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1. 发明申请

WO2008030558A3 MODIFIED HUMAN PLASMA POLYPEPTIDE OR FC SCAFFOLDS AND THEIR USES 审中-公开
标题翻译：改良人类等离子体聚合物或纤维素酶及其用途
公开(公告)号：WO2008030558A3
公开(公告)日：2008-11-13
申请号：PCT/US2007019528
申请日：2007-09-07
申请人： AMBRX INC , SHEFFER JOSEPH , NORMAN THEA , DIMARCHI RICHARD D , PUTNAM ANNA-MARIA A HAYS , FENG TIAN , CHU STEPHANIE , KRAWITZ DENISE , CHO HO SUNG
发明人： SHEFFER JOSEPH , NORMAN THEA , DIMARCHI RICHARD D , PUTNAM ANNA-MARIA A HAYS , FENG TIAN , CHU STEPHANIE , KRAWITZ DENISE , CHO HO SUNG
IPC分类号： C07K14/435 , C07K14/765 , C07K16/42 , C07K16/46
CPC分类号： C07K14/47 , A61K38/00 , C07K14/765 , C07K19/00 , C07K2319/00
摘要： Modified human plasma polypeptides or Fc and uses thereof are provided.
摘要翻译：提供了修饰的人血浆多肽或Fc及其用途。

2. 发明申请

WO2006069220A2 MODIFIED HUMAN GROWTH HORMONE 审中-公开
标题翻译：改良人体生长激素
公开(公告)号：WO2006069220A2
公开(公告)日：2006-06-29
申请号：PCT/US2005046542
申请日：2005-12-21
申请人： AMBRX INC , CHO HO SUNG , DANIEL THOMAS O , DIMARCHI RICHARD D , HAYS ANNA-MARIA , WILSON TROY E
发明人： CHO HO SUNG , DANIEL THOMAS O , DIMARCHI RICHARD D , HAYS ANNA-MARIA , WILSON TROY E , SIM BEE-CHENG , LITZINGER DAVID C
IPC分类号： C12Q1/68 , A61K38/27 , C07H21/04 , C07K14/61
CPC分类号： A61K38/27 , A61K9/0019 , A61K9/19 , A61K47/02 , A61K47/183 , A61K47/26 , C07K14/61 , C08G65/33396
摘要： Modified growth hormone polypeptide and uses thereof are provided.
摘要翻译：提供了改良的生长激素多肽及其用途。

3. 发明申请

WO2006069220A9 MODIFIED HUMAN GROWTH HORMONE 审中-公开
公开(公告)号：WO2006069220A9
公开(公告)日：2006-09-08
申请号：PCT/US2005046542
申请日：2005-12-21
申请人： AMBRX INC , CHO HO SUNG , DANIEL THOMAS O , DIMARCHI RICHARD D , HAYS ANNA-MARIA , WILSON TROY E
发明人： CHO HO SUNG , DANIEL THOMAS O , DIMARCHI RICHARD D , HAYS ANNA-MARIA , WILSON TROY E , SIM BEE-CHENG , LITZINGER DAVID C
IPC分类号： C12Q1/68 , A61K38/27 , C07H21/04 , C07K14/61
CPC分类号： A61K38/27 , A61K9/0019 , A61K9/19 , A61K47/02 , A61K47/183 , A61K47/26 , C07K14/61 , C08G65/33396
摘要： Modified growth hormone polypeptide and uses thereof are provided.

4. 发明专利

IL298338A Pth analogs for the treatment of hypoparathyroidism 未知
公开(公告)号：IL298338A
公开(公告)日：2023-01-01
申请号：IL29833822
申请日：2022-11-17
申请人： INDIANA UNIV RESEARCH AND TECHNOLOGY CORPORATION , DIMARCHI RICHARD D , ZHANG FA
发明人： ZHANG FA , DIMARCHI RICHARD D
IPC分类号： C07K14/635
摘要： A novel derivative of parathyroid hormone is provided that has an extended time of action relative to known native parathyroid hormone agonist peptides, while minimizing excessive action shortly after administration. Compositions comprising the novel parathyroid hormone conjugates can be used to treat hypoparathyroidism and osteoporosis.

5. 发明申请

WO2012088379A9 METHODS FOR TREATING METABOLIC DISORDERS AND OBESITY WITH GIP AND GLP-1 RECEPTOR-ACTIVE GLUCAGON-BASED PEPTIDES 审中-公开
标题翻译：用GIP和GLP-1受体活性基于葡萄糖的肽处理代谢障碍和肥胖的方法
公开(公告)号：WO2012088379A9
公开(公告)日：2012-11-08
申请号：PCT/US2011066739
申请日：2011-12-22
申请人： MARCADIA BIOTECH INC , VIGNATI LOUIS , DIMARCHI RICHARD D
发明人： VIGNATI LOUIS , DIMARCHI RICHARD D
IPC分类号： A61K38/26 , A61K31/195 , A61K31/198 , A61K38/08 , A61P3/04 , A61P3/10
CPC分类号： A61K38/26 , A61K9/0019 , A61K31/195 , A61K31/198 , A61K38/17 , A61K45/06 , A61K47/60 , A61K2300/00
摘要： Methods are provided for administering an extended half-life GLP-1/GIP coagonist peptide to a patient in need thereof for reducing weight gain, inducing weight loss, treating hyperglycemia, reducing blood glucose levels, or normalizing blood glucose levels in said patient.

6. 发明申请

WO2011094337A8 GLUCAGON ANTAGONIST - GIP AGONIST CONJUGATES AND COMPOSITIONS FOR THE TREATMENT OF METABOLIC DISORDERS AND OBESITY 审中-公开
标题翻译： GLUCAGON ANTAGONIST - GIP激素治疗组合物和组合物治疗代谢障碍和肥胖
公开(公告)号：WO2011094337A8
公开(公告)日：2012-08-16
申请号：PCT/US2011022608
申请日：2011-01-26
申请人： UNIV INDIANA RES & TECH CORP , DIMARCHI RICHARD D , MA TAO
发明人： DIMARCHI RICHARD D , MA TAO
IPC分类号： A61K38/26
CPC分类号： C07K14/605 , A61K38/26 , A61K2300/00
摘要： Provided herein are peptide combinations comprising a GIP agonist peptide and a glucagon antagonist peptide. In some embodiments, the peptide combination is provided as a composition, e.g., a pharmaceutical composition, while in other embodiments, the peptide combination is provided as a kit. In yet other embodiments, the peptide combination is provided as a conjugate, e.g., a fusion peptide, a heterodimer. In specific aspects, the GIP agonist peptide is an analog of native human glucagon. In specific aspects, the glucagon antagonist peptide is an analog of native human glucagon. In some embodiments, the GIP agonist peptide is covalently attached to the glucagon antagonist peptide via a linker. Methods of treating a disease, e.g., a metabolic disorder, such as diabetes and obesity, comprising administering the peptide compositions described herein are further provided.
摘要翻译：本文提供了包含GIP激动剂肽和胰高血糖素拮抗肽的肽组合。在一些实施方案中，肽组合作为组合物例如药物组合物提供，而在其它实施方案中，肽组合作为试剂盒提供。在其它实施方案中，肽组合作为缀合物提供，例如融合肽，异二聚体。在具体方面，GIP激动剂肽是天然人胰高血糖素的类似物。在具体方面，胰高血糖素拮抗剂肽是天然人胰高血糖素的类似物。在一些实施方案中，GIP激动剂肽通过接头共价连接到胰高血糖素拮抗剂肽。进一步提供治疗疾病例如代谢紊乱（例如糖尿病和肥胖症）的方法，包括施用本文所述的肽组合物。

7. 发明申请

WO2011159895A2 SINGLE CHAIN INSULIN AGONISTS EXHIBITING HIGH ACTIVITY AT THE INSULIN RECEPTOR 审中-公开
标题翻译：单链胰岛素激动剂在胰岛素受体中展示高活性
公开(公告)号：WO2011159895A2
公开(公告)日：2011-12-22
申请号：PCT/US2011040699
申请日：2011-06-16
申请人： UNIV INDIANA RES & TECH CORP , DIMARCHI RICHARD D , AZRIEL JULIA , KAUR ZACH , MEYERS JONATHAN , PARODY TODD , ZHAO YAN
发明人： DIMARCHI RICHARD D , AZRIEL JULIA , KAUR ZACH , MEYERS JONATHAN , PARODY TODD , ZHAO YAN
IPC分类号： A61K38/28
CPC分类号： C07K14/62 , A61K38/00 , A61K38/18 , A61K38/28 , A61K47/60 , C07K14/475
摘要： Single chain insulin analogs are provided having high potency and specificity for the insulin receptor. As disclosed herein optimally sized linking moieties can be used to link human insulin A and B chains, or analogs or derivatives thereof, wherein the carboxy terminus of the B25 amino acid of the B chain is linked to the amino terminus of the Al amino acid of the A chain via the intervening linking moiety. In on embodiment the linking moiety comprises a polyethylene glycol of 6-16 monomer units and in an alternative embodiment the linking moiety comprises a non-native amino acid sequence derived form the IGF-1 C-peptide and comprising at least 8 amino acids and no more than 12 amino acid in length. Also disclosed are prodrug and conjugate derivatives of the single chain insulin analogs.
摘要翻译：提供具有对胰岛素受体具有高效力和特异性的单链胰岛素类似物。如本文所公开的，最佳尺寸的连接部分可用于连接人胰岛素A和B链或其类似物或衍生物，其中B链的B25氨基酸的羧基末端连接到A链的氨基酸的氨基末端 A链通过中间连接部分。在实施方案中，连接部分包含6-16个单体单元的聚乙二醇，并且在替代实施方案中，连接部分包含衍生自IGF-1 C-肽的非天然氨基酸序列，并且包含至少8个氨基酸且不包含长度超过12个氨基酸。还公开了单链胰岛素类似物的前药和缀合物衍生物。

8. 发明申请

WO2011163012A3 AMIDE BASED GLUCAGON SUPERFAMILY PEPTIDE PRODRUGS 审中-公开
标题翻译：基于氨基酸的GLUCAGON超级肽系列产品
公开(公告)号：WO2011163012A3
公开(公告)日：2013-07-11
申请号：PCT/US2011040330
申请日：2011-06-14
申请人： UNIV INDIANA RES & TECH CORP , DIMARCHI RICHARD D , KOU BINBIN
发明人： DIMARCHI RICHARD D , KOU BINBIN
IPC分类号： A61K38/28 , A61K47/48 , C07K1/00 , C12P21/08
CPC分类号： C07K14/605 , A61K38/00
摘要： Prodrug formulations of glucagon superfamily peptides are provided wherein the glucagon superfamily peptide has been modified by the linkage of a dipeptide to the glucagon superfamily through an amide bond linkage. The prodrugs disclosed herein have extended half lives and are converted to the active form at physiological conditions through a non-enzymatic reaction driven by chemical instability.
摘要翻译：提供胰高血糖素超家族肽的前药制剂，其中胰高血糖素超家族肽已经通过二肽与胰高血糖素超家族通过酰胺键键连接而被修饰。本文公开的前体药物具有延长的半衰期并且通过由化学不稳定性驱动的非酶反应在生理条件下转化为活性形式。

9. 发明申请

WO2012177444A3 GLUCAGON/GLP-1 RECEPTOR CO-AGONISTS 审中-公开
标题翻译： GLUCAGON / GLP-1受体协同作用
公开(公告)号：WO2012177444A3
公开(公告)日：2013-04-25
申请号：PCT/US2012042085
申请日：2012-06-12
申请人： UNIV INDIANA RES & TECH CORP , DIMARCHI RICHARD D , SMILEY DAVID L , YANG BIN
发明人： DIMARCHI RICHARD D , SMILEY DAVID L , YANG BIN
IPC分类号： C07K14/605 , A61K38/17 , A61P3/10 , C07K14/435 , C07K14/575 , C07K19/00
CPC分类号： C07K14/605 , A61K38/00 , A61K47/60 , C07K2319/00 , G01N33/74 , G01N2333/605 , G01N2800/042 , G01N2800/085 , G01N2800/2821 , G01N2800/2835
摘要： Provided herein are peptides and variant peptides that exhibit enhanced activity at the GLP-1 receptor, as compared to native glucagon.
摘要翻译：本文提供了与天然胰高血糖素相比显示增强的GLP-1受体活性的肽和变体肽。

10. 发明申请

WO2012088116A3 GLUCAGON ANALOGS EXHIBITING GIP RECEPTOR ACTIVITY 审中-公开
标题翻译： GLUCAGON ANALOGS展示GIP受体活性
公开(公告)号：WO2012088116A3
公开(公告)日：2012-11-15
申请号：PCT/US2011066164
申请日：2011-12-20
申请人： UNIV INDIANA RES & TECH CORP , DIMARCHI RICHARD D , WARD BRIAN
发明人： DIMARCHI RICHARD D , WARD BRIAN
IPC分类号： A61K38/26 , C07K14/605
CPC分类号： C07K14/605 , A61K38/00
摘要： Provided herein are glucagon analogs which exhibit potent activity at the GIP receptor, and, as such are contemplated for use in treating diabetes and obesity. In exemplary embodiments, the glucagon analog of the present disclosures exhibit an EC50 at the GIP receptor which is within the nanomolar or picomolar range.
摘要翻译：本文提供了在GIP受体上表现出有效活性的胰高血糖素类似物，并且因此被预期用于治疗糖尿病和肥胖症。在示例性实施方案中，本公开的胰高血糖素类似物在GIP受体下显示EC50，其在纳摩尔或皮摩尔范围内。

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