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1. 发明申请

WO0046394A3 TRYPTOPHAN SYNTHASE AS A SITE OF HERBICIDE ACTION 审中-公开
标题翻译： TRYPTOPHAN SYNTHASE作为除草剂行动的一个场所
公开(公告)号：WO0046394A3
公开(公告)日：2000-12-21
申请号：PCT/US0003188
申请日：2000-02-04
申请人： AMERICAN CYANAMID CO , RODAWAY SHIRLEY , OTT KARL HEINZ , LANGEVINE CHARLES , SAROKIN LAURA , KAKEFUDA GENICHI
发明人： RODAWAY SHIRLEY , OTT KARL-HEINZ , LANGEVINE CHARLES , SAROKIN LAURA , KAKEFUDA GENICHI
IPC分类号： G01N33/15 , A01N57/22 , C07B61/00 , C12N15/00 , C12N15/09 , C12Q1/25 , C12Q1/527
CPC分类号： C12Q1/25 , C12Q1/527 , G01N2500/20
摘要： The invention relates to methods of identifying inhibitors of tryptophan synthase (TS) that are useful as herbicides, the TS inhibiting herbicides, methods of designing variants of the TS enzyme that are resistant to the herbicides of the invention and other known herbicides, the TS enzyme variants themselves, polynucleotides encoding these TS enzyme variants, plants expressing the TS enzyme variants, and methods of weed control.
摘要翻译：本发明涉及鉴定可用作除草剂的色氨酸合成酶（TS）抑制剂，TS抑制性除草剂的方法，设计对本发明的除草剂和其它已知除草剂具有抗性的TS酶的变体的方法，TS酶变体本身，编码这些TS酶变体的多核苷酸，表达TS酶变体的植物，以及杂草控制方法。

2. 发明申请

WO0026390A3 GENES AND VECTORS FOR CONFERRING HERBICIDE RESISTANCE IN PLANTS 审中-公开
标题翻译：用于防止植物中除草剂抗性的基因和载体
公开(公告)号：WO0026390A3
公开(公告)日：2000-08-31
申请号：PCT/US9925452
申请日：1999-10-28
申请人： AMERICAN CYANAMID CO
发明人： KAKEFUDA GENICHI , COSTELLO COLLEEN , SUN MING , HU WEIMING
IPC分类号： A01H5/00 , A01N63/00 , C12N5/10 , C12N9/88 , C12N15/09 , C12N15/29 , C12N15/60 , C12N15/82 , C12R1/91
CPC分类号： C12N15/8278 , C12N9/88
摘要： Genomic and cDNA sequences and plant expression vectors encoding for an eukaryotic AHAS small subunit protein are disclosed. The DNA sequences and vectors are used to transform plants to produce transgenic plants which possess elevated levels of tolerance or resistance to herbicides, such as imidazolinones.
摘要翻译：公开了编码真核生物AHAS小亚基蛋白的基因组和cDNA序列和植物表达载体。 DNA序列和载体用于转化植物以产生对除草剂如咪唑啉酮具有高水平耐受性或抗性的转基因植物。

3. 发明申请

WO0200915A3 CYANOBACTERIAL NUCLEIC ACID FRAGMENTS ENCODING PROTEINS USEFUL FOR CONTROLLING PLANT TRAITS VIA NUCLEAR OR PLASTOME TRANSFORMATION 审中-公开
标题翻译：编码蛋白质的氰基核酸片段通过核苷酸或质粒转化来控制植物性状
公开(公告)号：WO0200915A3
公开(公告)日：2002-04-18
申请号：PCT/US0120338
申请日：2001-06-27
申请人： AMERICAN CYANAMID CO , KAKEFUDA GENICHI , KOOP HANS ULRICH , STURNER STEPHEN , ZHEN RUI GUANG
发明人： KAKEFUDA GENICHI , KOOP HANS-ULRICH , STURNER STEPHEN , ZHEN RUI-GUANG
IPC分类号： C07K14/195 , C12Q1/68 , C12N9/00 , C07H21/04 , C12N1/20 , C12N9/88 , C12N15/00 , C12N15/87
CPC分类号： C07K14/195 , C12Q1/689
摘要： This invention provides cyanobacteria as an alternative source of ahas and pds genes for plant transformations and for selectable marking. In particular, it provides for cyanobacteria, for example, Synechocystis , as a source of genes encoding herbicide insensitive proteins, and elements of genes for control of expression in plastids. Nucleic acid fragments, both the acetolactate synthase ( ahas ) large subunit and the ahas small subunit, were found to provide herbicide resistance. Also, the present invention provides novel Synechocystis mutant phytoene desaturase ( PDS ) gene conferring resistance to 4'-fluoro-6-[(alpha,alpha,alpha,-trifluoro-m-tolyl)oxy]-picolinamide, a bleaching herbicide. The present invention provides improvements to method involving cyanobacteria for the screening of compounds, including a new high-through-put protocol that is a rapid and cost effective way to identify target site genes.
摘要翻译：本发明提供蓝藻作为用于植物转化和可选择标记的ahas和pds基因的替代来源。具体而言，它提供蓝细菌，例如，集胞藻属，作为编码除草剂不敏感性蛋白质的基因的来源，以及用于控制质体中表达的基因元件。发现乙酰乳酸合酶（ahas）大亚基和α亚基小亚基的核酸片段提供除草剂抗性。而且，本发明提供了赋予对4'-氟-6 - [（α，α，α，α-三氟-β-丙氨酸）的抗性的新的集胞藻属突变体八氢番茄红素去饱和酶（PDS）间甲苯基）氧基] - 吡啶酰胺，一种漂白除草剂。本发明为涉及用于筛选化合物的蓝细菌的方法提供了改进，包括新的高通量方案，其是快速且成本有效的方法来鉴定靶位点基因。

4. 发明申请

WO0046394A9 TRYPTOPHAN SYNTHASE AS A SITE OF HERBICIDE ACTION 审中-公开
标题翻译： TRYPTOPHAN SYNTHASE作为除草剂行动的一个场所
公开(公告)号：WO0046394A9
公开(公告)日：2001-10-18
申请号：PCT/US0003188
申请日：2000-02-04
申请人： AMERICAN CYANAMID CO , RODAWAY SHIRLEY , OTT KARL HEINZ , LANGEVINE CHARLES , SAROKIN LAURA , KAKEFUDA GENICHI , FINN JOHN
发明人： RODAWAY SHIRLEY , OTT KARL-HEINZ , LANGEVINE CHARLES , SAROKIN LAURA , KAKEFUDA GENICHI , FINN JOHN
IPC分类号： G01N33/15 , A01N57/22 , C07B61/00 , C12N15/00 , C12N15/09 , C12Q1/25 , C12Q1/527
CPC分类号： C12Q1/25 , C12Q1/527 , G01N2500/20
摘要： The invention relates to methods of identifying inhibitors of tryptophan synthase (TS) that are useful as herbicides, the TS inhibiting herbicides, methods of designing variants of the TS enzyme that are resistant to the herbicides of the invention and other known herbicides, the TS enzyme variants themselves, polynucleotides encoding these TS enzyme variants, plants expressing the TS enzyme variants, and methods of weed control.
摘要翻译：本发明涉及鉴定可用作除草剂的色氨酸合成酶（TS）抑制剂，TS抑制性除草剂的方法，设计对本发明的除草剂和其它已知除草剂具有抗性的TS酶的变体的方法，TS酶变体本身，编码这些TS酶变体的多核苷酸，表达TS酶变体的植物，以及杂草控制方法。

5. 发明专利

JP2007159577A Structure-based designed herbicide-resistant products 有权
标题翻译：基于结构设计的抗除草剂产品
公开(公告)号：JP2007159577A
公开(公告)日：2007-06-28
申请号：JP2006328154
申请日：2006-12-05
申请人： American Cyanamid Co , アメリカンシアナミドコンパニー
发明人： KAKEFUDA GENICHI , OTT KARL-HEINZ , KWAGH JAE-GYU , STOCKTON GERALD W
IPC分类号： A01H5/00 , C12N15/09 , A01M21/00 , C07K14/415 , C12N1/15 , C12N1/21 , C12N5/10 , C12N9/88 , C12N15/82 , C12P21/02 , C12R1/19
CPC分类号： C12N9/88 , C12N15/8278 , G06F19/16
摘要： PROBLEM TO BE SOLVED: To provide a method for selectively giving wide range and/or specific herbicide-resistance to cultivated crops. SOLUTION: The method comprises: aligning a target acetohydroxy acid synthase (AHAS) protein on a pyruvate oxidase template or an AHAS equivalent thereof to derive the three-dimensional structure of the target AHAS; modeling one or more herbicides into the three-dimensional structure to localize an herbicide binding pocket; selecting an amino acid position in the AHAS; mutating a DNA encoding the target AHAS; and expressing the mutated DNA in a first cell, under conditions in which the variant AHAS containing the mutation at the position is produced. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种选择性地给栽培作物提供广泛和/或特定除草剂抗性的方法。解决方案：该方法包括：将丙酮酸氧化酶模板或其AHAS等价物上的目标乙酰羟酸合酶（AHAS）蛋白质取向，得到目标AHAS的三维结构; 将一种或多种除草剂建模成三维结构以定位除草剂结合袋; 选择AHAS中的氨基酸位置; 突变编码目标AHAS的DNA; 并在其中产生含有该位置突变的变体AHAS的条件下，在第一个细胞中表达突变的DNA。版权所有（C）2007，JPO＆INPIT

6. 发明公开

EP0821729A4 STRUCTURE-BASED DESIGNED HERBICIDE RESISTANT PRODUCTS 失效
标题翻译：基于其结构DESIGNED除草剂产品具有耐
公开(公告)号：EP0821729A4
公开(公告)日：1999-12-08
申请号：EP96913160
申请日：1996-04-19
申请人： AMERICAN CYANAMID CO
发明人： KAKEFUDA GENICHI , OTT KARL-HEINZ , KWAGH JAE-GYU , STOCKTON GERALD W
IPC分类号： A01H5/00 , C07K14/415 , C12N1/15 , C12N1/21 , C12N5/10 , C12N9/88 , C12N15/09 , C12N15/82 , C12P21/02 , C12R1/19 , C12N15/00 , A01H5/10
CPC分类号： C12N9/88 , C12N15/8278 , G06F19/16

7. 发明专利

AU1457700A Genes and vectors for conferring herbicide resistance in plants 未知
公开(公告)号：AU1457700A
公开(公告)日：2000-05-22
申请号：AU1457700
申请日：1999-10-28
申请人： AMERICAN CYANAMID CO
发明人： KAKEFUDA GENICHI , COSTELLO COLLEEN , SUN MING , HU WEI-MING
IPC分类号： A01H5/00 , A01N63/00 , C12N5/10 , C12N9/88 , C12N15/09 , C12N15/29 , C12N15/60 , C12N15/82 , C12R1/91
摘要： A promoter sequence and plant expression vectors encoding for an eukaryotic AHAS small subunit protein are disclosed. The DNA sequences and vectors are used to transform plants to produce transgenic plants which possess elevated levels of tolerance or resistance to herbicides, such as imidazolinones.

8. 发明专利

CA2348701A1 GENES AND VECTORS FOR CONFERRING HERBICIDE RESISTANCE IN PLANTS 未知
公开(公告)号：CA2348701A1
公开(公告)日：2000-05-11
申请号：CA2348701
申请日：1999-10-28
申请人： AMERICAN CYANAMID CO
发明人： HU WEIMING , SUN MING , COSTELLO COLLEEN , KAKEFUDA GENICHI
IPC分类号： A01H5/00 , A01N63/00 , C12N5/10 , C12N9/88 , C12N15/09 , C12N15/29 , C12N15/60 , C12N15/82 , C12R1/91
摘要： Genomic and cDNA sequences and plant expression vectors encoding for an eukaryotic AHAS small subunit protein are disclosed. The DNA sequences and vectors are used to transform plants to produce transgenic plants which possess elevated levels of tolerance or resistance to herbicides, such as imidazolinones.

9. 发明专利

CA2218526A1 STRUCTURE-BASED DESIGNED HERBICIDE RESISTANT PRODUCTS 未知
公开(公告)号：CA2218526A1
公开(公告)日：1996-10-24
申请号：CA2218526
申请日：1996-04-19
申请人： AMERICAN CYANAMID CO
发明人： KAKEFUDA GENICHI , STOCKTON GERALD W , OTT KARL-HEINZ , KWAGH JAE-GYU
IPC分类号： A01H5/00 , C07K14/415 , C12N1/15 , C12N1/21 , C12N5/10 , C12N9/88 , C12N15/09 , C12N15/82 , C12P21/02 , C12R1/19 , C12N15/60 , A01N63/00 , A01H5/10 , C12Q1/527
摘要： Disclosed herein are structure-based modelling methods for the preparation of acetohydroxy acid synthase (AHAS) variants, including those that exhibit selectively increased resistance to herbicides such as imidazoline herbicides and AHAS inhibiting herbicides. The invention encompasses isolated DNAs encoding such variants, vectors that include the DNAs, and methods for producing the variant polypeptides and herbicide resistant plants containing specific AHAS gene mutations. Methods for weed control in crops are also provided.

10. 发明专利

AR035187A1 FRAGMENTOS DE ACIDOS NUCLEICOS DE CIANOBACTERIAS QUE CODIFICAN PROTEINAS UTILES PARA CONTROLAR CARACTERISTICAS DE PLANTAS POR MEDIO DE TRANSFORMACION NUCLEAR O DE PLASTOMAS 未知
公开(公告)号：AR035187A1
公开(公告)日：2004-05-05
申请号：ARP010103055
申请日：2001-06-27
申请人： AMERICAN CYANAMID CO
发明人： KAKEFUDA GENICHI , KOOP HANS-ULRICH , STURNER STEPHEN , ZHEN RUI-GUANG
IPC分类号： C07K14/195 , C12Q1/68 , C12Q1/689 , C12N15/31 , A01H5/00 , A01N43/40 , A01N43/50 , C12N1/20 , C12N9/00 , C12N9/02 , C12N9/88 , C12N15/82 , C12N15/90 , C12Q1/00 , C12Q1/26 , C12Q1/527 , G01N33/68
摘要： Se describen cianobacterias como fuente alternativa de los genes ahas y pds para las transformaciones de plantas y para su uso como marcadores seleccionables. En particular, se proveen cianobacterias, p.ej. Synechocystis, como fuente de los agentes que codifican proteínas que no son sensibles a herbicidas y elementos genéticos para controlar la expresión en plástidos. Se encontraron fragmentos de ácidos nucleicos, tanto de la subunidad grande como de la subunidad pequena de la acetolacto sintetasa (ahas) que proveen resistencia a herbicidas. Además, se provee un nuevo polinucleótido aislado y purificado que consiste en un gen mutante de la fitoeno desaturasa (pds) de Synechosystis que confiere resistencia a la 4'-fluoro-6-[(a,a,a-trifluoro-m-tolil)oxil]picolinamida, un herbicida decolorante. Asimismo se describe un vector de expresión replicable que comprende la secuencia polinucleotídica de cianobacteria, un genoma nuclear y un plastoma que comprenden este vector de expresión replicable, una planta transgénica que es producida por transformación con dicho vector de expresión replicable y que presenta resistencia y resistencia cruzada a ciertos herbicidas decolorantes e imidazolinonas, la progenie derivada de dicha planta, un marcador seleccionable para una transformación que comprende el gen pds mutante de cianobacterias, un proceso de selección que comprende el uso del gen pds mutante de cianobacterias acoplado a la selección de inhibidores de pds para seleccionar nuevas características tales como la resistencia a los herbicidas, un marcador seleccionable para una transformación que comprende una subunidad de ahas de cianobacterias, un proceso de selección que comprende el uso de una subunidad de ahas de cianobacteria acoplado a la selección de una imidazolinona para seleccionar nuevas características tales como la resistencia a los herbicidas, un método de búsqueda de ensayo rápido basado en placas disenado para identificar inhibidores de vías metabólicas específicas que solamente son comunes a las cianobacterias fotoautotróficas y plantas superiores, un método para aislar y seleccionar mutantes resistentes a los herbicidas, un método para mejorar la transformación genética de las cianobacterias, un método para la transformación de plastomas con fragmentos de ácido nucleico de cianobacterias que codifican la resistencia a herbicidas y un método para identificar el sitio blanco de un gen en un organismo cuya secuencia genómica completa se encuentra disponible. Por consiguiente se proveen mejoras a los métodos que utilizan cianobacterias para la búsqueda de compuestos, incluyendo un nuevo protocolo de Alto rendimiento que constituye una manera rápida y eficiente en cuanto al costo para identificar los genes del sitio blanco.

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