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1. 发明申请

WO1996016602A1 LIGATION CLIP REMOVER 审中-公开
公开(公告)号：WO1996016602A1
公开(公告)日：1996-06-06
申请号：PCT/US1995015437
申请日：1995-11-29
申请人： AMERICAN CYANAMID COMPANY , KELLER, John, W. , HELME, Daniel
发明人： AMERICAN CYANAMID COMPANY
IPC分类号： A61B17/00
CPC分类号： A61B17/076 , A61B17/122
摘要： A ligation clip remover (10) removes closed ligation clips (11, 13) from a ligated vessel (15). The remover includes a handle assembly (14) having a squeezable trigger (16) and a slender barrel assembly (12) connected to the handle assembly. A clip separating mechanism (22) is connected to a distal end of the barrel assembly, and a shaft (23) is slidably disposed in the barrel assembly for operating the clip separating mechanism when the trigger is squeezed.
摘要翻译：连接夹去除器（10）从结扎的容器（15）中去除封闭的结扎夹（11,13）。移除器包括具有可挤压触发器（16）的手柄组件（14）和连接到手柄组件的细长的筒组件（12）。夹子分离机构（22）连接到筒组件的远端，并且轴（23）可滑动地设置在筒组件中，用于当扳机被挤压时操作夹子分离机构。

2. 发明申请

WO1998026781A1 METHOD OF TREATING OR INHIBITING NEUTROPENIA 审中-公开
标题翻译：治疗或抑制中耳炎的方法
公开(公告)号：WO1998026781A1
公开(公告)日：1998-06-25
申请号：PCT/US1997023419
申请日：1997-12-17
申请人： AMERICAN CYANAMID COMPANY
发明人： AMERICAN CYANAMID COMPANY , EPSTEIN, Joseph, William , LEVIN, Jeremy, Ian , GIBBONS, James, Joseph , LUCAS, Judy
IPC分类号： A61K31/505
CPC分类号： A61K31/5377 , A61K31/519
摘要： The invention is a method of treating or inhibiting neutropenia, or accelerating neutrophil recovery in a mammal in need thereof, which comprises administering to said mammal an effective amount of a compound, or a medicament containing said compound having formula (I) wherein R1 and R2 are each, independently selected from the group consisting of hydrogen, alkyl of 1-6 carbon atoms, optionally substituted benzoyl, (a), (b), (c), (d), (e), (f), and -(CH2)n-R; or R1 and R2 are methylene groups which are taken together to form a 4-7 membered saturated heterocyclic ring; R is hydroxy, 4-morpholinyl, 1H-imidazol-1-yl, -CH(alkoxy of 1-6 carbon atoms)2, alpha -hydroxybenzyl, or optionally substituted phenyl; R3 is hydrogen or alkyl; R4 is hydrogen, halogen, alkyl, alkoxy, or trifluoromethyl; R5 is hydrogen or alkyl; and n = 1-3, or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明是一种治疗或抑制有需要的哺乳动物中性粒细胞减少或加速嗜中性粒细胞恢复的方法，其包括向所述哺乳动物施用有效量的化合物或含有所述具有式（I）的化合物的药物，其中R1和R2 （a），（b），（c），（d），（e），（f），和（f）中的至少一个选自氢，可以被取代的苯甲酰基，（CH 2）NR; 或R 1和R 2是亚甲基，它们一起形成4-7元饱和杂环; R是羟基，4-吗啉基，1H-咪唑-1-基，-CH（1-6个碳原子的烷氧基）2，α-羟基苄基或任选取代的苯基; R3是氢或烷基; R4是氢，卤素，烷基，烷氧基或三氟甲基; R5是氢或烷基; 和n = 1-3，或其药学上可接受的盐。

3. 发明申请

WO1998004550A1 HERBICIDAL SUBSTITUTED PYRIDINE COMPOUNDS 审中-公开
标题翻译：除草剂替代吡啶化合物
公开(公告)号：WO1998004550A1
公开(公告)日：1998-02-05
申请号：PCT/US1997013246
申请日：1997-07-29
申请人： AMERICAN CYANAMID COMPANY
发明人： AMERICAN CYANAMID COMPANY , BALTRUSCHAT, Helmut, Siegfried , MAIER, Thomas , SCHEIBLICH, Stefan , PONT, Joseph, Luke
IPC分类号： C07D401/14
CPC分类号： C07D213/69 , A01N43/40 , A01N43/56 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/12 , C07D409/14
摘要： The novel compounds of formula (I) wherein A represents an optionally substituted 5- or 6-membered heteroaromatic group or an optionally substituted aryl group or a difluorobenzodioxolyl group; B represents an optionally substituted cyclic hydrocarbon or thienyl, an alkyl, alkenyl or alkynyl group or independently has one of the meanings of A; n represents an integer from 0 to 2; R represents a hydrogen atom, a halogen atom, an optionally substituted alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl, dialkoxyalkyl, alkoxyalkoxy, alkylthio, amino, alkylamino, dialkylamino or alkoxyamino group or a hydroxy, formamidino or cyano group; X1 and X2 independently represent an oxygen or sulphur atom, and the agronomically acceptable salts thereof; and the herbicidal use of these compounds.
摘要翻译：式（I）的新化合物，其中A表示任选取代的5或6元杂芳族基团或任选取代的芳基或二氟苯并二恶唑基; B表示任选取代的环状烃或噻吩基，烷基，烯基或炔基或独立地具有A的含义; n表示0〜2的整数， R代表氢原子，卤原子，任选取代的烷基，烯基，炔基，烷氧基，烷氧基烷基，二烷氧基烷基，烷氧基烷氧基，烷硫基，氨基，烷基氨基，二烷基氨基或烷氧基氨基或羟基，甲脒基或氰基; X1和X2独立地表示氧或硫原子，及其农艺学上可接受的盐; 和这些化合物的除草用途。

4. 发明申请

WO1997036553A1 CRYSTALLINE COPOLYMERS AND METHODS OF PRODUCING SUCH COPOLYMERS 审中-公开
标题翻译：水溶性共聚物及其制备方法
公开(公告)号：WO1997036553A1
公开(公告)日：1997-10-09
申请号：PCT/US1997005294
申请日：1997-03-31
申请人： AMERICAN CYANAMID COMPANY , LICHKUS, Andrew, M. , KRAMER, Hildegard, I.
发明人： AMERICAN CYANAMID COMPANY
IPC分类号： A61F02/00
CPC分类号： C08G63/823 , A61L17/12 , A61L31/06 , C08G63/08 , A61L31/148 , C08L67/04
摘要： Crystalline copolymers of glycolide and optically inactive dl-lactide comprising sixty-two weight percent or less glycolide, methods of producing the same and absorbable medical devices manufactured therefrom having improved properties are disclosed.
摘要翻译：公开了含有62重量％或更少乙交酯的乙交酯和非活性的dl-丙交酯的结晶共聚物，其制造方法和由其制造的可吸收医疗器件具有改进的性能。

5. 发明申请

WO1996030405A1 PEPTIDES WITH GROWTH PROMOTION PROPERTIES 审中-公开
标题翻译：具有生长促进特性的肽
公开(公告)号：WO1996030405A1
公开(公告)日：1996-10-03
申请号：PCT/US1996003490
申请日：1996-03-15
申请人： AMERICAN CYANAMID COMPANY
发明人： AMERICAN CYANAMID COMPANY , BUCKWALTER, Brian, Lee , SHIEH, Hong-Ming , WANG, Bosco, Shang
IPC分类号： C07K14/61
CPC分类号： C07K14/61 , A61K38/00
摘要： Peptides are described which have well-defined secondary structure, preferably a helical conformation, which mimic the corresponding region of porcine somatotropin (pST) and which enhance the activity of pST and promote growth of warm-blooded animals. These peptides compete with pST for binding to the PS-7.6 monoclonal antibody. These peptides contain therein the sequence of amino acids Xaa-Xaa-Leu-Xaa-Xaa-Ile-Xaa-Xaa-Xaa-Leu-Xaa-Xaa-Val-Xaa-Xaa (SEQ ID No. 1), wherein the sequence differs from the native sequence of pST, as well as sequences in which the location of essential amino acids is shifted by three amino acids, representing almost one turn along the helix, which contain therein the sequence of amino acids Xaa-Xaa-Xaa-Xaa-Xaa-Leu-Xaa-Xaa-Xaa-Ile-Xaa-Xaa-Leu-Xaa-Xaa-Xaa-Val (SEQ ID No. 18) and wherein the sequence differs from the native sequence of pST.
摘要翻译：描述了具有明确二级结构，优选螺旋构象的肽，其模拟猪生长激素（pST）的相应区域并且增强pST的活性并促进温血动物的生长。这些肽与pST竞争结合PS-7.6单克隆抗体。这些肽中含有氨基酸Xaa-Xaa-Leu-Xaa-Xaa-Ile-Xaa-Xaa-Xaa-Leu-Xaa-Xaa-Val-Xaa-Xaa（SEQ ID No.1）的序列，其中序列不同来自pST的天然序列，以及其中必需氨基酸的位置被三个氨基酸位移的序列，沿着螺旋几乎转一圈，其中含有氨基酸序列Xaa-Xaa-Xaa-Xaa- Xaa-Leu-Xaa-Xaa-Xaa-Ile-Xaa-Xaa-Leu-Xaa-Xaa-Xaa-Val（SEQ ID No.18），其中该序列与pST的天然序列不同。

6. 发明申请

WO1996022282A1 TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS 审中-公开
标题翻译：三氯苯甲酸缓释拮抗剂
公开(公告)号：WO1996022282A1
公开(公告)日：1996-07-25
申请号：PCT/US1996001051
申请日：1996-01-16
申请人： AMERICAN CYANAMID COMPANY
发明人： AMERICAN CYANAMID COMPANY , ALBRIGHT, Jay, Donald , VENKATESAN, Aranapakam, Mudumbai , DELOS SANTOS, Efren, Guillermo
IPC分类号： C07D223/20
CPC分类号： C07D401/12 , C07D223/20 , C07D223/28 , C07D243/38 , C07D267/20 , C07D471/04 , C07D487/04 , C07D495/04
摘要： Tricyclic compound of general formula (I) as defined herein which exhibit antagonist activity at V1 and/or V2 receptors and exhibit in vivo vasopressin antagonist activity, methods for using such compounds in treating diseases characterized by excess renal reabsorption of water, and process for preparing such compounds.
摘要翻译：在V1和/或V2受体上表现出拮抗活性并显示体内血管加压素拮抗剂活性的如本文所定义的通式（I）的三环化合物，使用这些化合物治疗特征在于肾脏过度再吸收水的疾病的方法，以及制备方法这样的化合物。

7. 发明申请

WO1996020717A1 COMPOSITIONS AND METHODS FOR INHIBITING FUNGAL CELL WALL FORMATION 审中-公开
标题翻译：用于抑制真菌细胞壁形成的组合物和方法
公开(公告)号：WO1996020717A1
公开(公告)日：1996-07-11
申请号：PCT/US1996000752
申请日：1996-01-02
申请人： AMERICAN CYANAMID COMPANY , KOLLAR, Roman , CABIB, Enrico , SILVERMAN, Sanford, Jay , PETRAKOVA, Eva
发明人： AMERICAN CYANAMID COMPANY
IPC分类号： A61K31/70
CPC分类号： A61K36/07 , A61K31/70 , A61K31/7008 , A61K31/7016 , A61K31/702 , A61K36/06 , A61K36/062 , A61K36/064 , C12N9/1051 , A61K31/715 , A61K2300/00
摘要： Disclosed herein are antifungal compositions having an oligosaccharide that includes an N-acetylhexosamine residue linked beta (1}4) to a hexose and a biologically acceptable carrier. The isolation of the fungal enzyme chitin glucan beta (1}4) transferase (CG beta (1}4)T) is disclosed along with methods for using this enzyme in an assay for antifungal agents. CG beta (1}4)T catalyses the formation of a beta (1}4) linkage between the terminal reducing N-acetylglucosamine residue of chitin and the non-reducing glucose residue of beta (1}3) linked glucans. Inhibitors of the enzyme, antifungals including such inhibitors, methods for the prevention and the treatment of fungal infections in animals and plants, and screening methods for identifying antifungals are also disclosed.
摘要翻译：本文公开了具有寡糖的抗真菌组合物，其包含与己糖和生物学上可接受的载体连接的β-（1} 4）的N-乙酰基己糖胺残基。公开了真菌酶几丁质葡聚糖β（1）4）转移酶（CGβ（1）4）T）的分离以及在抗真菌剂测定中使用该酶的方法。 CG beta（1）4）T催化甲壳质N-乙酰氨基葡萄糖残基末端与β（1} 3）连接葡聚糖的非还原葡萄糖残基之间的β（1）4键连接的形成。还公开了酶的抑制剂，包括这些抑制剂的抗真菌剂，用于预防和治疗动物和植物中的真菌感染的方法，以及鉴定抗真菌剂的筛选方法。

8. 发明申请

WO1996005311A1 BIOLOGICALLY ACTIVE PORCINE SOMATOTROPIN POLYPEPTIDE AND METHODS OF USING THE SAME 审中-公开
标题翻译：生物活性磷脂素SOMATOTROPIN多肽及其使用方法
公开(公告)号：WO1996005311A1
公开(公告)日：1996-02-22
申请号：PCT/US1995010228
申请日：1995-08-10
申请人： AMERICAN CYANAMID COMPANY
发明人： AMERICAN CYANAMID COMPANY , SHIEH, Hong-Ming , BASS, Roy, T. , WANG, Bosco, S. , CORBETT, Martin , BUCKWALTER, Brian
IPC分类号： C12N15/18
CPC分类号： C07K14/61 , A61K38/00 , A61K39/00
摘要： An isolated polypeptide corresponding to the epitope of porcine somatotropin is provided by this invention as well as methods of enhancing the growth of an animal by administering to the animal this polypeptide in compositions.
摘要翻译：通过本发明提供了对应于猪生长激素表位的分离的多肽，以及通过在组合物中向动物施用该多肽来增强动物生长的方法。

9. 发明申请

WO1996004383A1 IDENTIFICATION OF A HUMAN CYTOMEGALOVIRUS GENE REGION INVOLVED IN DOWN-REGULATION OF MHC CLASS I HEAVY CHAIN EXPRESSION 审中-公开
标题翻译：鉴定参与MHC类别I重链表达下调的人类细胞因子基因区
公开(公告)号：WO1996004383A1
公开(公告)日：1996-02-15
申请号：PCT/US1995009607
申请日：1995-07-28
申请人： AMERICAN CYANAMID COMPANY , CAMPBELL, Ann, E.
发明人： AMERICAN CYANAMID COMPANY , JONES, Thomas, R.
IPC分类号： C12N15/38
CPC分类号： C07K14/005 , A61K38/00 , A61K39/12 , A61K39/245 , A61K48/00 , A61K2039/5156 , A61K2039/5254 , C12N7/00 , C12N15/86 , C12N2710/10343 , C12N2710/16121 , C12N2710/16122 , C12N2710/16134 , C12N2710/16143 , C12N2710/16151 , C12N2710/16161 , C12N2710/16162
摘要： Infection of human fibroblast cells with human cytomegalovirus (HCMV) causes down-regulation of cell surface expression of MHC class I. The present invention is directed to a mutant with a 9-kb deletion in the S component of the HCMV genome (including open reading frames IRS1-US9 and US11) which fails to down-regulate class I heavy chains. By examining the phenotypes of mutants with smaller deletions with this portion of the HCMV genome, a 7-kb region containing at least 9 open reading frames was shown to contain the genes required for reduction in heavy chain expression. Furthermore, it was determined that two subregions (A and B) of the 7-kb region each contained genes which were sufficient to cause heavy chain down-regulation. In subregion B, the US11 gene product is involved. It encodes an endoglycosidase H-sensitive glycoprotein which is intracytoplasmic, similar to the adenovirus type 2 E3-19K glycoprotein which inhibits surface expression of class I heavy chains.
摘要翻译：用人巨细胞病毒（HCMV）感染人成纤维细胞导致MHC I类细胞表面表达的下调。本发明涉及在HCMV基因组的S成分中具有9-kb缺失的突变体（包括开放读数框架IRS1-US9和US11），其不能下调I级重链。通过使用该部分HCMV基因组检查具有较小缺失的突变体的表型，显示含有至少9个开放阅读框的7-kb区域含有重链表达降低所需的基因。此外，确定7-kb区域的两个亚区域（A和B）各自含有足以引起重链下调的基因。在次区域B中，涉及US11基因产物。它编码内质网酶H敏感性糖蛋白，其是细胞质内的，类似于抑制I类重链表面表达的2型E3-19K糖蛋白。

10. 发明申请

WO1996003048A1 MIXTURES OF GENETICALLY MODIFIED INSECT VIRUSES WITH CHEMICAL AND BIOLOGICAL INSECTICIDES FOR ENHANCED INSECT CONTROL 审中-公开
标题翻译：与化学和生物杀虫剂相关的遗传改良的病毒病毒混合物，用于增强疫苗控制
公开(公告)号：WO1996003048A1
公开(公告)日：1996-02-08
申请号：PCT/US1995009525
申请日：1995-07-27
申请人： AMERICAN CYANAMID COMPANY
发明人： AMERICAN CYANAMID COMPANY , BLACK, Bruce, Christian, Black , KUKEL, Christine, Frances , TREACY, Micheal, Frank
IPC分类号： A01N63/00
CPC分类号： A01N63/00 , A01N53/00 , A01N47/34 , A01N43/36 , A01N37/52 , A01N37/28 , A01N2300/00
摘要： Insecticidal compositions are described for use against insects comprising mixtures of genetically modified insect viruses with chemical and biological insecticides for enhanced insect control. The genetic modification of the virus comprises the insertion of a gene which expresses an insect controlling or modifying substance, for example, a toxin, a neuropeptide or a hormone, or an enzyme. The genetic modification of the virus also comprises a deletion in a gene.
摘要翻译：描述了杀虫组合物用于包含转基因昆虫病毒与化学和生物杀虫剂的混合物的昆虫用于增强的昆虫控制。病毒的遗传修饰包括插入表达昆虫控制或修饰物质例如毒素，神经肽或激素或酶的基因。病毒的遗传修饰还包括基因中的缺失。

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