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1. 发明申请

WO2011091205A2 INTRACAMERAL SUSTAINED RELEASE THERAPEUTIC AGENT IMPLANTS 审中-公开
标题翻译：内镜持续释放治疗代理植入物
公开(公告)号：WO2011091205A2
公开(公告)日：2011-07-28
申请号：PCT/US2011/021971
申请日：2011-01-21
申请人： ALLERGAN, INC. , ROBINSON, Michael R. , BURKE, James , SCHIFFMAN, Rhett
发明人： ROBINSON, Michael R. , BURKE, James , SCHIFFMAN, Rhett
IPC分类号： A61K9/00
CPC分类号： A61K9/0051 , A61K9/0024 , A61K9/1647 , A61K31/5575 , A61K47/10 , A61K47/34 , A61L27/18 , A61L27/54 , A61L27/58
摘要： Described herein are intracameral implants including at least one therapeutic agent for treatment of at least one ocular condition. The implants described herein are not anchored to the ocular tissue, but rather are held in place by currents and gravity present in the anterior chamber of an eye. The implants are preferably polymeric, biodegradable and provide sustained release of at least one therapeutic agent to both the trabecular meshwork and associated ocular tissue and the fluids within the anterior chamber of an eye.
摘要翻译：本文描述的是包括用于治疗至少一种眼部病症的至少一种治疗剂的植入物植入物。本文所述的植入物不固定在眼组织上，而是通过存在于眼前房中的电流和重力保持在适当位置。植入物优选是聚合的，可生物降解的并且提供至少一种治疗剂持续释放到小梁网和相关联的眼组织和眼睛前房内的流体。

2. 发明申请

WO2011075481A1 INTRACAMERAL DEVICES FOR SUSTAINED DELIVERY 审中-公开
标题翻译：用于持续交付的内部设备
公开(公告)号：WO2011075481A1
公开(公告)日：2011-06-23
申请号：PCT/US2010/060314
申请日：2010-12-14
申请人： ALLERGAN, INC. , ROBINSON, Michael, R. , WERHNER, Orilla , NOVAKOVIC, Zoran , BURKE, James , GHEBREMESKEL, Alazar , SPADA, Lon
发明人： ROBINSON, Michael, R. , WERHNER, Orilla , NOVAKOVIC, Zoran , BURKE, James , GHEBREMESKEL, Alazar , SPADA, Lon
IPC分类号： A61F9/00 , A61F9/007 , A61K9/00
CPC分类号： A61F9/0017 , A61F9/00781 , A61K9/0051 , A61K9/0092
摘要： Described herein are intracameral drug and/or therapeutic bioactive agent delivery devices comprising a substantially cylindrical structure for at least partial placement into the anterior chamber of an eye The intracameral delivery devices have a sustained release material associated with at least a portion of the device and at least one drug and/or therapeutic bioactive agent associated with said sustained release material.
摘要翻译：本文描述的是包括用于至少部分地放置到眼睛前房中的基本圆柱形结构的腔内药物和/或治疗性生物活性剂递送装置。室内输送装置具有与装置的至少一部分相关联的持续释放材料，并且在与所述缓释材料相关的至少一种药物和/或治疗性生物活性剂。

3. 发明申请

WO2005110368A1 INTRAOCULAR IMPLANTS OF ALPHA-2 ADRENERGIC RECEPTOR AGONISTS AND METHODS FOR IMPROVING VISION 审中-公开
标题翻译： ALPHA-2 ADRENERGIC受体激动剂的内在植入物和改善视力的方法
公开(公告)号：WO2005110368A1
公开(公告)日：2005-11-24
申请号：PCT/US2005/014607
申请日：2005-04-26
申请人： ALLERGAN, INC. , BURKE, James , HUGHES, Patrick, M. , ZHANG, Kai-Ming , LIN, Ton , HUANG, Glenn , JACKSON, Brittany, A. , WHEELER, Larry, A. , DONN, Rosy, S.
发明人： BURKE, James , HUGHES, Patrick, M. , ZHANG, Kai-Ming , LIN, Ton , HUANG, Glenn , JACKSON, Brittany, A. , WHEELER, Larry, A. , DONN, Rosy, S.
IPC分类号： A61K9/00
CPC分类号： A61L31/148 , A61K9/0051 , A61K9/204 , A61K31/498 , A61K47/34 , A61L27/58 , A61L31/06 , A61L31/16 , A61L2300/436 , A61L2300/604 , C08L67/04 , Y02A50/401
摘要： Biocompatible intraocular implants include an alpha-2 adrenergic receptor agonist and a polymer associated with the alpha-2 adrenergic receptor agonist to facilitate release of the alpha-2 adrenergic receptor agonist into an eye for an extended period of time. The alpha-2 adrenergic receptor agonist may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. The implants can be placed in an eye to treat one or more ocular conditions, such as an ocular vasculopathy or glaucoma, among others or to improve vision in a normal eye.
摘要翻译：生物相容性眼内植入物包括α-2肾上腺素能受体激动剂和与α-2肾上腺素能受体激动剂相关的聚合物，以促进α-2肾上腺素能受体激动剂延长一段时间的眼睛释放。 α-2肾上腺素能受体激动剂可以与可生物降解的聚合物基质例如两种可生物降解的聚合物的基质相关联。植入物可以放置在眼睛中以治疗一种或多种眼部病症，例如眼睛血管病变或青光眼等，或改善正常眼睛的视力。

4. 发明申请

WO2005110367A2 SUSTAINED RELEASE INTRAOCULAR IMPLANTS AND METHODS FOR PREVENTING RETINAL DYSFUNCTION 审中-公开
标题翻译：可持续释放内镜植入物和预防后遗症的方法
公开(公告)号：WO2005110367A2
公开(公告)日：2005-11-24
申请号：PCT/US2005/014605
申请日：2005-04-26
申请人： ALLERGAN, INC. , BURKE, James , HUGUES, Patrick, M. , WERHNER, Orilla, C. , LIN, Ton , ESCOBAR, Maria , HUANG, Glenn , ZHANG, Kai-Ming , WHEELER, Larry, A. , DONN, Rosy, S.
发明人： BURKE, James , HUGUES, Patrick, M. , WERHNER, Orilla, C. , LIN, Ton , ESCOBAR, Maria , HUANG, Glenn , ZHANG, Kai-Ming , WHEELER, Larry, A. , DONN, Rosy, S.
IPC分类号： A61K9/00
CPC分类号： A61K31/498 , A61K9/0051 , A61K47/34
摘要： Biocompatible intraocular microspheres and implants include an alpha-2 adrenergic receptor agonist and a polymer associated with the alpha-2 adrenergic receptor agonist to facilitate release of the alpha-2 adrenergic receptor agonist into an eye for an extended period of time. The alpha-2 adrenergic receptor agonist may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. The implants may be placed in an eye to treat or to prevent the occurrence of one or more ocular conditions, to reduce one or more symptoms of an ocular condition, such as an ocular neurosensory disorder and the like, to enhance normal retinal function and/or to lower intraocular pressure.
摘要翻译：生物相容性眼内微球和植入物包括α-2肾上腺素能受体激动剂和与α-2肾上腺素能受体激动剂相关的聚合物，以促进α-2肾上腺素能受体激动剂延长一段时间的眼睛释放。 α-2肾上腺素能受体激动剂可以与可生物降解的聚合物基质例如两种可生物降解的聚合物的基质相关联。植入物可以放置在眼睛中以治疗或防止一种或多种眼部病症的发生，以减少眼部病症（例如眼部神经感觉障碍等）的一种或多种症状，以增强正常的视网膜功能和/ 或降低眼内压。

5. 发明申请

WO2004057839A2 SYSTEM AND METHOD FOR ROUTING VOICE/VIDEO/FAX MAIL AND VIEWING A FAX DOCUMENT 审中-公开
标题翻译：用于路由语音/视频/传真邮件和查看传真文档的系统和方法
公开(公告)号：WO2004057839A2
公开(公告)日：2004-07-08
申请号：PCT/US2003/040802
申请日：2003-12-19
申请人： BURKE, James
发明人： BURKE, James
IPC分类号： H04M
CPC分类号： H04N1/00214 , H04N1/00212 , H04N1/0022 , H04N1/00334 , H04N1/00392 , H04N1/00403 , H04N1/00408 , H04N1/00427 , H04N1/0044 , H04N1/00474 , H04N1/2158 , H04N1/32133 , H04N1/32765 , H04N1/4406 , H04N1/442 , H04N1/444 , H04N1/4446 , H04N1/446 , H04N1/4473 , H04N2201/0093 , H04N2201/3205 , H04N2201/3264 , H04N2201/3267 , H04N2201/3269 , H04N2201/3278
摘要： A fax machine (10) for a system and/or method for routing voice/video/fax mail includes a processor and memory, and the fax machine (10) is configured for routing voice/video/fax mail to associated recipients. The fax machine (10) includes an operating panel (12), an operating display screen (14), a microphone/speaker (16), a telephone handset (18), a sealed paper tray (20), an auxiliary paper tray (22), a printer, an audio/video recording camera (26), a voice/video/fax mail display monitor (28), a modem (30), a processor, memory, and a communication bus which interconnects of the elements of the fax machine. The fax machine (10) may also include an additional key pad, PCI slots, voice generator circuitry, voice recognition circuitry, a sound card, a paper scanner, a bar code reader, a finger/thumb print scanner, a retina scanner, a stylus pen, a signature pad, a shredder, a network control unit, input/output ports, etc.
摘要翻译：用于路由语音/视频/传真邮件的系统和/或方法的传真机（10）包括处理器和存储器，并且传真机（10）被配置用于将语音/视频/ 传真邮件给关联的收件人。传真机10包括操作面板12，操作显示屏幕14，麦克风/扬声器16，电话听筒18，密封纸盘20，辅助纸盘 22），打印机，音频/视频记录相机（26），语音/视频/传真邮件显示监视器（28），调制解调器（30），处理器，存储器和通信总线，传真机。传真机（10）还可以包括附加键盘，PCI插槽，语音发生器电路，语音识别电路，声卡，纸质扫描仪，条形码阅读器，手指/拇指印刷扫描仪，视网膜扫描仪，手写笔，签名板，碎纸机，网络控制单元，输入/输出端口等。

6. 发明申请

WO2006096770A2 METHOD AND APPARATUS FOR DRAINING PNEUMATIC SYSTEMS 审中-公开
标题翻译：排气系统的方法和装置
公开(公告)号：WO2006096770A2
公开(公告)日：2006-09-14
申请号：PCT/US2006/008246
申请日：2006-03-07
申请人： BURKE, James
发明人： BURKE, James
IPC分类号： F26B13/10
CPC分类号： B60T17/004 , Y10S55/17 , Y10T137/8359
摘要： Methods and apparatuses for determining the condition of a pneumatic system air dryer are provided. An output of the pneumatic valve or of a conduit interconnected to the outlet of the pneumatic valve is positioned such that a discharge passed through the pneumatic valve while the valve is open is in view of an operator and/or is directed to a moisture sensor. Moreover, the discharge and/or an output device interconnected to the moisture sensor is in view of the operator while the operator is in a position to operate the pneumatic valve. An observation volume with a sight glass or window and/or a moisture sensor can be provided to facilitate the observation or detection of moisture or oil in the discharge.
摘要翻译：提供了用于确定气动系统空气干燥器的状态的方法和装置。与气动阀的出口相互连接的气动阀或导管的输出被定位成使得在阀打开时通过气动阀的排放是由操作者观察和/或被定向到湿度传感器。此外，当操作员处于操作气动阀的位置时，与操作者相关的是与湿度传感器互连的排出口和/或输出装置。可以提供具有视镜或窗口和/或湿度传感器的观察体积，以便于观察或检测放电中的水分或油。

7. 发明授权

EP1758552B1 INTRAOCULAR IMPLANTS OF ALPHA-2 ADRENERGIC RECEPTOR AGONISTS FOR PREVENTING OR REDUCING OCULAR VASCULAR OCCLUSIONS 有权
标题翻译： α-2-肾上腺素能受体激动剂为防止及治疗血管眼封闭件的眼内植入物
公开(公告)号：EP1758552B1
公开(公告)日：2011-07-13
申请号：EP05741206.6
申请日：2005-04-26
申请人： ALLERGAN, INC.
发明人： BURKE, James , HUGHES, Patrick, M. , ZHANG, Kai-Ming , LIN, Ton , HUANG, Glenn , JACKSON, Brittany, A. , WHEELER, Larry, A. , DONN, Rosy, S.
IPC分类号： A61K31/498 , A61P27/02
CPC分类号： A61L31/148 , A61K9/0051 , A61K9/204 , A61K31/498 , A61K47/34 , A61L27/58 , A61L31/06 , A61L31/16 , A61L2300/436 , A61L2300/604 , C08L67/04 , Y02A50/401
摘要： The present invention refers to a method of making a biodegradable intraocular implant, comprising the step of extruding a mixture of an alpha-2 adrenergic receptor agonist and a biodegradable polymer component to form a biodegradable material that releases drug at a rate effective to sustain release of an amount of the alpha-2 adrenergic receptor agonist from the implant for a time effective to reduce ocular vascular occlusion in an eye in which the implant is placed, the time being at least about one week after the implant is placed in the eye.

8. 发明公开

EP1758552A1 INTRAOCULAR IMPLANTS OF ALPHA-2 ADRENERGIC RECEPTOR AGONISTS AND METHODS FOR IMPROVING VISION 有权
标题翻译： α-2-肾上腺素能受体激动剂为防止及治疗血管眼封闭件的眼内植入物
公开(公告)号：EP1758552A1
公开(公告)日：2007-03-07
申请号：EP05741206.6
申请日：2005-04-26
申请人： ALLERGAN, INC.
发明人： BURKE, James , HUGHES, Patrick, M. , ZHANG, Kai-Ming , LIN, Ton , HUANG, Glenn , JACKSON, Brittany, A. , WHEELER, Larry, A. , DONN, Rosy, S.
IPC分类号： A61K9/00 , A61K31/498 , A61P27/02 , A61P27/06
CPC分类号： A61L31/148 , A61K9/0051 , A61K9/204 , A61K31/498 , A61K47/34 , A61L27/58 , A61L31/06 , A61L31/16 , A61L2300/436 , A61L2300/604 , C08L67/04 , Y02A50/401
摘要： The present invention refers to a method of making a biodegradable intraocular implant, comprising the step of extruding a mixture of an alpha-2 adrenergic receptor agonist and a biodegradable polymer component to form a biodegradable material that releases drug at a rate effective to sustain release of an amount of the alpha-2 adrenergic receptor agonist from the implant for a time effective to reduce ocular vascular occlusion in an eye in which the implant is placed, the time being at least about one week after the implant is placed in the eye.

9. 发明公开

EP2525776A2 INTRACAMERAL SUSTAINED RELEASE THERAPEUTIC AGENT IMPLANTS 有权
标题翻译： INTRAKAMERALE IMPLANTATE MIT RETARD-THERAPEUTIKA
公开(公告)号：EP2525776A2
公开(公告)日：2012-11-28
申请号：EP11701723.6
申请日：2011-01-21
申请人： Allergan, Inc.
发明人： ROBINSON, Michael R. , BURKE, James , SCHIFFMAN, Rhett
IPC分类号： A61K9/00 , A61K31/5575 , A61K47/34
CPC分类号： A61K9/0051 , A61K9/0024 , A61K9/1647 , A61K31/5575 , A61K47/10 , A61K47/34 , A61L27/18 , A61L27/54 , A61L27/58
摘要： Described herein are intracameral implants including at least one therapeutic agent for treatment of at least one ocular condition. The implants described herein are not anchored to the ocular tissue, but rather are held in place by currents and gravity present in the anterior chamber of an eye. The implants are preferably polymeric, biodegradable and provide sustained release of at least one therapeutic agent to both the trabecular meshwork and associated ocular tissue and the fluids within the anterior chamber of an eye.
摘要翻译：本文描述的是植入物植入物，其包括用于治疗至少一种眼部病症的至少一种治疗剂。本文所述的植入物不固定于眼组织，而是通过存在于眼前房中的电流和重力保持在适当的位置。植入物优选是聚合的，可生物降解的并且提供至少一种治疗剂至小梁网和相关联的眼组织和眼睛前房内的流体的持续释放。

10. 发明授权

EP2525776B1 INTRACAMERAL SUSTAINED RELEASE THERAPEUTIC AGENT IMPLANTS 有权
标题翻译：与RETARD THERAPEUTICS房内植入物
公开(公告)号：EP2525776B1
公开(公告)日：2015-10-28
申请号：EP11701723.6
申请日：2011-01-21
申请人： ALLERGAN, INC.
发明人： ROBINSON, Michael R. , BURKE, James , SCHIFFMAN, Rhett , GHEBREMESKEL, Alazar N.
IPC分类号： A61K9/00 , A61K31/5575 , A61K47/34
CPC分类号： A61K9/0051 , A61K9/0024 , A61K9/1647 , A61K31/5575 , A61K47/10 , A61K47/34 , A61L27/18 , A61L27/54 , A61L27/58

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