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1. 发明申请

WO2009067636A2 MODIFIED INSULIN POLYPEPTIDES AND THEIR USES 审中-公开
标题翻译：改性胰岛素多糖及其用途
公开(公告)号：WO2009067636A2
公开(公告)日：2009-05-28
申请号：PCT/US2008/084252
申请日：2008-11-20
申请人： AMBRX, INC. , MIAO, Zhenwei , KRAWITZ, Denise , KRAYNOV, Vadim , TIAN, Feng , SIM, Bee-Cheng , HO, Lillian , PUTNAM, Anna-Maria, A. Hays , KNUDSEN, Nick , DEGUZMAN, Michael
发明人： MIAO, Zhenwei , KRAWITZ, Denise , KRAYNOV, Vadim , TIAN, Feng , SIM, Bee-Cheng , HO, Lillian , PUTNAM, Anna-Maria, A. Hays , KNUDSEN, Nick , DEGUZMAN, Michael
IPC分类号： G06K5/00
CPC分类号： C07K14/62 , A61K38/00 , A61K38/28
摘要： Modified insulin polypeptides and their uses thereof are provided.
摘要翻译：提供了修饰的胰岛素多肽及其用途。

2. 发明申请

WO2007056448A3 ACCELERANTS FOR THE MODIFICATION OF NON-NATURAL AMINO ACIDS AND NON-NATURAL AMINO ACID POLYPEPTIDES 审中-公开
公开(公告)号：WO2007056448A3
公开(公告)日：2007-05-18
申请号：PCT/US2006/043472
申请日：2006-11-08
申请人： AMBRX, INC. , TIAN, Feng , MIAO, Zhenwei
发明人： TIAN, Feng , MIAO, Zhenwei
IPC分类号： C07C249/08 , C07C249/14 , C07C251/54
摘要： Disclosed herein are accelerants for the formation of oxime-containing compounds from the reaction of a carbonyl-containing compound and a hydroxylamine-containing compound. The oxime-containing compound, the carbonyl-containing compound and the hydroxylamine-containing compound can each be a non-natural amino acid or a non-natural amino acid polypeptide. Also disclosed is the use of such accelerants to form oxime-containing compounds, the resulting oxime-containing compounds, and reaction mixtures containing such accelerants.

3. 发明申请

WO2007059312A3 METHODS AND COMPOSITIONS COMPRISING NON-NATURAL AMINO ACIDS 审中-公开
公开(公告)号：WO2007059312A3
公开(公告)日：2007-05-24
申请号：PCT/US2006/044682
申请日：2006-11-16
申请人： AMBRX, INC. , MIAO, Zhenwei , TIAN, Feng , HAYS PUTNAM, Anna-Maria A. , BUECHLER, Ying
发明人： MIAO, Zhenwei , TIAN, Feng , HAYS PUTNAM, Anna-Maria A. , BUECHLER, Ying
IPC分类号： C12P21/06 , A61K38/00
摘要： Disclosed herein are methods of detecting non-natural amino acids and polypeptides that include at least one non-natural amino acid. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of functionalities, including but not limited to oxime, carbonyl, and/or hydroxy lamine groups. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, and methods for detecting such polypeptides.

4. 发明申请

WO2008030614A2 SUPPRESSOR TRNA TRANSCRIPTION IN VERTEBRATE CELLS 审中-公开
标题翻译：抑制剂TRNA在脊椎细胞中的转录
公开(公告)号：WO2008030614A2
公开(公告)日：2008-03-13
申请号：PCT/US2007/019656
申请日：2007-09-07
申请人： AMBRX, INC. , TIAN, Feng , NORMAN, Thea , CHU, Stephanie
发明人： TIAN, Feng , NORMAN, Thea , CHU, Stephanie
IPC分类号： C12P21/06 , C12N1/21
CPC分类号： C12N15/85 , C12N9/93 , C12N15/11 , C12P21/02
摘要： This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in vertebrate cells. The components include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNA's/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in vertebrate cells are also provided.
摘要翻译：本发明提供了用于产生翻译组分的组合物和方法，所述翻译组分增加了脊椎动物细胞中遗传编码的氨基酸的数量。这些成分包括正交tRNA，正交氨酰-tRNA合成酶，正交tRNA /合成酶和非天然氨基酸。还提供了在脊椎动物细胞中产生非天然氨基酸的蛋白质和方法。

5. 发明申请

WO2008030612A2 SITE SPECIFIC INCORPORATION OF NON-NATURAL AMINO ACIDS BY VERTEBRATE CELLS 审中-公开
标题翻译：通过VERTEBRATE CELLS的非天然氨基酸的特定地点
公开(公告)号：WO2008030612A2
公开(公告)日：2008-03-13
申请号：PCT/US2007/019654
申请日：2007-09-07
申请人： AMBRX, INC. , TIAN, Feng , NORMAN, Thea , CHU, Stephanie
发明人： TIAN, Feng , NORMAN, Thea , CHU, Stephanie
IPC分类号： C12P21/06 , C12N1/21
CPC分类号： C12N9/93 , C12P21/02
摘要： This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in vertebrate cells. The components include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNA's/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in vertebrate cells are also provided.
摘要翻译：本发明提供用于生产翻译成分的组合物和方法，其扩展脊椎动物细胞中遗传编码氨基酸的数目。组分包括正交tRNA，正交氨酰-tRNA合成酶，tRNA /合成酶和非天然氨基酸的正交对。还提供了在脊椎动物细胞中产生具有非天然氨基酸的蛋白质的蛋白质和方法。

6. 发明申请

WO2010037062A1 NON-NATURAL AMINO ACID REPLICATION-DEPENDENT MICROORGANISMS AND VACCINES 审中-公开
标题翻译：非天然氨基酸复制相关微生物和疫苗
公开(公告)号：WO2010037062A1
公开(公告)日：2010-04-01
申请号：PCT/US2009/058668
申请日：2009-09-28
申请人： AMBRX, INC. , TIAN, Feng , HEHLI, Brad
发明人： TIAN, Feng , HEHLI, Brad
IPC分类号： C12N1/36 , C12P21/00
CPC分类号： C12N15/70 , A61K39/0258 , C12N1/36 , C12N9/93
摘要： Compositions and methods of producing vaccines, including methods wherein whole organism vaccines are provided with limited replication abilities, thereby increasing vaccine safety and efficacy, through the use of non-natural, unnatural, or non-naturally encoded amino acids.
摘要翻译：制备疫苗的组合物和方法，包括通过使用非天然的，非天然的或非天然编码的氨基酸使整个生物体疫苗具有有限的复制能力，从而增加疫苗安全性和功效的方法。

7. 发明申请

WO2008030613A2 HYBRID SUPPRESSOR TRNA FOR VERTEBRATE CELLS 审中-公开
标题翻译：杂交细胞的杂交抑制剂TRNA
公开(公告)号：WO2008030613A2
公开(公告)日：2008-03-13
申请号：PCT/US2007/019655
申请日：2007-09-07
申请人： AMBRX, INC. , TIAN, Feng , NORMAN, Thea , CHU, Stephanie
发明人： TIAN, Feng , NORMAN, Thea , CHU, Stephanie
IPC分类号： C12P21/06 , C12N1/21
CPC分类号： C12P21/02 , C12N9/93 , C12N15/11
摘要： This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in vertebrate cells. The components include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNA's/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in vertebrate cells are also provided. The present invention provides vertebrate cells with translation components, e.g., pairs of orthogonal aminoacyl-tRNA synthetases (O-RSs) and orthogonal tRNA's (O- tRNA's) and individual components thereof, that are used in vertebrate protein biosynthetic machinery to incorporate an unnatural amino acid in a growing polypeptide chain, in a vertebrate cell.
摘要翻译：本发明提供了用于产生翻译组分的组合物和方法，所述翻译组分增加了脊椎动物细胞中遗传编码的氨基酸的数量。这些成分包括正交tRNA，正交氨酰-tRNA合成酶，正交tRNA /合成酶和非天然氨基酸。还提供了在脊椎动物细胞中产生具有非天然氨基酸的蛋白质和方法。本发明提供了具有翻译组分的脊椎动物细胞，例如用于脊椎动物蛋白质生物合成机器中的正交氨酰基-tRNA合成酶（O-RS）和正交tRNA（O-tRNA's）及其单个组分的成对以掺入非天然氨基酸在增长的多肽链中，在脊椎动物细胞中。

8. 发明申请

WO2010036964A2 MODIFIED ANIMAL ERYTHROPOIETIN POLYPEPTIDES AND THEIR USES 审中-公开
标题翻译：改性动物抗坏血酸多肽及其用途
公开(公告)号：WO2010036964A2
公开(公告)日：2010-04-01
申请号：PCT/US2009/058482
申请日：2009-09-25
申请人： AMBRX INC. , ELI LILLY AND COMPANY , TIAN, Feng , HAYS PUTNAM, Anna-maria, A. , SONG, Frank , CHU, Stephanie , SHEFFER, Joseph , BARNETT, Richard, S. , SILADI, Marc , ATKINSON, Kyle , LEE, Darin , CANNING, Peter, C.
发明人： TIAN, Feng , HAYS PUTNAM, Anna-maria, A. , SONG, Frank , CHU, Stephanie , SHEFFER, Joseph , BARNETT, Richard, S. , SILADI, Marc , ATKINSON, Kyle , LEE, Darin , CANNING, Peter, C.
IPC分类号： C07K14/505 , C12N15/11 , C12N15/16 , C12N5/10 , C12P21/02 , A61P7/06
CPC分类号： C07K14/505 , A61K38/00 , A61K38/1816 , A61K47/60 , C12N15/102
摘要： modified animal erythropoietin polypetides and uses thereof are provide.
摘要翻译：提供改良的动物促红细胞生成素多肽及其用途。

9. 发明申请

WO2013070808A1 PEPTIDE-BASED COMPOUNDS AS INHIBITORS OF NEUROTRANSMITTER SECRETION 审中-公开
标题翻译：基于肽的化合物作为神经递质分泌物的抑制剂
公开(公告)号：WO2013070808A1
公开(公告)日：2013-05-16
申请号：PCT/US2012/064001
申请日：2012-11-07
申请人： TIAN, Feng , ZOU, Daniel Liang , JI, Lingyun
发明人： TIAN, Feng , ZOU, Daniel Liang , JI, Lingyun
IPC分类号： A61K38/00
CPC分类号： A61K8/64 , A61K38/00 , A61Q19/08 , C07K7/06
摘要： Peptide-based compound according to Formula I. The peptide-based compounds administered to inhibit neurotransmitter release and muscle contraction as a treatment for facial wrinkles and facial asymmetry.
摘要翻译：基于式I的肽类化合物。用于抑制神经递质释放和肌肉收缩的基于肽的化合物作为面部皱纹和面部不对称的治疗。

10. 发明申请

WO2009099486A1 RADIO FREQUENCY POWER DELIVERY SYSTEM 审中-公开
标题翻译：无线电频率供电系统
公开(公告)号：WO2009099486A1
公开(公告)日：2009-08-13
申请号：PCT/US2008/087921
申请日：2008-12-22
申请人： MKS INSTRUMENTS, INC. , NAGARKATTI, Siddharth, P. , BARSKIY, Yevgeniy , TIAN, Feng , BYSTRYAK, Ilya
发明人： NAGARKATTI, Siddharth, P. , BARSKIY, Yevgeniy , TIAN, Feng , BYSTRYAK, Ilya
IPC分类号： H03F3/191 , H01J37/32 , H03H7/40
CPC分类号： H03F3/20 , H01J37/32082 , H01J37/32183 , H03F1/565 , H03F3/195 , H03F2200/321 , H03F2200/387 , H03F2200/391 , H03F2200/393 , H03F2200/451 , H03H7/40 , Y10T307/305
摘要： A system and method are provided for delivering power to a dynamic load (260). The system includes a power supply (210) providing DC power having a substantially constant power open loop response, a power amplifier (220) for converting the DC power to RF power, a sensor (240) for measuring voltage, current and phase angle between voltage and current vectors associated with the RF power, an electrically controllable impedance matching system (250) to modify the impedance of the power amplifier (220) to at least a substantially matched impedance of a dynamic load (260), and a controller (252) for controlling the electrically controllable impedance matching system. The system further includes a sensor calibration measuring module for determining power delivered by the power amplifier, an electronic matching system calibration module for determining power delivered to a dynamic load, and a power dissipation module for calculating power dissipated in the electrically controllable impedance matching system.
摘要翻译：提供了一种将功率传递给动态负载（260）的系统和方法。该系统包括提供具有基本上恒定的功率开环响应的DC电力的电源（210），用于将DC功率转换成RF功率的功率放大器（220），用于测量DC功率的电压，电流和相位角的传感器（240）与RF功率相关联的电压和电流矢量，将电力可控阻抗匹配系统（250）修改为功率放大器（220）的阻抗至少为动态负载（260）的基本上匹配的阻抗;以及控制器（252）），用于控制电可控阻抗匹配系统。该系统还包括用于确定由功率放大器输出的功率的传感器校准测量模块，用于确定输送到动态负载的功率的电子匹配系统校准模块，以及用于计算在电气可控阻抗匹配系统中消耗的功率的功率耗散模块。

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