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1. 发明申请

WO2009047321A2 A PHARMACEUTICAL COMPOSITION FOR THE SUBLINGUAL ADMINISTRATION OF PROGESTERONE, AND A METHOD FOR ITS PREPARATION 审中-公开
标题翻译：用于孕激素的次要施用的药物组合物及其制备方法
公开(公告)号：WO2009047321A2
公开(公告)日：2009-04-16
申请号：PCT/EP2008/063595
申请日：2008-10-10
申请人： ALTERGON S.A. , BELLORINI, Lorenzo , NOCELLI, Luca , ZOPPETTI, Giorgio
发明人： BELLORINI, Lorenzo , NOCELLI, Luca , ZOPPETTI, Giorgio
IPC分类号： A61K9/46
CPC分类号： A61K31/57 , A61K9/0007 , A61K9/0056 , A61K9/006 , A61K9/2009 , A61K9/205 , A61K31/00 , A61K47/02 , A61K47/12 , A61K47/6951 , B82Y5/00 , C08B37/0015 , C08L5/16
摘要： A pharmaceutical composition is described for the sublingual administration of progesterone in the form of a rapidly-disintegrating tablet, which is capable of promoting a greater bioavailability of the progesterone; a method for preparing said pharmaceutical composition is also described.
摘要翻译：描述了用于以快速崩解片剂形式舌下施用孕酮的药物组合物，其能够促进更大的孕酮的生物利用度; 还描述了制备所述药物组合物的方法。

2. 发明申请

WO2006095026A2 NEW SOFT GELATIN CAPSULES 审中-公开
标题翻译：新软胶囊
公开(公告)号：WO2006095026A2
公开(公告)日：2006-09-14
申请号：PCT/EP2006/060649
申请日：2006-03-13
申请人： ALTERGON S.A. , ZOPPETTI, Giorgio , MARCHIORRI, Maurizio
发明人： ZOPPETTI, Giorgio , MARCHIORRI, Maurizio
CPC分类号： A61K9/4825 , A61K31/355 , A61K31/4415 , A61K31/51 , A61K31/525 , A61K31/57 , A61K31/593 , A61K31/616 , A61K31/714 , A61K33/04 , A61K33/08 , A61K33/10 , A61K33/18 , A61K33/30 , A61K47/40
摘要： The present invention relates to soft gelatin capsules characterized in that the shell includes a cyclodextrin and in that the filling material contains a liposoluble drug capable of forming a complex with said cyclodextrin for improving the solubility of the active ingredient upon disintegration of the soft gelatin capsule.
摘要翻译：本发明涉及软明胶胶囊，其特征在于该壳包括环糊精，并且填充材料含有能够与所述环糊精形成络合物的脂溶性药物，以改善活性成分在软明胶胶囊分解时的溶解度。

3. 发明申请

WO2010108553A1 COMPOSITIONS AND PHARMACEUTICAL FORMS FOR THE ORAL ADMINISTRATION OF THYROID HORMONES ABLE TO COMBAT THE ACTION OF SEQUESTRANTS IN THE GASTROINTESTINAL TRACT 审中-公开
标题翻译：用于口服葡萄球菌的口服药物的组合物和药物形式可以在胃肠道诱导中调节序列的作用
公开(公告)号：WO2010108553A1
公开(公告)日：2010-09-30
申请号：PCT/EP2009/054879
申请日：2009-04-23
申请人： ALTERGON S.A. , ZOPPETTI, Giorgio , MAZZUCCHELLI, Paolo , RIVA, Marta
发明人： ZOPPETTI, Giorgio , MAZZUCCHELLI, Paolo , RIVA, Marta
IPC分类号： A61K9/00 , A61K9/48 , A61K31/198
CPC分类号： A61K9/4858 , A61K9/0053 , A61K9/0095
摘要： The invention concerns the use of a substance chosen among animal or vegetable gelatine, peptones, dextrins, native or modified cyclodextrins, starch, and starch hydrolysates in the preparation of pharmaceutical forms for the oral administration of thyroid hormones to combat the action of sequestrant agents present in the gastrointestinal tract, and related pharmaceutical forms.
摘要翻译：本发明涉及在动物或植物明胶，胨，糊精，天然或改性环糊精，淀粉和淀粉水解产物中选择的物质在制备用于口服施用甲状腺激素以抵抗存在的螯合剂的作用的药物形式中的用途在胃肠道和相关的药物形式。

4. 发明申请

WO2009109214A1 PROCESS FOR PREPARING A PHARMACEUTICAL COMPOSITION WITH ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY FOR ADMINISTRATION VIA A PATCH FOR EXTERNAL USE, AND COMPOSITION THUS OBTAINED 审中-公开
标题翻译：用于制备具有抗炎和药物活性的药物组合物的方法，用于通过用于外部使用的药剂和用于治疗的组合物
公开(公告)号：WO2009109214A1
公开(公告)日：2009-09-11
申请号：PCT/EP2008/052547
申请日：2008-03-03
申请人： ALTERGON S.A. , TROIANO, Angelo , ZOPPETTI, Giorgio
发明人： TROIANO, Angelo , ZOPPETTI, Giorgio
IPC分类号： A61K9/70 , A61K31/196
CPC分类号： A61K9/7023 , A61K31/196
摘要： The present invention relates to a process for preparing a pharmaceutical composition with anti-inflammatory and analgesic activity for administration via a patch for external use, its components including as active principle a salt of diclofenac, 2[(2,6-dichlorophenyl)amino]benzene-acetic acid, with a cyclic organic base chosen from hydroxyethylpyrrolidine or hydroxyethylpiperidine characterized in that said active principle is added to a mixture of one or more of said components, in the form of a solution in water and propylene glycol in a ratio of about 1:1 parts by weight.
摘要翻译：本发明涉及一种制备具有抗炎和止痛活性的药物组合物的方法，其通过外用贴剂进行给药，其组分包括双氯芬酸盐，2 [（2,6-二氯苯基）氨基] 苯 - 乙酸与选自羟乙基吡咯烷或羟乙基哌啶的环状有机碱，其特征在于所述活性成分以一种或多种所述组分的混合物形式，以水和丙二醇溶液的形式，以约 1：1重量份。

5. 发明申请

WO2008025819A3 FORMULATIONS OF ACETYLSALICYLIC ACID OR ITS DERIVATIVES IN SOFT CAPSULES, EXHIBITING HIGH STABILITY 审中-公开
公开(公告)号：WO2008025819A3
公开(公告)日：2008-03-06
申请号：PCT/EP2007/059047
申请日：2007-08-30
申请人： ALTERGON S.A. , ECHANAGORRIA, Angel Mateo , MARCHIORRI, Maurizio , ZOPPETTI, Giorgio
发明人： ECHANAGORRIA, Angel Mateo , MARCHIORRI, Maurizio , ZOPPETTI, Giorgio
IPC分类号： A61K31/60 , A61K47/40
摘要： The present invention relates to new formulations comprising acetylsalicylic acid or its derivatives an oil phase and a cyclodextria in soft capsules, characterized by a high stability.

6. 发明申请

WO2010086030A1 CONTAINER FOR PHARMACEUTICAL USE FOR THE QUANTITATIVE RELEASE OF A SINGLE DOSE FOR ORAL ADMINISTRATION OF T3 AND T4 THYROID HORMONES IN SOLUTION 审中-公开
标题翻译：用于定量释放单次剂量用于口服T3和T4甲状腺激素溶液的药物容器
公开(公告)号：WO2010086030A1
公开(公告)日：2010-08-05
申请号：PCT/EP2009/051984
申请日：2009-02-19
申请人： ALTERGON S.A. , ZOPPETTI, Giorgio , FONTANA, Antonio
发明人： ZOPPETTI, Giorgio , FONTANA, Antonio
IPC分类号： A61J3/07 , A61K9/48 , A61K38/29
CPC分类号： H01H1/225 , H01H71/1009 , H01H2001/223 , H01H2071/1036
摘要： The present invention relates to a container for pharmaceutical use for the quantitative release of a single-dose for oral administration of the T3 and T4 thyroid hormones in solution, characterized by the fact of being formed with a plastic material having a Young's modulus between 10 and 80 MPa.
摘要翻译：本发明涉及用于定量释放溶液中T3和T4甲状腺激素口服单次剂量的药物用容器，其特征在于用塑料材料形成，杨氏模量为10和 80 MPa。

7. 发明申请

WO2007138014A1 COMPOSITIONS COMPRISING GLYCOSAMINOGLYCANS OF LOW VISCOSITY AND USE OF SAID COMPOSITION IN THERAPY OF CHRONIC CYSTITIS 审中-公开
标题翻译：包含低粘度的糖蛋白酶组合物和在慢性CYSTITIS治疗中使用合成组合物的组合物
公开(公告)号：WO2007138014A1
公开(公告)日：2007-12-06
申请号：PCT/EP2007/055107
申请日：2007-05-25
申请人： ALTERGON S.A. , ZOPPETTI, Giorgio , PUPPINI, Nadia , PIZZUTTI, Marco
发明人： ZOPPETTI, Giorgio , PUPPINI, Nadia , PIZZUTTI, Marco
IPC分类号： A61K9/08
CPC分类号： A61K9/0019 , A61K9/0034
摘要： The present invention concerns new compositions comprising glycosaminoglycans, intended for use in interstitial cystitis therapy, and characterized by a controlled viscosity.
摘要翻译：本发明涉及旨在用于间质性膀胱炎治疗的糖胺聚糖的新组合物，其特征在于受控的粘度。

8. 发明申请

WO2003106506A1 LOW MOLECULAR WEIGHT OVERSULFATED POLYSACCHARIDE 审中-公开
标题翻译：低分子量超声波多糖
公开(公告)号：WO2003106506A1
公开(公告)日：2003-12-24
申请号：PCT/IB2003/002347
申请日：2003-06-17
申请人： ORESTE, Pasqua, Anna , ZOPPETTI, Giorgio
发明人： ORESTE, Pasqua, Anna , ZOPPETTI, Giorgio
IPC分类号： C08B37/00
CPC分类号： A61K31/726 , A61K31/727 , A61K31/737 , C07H1/00 , C08B37/006 , C08B37/0075 , C08B37/0078
摘要： LMW-K5-N,O-oversulfates are described, having a sulfation degree of from 3.2 to 4 and a mean molecular weight of from about 3,000 to about 6,000, obtainable by depolymerization of corresponding K5-N,O-oversulfates or starting from LMW-K5-N-sulfates by O-oversulfation of a tertiary amine or quaternary ammonium salt thereof and subsequent N-resulfation of the K5-amine-O-oversulfate thus obtained. Furthermore, pharmaceutical compositions containing these LMW-K5-N,Ooversulfates having antiangiogenetic and antiviral, in particular anti-HIV-1 activity. Intermediate LMW-K5-N-sulfates are also described.
摘要翻译：描述了LMW-K5-N，过硫酸盐，其硫酸化度为3.2至4，平均分子量为约3,000至约6,000，可通过相应的K5-N，O-硫酸盐的解聚或从LMW开始获得 -K5-N-硫酸盐，其通过叔胺或其季铵盐的过氧化和随后的N-重硫化由此获得的K5-胺-O-硫酸盐。此外，含有具有抗血管发生和抗病毒药物的这些LMW-K5-N，过硫酸盐的药物组合物，特别是抗HIV-1活性。还描述了中间体LMW-K5-N-硫酸盐。

9. 发明申请

WO2002083155A1 USE OF SULFATED BACTERIAL POLYSACCHARIDES SUITABLE FOR THE INHIBITION OF ANGIOGENESIS 审中-公开
标题翻译：使用适合抑制血管生成的硫酸多糖
公开(公告)号：WO2002083155A1
公开(公告)日：2002-10-24
申请号：PCT/IB2002/001138
申请日：2002-04-10
申请人： UNIVERSITA' DEGLI STUDI DI BRESCIA , ZOPPETTI, Giorgio , ORESTE, Pasqua, Anna , PRESTA, Marco
发明人： ZOPPETTI, Giorgio , ORESTE, Pasqua, Anna , PRESTA, Marco
IPC分类号： A61K31/737
CPC分类号： A61K31/737
摘要： The present invention refers to the use of N,O sulfated K5 having a degree of sulfation of at least 2, and of their pharmaceutical acceptable salts for the preparation of medicaments for treating angiogenesis-dependent diseases.
摘要翻译：本发明涉及硫酸化程度至少为2的N，O硫酸化K5及其药学上可接受的盐在制备用于治疗血管发生依赖性疾病的药物中的应用。

10. 发明申请

WO2005058976A2 LOW MOLECULAR WEIGHT POLYSACCHARIDES HAVING ANTHROMBOTIC ACTIVITY 审中-公开
标题翻译：低分子量多糖具有抗氧化活性
公开(公告)号：WO2005058976A2
公开(公告)日：2005-06-30
申请号：PCT/IB2004/004128
申请日：2004-12-15
申请人： GLYCORES 2000 S.R.L. , ORESTE, Pasqua, Anna , ZOPPETTI, Giorgio
发明人： ORESTE, Pasqua, Anna , ZOPPETTI, Giorgio
IPC分类号： C08B37/00
CPC分类号： C08B37/0063
摘要： Novel depolymerized-LMWepiK5-N,O-sulfates obtainable starting from a LMW epiK5-N-sulfate prepared by nitrous depolymerization of an epiK5-N-sulfate or by C5-epimerization of a LMW-K5-N-sulfate obtained by nitrous depolymerization of a KS-N-sulfate. A process consists of submitting the starting depolymerized-LMW-epiK5-N-sulfate to four steps: a O-oversulfation, a partila 0-desulfation, a 6-0-sulfation and a N-sulfation. The new depolymerizedLMWepiK5-N,O-sulfates present a di- or trisulfated 2,5-anhydromannitol unit at the reducing end of the majority of its chains, have a content of iduronic acid of 40-60%, a sulfation degree of from 2.3 to 2.9 and a mean molecular weight of from about 1,500 to about 12,000. They exhibit a good antithrombotic activity with a low pro-hemorrhagic risk.
摘要翻译：新型解聚LMWepiK5-N，O-硫酸酯可从LMW＆shy开始获得; 通过epiK5-N-硫酸盐的亚硝基解聚反应制备的epiK5-N-硫酸酯或通过KS-N-硫酸酯的亚硝基解聚反应获得的LMW-K5-N-硫酸酯的C5-差向异构化制备。一种方法包括将起始解聚的LMW-epiK5-N-硫酸酯分成四个步骤：O-过硫酸盐，partila-脱硫酸盐，6-0-硫酸盐化和N-硫酸盐化。新的解聚＆害羞的; LMWepiK5-N，O-硫酸盐在其大部分链的还原端呈现二 - 或三硫酸化的2,5-脱水甘露糖醇单元，具有40-60％的艾杜糖醛酸含量，硫酸化度从2.3到2.9，平均分子量从约1,500到约12,000。它们表现出良好的抗血栓形成活性，具有低的出血前风险。

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