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1. 发明申请

WO2005044366A2 SYSTEM AND METHOD FOR TRANSDERMAL VACCINE DELIVERY 审中-公开
标题翻译：用于真菌传播的系统和方法
公开(公告)号：WO2005044366A2
公开(公告)日：2005-05-19
申请号：PCT/US2004034924
申请日：2004-10-21
申请人： ALZA CORP , SUBRAMONY JANARDHANAN , PHIPPS JOSEPH B , CORMIER MICHEL J N , WIDERA GEORG
发明人： SUBRAMONY JANARDHANAN , PHIPPS JOSEPH B , CORMIER MICHEL J N , WIDERA GEORG
IPC分类号： A61B17/00 , A61B17/20 , A61K9/00 , A61K39/02 , A61M37/00 , A61N20060101 , A61N1/30 , A61N
CPC分类号： A61B17/205 , A61B2017/00765 , A61K9/0021 , A61M37/0015 , A61M2037/0023 , A61N1/30
摘要： A system and method for trandermally delivering a vaccine to a patient including an iontophoresis delivery device having a donor electrode, a Counter electrode, and electric circuitry for supplying iontophoresis energy to the electrodes, and a non-electroactive microprojection member having a plurality of stratum corneum-piercing microprojections extending therefrom. The vaccine can be contained in a hydrogel formulation in an agent reservoir disposed proximate the donor electrode, in a biocompatible coating that is disposed on the microprojections or in both.
摘要翻译：一种用于向患者手术递送疫苗的系统和方法，包括具有供体电极的离子电渗递送装置，对电极和用于向电极提供离子电渗能量的电路，以及具有多个角质层的非电活性微突出物构件从其延伸的微喷射。疫苗可以包含在设置在供体电极附近的药剂容器中的水凝胶制剂中，该生物相容性涂层设置在微喷射体上或两者中。

2. 发明申请

WO2009051802A3 ANODIC RESERVOIR FOR ELECTROTRANSPORT OF CATIONIC DRUG 审中-公开
标题翻译：阳离子药物电泳阳极水库
公开(公告)号：WO2009051802A3
公开(公告)日：2009-08-20
申请号：PCT/US2008011884
申请日：2008-10-17
申请人： ALZA CORP , PADMANABHAN RAMA , PHIPPS JOSEPH B , SUBRAMONY JANARDHANAN
发明人： PADMANABHAN RAMA , PHIPPS JOSEPH B , SUBRAMONY JANARDHANAN
IPC分类号： A61N1/30
CPC分类号： A61N1/30 , A61N1/0436 , A61N1/0448 , Y10T29/49002
摘要： An electrotransport system for delivery of a cationic drug. The system has a donor anodic reservoir having an insoluble biocompatible polymeric anion source embedded in the reservoir. The anion source has precipitating anions that can precipitate out metal ions generated from sacrificial metal of the anode during electrotransport.
摘要翻译：用于递送阳离子药物的电转运系统。该系统具有供体阳极储库，其具有嵌入储库中的不溶性生物相容性聚合物阴离子源。阴离子源具有沉淀阴离子，所述阴离子可以在电转运过程中沉淀由阳极的牺牲金属产生的金属离子。

3. 发明申请

WO2007076083A2 DRY MATRICES AS DRUG RESERVOIRS IN ELECTROTRANSPORT APPLICATIONS 审中-公开
标题翻译： DRY MATRICES作为药物储存在电子运动应用中
公开(公告)号：WO2007076083A2
公开(公告)日：2007-07-05
申请号：PCT/US2006049159
申请日：2006-12-21
申请人： ALZA CORP , SUBRAMONY JANARDHANAN A , PADMANABHAN RAMA V , PHIPPS JOSEPH B
发明人： SUBRAMONY JANARDHANAN A , PADMANABHAN RAMA V , PHIPPS JOSEPH B
IPC分类号： A61N1/30
CPC分类号： A61N1/30 , A61N1/0448
摘要： The present invention provides methods and devices for the electrotransport delivery of beneficial agents that utilize polymer electrolyte matrices as drug reservoirs. In certain aspects of the invention, the beneficial agents are hydrolytically unstable, and methods are provided for enhancing the stability of the hydrolytically unstable beneficial agents during long-term storage of devices for the electrotransport delivery of the hydrolytically unstable beneficial agents and during electrotransport delivery of the hydrolytically unstable beneficial agents.
摘要翻译：本发明提供了利用聚合物电解质基质作为药物储库的用于电转运递送有益物质的方法和装置。在本发明的某些方面中，有益物质是水解不稳定的，并且提供了用于在用于电转运递送水解不稳定的有益物质的装置的长期储存过程中和在电转运递送过程中增强水解不稳定的有益物质的稳定性的方法水解不稳定的有益剂。

4. 发明申请

WO2005049108A3 SYSTEM AND METHOD FOR TRANSDERMAL DELIVERY 审中-公开
标题翻译：用于远程传送的系统和方法
公开(公告)号：WO2005049108A3
公开(公告)日：2006-05-18
申请号：PCT/US2004036180
申请日：2004-11-01
申请人： ALZA CORP , JANARDHANAN SUBRAMONY , WIDERA GEORG , PHIPPS JOSEPH B
发明人： JANARDHANAN SUBRAMONY , WIDERA GEORG , PHIPPS JOSEPH B
IPC分类号： A61M20060101 , A61M37/00 , A61N1/30 , A61N1/32
CPC分类号： A61N1/303 , A61M37/0015 , A61M2037/0023 , A61N1/0424 , A61N1/044 , A61N1/0476 , A61N1/306 , A61N1/327
摘要： A system and method for transdermally delivering a biologically active agent comprising one or more electrodes having stratum corneum-piercing projections and a circuit that delivers an electrical signal to the electrodes to electroporate a cell membrane. Preferably, the system is configured to generate homogeneous electrical fields and, more preferably, to generate spherically or semispherically symmetrical electric fields. Methods of the invention include applying a first electric signal to facilitate transdermal transport of the agent and applying a second electric signal to facilitate intracellular transport of the agent.
摘要翻译：一种用于透皮递送生物活性剂的系统和方法，所述生物活性剂包括一个或多个具有角质层刺穿突起的电极和将电信号传递到电极以电穿孔细胞膜的电路。优选地，该系统被配置为产生均匀的电场，并且更优选地，以产生球形或半对称电场。本发明的方法包括施加第一电信号以促进试剂的透皮转运并施加第二电信号以促进药剂的细胞内运输。

5. 发明申请

WO2009123970A3 ELECTROTRANSPORT FENTANYL DELIVERY DEVICE WITH CONSISTENT DELIVERY 审中-公开
标题翻译：电子运输FENTANYL交付设备与一致交付
公开(公告)号：WO2009123970A3
公开(公告)日：2010-01-07
申请号：PCT/US2009038794
申请日：2009-03-30
申请人： ALZA CORP , PANOS RODNEY M , TAMADA JANET A , PADMANABHAN RAMA V , KALM MICHAEL L , SATHYAN GAYATRI , PHIPPS JOSEPH B
发明人： PANOS RODNEY M , TAMADA JANET A , PADMANABHAN RAMA V , KALM MICHAEL L , SATHYAN GAYATRI , PHIPPS JOSEPH B
IPC分类号： A61N1/32
CPC分类号： A61N1/325 , A61N1/0432 , A61N1/0436 , A61N1/0448 , A61N1/30
摘要： A transdermal electrotransport fentanyl delivery system having relatively stable fentanyl flux. The system has a controller that controls a current through a donor reservoir wherein the current generally changes with time nonlinearly and nonexponentially to result in a relatively stable fentanyl flux.
摘要翻译：具有相对稳定的芬太尼通量的透皮电转运芬太尼递送系统。该系统具有控制器，其控制通过供体储存器的电流，其中电流通常随时间非线性地和非指数地变化以产生相对稳定的芬太尼通量。

6. 发明申请

WO9609850A3 ELECTROTRANSPORT DELIVERY DEVICE HAVING IMPROVED SAFETY AND REDUCED ABUSE POTENTIAL 审中-公开
标题翻译：具有改善安全性和减少潜力的电子输送设备
公开(公告)号：WO9609850A3
公开(公告)日：1996-05-30
申请号：PCT/US9512003
申请日：1995-09-21
申请人： ALZA CORP
发明人： MCNICHOLS LARRY A , BADZINSKI JOHN D , REINING WILLIAM N , LATTIN GARY A , HAAK RONALD P , PHIPPS JOSEPH B
IPC分类号： A61N1/30 , A61N1/32
CPC分类号： A61N1/0436 , A61N1/0412 , A61N1/0428 , A61N1/0448 , A61N1/30 , A61N1/325
摘要： An electrotransport device (20) for delivering one or more therapeutic agents through the skin includes electrodes (30, 32) for contacting the skin (34), at least one electrode containing the agent, a power source (22) for generating electrical current (IL) for delivering the agent, a current generating and controlling means (24), and a disabling means (26) for permanently and irreversibly disabling the current. The disabling means (26) may include a timer means (66), a counter means (82), or a body parameter sensor (134) and limit comparator (132) to effect permanent disabling. The disabling means may be a permanent transition to a disabled logic state, a permanent discharge of a power supply source (22), or a permanent diversion of electrotransport current from the electrodes (30, 32), or a combination of the above. The permanent disabling means may include a circuit connection means (304, 308, 326, 328) having a frangible conducting member (332) which permanently fractures and causes an irreversible open circuit in the connection to the electrodes (334, 342) upon removing a disposable/single use electrode assembly (300) from a reusable portion of an electrotransport device.

7. 发明专利

JP2008178717A Device for transdermal electrotransport delivery of fentanyl and sufentanyl 审中-公开
标题翻译： FENTANYL和SUFENTANYL的电子电子输送设备
公开(公告)号：JP2008178717A
公开(公告)日：2008-08-07
申请号：JP2008097671
申请日：2008-04-04
申请人： Alza Corp , アルザコーポレイション
发明人： PHIPPS JOSEPH B
IPC分类号： A61N1/04 , A61N1/30 , A61K9/06 , A61K9/08 , A61K31/4468 , A61K31/4535 , A61K47/32 , A61K47/38 , A61P25/04 , A61P29/02
CPC分类号： A61N1/0448
摘要： PROBLEM TO BE SOLVED: To provide an improved electrotransport delivery system for analgesic medicine, namely fentanyl and sufentanyl.
SOLUTION: The fentanyl/sufentanyl is provided as a water-soluble salt dispersed in a hydrogel compound(fentanyl hydrochloride for example) to be used in an electrotransport device (10). The concentration of the fentanyl/sufentanyl in the solution of a donator reservoir (26) is maintained at a prescribed or higher minimum concentration where a transdermal electrotransport flux of the fentanyl/sufentanyl depends on the concentration of the fentanyl/sufentanyl. The instrument has a circuit board assembly (18) to delivery the analgesic.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供一种改进的止痛药输送系统，即芬太尼和舒芬太尼。解决方案：芬太尼/舒芬太尼作为分散在水凝胶化合物（例如盐酸芬太尼）中的水溶性盐提供，用于电输送装置（10）中。在芬太尼/舒芬太尼的透皮电转运通量取决于芬太尼/舒芬太尼的浓度，芬太尼/舒芬太尼在供体储器（26）溶液中的浓度保持在规定的或更高的最低浓度。仪器具有用于输送止痛剂的电路板组件（18）。版权所有（C）2008，JPO＆INPIT

8. 发明专利

JP2005261970A Apparatus for transcutaneous electrical translocation delivery of fentanyl and sufentanyl 有权
标题翻译： FENTANYL和SUFENTANYL交通电力交换装置的设备
公开(公告)号：JP2005261970A
公开(公告)日：2005-09-29
申请号：JP2005145199
申请日：2005-05-18
申请人： Alza Corp , アルザコーポレイション
发明人： PHIPPS JOSEPH B , SOUTHAM MARY , BERNSTEIN KEITH J , NOORDUIN HENK
IPC分类号： A61K9/00 , A61K31/4468 , A61K31/4535 , A61N1/30 , A61P25/04
CPC分类号： A61N1/0436 , A61N1/0448
摘要： PROBLEM TO BE SOLVED: To provide an apparatus without cutaneous discoloration and an anode composition used for this apparatus in the transcutaneous electrical translocation delivery of fentanyl and sufentanyl as an analgesic agent.
SOLUTION: In the transcutaneous electrical translocation delivery apparatus, an anode composition contains a hydrophilic matrix containing at least one salt aqueous solution which is selected from the group consisting of fentanyl halide salts and sufentanyl halides. The amount of charge of the salt is (i) at least nearly double of a prescribed dose; (ii) it is a sufficient quantity in order to prevent temporary epidermis cutaneous discoloration during the transcutaneous electrical translocation delivery of fentanyl and after that.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供无皮肤变色的装置和用于该装置的经皮电移位递送芬太尼和舒芬太尼作为止痛剂的阳极组合物。解决方案：在经皮电转移递送装置中，阳极组合物含有含有至少一种盐水溶液的亲水基质，所述盐水溶液选自芬太尼卤化物盐和西芬太尼卤化物。盐的量是（i）至少接近规定剂量的两倍; （ii）为了防止在经皮电转运芬太尼期间的临时表皮皮肤变色之后，这是足够的量。版权所有（C）2005，JPO＆NCIPI

9. 发明专利

JP2008220985A Electrotransport delivery device having improved safety and reduced abuse potential 有权
标题翻译：具有改进的安全和减少电力潜力的电子输送设备
公开(公告)号：JP2008220985A
公开(公告)日：2008-09-25
申请号：JP2008121143
申请日：2008-05-07
申请人： Alza Corp , アルザ・コーポレーション
发明人： MCNICHOLS LARRY A , BADZINSKI JOHN D , REINING WILLIAM N , LATTIN GARY A , HAAK RONALD P , PHIPPS JOSEPH B
IPC分类号： A61N1/30 , A61N1/32
CPC分类号： A61N1/0436 , A61N1/0412 , A61N1/0428 , A61N1/0448 , A61N1/30 , A61N1/325
摘要： PROBLEM TO BE SOLVED: To provide a device and a method for delivering therapeutic agents through the skin by electrotransport which is in compliance with established standard of safety for therapeutic delivery and improved efficiency and reliability. SOLUTION: An electrotransport device includes electrodes 30, 32 for coming into contact with the skin 34, a power source 22 for generating electrical current for delivering the agent, a current generating and controlling means 24 and a suspending means for permanently and irreversibly suspending the current. The suspending means may include a timer means 66, a counter means, or a body parameter sensor and limit comparator to effect permanent suspension. The suspending means may be a permanent transition to a disabled logic state, a permanent discharge of a power supply source, or a permanent diversion of electrotransport current from the electrodes, or a combination of the above. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供一种通过电传输通过皮肤递送治疗剂的装置和方法，该传输符合用于治疗递送的安全标准和提高的效率和可靠性。解决方案：电输送装置包括用于与皮肤34接触的电极30,32，用于产生用于输送药剂的电流的电源22，电流产生和控制装置24和用于永久和不可逆地的悬挂装置暂停当前悬挂装置可以包括定时器装置66，计数器装置或身体参数传感器和限制比较器以实现永久性悬挂。悬挂装置可以是永久性转换到禁用的逻辑状态，电源的永久放电，或者电极的电输送电流的永久转移，或者上述的组合。版权所有（C）2008，JPO＆INPIT

10. 发明专利

JP2011057684A Transdermal analgesic system with reduced abuse potential 有权
标题翻译：具有减少吸收潜力的透皮灭菌系统
公开(公告)号：JP2011057684A
公开(公告)日：2011-03-24
申请号：JP2010233859
申请日：2010-10-18
申请人： Alza Corp , アルザ・コーポレーシヨン
发明人： GALE ROBERT , STEIN THOMAS M , AUDETT JAY , STEPIC JANE , PHIPPS JOSEPH B , CORMIER MICHEL J N
IPC分类号： A61K31/4468 , A61K9/70 , A61K31/4535 , A61K31/485 , A61K45/00 , A61K45/06 , A61K47/32 , A61K47/34 , A61P25/04 , A61P29/00
CPC分类号： A61K9/7092 , A61K9/7061 , A61K31/4468 , A61K31/4535 , A61K45/06 , A61K2300/00
摘要： PROBLEM TO BE SOLVED: To provide a transdermal analgesic system with reduced abuse potential without reducing therapeutic and beneficial effects of an analgesic. SOLUTION: The transdermal system for administering an analgesic via a transdermal route comprises: (a) an analgesic reservoir comprising an analgesic selected from the group consisting of fentanyl and analogs thereof; (b) an antagonist reservoir comprising an antagonist for the analgesic; and (c) a barrier layer that separates the antagonist reservoir from the analgesic reservoir and is substantially impermeable to the analgesic and to the antagonist. The system releases the antagonist in a controlled manner at a rate sufficient to provide an abuse-limiting ratio of release rates of the antagonist to the analgesic when the dosage form is subject to abuse. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供具有降低的滥用潜力的透皮止痛系统，而不降低止痛剂的治疗和有益效果。解决方案：通过经皮途径给药镇痛剂的透皮系统包括：（a）止痛剂储存器，其包含选自芬太尼及其类似物的止痛剂; （b）包含止痛剂拮抗剂的拮抗剂储库; 和（c）阻隔层，其将拮抗剂储存器与镇痛药物储存器分离，并且对止痛剂和拮抗剂基本上是不可渗透的。该系统以受控的方式释放拮抗剂，其速率足以在剂型受到滥用时提供拮抗剂与镇痛剂的释放速率的限制比例。版权所有（C）2011，JPO＆INPIT

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