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1. 发明申请

WO2005058798A8 COMPOUNDS HAVING SELECTIVE CYTOCHROME P450RAI-1 OR SELECTIVE CYTOCHROME P450RAI-2 INHIBITORY ACTIVITY AND METHODS OF OBTAINING THE SAME 审中-公开
标题翻译：具有选择性细胞色素P450RAI-1或选择性细胞色素P450RAI-2抑制活性的化合物及获得相同物质的方法
公开(公告)号：WO2005058798A8
公开(公告)日：2005-10-13
申请号：PCT/US2004042897
申请日：2004-12-17
申请人： ALLERGAN INC , VASUDEVAN JAYASREE , WANG LIMING , LIU XIAOXIA , TSANG KWOK YIN , LI LING , TAKEUCHI JANET A , VU THONG , BEARD RICHARD L , BHAT SMITA , VULIGONDA VIDYASAGAR , CHANDRARATNA ROSHANTHA A
发明人： VASUDEVAN JAYASREE , WANG LIMING , LIU XIAOXIA , TSANG KWOK YIN , LI LING , TAKEUCHI JANET A , VU THONG , BEARD RICHARD L , BHAT SMITA , VULIGONDA VIDYASAGAR , CHANDRARATNA ROSHANTHA A
IPC分类号： C07C57/42 , C07C59/64 , C07C59/86 , C07C69/18 , C07C69/73 , C07C69/753 , C07C69/76 , C07C229/34 , C07C229/38 , C07C229/46 , C07C229/50 , C07C275/42 , C07D311/58 , C07D311/64 , C07D311/96
CPC分类号： C07C69/73 , C07C57/42 , C07C59/64 , C07C59/86 , C07C69/753 , C07C69/76 , C07C229/34 , C07C229/38 , C07C229/46 , C07C229/50 , C07C275/42 , C07C2601/02 , C07C2602/10 , C07D311/58 , C07D311/64 , C07D311/96
摘要： Compounds of formulas 1 through 17 provided in the specification specifically or selectively inhibit either the cytochrome P450RAI-1 enzyme or the cytochrome P450RAI-2 enzyme.
摘要翻译：说明书中提供的式1至17的化合物特异性地或选择性地抑制细胞色素P450RAI-1酶或细胞色素P450RAI-2酶。

2. 发明申请

WO2005058798A3 Compounds having selective cyrochrome P450RA-1 or selective cytochrome P450RA-2 inhibitory activity and methods of obtaining the same 审中-公开
标题翻译：具有选择性细胞色素P450RA-1或选择性细胞色素P450RA-2抑制活性的化合物及其获得方法
公开(公告)号：WO2005058798A3
公开(公告)日：2006-02-16
申请号：PCT/US2004042897
申请日：2004-12-17
申请人： ALLERGAN INC , VASUDEVAN JAYASREE , WANG LIMING , LIU XIAOXIA , TSANG KOWK YIN , LI LING , TAKEUCHI JANET A , VU THONG , BEARD RICHARD L , BHAT SMITA , VULIGONDA VIDYASAGAR , CHADRARATNA ROSHANTA A
发明人： VASUDEVAN JAYASREE , WANG LIMING , LIU XIAOXIA , TSANG KOWK YIN , LI LING , TAKEUCHI JANET A , VU THONG , BEARD RICHARD L , BHAT SIMITA , VULIGONDA VIDYASAGAR , CHADRARATNA ROSHANTA A
IPC分类号： C07C57/42 , C07C59/64 , C07C59/86 , C07C69/18 , C07C69/73 , C07C69/753 , C07C69/76 , C07C229/34 , C07C229/38 , C07C229/46 , C07C229/50 , C07C275/42 , C07D311/58 , C07D311/64 , C07D311/96 , C07C299/46
CPC分类号： C07C69/73 , C07C57/42 , C07C59/64 , C07C59/86 , C07C69/753 , C07C69/76 , C07C229/34 , C07C229/38 , C07C229/46 , C07C229/50 , C07C275/42 , C07C2601/02 , C07C2602/10 , C07D311/58 , C07D311/64 , C07D311/96
摘要： Compounds of formulas 1 through 17 provided in the specification specifically or selectively inhibit either the cytochrome P450RAI-1 enzyme or the cytochrome P450RAI-2 enzyme.

3. 发明申请

WO2005042509A8 7-`(7-ALKOXY)-CHROM-3-EN-6-YL!-HEPTATRIENOIC ACID AND 7-`(3ALKOXY)-5,6-DIHYDRONAPHTHALEN-2-YL!-HEPTATRIENOIC ACID DERIVATIVES MODULATORS 审中-公开
标题翻译： 7-（3-羟基）-CHROM-3-EN-6-YL！ - 庚酸和7-（3-羟基）-5,6-二氢萘-2-炔-1-羧酸衍生物调节剂
公开(公告)号：WO2005042509A8
公开(公告)日：2005-11-10
申请号：PCT/US2004035965
申请日：2004-10-29
申请人： ALLERGAN INC , BEARD RICHARD L , DUONG TIEN T , TAKEUCHI JANET A , LI LING , TSANG KWOK YIN , LIU XIAOXIA , VASUDEVAN JAYASREE , WANG LIMING , SINHA SANTOSH C , YUAN HAIQING , CHANDRARATNA ROSHANTHA A
发明人： BEARD RICHARD L , DUONG TIEN T , TAKEUCHI JANET A , LI LING , TSANG KWOK YIN , LIU XIAOXIA , VASUDEVAN JAYASREE , WANG LIMING , SINHA SANTOSH C , YUAN HAIQING , CHANDRARATNA ROSHANTHA A
IPC分类号： A61K31/21 , A61K31/335 , C07C59/72 , C07C69/587 , C07C69/734 , C07D311/58 , A61P3/00
CPC分类号： C07C69/734 , C07C59/72 , C07C2601/02 , C07C2602/28 , C07D311/58
摘要： Compounds for the formula (I) where the variables have the meaning defined in the specification are capable of reducing serum glucose levels in diabetic mammals without the undesirable side effects on transiently increasing triglyceride levels and reducing serum thyroxine levels.
摘要翻译：式（I）化合物，其中变量具有本说明书中定义的含义，能够降低糖尿病哺乳动物血清葡萄糖水平，而不会对短暂增加甘油三酯水平和降低血清甲状腺素水平产生不良副作用。

4. 发明申请

WO2012044904A3 METHOD TO REDUCE ADHERED GLASS FROM LCD SUBSTRATE 审中-公开
标题翻译：从LCD基板降低附着玻璃的方法
公开(公告)号：WO2012044904A3
公开(公告)日：2012-08-02
申请号：PCT/US2011054168
申请日：2011-09-30
申请人： CORNING INC , MCELHENY DOUGLAS E , MOSELEY GLEN R , WANG LIMING
发明人： MCELHENY DOUGLAS E , MOSELEY GLEN R , WANG LIMING
IPC分类号： C03B20/00 , C03B5/00 , C03B33/00
CPC分类号： C03B33/0215 , C03C17/002 , C03C2218/355 , Y02P40/57
摘要： A method of making a sheet of glass comprises the steps of machining a target area of a strip of glass, wherein glass fragments are formed and detach from the strip of glass, and applying a slip agent on the glass fragments. Moreover, an apparatus for making a sheet of glass includes a machining tool including an edge configured to machine a target area of a strip of glass such that glass fragments are formed and detach from the strip of glass; and an emitting device configured to apply a slip agent on the glass fragments.
摘要翻译：制造玻璃板的方法包括以下步骤：加工玻璃条的目标区域，其中形成玻璃碎片并从玻璃条上分离，并将滑爽剂施加在玻璃碎片上。此外，用于制造玻璃板的装置包括：加工工具，其包括边缘，该边缘被配置为加工玻璃条的目标区域，使得玻璃碎片形成并从玻璃条带分离; 以及配置成将滑爽剂施加在玻璃碎片上的发射装置。

5. 发明申请

WO2010099304A2 METHOD FOR SHAPING REGIONS ON A GLASS RIBBON 审中-公开
标题翻译：在玻璃纤维上形成区域的方法
公开(公告)号：WO2010099304A2
公开(公告)日：2010-09-02
申请号：PCT/US2010025390
申请日：2010-02-25
申请人： CORNING INC , DANNOUX THIERRY L , WANG LIMING
发明人： DANNOUX THIERRY L , WANG LIMING
IPC分类号： C03B18/02 , C03B17/06 , C03B18/04
CPC分类号： C03B17/068 , C03B17/065 , C03B17/067
摘要： A method of shaping a region (26) on a glass ribbon (20), the glass ribbon including a softening point, and a thickness (24). The method includes, at a location where the glass ribbon has a viscosity less than or equal to 7x1014 poise: causing the region of the glass ribbon to be at a temperature at or above the softening point temperature; and applying tension (35, 37) to the glass ribbon, across the region, so as to form a necked-down section (27) in the region, wherein the necked-down section has a thickness (28) that is less than the thickness of the glass ribbon on each side of the region. Non-sharp portions (29) may be formed together with the necked-down section. The ribbon may then be broken along the necked-down section to separate portions from one another.
摘要翻译：一种在玻璃带（20）上形成区域（26）的方法，所述玻璃带包括软化点和厚度（24）。该方法包括在玻璃带的粘度小于或等于7×10 14泊的位置处：使玻璃带的区域处于软化点温度以上的温度; 并且在所述区域中向所述玻璃带施加张力（35,37），以便在所述区域中形成缩颈部分（27），其中所述颈缩部分具有小于所述颈缩部分的厚度（28）玻璃带的厚度在该区域的每一侧。非锐利部分（29）可以与颈缩部分一起形成。然后，带可以沿着颈缩部分断开以将部分彼此分开。

6. 发明申请

WO2005074995A2 COMBINED USE OF PRAME INHIBITORS AND HDAC INHIBITORS 审中-公开
标题翻译： PRAME抑制剂和HDAC抑制剂的组合使用
公开(公告)号：WO2005074995A2
公开(公告)日：2005-08-18
申请号：PCT/EP2005000937
申请日：2005-01-27
申请人： VERENIGING HET NL KANKER I , BERNARDS RENE , EPPING MIRJAM , WANG LIMING
发明人： BERNARDS RENE , EPPING MIRJAM , WANG LIMING
IPC分类号： A61K31/16 , A61K31/203 , A61K45/06 , A61K48/00 , C12N15/113
CPC分类号： A61K31/7088 , A61K31/16 , A61K31/18 , A61K31/203 , A61K45/06 , A61K48/00 , C12N15/113 , C12N2310/111 , C12N2310/14 , C12N2320/31 , A61K2300/00
摘要： The invention relates to the cancer antigen PRAME (PReferentially expressed Antigen in MElanoma) and its use in a method of treatment of a tumour which comprises administering to a subject in need of treatment an effective amount of an inhibitor of PRAME, in combination with a second agent selected from the group of an inhibitor of HDAC (an HDACi) and a retinoid.
摘要翻译：本发明涉及癌抗原PRAME（MElanoma中PRELY表达的抗原）及其在治疗肿瘤的方法中的应用，其包括向需要治疗的受试者施用有效量的PRAME抑制剂，与第二选自HDAC抑制剂（HDACi）和类视黄醇类的药剂。

7. 发明申请

WO2008005899A2 MULTIPLEXED RAMAN DETECTION WITH FILTER SET 审中-公开
标题翻译：多功能拉曼探测与滤波器组
公开(公告)号：WO2008005899A2
公开(公告)日：2008-01-10
申请号：PCT/US2007072595
申请日：2007-06-29
申请人： INTEL CORP , SUN LEI , KOO TAE WOONG , WANG LIMING
发明人： SUN LEI , KOO TAE WOONG , WANG LIMING
CPC分类号： G01N21/658 , G01J3/36 , G01J3/44
摘要： A device (and methods of using and manufacturing the device) that utilize a plurality of photomultipliers (PMT)s or a photodiodes coupled with a set of filters to collect Raman signal from samples. Also a method of detecting Raman signals includes receiving Raman signals from a sample utilizing a plurality of photomultiplier tubes (PMT)s or photodiodes, wherein at least one PMT or photodiode provides a different Raman signal than at least one other PMT or photodiode.
摘要翻译：使用多个光电倍增管（PMT）或与一组滤波器耦合的光电二极管以从样品收集拉曼信号的装置（以及使用和制造该装置的方法）。检测拉曼信号的方法还包括利用多个光电倍增管（PMT）或光电二极管从样品接收拉曼信号，其中至少一个PMT或光电二极管提供与至少一个其它PMT或光电二极管不同的拉曼信号。

8. 发明申请

WO2010138451A3 LASER SCORING OF GLASS AT ELEVATED TEMPERATURES 审中-公开
标题翻译：在高温下激光玻璃的分级
公开(公告)号：WO2010138451A3
公开(公告)日：2011-03-10
申请号：PCT/US2010035954
申请日：2010-05-24
申请人： CORNING INC , ABRAMOV ANATOLI A , KELLEY MICHAEL T , WANG LIMING , ZHOU NAIYUE
发明人： ABRAMOV ANATOLI A , KELLEY MICHAEL T , WANG LIMING , ZHOU NAIYUE
IPC分类号： B23K26/08 , B23K26/04 , B23K26/36 , C03B33/033 , C03B33/09 , H01S3/10
CPC分类号： C03B33/091 , C03B33/0215 , Y02P40/57
摘要： Laser scoring of individual glass sheets (45, 112) and glass ribbons (27) at elevated temperatures is disclosed. A uniform vent can be created along an intended score line (31, 115) by heating a glass surface (114) with a laser beam (113) up to a temperature in a range whose lower limit (11) is defined by the stress required to maintain propagation of an initial flaw (111) to form the vent and whose upper limit (13) is equal to or less than the strain point of the glass. In certain embodiments, the glass temperature under the laser beam (113) stays within these limits regardless of the background temperature of the glass through the use of flexible laser power control provided by a controller (35) which causes a laser (37) to produce a laser power profile along the score line (31, 115) which varies inversely with the glass temperature gradient. The glass temperature gradient can, for example, be detected in real time using a detector (33), e.g., an infrared camera. By controlling the laser beam power in this way, process margins can be significantly increased during the scoring of individual glass sheets (45, 112) and glass ribbons (27) that exhibit significant glass temperature variations.
摘要翻译：公开了单个玻璃板（45,112）和玻璃带（27）在高温下的激光刻痕。可以通过用激光束（113）加热玻璃表面（114）直到其下限（11）由所需应力限定的范围内的温度，沿着预期刻痕线（31,115）产生均匀的排气口以保持初始缺陷（111）的传播以形成通气口，并且其上限（13）等于或小于玻璃的应变点。在某些实施例中，激光束（113）下的玻璃温度通过使用由激光器（37）产生的控制器（35）提供的柔性激光功率控制而与玻璃的背景温度无关地保持在这些限制内沿着与玻璃温度梯度成反比变化的刻痕线（31,115）的激光功率分布。玻璃温度梯度可以例如使用例如红外摄像机的检测器（33）实时检测。通过以这种方式控制激光束功率，在显示显着的玻璃温度变化的单个玻璃板（45,112）和玻璃带（27）的刻痕过程中，可以显着增加工艺边缘。

9. 发明申请

WO2008066667A3 FORMING GLASS SHEETS WITH IMPROVED SHAPE STABILITY 审中-公开
标题翻译：具有改进形状稳定性的成型玻璃板
公开(公告)号：WO2008066667A3
公开(公告)日：2008-08-28
申请号：PCT/US2007023392
申请日：2007-11-08
申请人： CORNING INC , BURDETTE STEVEN R , HE LONGTING , KLINGENSMITH LEWIS K , WANG LIMING
发明人： BURDETTE STEVEN R , HE LONGTING , KLINGENSMITH LEWIS K , WANG LIMING
IPC分类号： C03B17/06
CPC分类号： C03B17/064 , C03B17/065 , Y10T428/24
摘要： Systems, methods, apparatus and products relate to display glass from curved glass ribbons, to improve shape stability in glass ribbons, to creation of reduced stress glass ribbons, and to creation of improved shape stability and reduced stress of display glass, which may include forming slightly a curved glass ribbon in a fusion draw machine (FDM). One or more embodiments may include an isopipe having a desired curvature; an isopipe having a desired incline; an offset draw device operable to draw the glass ribbon in an inclined ribbon draw direction; one or more air jets or vacuum operable to apply air pressure to a first side of the glass ribbon, thereby creating a pressure differential on the first side; and/or one or more electrostatic force generators operable to apply electrostatic force to a first side of the glass ribbon, thereby generating an electric field differential across the glass ribbon.
摘要翻译：系统，方法，装置和产品涉及从弯曲的玻璃带展示玻璃，以改善玻璃带中的形状稳定性，产生减少应力的玻璃带，以及改善形状稳定性和降低显示玻璃的应力，这可能包括形成在熔融拉丝机（FDM）中稍微弯曲的玻璃带。一个或多个实施例可以包括具有期望曲率的等压槽; 具有期望倾斜度的等压槽; 偏移绘制装置，其可操作以将所述玻璃带画成倾斜的色带拉伸方向; 一个或多个空气喷嘴或真空可操作以将空气压力施加到玻璃带的第一侧，从而在第一侧上产生压力差; 和/或一个或多个静电力发生器可操作以将静电力施加到玻璃带的第一侧，由此在玻璃带上产生电场差。

10. 发明申请

WO2005112102A2 CHEMICAL-ENHANCED PACKAGE SINGULATION PROCESS 审中-公开
标题翻译：化学增强包装整理工艺
公开(公告)号：WO2005112102A2
公开(公告)日：2005-11-24
申请号：PCT/US2005016482
申请日：2005-05-10
申请人： GEM SERVICES INC , YILMAZ HAMZA , CHIA ANTHONY , ZENG XIAOGUANG , WONG HIE MING , WANG LIMING , ZHANG YIJU
发明人： YILMAZ HAMZA , CHIA ANTHONY , ZENG XIAOGUANG , WONG HIE MING , WANG LIMING , ZHANG YIJU
IPC分类号： H01L21/44 , H01L21/68 , H01L23/31 , H01L23/495
CPC分类号： H01L23/49548 , H01L21/6835 , H01L23/3107 , H01L24/48 , H01L24/97 , H01L2221/68331 , H01L2224/32245 , H01L2224/48247 , H01L2224/48257 , H01L2224/73265 , H01L2224/97 , H01L2924/00014 , H01L2924/01005 , H01L2924/01006 , H01L2924/01011 , H01L2924/01015 , H01L2924/01019 , H01L2924/01029 , H01L2924/01033 , H01L2924/01046 , H01L2924/01047 , H01L2924/01075 , H01L2924/01078 , H01L2924/01079 , H01L2924/01082 , H01L2924/15311 , H01L2924/181 , H01L2924/00 , H01L2924/00012 , H01L2224/45099 , H01L2224/45015 , H01L2924/207
摘要： Singulation of individual electronic packages fabricated as part of a common matrix, is accomplished by mask patterning and chemical exposure in combination with physical sawing. In one embodiment of a singulation process in accordance with the present invention, an initial, shallow saw cut into inter-package regions of the matrix exposes underlying metal to subsequent chemical etching steps. In an alternative embodiment, a separate photoresist mask may be patterned over the matrix to selectively expose metal in inter-package regions to chemical etching.
摘要翻译：作为公共矩阵的一部分制造的单个电子封装的分割是通过掩模图案化和化学暴露与物理锯切结合来实现的。在根据本发明的切割工艺的一个实施例中，切割成基体的封装间区域的初始的浅锯将暴露下面的金属到随后的化学蚀刻步骤。在替代实施例中，单独的光致抗蚀剂掩模可以在基体上图案化以选择性地将包装区域中的金属暴露于化学蚀刻。

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