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1. 发明申请

WO2012054297A3 INTRAGASTRIC IMPLANTS WITH COLLAPSIBLE FRAMES 审中-公开
标题翻译：具有可拉框的INTRAGASTRIC植入物
公开(公告)号：WO2012054297A3
公开(公告)日：2012-08-02
申请号：PCT/US2011056167
申请日：2011-10-13
申请人： ALLERGAN INC , DOMINGUEZ ZACHARY P , BABKES MITCHELL H , SCHWAB JUSTIN J , MUDD CHRISTOPHER S , HOOVER JASON
发明人： DOMINGUEZ ZACHARY P , BABKES MITCHELL H , SCHWAB JUSTIN J , MUDD CHRISTOPHER S , HOOVER JASON
IPC分类号： A61F5/00
CPC分类号： A61F5/0036 , A61F5/0033 , A61F5/0079 , A61F5/0086 , A61F5/0089
摘要： Transoral obesity treatment devices and related methods for operation thereof are described which occupy space within a stomach and/or stimulate the stomach wall. The transoral obesity treatment devices and related methods are intended to assist a patient in maintaining a healthy body weight. Features of the devices include insertion transorally and without invasive surgery, without associated patient risks of invasive surgery, and without substantial patient discomfort. The life span of these devices may be material-dependent upon long-term survivability within an acidic stomach, but is intended to last one year or longer. The devices have the capacity to vary in size and are desirably self-actuating in that they change shape and/or volume using internal motors or actuators. The changing character of the devices helps prevent the person's stomach from compensating for the implant, such as sometimes happens with static intragastric devices.
摘要翻译：描述了跨腹部肥胖症治疗装置及其相关操作方法，其占据胃内的空间和/或刺激胃壁。经腹肥胖治疗装置和相关方法旨在帮助患者保持健康的体重。器件的特征包括经皮插入和无侵入性手术，无相关患者的侵入性手术风险，无明显的患者不适。这些装置的使用寿命可能依赖于酸性胃内的长期生存能力，但意图持续一年或更长时间。这些装置具有在尺寸上变化的能力，并且希望是自动致动，因为它们使用内部电动机或致动器改变形状和/或体积。设备的变化特性有助于防止人的胃部补偿植入物，例如有时会发生静态胃内装置。

2. 发明申请

WO2012054297A4 INTRAGASTRIC IMPLANTS WITH COLLAPSIBLE FRAMES 审中-公开
标题翻译：具有可折叠框架的INTRAGASTRIC植入物
公开(公告)号：WO2012054297A4
公开(公告)日：2012-09-20
申请号：PCT/US2011056167
申请日：2011-10-13
申请人： ALLERGAN INC , DOMINGUEZ ZACHARY P , BABKES MITCHELL H , SCHWAB JUSTIN J , MUDD CHRISTOPHER S , HOOVER JASON
发明人： DOMINGUEZ ZACHARY P , BABKES MITCHELL H , SCHWAB JUSTIN J , MUDD CHRISTOPHER S , HOOVER JASON
IPC分类号： A61F5/00
CPC分类号： A61F5/0036 , A61F5/0033 , A61F5/0079 , A61F5/0086 , A61F5/0089
摘要： Transoral obesity treatment devices and related methods for operation thereof are described which occupy space within a stomach and/or stimulate the stomach wall. The transoral obesity treatment devices and related methods are intended to assist a patient in maintaining a healthy body weight. Features of the devices include insertion transorally and without invasive surgery, without associated patient risks of invasive surgery, and without substantial patient discomfort. The life span of these devices may be material-dependent upon long-term survivability within an acidic stomach, but is intended to last one year or longer. The devices have the capacity to vary in size and are desirably self-actuating in that they change shape and/or volume using internal motors or actuators. The changing character of the devices helps prevent the person's stomach from compensating for the implant, such as sometimes happens with static intragastric devices.
摘要翻译：描述了口腔肥胖治疗装置及其操作的相关方法，其占据胃内空间和/或刺激胃壁。口腔肥胖治疗装置和相关方法旨在帮助患者维持健康的体重。这些装置的特征包括经口插入并且没有侵入性手术，没有相关的患者侵入性手术风险，并且没有实质性的患者不适。这些装置的使用寿命可能与材料有关，因为这些装置在酸性胃中具有长期生存能力，但意图持续一年或更长时间。这些装置具有能够在尺寸上变化的能力，并且期望自动致动，因为它们使用内部马达或致动器改变形状和/或体积。装置的变化特征有助于防止人的胃部补偿植入物，例如有时会发生静态的胃内装置。

3. 发明申请

WO2012054522A3 ANCHORED NON- PIERCING DUODENAL SLEEVE 审中-公开
标题翻译：锚定式非刺激式套管
公开(公告)号：WO2012054522A3
公开(公告)日：2012-07-05
申请号：PCT/US2011056765
申请日：2011-10-18
申请人： ALLERGAN INC , BABKES MITCHELL H , DOMINGUEZ ZACHARY P , MUDD CHRISTOPHER S
发明人： BABKES MITCHELL H , DOMINGUEZ ZACHARY P , MUDD CHRISTOPHER S
IPC分类号： A61F5/00
CPC分类号： A61F5/0079 , A61F5/0076
摘要： An intragastric implant for obesity treatment is disclosed. The device delays digestion by providing a duodenal sleeve, and may also slows gastric emptying by limiting flow through the pyloric sphincter. The implant includes an elongated axially-compressible duodenal sleeve having a non-tissue-piercing anchor on a proximal end sized to lodge within the duodenal bulb. The anchor may have oppositely-directed anchoring flanges to resists migration in both directions. The sleeve may also have barbed ribs to resist proximal movement back up into the stomach. A method of implant includes collapsing/compressing the device and transorally advancing it through the esophagus to be deployed within the duodenum. A dissolvable jacket may constrain the implant for delivery and naturally dissolve upon implant. Removal of the implant may occur in the reverse.
摘要翻译：公开了一种用于肥胖症治疗的胃内植入物。该装置通过提供十二指肠套管来延迟消化，并且还可以通过限制通过幽门括约肌的流动来减缓胃排空。植入物包括细长的可轴向压缩的十二指肠套管，其具有在近端上的非组织穿刺锚固件，其尺寸设置成保持在十二指肠球囊内。锚固件可以具有相反方向的锚固凸缘以抵抗两个方向上的迁移。套筒还可以具有倒钩肋，以抵抗近端移动回到胃中。一种植入物的方法包括塌缩/压缩装置并将其经过食道通过食管进行部署在十二指肠内。可溶解的护套可以限制植入物用于递送，并且在植入时自然地溶解。相反，可能会发生植入物的移除。

4. 发明申请

WO2012054410A2 INTRAGASTRIC IMPLANTS WITH MULTIPLE FLUID CHAMBERS 审中-公开
标题翻译：具有多个流体泡沫的INTRAGASTRIC植入物
公开(公告)号：WO2012054410A2
公开(公告)日：2012-04-26
申请号：PCT/US2011056605
申请日：2011-10-18
申请人： ALLERGAN INC , BABKES MITCHELL H , DOMINGUEZ ZACHARY P , MUDD CHRISTOPHER S , OLROYD CRAIG , D AUGUSTA JONATHAN M
发明人： BABKES MITCHELL H , DOMINGUEZ ZACHARY P , MUDD CHRISTOPHER S , OLROYD CRAIG , D AUGUSTA JONATHAN M
IPC分类号： A61F5/00 , A61B10/00
CPC分类号： A61F5/0033 , A61F5/0036
摘要： An intragastric obesity treatment implant promotes a feeling of satiety in the patient by contacting the insides of the stomach wall, reducing the space in the stomach, or otherwise reducing the amount of food consumed. One intragastric obesity treatment implant two inflatable balloons coupled via a flow restrictor through which fluid may flow in response to peristaltic motions of a patient's stomach. Additionally, one implant comprises a pumping chamber coupled to a reservoir, where the pumping chamber moves stomach fluids into the reservoir in response to peristaltic motions of the patient's stomach.
摘要翻译：胃内肥胖治疗植入物通过接触胃壁的内部，减少胃中的空间或以其他方式减少消耗的食物量来促进患者的饱腹感。一个胃内肥胖症治疗植入两个通过限流器联接的可充气气囊，流体可以响应于患者胃的蠕动运动而流动。另外，一个植入物包括联接到储存器的泵送室，其中泵送室响应于患者胃的蠕动运动将胃液移动到储存器中。

5. 发明申请

WO2012051108A4 RE-SHAPING INTRAGASTRIC IMPLANTS 审中-公开
标题翻译：重新形成INTRAGASTRIC植入物
公开(公告)号：WO2012051108A4
公开(公告)日：2012-08-23
申请号：PCT/US2011055598
申请日：2011-10-10
申请人： ALLERGAN INC , BABKES MITCHELL H , DOMINGUEZ ZACHARY P , MUDD CHRISTOPHER S , RAVEN JOSEPH S
发明人： BABKES MITCHELL H , DOMINGUEZ ZACHARY P , MUDD CHRISTOPHER S , RAVEN JOSEPH S
IPC分类号： A61F5/00
CPC分类号： A61F5/0036
摘要： The present application provides implantable intragastric devices for the treatment of obesity. The intragastric devices advantageously act as a volume-occupying device, and is able to survive implantation in a patient's stomach for a year or longer. In addition, the intragastric devices may be configured to stimulate an inner stomach wall and/or temporarily block the pylorus to slow gastric emptying and/or be rotationally variant, thereby encouraging different stimulation points on the inner wall of the stomach and limiting the stomach's ability to adapt over long term implantation. The intragastric devices may reshape the stomach cavity, such as by pushing on opposite sides so as to "planarize" the stomach. For instance, the device may be an inflated disk, or an implantable loop or a springy coil that may be straightened for delivery/extraction yet assume the loop or coil shape upon implant.
摘要翻译：本申请提供了用于治疗肥胖的可植入胃内装置。胃内装置有利地用作体积占有装置，并且能够在患者的胃中植入一年或更长时间。此外，胃内装置可以被配置为刺激内部胃壁和/或临时阻塞幽门以减缓胃排空和/或旋转变异，由此鼓励胃内壁上的不同刺激点并限制胃的能力适应长期植入。胃内装置可以重新形成胃腔，例如通过推动相对侧以便使胃平坦化。例如，该装置可以是充气盘，或可植入环或弹性线圈，其可以被拉直以用于递送/提取，但在植入时呈现环或线圈形状。

6. 发明申请

WO2012051108A3 RE-SHAPING INTRAGASTRIC IMPLANTS 审中-公开
标题翻译：重新形成的INTRAGASTRIC植入
公开(公告)号：WO2012051108A3
公开(公告)日：2012-07-05
申请号：PCT/US2011055598
申请日：2011-10-10
申请人： ALLERGAN INC , BABKES MITCHELL H , DOMINGUEZ ZACHARY P , MUDD CHRISTOPHER S , RAVEN JOSEPH S
发明人： BABKES MITCHELL H , DOMINGUEZ ZACHARY P , MUDD CHRISTOPHER S , RAVEN JOSEPH S
IPC分类号： A61F5/00
CPC分类号： A61F5/0036
摘要： The present application provides implantable intragastric devices for the treatment of obesity. The intragastric devices advantageously act as a volume-occupying device, and is able to survive implantation in a patient's stomach for a year or longer. In addition, the intragastric devices may be configured to stimulate an inner stomach wall and/or temporarily block the pylorus to slow gastric emptying and/or be rotationally variant, thereby encouraging different stimulation points on the inner wall of the stomach and limiting the stomach's ability to adapt over long term implantation. The intragastric devices may reshape the stomach cavity, such as by pushing on opposite sides so as to "planarize" the stomach. For instance, the device may be an inflated disk, or an implantable loop or a springy coil that may be straightened for delivery/extraction yet assume the loop or coil shape upon implant.
摘要翻译：本申请提供了用于治疗肥胖症的可植入胃内装置。胃内装置有利地用作体积占用装置，并且能够在患者的胃中植入一年或更长时间。此外，胃内装置可构造成刺激胃内壁和/或暂时阻塞幽门以减缓胃排空和/或旋转变化，从而促进胃内壁上的不同刺激点并限制胃的能力以适应长期植入。胃内装置可以重塑胃腔，例如通过推动相对侧以便“平面化”胃。例如，该装置可以是充气盘，或者可植入环或弹性线圈，其可以被拉直以用于递送/提取，但在植入时呈现环或线圈形状。

7. 发明申请

WO2009158145A3 INJECTION DEVICE FOR SOFT-TISSUE AUGMENTATION FILLERS, BIOACTIVE AGENTS AND OTHER BIOCOMPATIBLE MATERIALS IN LIQUID OR GEL FORM 审中-公开
标题翻译：用于软组织填充填料，生物剂和液体或凝胶形式中的其他生物成分材料的注射装置
公开(公告)号：WO2009158145A3
公开(公告)日：2010-04-29
申请号：PCT/US2009045831
申请日：2009-06-01
申请人： ALLERGAN INC , MUDD CHRISTOPHER S , TEZEL AHMET
发明人： MUDD CHRISTOPHER S , TEZEL AHMET
IPC分类号： A61M5/20
CPC分类号： A61M5/2053 , A61B5/150129 , A61M5/19 , A61M5/20 , A61M5/24 , A61M5/2448 , A61M5/31575 , A61M5/422 , A61M5/427 , A61M5/46 , A61M39/24 , A61M2005/2006 , A61M2005/2411 , A61M2005/3125 , A61M2005/3126 , A61M2005/3128 , A61M2005/31588 , A61M2202/0007 , A61M2202/049 , A61M2202/09 , A61M2202/20 , A61M2205/19 , A61M2205/3569 , A61M2205/36 , A61M2205/3606 , A61M2205/502 , A61M2205/52 , A61M2205/586 , A61M2205/587 , A61M2205/6045 , A61M2205/6063 , A61M2205/8206 , A61M2205/8212 , A61M2205/8237 , A61M2205/8243 , A61M2210/04
摘要： Described herein are injection devices capable of automatically injecting substances into the soft tissue of a patient. The devices can inject low to high viscosity materials at predetermined, user selected injection rates, allowing the operator more control than a traditional syringe. The devices can allow mixing of more than one substance and/or reconstitution of a solid substance for injection. The injection devices described herein can allow the operator to easily inject one or more low to high viscosity liquid or gel soft-tissue augmentation fillers, one or more drugs, one or more other biocompatible materials, or combinations thereof.
摘要翻译：这里描述的是能够将物质自动注射到患者的软组织中的注射装置。这些装置可以以预定的用户选择的注射速率注入低至高粘度的材料，使得操作者比传统注射器更加控制。该装置可以允许多于一种物质的混合和/或用于注射的固体物质的重建。本文所述的注射装置可以允许操作者容易地注入一种或多种低至高粘度液体或凝胶软组织增强填料，一种或多种药物，一种或多种其它生物相容性材料或其组合。

8. 发明申请

WO2012051434A3 IMPLANTABLE COUPLING DEVICE 审中-公开
标题翻译：可植入的耦合装置
公开(公告)号：WO2012051434A3
公开(公告)日：2012-06-14
申请号：PCT/US2011056181
申请日：2011-10-13
申请人： ALLERGAN INC , HONARYAR BABAK , BORRELL MARCOS , MUDD CHRISTOPHER S , RAVEN JOSEPH S , SNOW SEAN , VINCENT VERNON L
发明人： HONARYAR BABAK , BORRELL MARCOS , MUDD CHRISTOPHER S , RAVEN JOSEPH S , SNOW SEAN , VINCENT VERNON L
IPC分类号： A61M39/02 , A61F5/00
CPC分类号： A61M39/0208 , A61B17/064 , A61F5/0056 , A61M39/04 , A61M2039/0223 , A61M2210/1053
摘要： The present invention provides a system for attaching a fluid access port to a patient. The system generally comprises an implantable access port and method for attaching an access port to a patient. In addition, a tube guard, tube shroud, tissue guard, porous coupling member and a prefabricated mesh member may be attached to the access port. For example, the prefabricated mesh may be coupled to the access port to facilitate securing the access port to the tissue of the patient.
摘要翻译：本发明提供了一种用于将流体入口连接到患者的系统。该系统通常包括可植入的入口和用于将入口连接到患者的方法。另外，管护罩，管护罩，组织防护装置，多孔联接构件和预制网状构件可以连接到进入端口。例如，预制网状物可以连接到进入端口以便于将进入端口固定到患者的组织。

9. 发明申请

WO2014190222A3 MECHANICAL SYRINGE ACCESSORY 审中-公开
标题翻译：机械式注射附件
公开(公告)号：WO2014190222A3
公开(公告)日：2015-01-15
申请号：PCT/US2014039263
申请日：2014-05-23
申请人： ALLERGAN INC
发明人： SCHWAB JUSTIN J , KAYDA EDWIN J , DOMINGUEZ ZACHARY P , MUDD CHRISTOPHER S
IPC分类号： A61M5/315
CPC分类号： A61M5/31551 , A61M5/31501 , A61M5/31526 , A61M5/31535 , A61M5/31578 , A61M5/31595 , A61M2005/3126 , A61M2205/581 , A61M2205/582 , A61M2205/583
摘要： Described herein are syringe accessories that can be attached to standard syringes. These accessories utilize one or more mechanisms that can provide at least one additional sensory feedback to the user when performing an aliquot or dosed injection. In other embodiments, the accessories can prevent overdosing.
摘要翻译：这里描述的是可附接到标准注射器的注射器附件。这些附件利用一个或多个机构，当执行等分试样或剂量注射时，可以向使用者提供至少一种额外的感官反馈。在其他实施例中，附件可以防止过量。

10. 发明专利

ES2805841T3 Dispositivo de inyección 未知
公开(公告)号：ES2805841T3
公开(公告)日：2021-02-15
申请号：ES17155371
申请日：2009-12-02
申请人： ALLERGAN INC
发明人： TEZEL AHMET , MCNERNEY KEVIN , MUDD CHRISTOPHER S , STORIE BLAKE R , MANDAROUX BASTIEN
IPC分类号： A61M5/34 , A61M5/32
摘要： Un dispositivo de inyección (10) que comprende: una jeringa (12) que tiene un cuerpo (14) adecuado para contener fluido (62), teniendo el cuerpo (14) un pistón (18) dispuesto en el mismo y un extremo distal abierto (22); un conjunto de aguja (26) que comprende una cánula (30) y un conector luer (38) acoplable con el extremo distal de jeringa (22), dicho conector luer (38) comprende un conectador (42) con un extremo distal (46) que soporta dicha cánula (30) y un extremo proximal (50) emparejable con el extremo distal de jeringa (22); una cavidad de retención de conectador (80) dispuesto en dicho conectador (42) para impedir la desconexión de dicho conectador (42) del extremo distal de jeringa (22) durante la inyección del fluido (62); y roscas internas (52, 54) dispuestas en el extremo distal de jeringa (22) y roscas externas (56, 58) dispuestas sobre dicho conectador (42) que permiten acoplamiento de emparejamiento y eyección del fluido (62) a través de dicha cánula (30) al hacer funcionar dicho pistón (18), caracterizado porque la cánula (30) tiene un calibre de aproximadamente 18 o mayor, dichas roscas internas (52, 54) tienen un paso (P) de entre aproximadamente 2 mm y aproximadamente 5 mm, suficiente para impedir adicionalmente la desconexión del conectador (42) y el extremo distal de jeringa (22) durante la inyección de fluido (62), y el dispositivo de inyección es para dispensar fluidos de alta viscosidad que comprenden una viscosidad de entre aproximadamente 50.000 cps y aproximadamente 500.000 cps.

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