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1. 发明申请

WO2006092417A1 6 -HETEROARYL-1, 2, 3,4,4A, 1OB-HEXAHYDRO-PHENANTHRIDINES AS PDE-4 INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISORDERS 审中-公开
标题翻译： 6 -HETEROARYL-1,2,4,4,4A，1-B-HEXAHYDRO-PHENANTHRIDINES作为治疗炎症性疾病的PDE-4抑制剂
公开(公告)号：WO2006092417A1
公开(公告)日：2006-09-08
申请号：PCT/EP2006/060370
申请日：2006-03-01
申请人： ALTANA PHARMA AG , KAUTZ, Ulrich , SCHMIDT, Beate , FLOCKERZI, Dieter , CHIESA, Maria Vittoria , HATZELMANN, Armin , ZITT, Christof , WOHLSEN, Andrea , MARX, Degenhard , KLEY, Hans-peter
发明人： KAUTZ, Ulrich , SCHMIDT, Beate , FLOCKERZI, Dieter , CHIESA, Maria Vittoria , HATZELMANN, Armin , ZITT, Christof , WOHLSEN, Andrea , MARX, Degenhard , KLEY, Hans-peter
IPC分类号： C07D401/04 , C07D401/14 , A61K31/473 , A61P29/00 , A61P11/00
CPC分类号： C07D401/04
摘要： Compounds of a certain formula (I), in which R1 , R2, R3, R31, R4, R5, R51 and Har have the meanings indicated in the description, are novel effective PDE4 inhibitors.
摘要翻译：其中R1，R2，R3，R31，R4，R5，R51和Har具有说明书中所示含义的某种式（I）的化合物是新的有效的PDE4抑制剂。

2. 发明申请

WO2005090345A1 NOVEL N- (ALKOXYALKYL) CARBAMOYL - SUBSTITUTED 6-PHENYL-BENZONAPHTHYRIDINE DERIVATIVES AND THEIR USE AS PDE3/4 INHIBITORS 审中-公开
标题翻译：新型N-（烷氧基）羰基 - 取代的6-苯基 - 苯并噻吩衍生物及其作为PDE3 / 4抑制剂的用途
公开(公告)号：WO2005090345A1
公开(公告)日：2005-09-29
申请号：PCT/EP2005/051204
申请日：2005-03-16
申请人： ALTANA PHARMA AG , FLOCKERZI, Dieter
发明人： FLOCKERZI, Dieter , KAUTZ, Ulrich , HATZELMANN, Armin , BARSIG, Johannes , MARX, Degenhard , KLEY, Hans-Peter
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： Compounds of formula (1), in which R1 is 1-4C-alkyl, R2 is hydroxyl, 1-4C-alkoxy. 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy, or 1-4C-alkoxy which is completely or predominantly substituted by fluorine, R3 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy, or 1-4C-alkoxy which is completely or predominantly substituted by fluorine, or in which R2 and R3 together are a 1-2C-alkylenedioxy group, R4 is hydrogen, halogen, nitro, 1-4C-alkyl, trifluoromethyl or 1-4C-alkoxy, R5 is hydrogen, 1-8C-alkyl, 3-7C-cycloalkyl or phenyl-1-4C-alkyl, R6 is 1-4C-alkyl, phenyl-1-4C-alkyl, or Aryl-1-4C-alkyl, in which Aryl is R61 - and/or R62-substituted phenyl, in which R61 is 1-4C-alkoxy, trifluoromethyl or cyano, R62 is 1-4C-alkoxy, and in which either R7 is 1-4C-alkyl, and n is 1 or 2, or R7 is hydrogen, and n is 1, 2 or 3, the salts, the N-oxides of these compounds and the salts of the latter are novel effective PDE3/4 inhibitors.
摘要翻译：式（1）的化合物，其中R 1是1-4C-烷基，R 2是羟基，1-4C-烷氧基。完全或主要被氟取代的3-7C-环烷氧基，3-7C-环烷基甲氧基或1-4C-烷氧基，R3是羟基，1-4C-烷氧基，3-7C-环烷氧基，3-7C-环烷基甲氧基或完全或主要被氟取代的1-4C-烷氧基，或其中R2和R3一起是1-2C-亚烷基二氧基，R4是氢，卤素，硝基，1-4C-烷基，三氟甲基或1-4C- 烷氧基，R 5是氢，1-8C-烷基，3-7C-环烷基或苯基1-4C-烷基，R6是1-4C-烷基，苯基1-4C-烷基或芳基 - 1-4C-烷基其中芳基是R61 - 和/或R62-取代的苯基，其中R61是1-4C-烷氧基，三氟甲基或氰基，R62是1-4C-烷氧基，其中R7是1-4C-烷基，和 n为1或2，或R7为氢，n为1,2或3，这些化合物的N-氧化物和后者的盐为新的有效的PDE3 / 4抑制剂。

3. 发明申请

WO2006095009A1 AMIDO-SUBSTITUTED 6-PHENYLPHENANTHRIDINES 审中-公开
标题翻译：氨基取代的6-苯基苯胺
公开(公告)号：WO2006095009A1
公开(公告)日：2006-09-14
申请号：PCT/EP2006/060595
申请日：2006-03-09
申请人： ALTANA PHARMA AG , KAUTZ, Ulrich , SCHMIDT, Beate , FLOCKERZI, Dieter , CHIESA, Maria Vittoria , HATZELMANN, Armin , ZITT, Christof , BARSIG, Johannes , MARX, Degenhard , KLEY, Hans-Peter
发明人： KAUTZ, Ulrich , SCHMIDT, Beate , FLOCKERZI, Dieter , CHIESA, Maria Vittoria , HATZELMANN, Armin , ZITT, Christof , BARSIG, Johannes , MARX, Degenhard , KLEY, Hans-Peter
IPC分类号： C07D401/10 , C07D221/12 , A61K31/473 , A61P11/00
CPC分类号： C07D401/10 , C07D221/12
摘要： Compounds of a certain formula (I), in which R1, R2, R3, R31, R4, R5, R51, R6 and R7 have the meanings indicated in the description, are novel effective PDE4 inhibitors.
摘要翻译：其中R 1，R 2，R 3，R 31，R 4，R 5，R 51，R 6和R 7具有说明书中所示含义的某种式（I）的化合物是新的有效的PDE4抑制剂。

4. 发明申请

WO2006027345A3 NOVEL 3-THIA-10-AZA-PHENANTHRENE DERIVATIVES 审中-公开
公开(公告)号：WO2006027345A3
公开(公告)日：2006-03-16
申请号：PCT/EP2005/054365
申请日：2005-09-05
申请人： ALTANA PHARMA AG , FLOCKERZI, Dieter , KAUTZ, Ulrich , HATZELMANN, Armin , ZITT, Christof , WOHLSEN, Andrea , MARX, Degenhard , KLEY, Hans-Peter , CHRISTOFFERS, Jens , ROSIAK, Anna
发明人： FLOCKERZI, Dieter , KAUTZ, Ulrich , HATZELMANN, Armin , ZITT, Christof , WOHLSEN, Andrea , MARX, Degenhard , KLEY, Hans-Peter , CHRISTOFFERS, Jens , ROSIAK, Anna
IPC分类号： C07D495/06 , A61P11/00 , A61K31/4745
摘要： Compounds of a certain formula 1, in which A, R1, R2 and R3 have the meanings indicated in the de- scription, are novel effective PDE4 inhibitors.

5. 发明申请

WO2006027344A2 NOVEL 3-OXA-10-AZA-PHENANTHRENES 审中-公开
标题翻译：新型3-OXA-10-AZA-PHENANTHRENES
公开(公告)号：WO2006027344A2
公开(公告)日：2006-03-16
申请号：PCT/EP2005/054364
申请日：2005-09-05
申请人： ALTANA PHARMA AG , FLOCKERZI, Dieter , KAUTZ, Ulrich , HATZELMANN, Armin , ZITT, Christof , WOHLSEN, Andrea , MARX, Degenhard , KLEY, Hans-Peter , CHRISTOFFERS, Jens , ROSIAK, Anna
发明人： FLOCKERZI, Dieter , KAUTZ, Ulrich , HATZELMANN, Armin , ZITT, Christof , WOHLSEN, Andrea , MARX, Degenhard , KLEY, Hans-Peter , CHRISTOFFERS, Jens , ROSIAK, Anna
CPC分类号： C07D491/04
摘要： Compounds of a certain formula 1, in which R1, R2 and R3 have the meanings indicated in the description, are novel effective PDE4 inhibitors.
摘要翻译： R1，R2和R3具有说明书中所示含义的某种式1的化合物是新的有效的PDE4抑制剂。

6. 发明申请

WO2006082185A1 NOVEL 6-PYRIDYLPHENANTHRIDINES 审中-公开
标题翻译：新型6-吡啶基亚胺
公开(公告)号：WO2006082185A1
公开(公告)日：2006-08-10
申请号：PCT/EP2006/050557
申请日：2006-01-31
申请人： ALTANA Pharma AG , KAUTZ, Ulrich , SCHMIDT, Beate , FLOCKERZI, Dieter , CHIESA, Maria Vittoria , HATZELMANN, Armin , ZITT, Christof , BARSIG, Johannes , WOHLSEN, Andrea , MARX, Degenhard , KLEY, Hans-peter
发明人： KAUTZ, Ulrich , SCHMIDT, Beate , FLOCKERZI, Dieter , CHIESA, Maria Vittoria , HATZELMANN, Armin , ZITT, Christof , BARSIG, Johannes , WOHLSEN, Andrea , MARX, Degenhard , KLEY, Hans-peter
IPC分类号： C07D401/04 , A61K31/473 , A61P11/06
CPC分类号： C07D401/04
摘要： Compounds of a certain formula I, in which R1, R2, R3, R31, R4, R5, R51 and Har have the meanings indicated in the description, are novel effective PDE4 inhibitors.
摘要翻译：其中R1，R2，R3，R31，R4，R5，R51和Har具有说明书中所示含义的某种式I的化合物是新的有效的PDE4抑制剂。

7. 发明申请

WO2006072615A2 TRIAZOLOPHTHALAZINES 审中-公开
公开(公告)号：WO2006072615A2
公开(公告)日：2006-07-13
申请号：PCT/EP2006/050041
申请日：2006-01-04
申请人： ALTANA Pharma AG , SCHMIDT, Beate , WEINBRENNER, Steffen , FLOCKERZI, Dieter , KÜLZER, Raimund , TENOR, Hermann , KLEY, Hans-Peter
发明人： SCHMIDT, Beate , WEINBRENNER, Steffen , FLOCKERZI, Dieter , KÜLZER, Raimund , TENOR, Hermann , KLEY, Hans-Peter
CPC分类号： C07D487/04
摘要： The compounds of formula (I) in which R1 and R2 have the meanings as given in the description are novel effective PDE2 inhibitors.
摘要翻译：其中R1和R2具有如说明书中给出的含义的式（I）化合物是新的有效的PDE2抑制剂。

8. 发明申请

WO2002066476A1 6-PHENYLBENZONAPHTHYRIDINES 审中-公开
标题翻译： 6- PHENYLBENZONAPHTHYRIDINES
公开(公告)号：WO2002066476A1
公开(公告)日：2002-08-29
申请号：PCT/EP2002/001819
申请日：2002-02-21
申请人： ALTANA Pharma AG , FLOCKERZI, Dieter
发明人： FLOCKERZI, Dieter , GUTTERER, Beate , GRUNDLER, Gerhard , HATZELMANN, Armin , BEUME, Rolf , BUNDSCHUH, Daniela , KLEY, Hans-Peter , NAVE, Rüdiger , ZECH, Karl , REUTTER, Felix
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , A61K31/47 , Y02A50/409 , Y02A50/411
摘要： Compounds of the formula (I), in which R1, R2, R3, R4 and R5 have the meanings indicated in the description, are novel effective PDE3/4 inhibitors.
摘要翻译：其中R1，R2，R3，R4和R5具有说明书中所示含义的式（I）化合物是新型有效的PDE3 / 4抑制剂。

9. 发明申请

WO2006072612A2 TRIAZOLOPHTHALAZINES 审中-公开
公开(公告)号：WO2006072612A2
公开(公告)日：2006-07-13
申请号：PCT/EP2006/050032
申请日：2006-01-04
申请人： ALTANA PHARMA AG , SCHMIDT, Beate , WEINBRENNER, Steffen , FLOCKERZI, Dieter , KÜLZER, Raimund , TENOR, Hermann , KLEY, Hans-peter
发明人： SCHMIDT, Beate , WEINBRENNER, Steffen , FLOCKERZI, Dieter , KÜLZER, Raimund , TENOR, Hermann , KLEY, Hans-peter
CPC分类号： C07D487/04
摘要： The compounds of formula I in which R1, R2 and R3 have the meanings as given in the description are novel effective PDE2 inhibitors.
摘要翻译：其中R1，R2和R3具有本说明书中给出的含义的式I化合物是新型有效的PDE2抑制剂。

10. 发明申请

WO2006024640A2 TRIAZOLOPHTHALAZINES 审中-公开
公开(公告)号：WO2006024640A2
公开(公告)日：2006-03-09
申请号：PCT/EP2005/054266
申请日：2005-08-31
申请人： ALTANA PHARMA AG , SCHMIDT, Beate , WEINBRENNER, Steffen , FLOCKERZI, Dieter , KUELZER, Raimund , TENOR, Hermann , KLEY, Hans-Peter
发明人： SCHMIDT, Beate , WEINBRENNER, Steffen , FLOCKERZI, Dieter , KUELZER, Raimund , TENOR, Hermann , KLEY, Hans-Peter
CPC分类号： C07D487/04
摘要： The compounds of formula (I) in which R1 and R2 have the meanings as given in the description are novel effective PDE2 inhibitors.
摘要翻译：其中R 1和R 2具有如在说明书中给出的含义的式（I）化合物是新的有效PDE 2抑制剂。

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