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1. 发明申请

WO2006133089A3 IMPROVED HUMAN INTERFERON MOLECULES AND THEIR USES 审中-公开
标题翻译：改进的人干扰素分子及其用途
公开(公告)号：WO2006133089A3
公开(公告)日：2007-05-24
申请号：PCT/US2006021738
申请日：2006-06-02
申请人： AMBRX INC , HAYS ANNA-MARIA , KIMMEL BRUCE E , CHO HO SUNG , SIM BEE-CHENG , LITZINGER DAVID C , MARIANI ROBERTO , KRAYNOV VADIM , KNUDSEN NICK , DANIEL THOMAS O , KODER ALAN , BUSSELL STUART , LIU JUNJIE , MIAO ZHENWEI , MORROW THERESA
发明人： HAYS ANNA-MARIA , KIMMEL BRUCE E , CHO HO SUNG , SIM BEE-CHENG , LITZINGER DAVID C , MARIANI ROBERTO , KRAYNOV VADIM , KNUDSEN NICK , DANIEL THOMAS O , KODER ALAN , BUSSELL STUART , LIU JUNJIE , MIAO ZHENWEI , MORROW THERESA
IPC分类号： A61K38/21
CPC分类号： C07K14/555 , A61K38/00 , C07K14/56
摘要： Modified human interferon polypeptides and uses thereof are provided.
摘要翻译：提供了修饰的人干扰素多肽及其用途。

2. 发明申请

WO2009067636A3 MODIFIED INSULIN POLYPEPTIDES AND THEIR USES 审中-公开
标题翻译：改性胰岛素多糖及其用途
公开(公告)号：WO2009067636A3
公开(公告)日：2010-01-21
申请号：PCT/US2008084252
申请日：2008-11-20
申请人： AMBRX INC , MIAO ZHENWEI , KRAWITZ DENISE , KRAYNOV VADIM , TIAN FENG , SIM BEE-CHENG , HO LILLIAN , PUTNAM ANNA-MARIA A HAYS , KNUDSEN NICK , DEGUZMAN MICHAEL
发明人： MIAO ZHENWEI , KRAWITZ DENISE , KRAYNOV VADIM , TIAN FENG , SIM BEE-CHENG , HO LILLIAN , PUTNAM ANNA-MARIA A HAYS , KNUDSEN NICK , DEGUZMAN MICHAEL
IPC分类号： A61K38/28
CPC分类号： C07K14/62 , A61K38/00 , A61K38/28
摘要： Modified insulin polypeptides and their uses thereof are provided.
摘要翻译：提供了修饰的胰岛素多肽及其用途。

3. 发明申请

WO2007059312A2 METHODS AND COMPOSITIONS COMPRISING NON-NATURAL AMINO ACIDS 审中-公开
标题翻译：包含非天然氨基酸的方法和组合物
公开(公告)号：WO2007059312A2
公开(公告)日：2007-05-24
申请号：PCT/US2006044682
申请日：2006-11-16
申请人： AMBRX INC , MIAO ZHENWEI , TIAN FENG , HAYS ANNA-MARIA , BUECHLER YING
发明人： MIAO ZHENWEI , TIAN FENG , HAYS ANNA-MARIA , BUECHLER YING
IPC分类号： G01N33/53
CPC分类号： G01N33/6812
摘要： Disclosed herein are methods of detecting non-natural amino acids and polypeptides that include at least one non-natural amino acid. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of functionalities, including but not limited to oxime, carbonyl, and/or hydroxy lamine groups. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, and methods for detecting such polypeptides.
摘要翻译：本文公开了检测包括至少一种非天然氨基酸的非天然氨基酸和多肽的方法。非天然氨基酸本身或作为多肽的一部分可以包括宽范围的官能团，包括但不限于肟，羰基和/或羟基胺基团。本文还公开了在翻译后进一步修饰的非天然氨基酸多肽，以及用于检测这些多肽的方法。

4. 发明申请

WO2011028195A3 COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACIDS AND POLYPEPTIDES 审中-公开
标题翻译：包含的组合物，涉及的方法和非天然氨基酸和多肽的使用
公开(公告)号：WO2011028195A3
公开(公告)日：2011-06-16
申请号：PCT/US2007088009
申请日：2007-12-18
申请人： AMBRX INC , MIAO ZHENWEI , LIU JUNJIE
发明人： MIAO ZHENWEI , LIU JUNJIE
IPC分类号： C07D209/20 , A61K38/02 , C07D209/08 , C07D209/56 , C07K1/107 , C07K2/00 , G01N33/68
CPC分类号： C07D209/10 , C07D209/20 , C07D209/94
摘要： Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of functionalities, but typically have at least one indole, carbonyl, and/or hydrazine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one indole, carbonyl, and/or hydrazine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.
摘要翻译：本文公开了包含至少一种非天然氨基酸的非天然氨基酸和多肽，以及制备这种非天然氨基酸和多肽的方法。非天然氨基酸本身或作为多肽的一部分可以包括宽范围的官能团，但通常具有至少一个吲哚，羰基和/或肼基团。本文还公开了在翻译后进一步修饰的非天然氨基酸多肽，用于实现这种修饰的方法，以及纯化这些多肽的方法。通常，经修饰的非天然氨基酸多肽包括至少一个吲哚，羰基和/或肼基团。进一步披露的是使用这种非天然氨基酸多肽和修饰的非天然氨基酸多肽的方法，包括治疗，诊断和其他生物技术用途。

5. 发明申请

WO2006069246A3 COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACIDS AND POLYPEPTIDES 审中-公开
标题翻译：包含的组合物，涉及的方法和非天然氨基酸和多肽的使用
公开(公告)号：WO2006069246A3
公开(公告)日：2008-09-25
申请号：PCT/US2005046618
申请日：2005-12-21
申请人： AMBRX INC , MIAO ZHENWEI , LIU JUNJIE , NORMAN THEA , DRIVER RUSSELL
发明人： MIAO ZHENWEI , LIU JUNJIE , NORMAN THEA , DRIVER RUSSELL
IPC分类号： C07C22/00 , A61K38/00 , C07C227/00 , C07K2/00
CPC分类号： C07C225/10 , A61K31/198 , A61K38/17 , A61K47/08 , A61K47/10 , A61K47/34 , C07C229/36 , C07C237/32 , C07C251/28 , C07C251/54 , C07C251/60 , C07C251/86 , C07C323/63 , C07C2601/08 , C07D209/38 , C07D209/46 , C07D307/83 , C07D307/88 , C07D307/89 , C07D317/22 , C07D317/26 , C07D317/28 , C07D317/30 , C07D333/72 , C07K14/61 , C12P21/02 , G01N33/5008 , G01N33/68 , G01N33/6848 , G01N2500/00 , Y02P20/55
摘要： Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.
摘要翻译：本文公开了包含至少一种非天然氨基酸的非天然氨基酸和多肽，以及制备这种非天然氨基酸和多肽的方法。非天然氨基酸本身或作为多肽的一部分可以包括广泛范围的可能的官能团，但是通常具有至少一个肟，羰基，二羰基和/或羟胺基团。本文还公开了在翻译后进一步修饰的非天然氨基酸多肽，用于实现这种修饰的方法，以及纯化这些多肽的方法。通常，修饰的非天然氨基酸多肽包括至少一个肟，羰基，二羰基和/或羟胺基团。进一步披露的是使用这种非天然氨基酸多肽和修饰的非天然氨基酸多肽的方法，包括治疗，诊断和其他生物技术用途。

6. 发明申请

WO2007079130A3 COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACIDS AND POLYPEPTIDES 审中-公开
标题翻译：包含的组合物，涉及的方法和非天然氨基酸和多肽的使用
公开(公告)号：WO2007079130A3
公开(公告)日：2008-09-25
申请号：PCT/US2006049397
申请日：2006-12-27
申请人： AMBRX INC , MIAO ZHENWEI , LIU JUNJIE
发明人： MIAO ZHENWEI , LIU JUNJIE
IPC分类号： A01N37/18 , A61K38/00
CPC分类号： C07K1/1072 , C07D231/12 , C07K14/61 , C12N9/93
摘要： Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one heterocycle, aldol-based, dicarbonyl, and/or diamine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one heterocycle, aldol-based, dicarbonyl, and/or diamine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.
摘要翻译：本文公开了包含至少一种非天然氨基酸的非天然氨基酸和多肽，以及制备这种非天然氨基酸和多肽的方法。非天然氨基酸本身或作为多肽的一部分可以包括多种可能的功能，但典型的具有至少一个杂环，醛醇基，二羰基和/或二胺基团。本文还公开了在翻译后进一步修饰的非天然氨基酸多肽，用于实现这种修饰的方法，以及纯化这些多肽的方法。通常，修饰的非天然氨基酸多肽包括至少一个杂环，醛醇基，二羰基和/或二胺基团。进一步披露的是使用这种非天然氨基酸多肽和修饰的非天然氨基酸多肽的方法，包括治疗，诊断和其他生物技术用途。

7. 发明申请

WO2007070659A2 COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACIDS AND POLYPEPTIDES 审中-公开
标题翻译：包含的组合物，涉及的方法和非天然氨基酸和多肽的使用
公开(公告)号：WO2007070659A2
公开(公告)日：2007-06-21
申请号：PCT/US2006047822
申请日：2006-12-13
申请人： AMBRX INC , MIAO ZHENWEI , LIU JUNJIE , NORMAN THEA
发明人： MIAO ZHENWEI , LIU JUNJIE , NORMAN THEA
IPC分类号： A61K39/395 , C12P21/06
CPC分类号： C07K2/00 , C07C229/42 , C07K1/006
摘要： Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one aromatic amine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one alkylated amine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.
摘要翻译：本文公开了包含至少一种非天然氨基酸的非天然氨基酸和多肽，以及制备这种非天然氨基酸和多肽的方法。非天然氨基酸本身或作为多肽的一部分可以包括广泛范围的可能的官能团，但典型地具有至少一个芳族胺基团。本文还公开了在翻译后进一步修饰的非天然氨基酸多肽，用于实现这种修饰的方法，以及纯化这些多肽的方法。通常，修饰的非天然氨基酸多肽包括至少一个烷基化胺基团。进一步披露的是使用这种非天然氨基酸多肽和修饰的非天然氨基酸多肽的方法，包括治疗，诊断和其他生物技术用途。

8. 发明申请

WO2006069246A9 COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACIDS AND POLYPEPTIDES 审中-公开
标题翻译：含有的组合物，涉及非天然氨基酸和多肽的方法和用途
公开(公告)号：WO2006069246A9
公开(公告)日：2006-08-31
申请号：PCT/US2005046618
申请日：2005-12-21
申请人： AMBRX INC , MIAO ZHENWEI , LIU JUNJIE , NORMAN THEA , DRIVER RUSSELL
发明人： MIAO ZHENWEI , LIU JUNJIE , NORMAN THEA , DRIVER RUSSELL
IPC分类号： C07K1/02
CPC分类号： C07C225/10 , A61K31/198 , A61K38/17 , A61K47/08 , A61K47/10 , A61K47/34 , C07C229/36 , C07C237/32 , C07C251/28 , C07C251/54 , C07C251/60 , C07C251/86 , C07C323/63 , C07C2601/08 , C07D209/38 , C07D209/46 , C07D307/83 , C07D307/88 , C07D307/89 , C07D317/22 , C07D317/26 , C07D317/28 , C07D317/30 , C07D333/72 , C07K14/61 , C12P21/02 , G01N33/5008 , G01N33/68 , G01N33/6848 , G01N2500/00 , Y02P20/55
摘要： Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.
摘要翻译：本文公开了包含至少一个非天然氨基酸的非天然氨基酸和多肽，以及制备此类非天然氨基酸和多肽的方法。非天然氨基酸本身或作为多肽的一部分可包括广泛范围的可能官能团，但通常具有至少一个肟，羰基，二羰基和/或羟胺基团。本文还公开了在翻译后进一步修饰的非天然氨基酸多肽，实现这种修饰的方法和纯化这些多肽的方法。通常，修饰的非天然氨基酸多肽包括至少一个肟，羰基，二羰基和/或羟胺基团。进一步公开了使用这种非天然氨基酸多肽和修饰的非天然氨基酸多肽的方法，包括治疗，诊断和其他生物技术用途。

9. 发明申请

WO2007056448A2 ACCELERANTS FOR THE MODIFICATION OF NON-NATURAL AMINO ACIDS AND NON-NATURAL AMINO ACID POLYPEPTIDES 审中-公开
标题翻译：非天然氨基酸和非天然氨基酸多肽的修饰助剂
公开(公告)号：WO2007056448A2
公开(公告)日：2007-05-18
申请号：PCT/US2006043472
申请日：2006-11-08
申请人： AMBRX INC , TIAN FENG , MIAO ZHENWEI
发明人： TIAN FENG , MIAO ZHENWEI
IPC分类号： C07K1/02
CPC分类号： C07K14/61 , C07K1/1077
摘要： Disclosed herein are accelerants for the formation of oxime-containing compounds from the reaction of a carbonyl-containing compound and a hydroxylamine-containing compound. The oxime-containing compound, the carbonyl-containing compound and the hydroxylamine-containing compound can each be a non-natural amino acid or a non-natural amino acid polypeptide. Also disclosed is the use of such accelerants to form oxime-containing compounds, the resulting oxime-containing compounds, and reaction mixtures containing such accelerants.
摘要翻译：本文公开了用于由含羰基化合物和含羟胺化合物的反应形成含肟化合物的促进剂。含肟化合物，含羰基化合物和含羟胺化合物各自可以是非天然氨基酸或非天然氨基酸多肽。还公开了使用这种促进剂来形成含肟化合物，所得到的含肟化合物和含有这种促进剂的反应混合物。

10. 发明申请

WO2004093798A3 QUINOXALINYL MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS 审中-公开
标题翻译：喹诺酮类大环内酯类抗生素C丝氨酸蛋白酶抑制剂
公开(公告)号：WO2004093798A3
公开(公告)日：2005-12-08
申请号：PCT/US2004011841
申请日：2004-04-16
申请人： ENANTA PHARM INC , NAKAJIMA SUANNE , SUN YING , TANG DATONG , XU GOUYOU , PORTER BRIAN , OR YAT SUN , WANG ZHE , MIAO ZHENWEI
发明人： NAKAJIMA SUANNE , SUN YING , TANG DATONG , XU GOUYOU , PORTER BRIAN , OR YAT SUN , WANG ZHE , MIAO ZHENWEI
IPC分类号： A61K20060101 , A61K31/00 , A61K31/38 , A61K31/395 , A61P31/12 , C07D401/12 , C07D409/14 , C07D487/04 , C07K5/083
CPC分类号： C07K5/0804 , C07D487/04
摘要： The present invention relates to compounds of Formula (I) or (II), or a pharmaceutically acceptable salt, ester, or prodrug, thereof: formula (I), formula (II): which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
摘要翻译：本发明涉及式（I）或（II）化合物或其药学上可接受的盐，酯或前药：抑制丝氨酸蛋白酶活性，特别是肝炎活性的式（I），式（II） C病毒（HCV）NS3-NS4A蛋白酶。因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。

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