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1. 发明专利

JP2012228573A Transdermal drug delivery patch system, method of making the same and method of using the same 有权
标题翻译：超导药物递送管理系统及其制造方法及其使用方法
公开(公告)号：JP2012228573A
公开(公告)日：2012-11-22
申请号：JP2012180578
申请日：2012-08-16
申请人： Altea Therapeutics Corp , アルテアセラピューティクスコーポレイション
发明人： EPPSTEIN JONATHAN , MCRAE STUART , SMITH ALAN
IPC分类号： A61M5/30 , A61M37/00 , A61F13/00 , A61M20060101 , A61M5/24 , A61N1/30 , A61N1/32
CPC分类号： A61M37/0015 , A61M37/00 , A61M2037/0007 , A61M2037/0023 , A61M2037/0061 , A61M2205/33 , A61M2205/3303 , A61M2210/04 , A61M2230/20 , A61N1/0424 , A61N1/044 , A61N1/0476 , A61N1/325 , A61N1/326 , A61N1/327
摘要： PROBLEM TO BE SOLVED: To provide an improved method and device for transdermaly delivering a drug, or the like, and monitoring analyte such as blood component.SOLUTION: A transdermal drug delivery device for forming a drug delivery patch system, includes: an actuator (including an outer body, a controller board and interface connection port); a porator array (including a top surface, a top surface, an extension tab and a release liner); and a reservoir patch attached to the extension tab (the reservoir patch is applied to a microporated area of a tissue membrane after poration) Moreover, methods of making and using the system are provided.
摘要翻译：要解决的问题：提供用于透皮递送药物等的改进方法和装置，并监测诸如血液成分的分析物。解决方案：一种用于形成药物递送贴片系统的透皮药物递送装置，包括：致动器（包括外部主体，控制器板和接口连接端口）; 搬运器阵列（包括顶表面，顶表面，延伸片和释放衬垫）; 和附着在延伸片上的储液器贴片（储液器贴片在点心后施加到组织膜的微孔区域）。此外，提供制造和使用该系统的方法。版权所有（C）2013，JPO＆INPIT

2. 发明专利

JP2013215592A Transdermal drug delivery patch system, method of making the same and method of using the same 审中-公开
标题翻译：超导药物递送管理系统及其制造方法及其使用方法
公开(公告)号：JP2013215592A
公开(公告)日：2013-10-24
申请号：JP2013120808
申请日：2013-06-07
申请人： Altea Therapeutics Corp , アルテアセラピューティクスコーポレイション
发明人： EPPSTEIN JONATHAN , MCRAE STUART , SMITH ALAN
IPC分类号： A61M5/30 , A61M37/00 , A61F13/00 , A61M20060101 , A61M5/24 , A61N1/30 , A61N1/32
CPC分类号： A61M37/0015 , A61M37/00 , A61M2037/0007 , A61M2037/0023 , A61M2037/0061 , A61M2205/33 , A61M2205/3303 , A61M2210/04 , A61M2230/20 , A61N1/0424 , A61N1/044 , A61N1/0476 , A61N1/325 , A61N1/326 , A61N1/327
摘要： PROBLEM TO BE SOLVED: To provide improved methods and devices for transdermal delivery of agents such as drugs and monitoring of analytes such as blood components.SOLUTION: The invention provides a transdermal drug delivery device for forming a drug delivery patch system comprising: an actuator (comprising an outer body, a controller board, and an interface connection port), a porator array (comprising a top surface, a bottom surface, an extension tub, and a release liner), and a reservoir patch attached to the extension tub (the reservoir patch being applied to a microporated area of a tissue membrane after microporation). A method of making the system and a method of using the system are also provided.
摘要翻译：要解决的问题：提供用于透皮递送药物如药物和监测诸如血液成分的分析物的改进的方法和装置。解决方案：本发明提供了一种用于形成药物递送贴片系统的透皮药物递送装置，包括：致动器包括外体，控制器板和接口连接端口），搬运器阵列（包括顶表面，底表面，延伸槽和释放衬垫）和附接到延伸桶的储存器贴片储层补片在微孔化后应用于组织膜的微孔区域）。还提供了制造系统的方法和使用该系统的方法。

3. 发明专利

JP2010279808A Transdermal drug delivery patch system, method of making the same, and method of using the same 有权
标题翻译：透皮药物递送管理系统及其制造方法及其使用方法
公开(公告)号：JP2010279808A
公开(公告)日：2010-12-16
申请号：JP2010214583
申请日：2010-09-24
申请人： Altea Therapeutics Corp , アルテアセラピューティクスコーポレイション
发明人： EPPSTEIN JONATHAN , MCRAE STUART , SMITH ALAN
IPC分类号： A61M5/30 , A61M37/00 , A61F13/00 , A61M20060101 , A61M5/24 , A61N1/30 , A61N1/32
CPC分类号： A61M37/0015 , A61M37/00 , A61M2037/0007 , A61M2037/0023 , A61M2037/0061 , A61M2205/33 , A61M2205/3303 , A61M2210/04 , A61M2230/20 , A61N1/0424 , A61N1/044 , A61N1/0476 , A61N1/325 , A61N1/326 , A61N1/327
摘要： PROBLEM TO BE SOLVED: To provide an improved method and device for transdermally delivering elements like drugs as well as for monitoring analytes like blood components. SOLUTION: This transdermal drug delivery device for forming a drug delivery patch system comprises: an actuator including an outer body, a controller board, and an interface connection port; a porator array including a top surface, a bottom surface, an extension tab, and a release liner; and a reservoir patch attached to the extension tab, which is to be applied to a microporated region of tissue membrane after microporation. Methods of making and using the system are also provided. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种改进的方法和装置，用于经皮递送诸如药物的元件以及用于监测诸如血液成分的分析物。解决方案：用于形成药物递送贴片系统的透皮药物递送装置包括：致动器，包括外部主体，控制器板和接口连接端口; 包括顶表面，底表面，延伸片和释放衬垫的搬运器阵列; 以及附着在延伸片上的储存器贴片，其在微量化后应用于组织膜的微孔区域。还提供了制造和使用系统的方法。版权所有（C）2011，JPO＆INPIT

4. 发明申请

WO2006138658A2 PERMEANT DELIVERY SYSTEM AND METHODS FOR USE THEREOF 审中-公开
标题翻译：渗透剂输送系统及其使用方法
公开(公告)号：WO2006138658A2
公开(公告)日：2006-12-28
申请号：PCT/US2006023640
申请日：2006-06-19
申请人： ALTEA THERAPEUTICS CORP , EPPSTEIN JONATHAN , ENSCORE DAVID , TAGLIAFERRI FRANK , TOLIA GAURAV , CHANG SHULUN , SMITH ALAN , PATEL YOGI , MCRAE STUART
发明人： EPPSTEIN JONATHAN , ENSCORE DAVID , TAGLIAFERRI FRANK , TOLIA GAURAV , CHANG SHULUN , SMITH ALAN , PATEL YOGI , MCRAE STUART
IPC分类号： A61K9/24
CPC分类号： A61K9/7053 , A61K9/0009
摘要： Disclosed is a device for causing the transdermal flux of a permeant into a subject via at least one formed pathway through a skin layer of the subject. The device comprises a delivery reservoir comprising: i) a non-biodegradable matrix having a bottom surface and defining a plurality of conduits therein the matrix, at least a portion of the plurality of conduits being in communication with the bottom surface; and ii) an undissolved hydrophilic permeant disposed therein at least a portion of the plurality of conduits of the matrix, wherein the hydrophilic permeant can come in contact with subcutaneous fluid from the subject when the bottom surface of the matrix is positioned in fluid communication with the at least one formed pathway. Also disclosed are systems and methods for causing the transdermal flux of a permeant into a subject via at least one formed pathway through a skin layer of the subject.
摘要翻译：公开了一种用于通过穿过受试者的皮肤层的至少一个形成的途径使得渗透物经皮通流入受试者的装置。所述装置包括输送储存器，其包括：i）具有底表面并且在其中限定所述基质中的多个导管的不可生物降解的基质，所述多个导管的至少一部分与所述底表面连通; 和ii）在所述基质的所述多个导管的至少一部分中设置未溶解的亲水性渗透物，其中当所述基质的底表面位于与所述基质的流体连通时，所述亲水性透过物可与来自所述受试者的皮下流体接触至少一个形成的途径。还公开了一种系统和方法，用于通过穿过受试者的皮肤层的至少一个形成的途径使渗透物的经皮通流进入受试者。

5. 发明申请

WO2005042051A3 METHOD FOR TRANSDERMAL DELIVERY OF PERMEANT SUBSTANCES 审中-公开
标题翻译：渗透物质传递方法
公开(公告)号：WO2005042051A3
公开(公告)日：2006-04-20
申请号：PCT/US2004034715
申请日：2004-10-21
申请人： ALTEA THERAPEUTICS CORP
发明人： SMITH ALAN , EPPSTEIN JONATHAN A , MESSIER BERNADETTE , NOVAKOVIC ZORAN , MCRAE STUART
IPC分类号： A61K9/00 , A61M20060101 , A61M31/00
CPC分类号： A61M37/00 , A61K9/0009 , A61K9/0046 , A61M37/0015 , A61M37/0092 , A61M2037/0007 , A61M2037/0023 , A61M2037/0061 , A61N1/0412 , A61N1/30 , A61N1/327
摘要： A method for delivering permeant substances transdermally into a membrane of an animal includes forming a least one delivery opening in the skin tissue, with the at least one delivery opening having a mean opening depth of between about 40 and about 90 microns.
摘要翻译：透皮物质经皮递送到动物膜中的方法包括在皮肤组织中形成至少一个输送开口，其中该至少一个输送开口的平均开口深度在约40至约90微米之间。

6. 发明公开

EP2268244A4 PERMEANT DELIVERY SYSTEM AND METHODS FOR USE THEREOF 有权转让
标题翻译：采取紧急供电系统及其使用方法
公开(公告)号：EP2268244A4
公开(公告)日：2013-07-17
申请号：EP09727038
申请日：2009-03-31
申请人： ALTEA THERAPEUTICS CORP
发明人： TAGLIFERRI FRANK , SMITH ALAN , ENSCORE DAVID , TOLIA GAURAV , BAUDYS MIREK
IPC分类号： A61F13/00
CPC分类号： A61M37/00 , A61K9/7053 , A61K31/4468 , A61K31/485 , A61K47/12 , A61K47/183 , A61K47/38
摘要： Disclosed are a patch, system, and method for delivery of a permeant composition into a subject via at least one formed pathway through a biological membrane of the subject. The patch comprises a matrix, at least one hydrophilic permeant disposed within the matrix, wherein at least a portion of the permeant can dissolve in biological moisture received from the subject, and at least one permeability enhancer disposed within the matrix. Also disclosed are systems and methods for delivery of a permeant composition into a subject via at least one formed pathway through a skin layer of the subject.

7. 发明公开

EP1689483A4 METHOD FOR TRANSDERMAL DELIVERY OF PERMEANT SUBSTANCES 无效转让
标题翻译：程序对PERMEATIONSSUBSTANZEN透皮给药
公开(公告)号：EP1689483A4
公开(公告)日：2007-09-12
申请号：EP04795823
申请日：2004-10-21
申请人： ALTEA THERAPEUTICS CORP
发明人： SMITH ALAN , EPPSTEIN JONATHAN A , MESSIER BERNADETTE , NOVAKOVIC ZORAN , MCRAE STUART
IPC分类号： A61M31/00 , A61K9/00 , A61M20060101
CPC分类号： A61M37/00 , A61K9/0009 , A61K9/0046 , A61M37/0015 , A61M37/0092 , A61M2037/0007 , A61M2037/0023 , A61M2037/0061 , A61N1/0412 , A61N1/30 , A61N1/327
摘要： A method for delivering permeant substances transdermally into a membrane of an animal includes forming a least one delivery opening in the skin tissue, with the at least one delivery opening having a mean opening depth of between about 40 and about 90 microns.

8. 发明公开

EP1906846A4 PERMEANT DELIVERY SYSTEM AND METHODS FOR USE THEREOF 有权转让
标题翻译：退休人员安哥拉
公开(公告)号：EP1906846A4
公开(公告)日：2012-12-19
申请号：EP06773439
申请日：2006-06-19
申请人： ALTEA THERAPEUTICS CORP
发明人： PATEL YOGI , TOLIA GAURAV , TAGLIAFERRI FRANK , ENSCORE DAVID , EPPSTEIN JONATHAN , SMITH ALAN , MCRAE STUART , CHANG SHULUN
IPC分类号： A61B17/20 , A61K9/00 , A61K9/70
CPC分类号： A61K9/7053 , A61K9/0009
摘要： Disclosed is a device for causing the transdermal flux of a permeant into a subject via at least one formed pathway through a skin layer of the subject. The device comprises a delivery reservoir comprising: i) a non-biodegradable matrix having a bottom surface and defining a plurality of conduits therein the matrix, at least a portion of the plurality of conduits being in communication with the bottom surface; and ii) an undissolved hydrophilic permeant disposed therein at least a portion of the plurality of conduits of the matrix, wherein the hydrophilic permeant can come in contact with subcutaneous fluid from the subject when the bottom surface of the matrix is positioned in fluid communication with the at least one formed pathway. Also disclosed are systems and methods for causing the transdermal flux of a permeant into a subject via at least one formed pathway through a skin layer of the subject.
摘要翻译：公开了一种用于通过穿过受试者的皮肤层的至少一个形成的途径使每个意图的经皮通量引入受试者的装置。所述装置包括输送储存器，其包括：i）具有底表面并且在其中限定所述基质中的多个导管的不可生物降解的基质，所述多个导管的至少一部分与所述底表面连通; 和ii）未溶解的亲水剂，其中每个意图在其中设置多个基质管道的至少一部分，其中当基质的底表面位于流体连通中时，每个意图的亲水剂可以与来自受试者的皮下流体接触与至少一个形成的途径。还公开了用于通过穿过受试者的皮肤层的至少一个形成的途径使每个意图的经皮通量引入受试者的系统和方法。

9. 发明公开

EP1483019A4 TRANSDERMAL DRUG DELIVERY PATCH SYSTEM, METHOD OF MAKING SAME AND METHOD OF USING SAME 审中-公开
标题翻译：透皮药物充电系统补丁，方法用于生产和使用方法的THEREOF
公开(公告)号：EP1483019A4
公开(公告)日：2007-07-04
申请号：EP03744634
申请日：2003-03-11
申请人： ALTEA THERAPEUTICS CORP
发明人： EPPSTEIN JONATHAN , MCRAE STUART , SMITH ALAN
IPC分类号： A61M5/30 , A61F13/00 , A61M20060101 , A61M5/24 , A61M37/00 , A61N1/30 , A61N1/32
CPC分类号： A61M37/0015 , A61M37/00 , A61M2037/0007 , A61M2037/0023 , A61M2037/0061 , A61M2205/33 , A61M2205/3303 , A61M2210/04 , A61M2230/20 , A61N1/0424 , A61N1/044 , A61N1/0476 , A61N1/325 , A61N1/326 , A61N1/327

10. 发明专利

CA2478822A1 TRANSDERMAL DRUG DELIVERY PATCH SYSTEM, METHOD OF MAKING SAME AND METHOD OF USING SAME 未知
公开(公告)号：CA2478822A1
公开(公告)日：2003-09-25
申请号：CA2478822
申请日：2003-03-11
申请人： ALTEA THERAPEUTICS CORP
发明人： EPPSTEIN JONATHAN , MCRAE STUART , SMITH ALAN
IPC分类号： A61M5/30 , A61F13/00 , A61M20060101 , A61M5/24 , A61M37/00 , A61N1/30 , A61N1/32
摘要： The invention provides for a transdermal drug delivery device for forming a drug delivery patch system comprising: a) an actuator (100) comprising: i) a n outer body defining a top of the actuator, the outer body containing a cavit y; ii) a controller board comprising driving electronics and a battery, the controller board being positioned within the cavity; and iii) an interface connection port for receiving a porator array, the interface connection port containing an anode and a cathode; b) a reservoir patach attached to the an extention tub, the reservoir patch being applied to the microporated area of a tissue membrane after poration.

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