividades de la activina A, miostatina, o GDF-11. La invencion proporciona, ademas, polinucleotidos, vectores y celulas hospederas capaces de producir los polipeptidos y proteinas estabilizados. Se proporcionan, ademas, composiciones para tratar las enfermedades de atrofia muscular y trastornos metabolicos

6. 发明专利

NZ604818A Variants of activin iib receptor polypeptides and uses thereof 未知
公开(公告)号：NZ604818A
公开(公告)日：2014-07-25
申请号：NZ60481809
申请日：2009-11-24
申请人： AMGEN INC
发明人： TAM LEI-TING TONY , MICHAELS MARK LEO , SUN JEONGHOON , BOONE THOMAS C , DESHPANDE ROHINI , LI YUE-SHENG , HAN HQ
IPC分类号： C07K14/705 , C07K14/71 , C07K14/72
摘要： Disclosed is an isolated protein comprising a stabilised activin IIB receptor polypeptide, wherein said polypeptide is selected from the group consisting of: (a) a polypeptide consisting of an amino acid sequence set forth in the group consisting of SEQ ID NO: 4, SEQ ID NO: 6, SEQ ID NO: 12 and SEQ ID NO: 14; (b) a polypeptide having at least 90 % sequence identity to (a), wherein the polypeptide has a W or a Y at a position corresponding to position 28 of an amino acid sequence set forth in SEQ ID NO: 2 and a T at a position corresponding to position 44 of the amino acid sequence set forth in SEQ ID NO:2, wherein the polypeptide is capable of binding myostatin, activin A, or GDF-11, and (c) a polypeptide having at least 95 % sequence identity to (a), wherein the polypeptide has a W or a Y at a position corresponding to position 28 of the amino acid sequence set forth in SEQ ID NO: 2 and a T at a position corresponding to position 44 of the amino acid sequence set forth in SEQ ID NO:2, wherein the polypeptide is capable of binding myostatin, activin A, or GDF-11;wherein the sequences are disclosed in the specification. Also disclosed is a method of producing the above mentioned stabilised activin IIB receptor (svActRIIB) protein and the use of the protein in the manufacture of a medicament for increasing lean muscle mass.

7. 发明专利

AU2013216639A1 Variants of activin IIB receptor polypeptides and uses thereof 未知
公开(公告)号：AU2013216639A1
公开(公告)日：2013-08-29
申请号：AU2013216639
申请日：2013-08-15
申请人： AMGEN INC
发明人： SUN JEONGHOON , TAM LEI-TING TONY , MICHAELS MARK LEO , BOONE THOMAS C , DESHPANDE ROHINI , LI YUE-SHENG , HAN HQ
IPC分类号： C07K14/705 , C07K14/71 , C07K14/72
摘要： The present invention provides stabilized activin IB receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF- 11. The present invention also provides polynucleotides, vectors and host cells capable of producing the stabilized polypeptides and proteins. Compositions and methods for treating muscle-wasting diseases and metabolic disorders are also provided.

8. 发明专利

IL275054D0 Continuous manufacturing process for bispecific antibody products 未知
公开(公告)号：IL275054D0
公开(公告)日：2020-07-30
申请号：IL27505420
申请日：2020-06-02
申请人： WANG YAN , AMGEN INC , GOUDAR CHETAN , DESHPANDE ROHINI , GOMEZ NATALIA , BARKHORDARIAN HEDIEH
发明人： WANG YAN , GOUDAR CHETAN , DESHPANDE ROHINI , GOMEZ NATALIA , BARKHORDARIAN HEDIEH
IPC分类号： C07K16/24 , C07K16/28
摘要： The present invention provides a continuous upstream manufacturing process for the production of bispecific antibody products, which comprise at least two binding domains. The process comprises at least the steps of (i) providing in a perfusion bioreactor at least one mammalian cell culture, which is capable of expressing the bispecific antibody product, (ii) growing the mammalian cell culture at a first perfusion rate until a set point viable cell density is reached, and (iii) maintaining perfusion culture at a second perfusion rate, wherein the bispecific antibody product concentration in the bioreactor is kept below a threshold value. The bispecific antibody product is then subject to subsequent downstream processing. Moreover, the invention provides a bispecific antibody product produced by the continuous upstream manufacturing process.

9. 发明专利

SG11202004273YA CONTINUOUS MANUFACTURING PROCESS FOR BISPECIFIC ANTIBODY PRODUCTS 未知
公开(公告)号：SG11202004273YA
公开(公告)日：2020-06-29
申请号：SG11202004273Y
申请日：2018-12-11
申请人： AMGEN INC
发明人： GOUDAR CHETAN , DESHPANDE ROHINI , GOMEZ NATALIA , BARKHORDARIAN HEDIEH , WANG YAN
IPC分类号： C07K16/28 , B01D15/14 , C07K16/24 , C12M1/34
摘要： The present invention provides a continuous upstream manufacturing process for the production of bispecific antibody products, which comprise at least two binding domains. The process comprises at least the steps of (i) providing in a perfusion bioreactor at least one mammalian cell culture, which is capable of expressing the bispecific antibody product, (ii) growing the mammalian cell culture at a first perfusion rate until a set point viable cell density is reached, and (iii) maintaining perfusion culture at a second perfusion rate, wherein the bispecific antibody product concentration in the bioreactor is kept below a threshold value. The bispecific antibody product is then subject to subsequent downstream processing. Moreover, the invention provides a bispecific antibody product produced by the continuous upstream manufacturing process.

10. 发明专利

CA2743850C VARIANTS OF ACTIVIN IIB RECEPTOR POLYPEPTIDES AND USES THEREOF 未知
公开(公告)号：CA2743850C
公开(公告)日：2018-04-17
申请号：CA2743850
申请日：2009-11-24
申请人： AMGEN INC
发明人： SUN JEONGHOON , TAM LEI-TING TONY , MICHAELS MARK LEO , BOONE THOMAS C , DESHPANDE ROHINI , LI YUE-SHENG , HAN HQ
IPC分类号： C07K14/705 , C07K14/71 , C07K14/72
摘要： The present invention provides stabilized activin IIB receptor polypeptides and proteins capable of binding and in-hibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the stabilized polypeptides and proteins. Compositions and methods for treating muscle-wasting dis-eases and metabolic disorders are also provided.

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