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1. 发明申请

WO2010074607A2 ACTIVE SUBSTANCE AND PHARMACEUTICAL COMPOSITION FOR TREATING ALCOHOL DEPENDENCE, AND A METHOD FOR OBTAINING AND THE USE OF SAID ACTIVE SUBSTANCE 审中-公开
标题翻译：用于处理酒精依赖性的活性物质和药物组合物，以及获得和使用有效物质的方法
公开(公告)号：WO2010074607A2
公开(公告)日：2010-07-01
申请号：PCT/RU2009000691
申请日：2009-12-15
申请人： IVASHCHENKO ANDREY ALEXANDROVICH , ALLA CHEM LLC , IVACHTCHENKO ALEXANDRE VASILIEVICH , SAVCHUK NIKOLAY FILIPPOVICH
发明人： IVASHCHENKO ANDREY ALEXANDROVICH , IVACHTCHENKO ALEXANDRE VASILIEVICH , SAVCHUK NIKOLAY FILIPPOVICH
IPC分类号： C07D235/28 , A61K31/4164 , A61K31/4192 , A61K31/4245 , A61K31/4439 , A61K31/454 , A61K31/4985 , A61K31/5377 , A61P25/24 , A61P25/32 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D487/04
CPC分类号： C07D235/28 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D487/04
摘要： The invention relates to an active substance for treating alcohol dependence, a pharmaceutical composition, a medicinal agent and a method for treating dependence on the consumption of products containing ethyl alcohol. An active substance is proposed for treating alcohol dependence in humans and warm-blooded animals, comprising substituted 1H-benzimidazoles of the general formula 1 or the pharmaceutically acceptable salts and/or hydrates thereof, in which W denotes an atom of sulphur or the group S=O; R1 denotes one or more substituents selected from hydrogen, halogen, C1-C4 alkyl, C1-C4 alkyloxy, optionally substituted azaheterocyclyl; R2 denotes hydrogen or optionally substituted C1-C4 alkyl; R3 and R4 independently of one another denote optionally identical substituents selected from hydrogen or optionally substituted C1-C4 alkyl; R5 denotes an alkyl substituent selected from hydrogen, optionally substituted C1-C7 alkyl, optionally substituted aryl, optionally substituted heterocyclyl, C1-C4 alkoxycarbonyl, or optionally substituted aminocarbonyl.
摘要翻译：本发明涉及用于治疗酒精依赖性的活性物质，药物组合物，药剂和用于治疗对含有乙醇的产品的消耗的依赖性的方法。提出一种活性物质用于治疗人和温血动物的酒精依赖性，包括通式1的取代的1H-苯并咪唑或其药学上可接受的盐和/或水合物，其中W表示硫原子或S组 = O; R1表示一个或多个选自氢，卤素，C 1 -C 4烷基，C 1 -C 4烷氧基，任选取代的杂环基的取代基; R2表示氢或任选取代的C 1 -C 4烷基; R 3和R 4彼此独立地表示任选相同的取代基，其选自氢或任选取代的C 1 -C 4烷基; R5表示选自氢，任选取代的C 1 -C 7烷基，任选取代的芳基，任选取代的杂环基，C 1 -C 4烷氧基羰基或任选取代的氨基羰基的烷基取代基。

2. 发明申请

WO2012087182A3 SUBSTITUTED METHYL AMINES, SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS, METHODS FOR THE PRODUCTION AND USE THEREOF 审中-公开
标题翻译：取代的甲基氨基磺酸盐，丝氨酸5-HT6受体拮抗剂，其生产和使用方法
公开(公告)号：WO2012087182A3
公开(公告)日：2012-09-13
申请号：PCT/RU2011000981
申请日：2011-12-13
申请人： IVACHTCHENKO ALEXANDRE VASILIEVICH , ALLA CHEM LLC , MITKIN OLEG DMITRIEVICH , KADIEVA MADINA GEORGIEVNA
发明人： IVACHTCHENKO ALEXANDRE VASILIEVICH , MITKIN OLEG DMITRIEVICH , KADIEVA MADINA GEORGIEVNA
IPC分类号： C07C317/36 , A61K31/13 , A61K31/341 , A61K31/381 , A61K31/421 , A61K31/422 , A61K31/437 , A61K31/44 , A61K31/4706 , A61K31/4709 , A61K31/495 , A61K31/496 , A61P3/06 , A61P9/10 , A61P25/08 , A61P25/18 , A61P25/24 , A61P25/28 , C07D211/84 , C07D213/34 , C07D213/38 , C07D215/38 , C07D215/42 , C07D263/48 , C07D295/096 , C07D307/64 , C07D307/66 , C07D317/32 , C07D333/34 , C07D333/36 , C07D401/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D413/14 , C07D471/04
CPC分类号： C07D471/04 , C07C317/36 , C07D213/40 , C07D215/42 , C07D295/135 , C07D413/04 , C07D413/14
摘要： The invention relates to novel substituted methyl amines, serotonin 5-HT6 receptor antagonists, active ingredients, pharmaceutical compositions and a method for preventing and treating diseases of the central nervous system, as well as to molecular instruments, wherein the novel substituted methyl amines are compounds of general formula 1 and crystalline forms, polycrystalline forms, pharmaceutically acceptable salts and/or hydrates thereof, where: W is naphthalene, indolizine or quinoline; R1 is hydrogen, fluorine, chlorine, methyl; R2 is hydrogen, fluorine, methyl, phenyl, thiophen-2-yl, furan-2-yl, pyridyl, piperazin-1-yl or 4-methylpiperazin-1-yl; R3 is methyl; or W is benzene, R3 has the above meaning; R1 is 3-C 1, R2 is ?-piperazin-1-yl or 3-(4-methylpiperazin-1-yl); or R1 is hydrogen, R2 is phenyl or pyridyl; or R1 is hydrogen, fluorine, chlorine, methyl; R2 is 4-piperazin-1-yl or 4-(4-methylpiperazin-1-yl); or W is oxazole, R3 is optionally substituted methyl; R1 is chlorine or fluorine, R2 is methyl, or R1 is hydrogen, fluorine, chlorine, methyl; R2 is piperazin-1-yl, 4-methylpiperazin-1-yl, or R1 is chlorine, fluorine or methyl; R2 is furan-2-yl, or R1 is hydrogen, fluorine, chlorine, methyl; R2 is furan-2-yl, R3 is (tetrahydrofuran-2-yl)methyl, or R1 is hydrogen, fluorine, chlorine, methyl; R2 is thiophen-2-yl, R3 is 2-methoxyethyl, or R1 is chlorine or fluorine, R2 is thiophen-2-yl, R3 is methyl.
摘要翻译：本发明涉及新型取代的甲胺，5-羟色胺5-HT 6受体拮抗剂，活性成分，药物组合物和预防和治疗中枢神经系统疾病的方法，以及分子仪器，其中新取代的甲胺是化合物通式1和结晶形式，多晶形式，其药学上可接受的盐和/或水合物，其中：W是萘，中氮茚或喹啉; R1是氢，氟，氯，甲基; R 2是氢，氟，甲基，苯基，噻吩-2-基，呋喃-2-基，吡啶基，哌嗪-1-基或4-甲基哌嗪-1-基; R3是甲基; 或W为苯，R3具有上述含义; R1是3-C 1，R2是α-哌嗪-1-基或3-（4-甲基哌嗪-1-基）; 或R 1为氢，R 2为苯基或吡啶基; 或R 1为氢，氟，氯，甲基; R2是4-哌嗪-1-基或4-（4-甲基哌嗪-1-基）; 或W为恶唑，R3为任选取代的甲基; R1是氯或氟，R2是甲基，或R1是氢，氟，氯，甲基; R2是哌嗪-1-基，4-甲基哌嗪-1-基，或R1是氯，氟或甲基; R2是呋喃-2-基，或R1是氢，氟，氯，甲基; R2是呋喃-2-基，R3是（四氢呋喃-2-基）甲基，或R1是氢，氟，氯，甲基; R2是噻吩-2-基，R3是2-甲氧基乙基，或R1是氯或氟，R2是噻吩-2-基，R3是甲基。

3. 发明申请

WO2014011083A3 PHARMACEUTICAL COMPOSITION HAVING IMPROVED FLOWABILITY, MEDICINAL AGENT, AND METHOD FOR PRODUCING AND USING SAME 审中-公开
标题翻译：具有改善流动性的药物组合物，药物代理及其生产和使用方法
公开(公告)号：WO2014011083A3
公开(公告)日：2014-03-06
申请号：PCT/RU2013000572
申请日：2013-07-05
申请人： IVACHTCHENKO ALEXANDRE VASILIEVICH , ALLA CHEM LLC
发明人： IVACHTCHENKO ALEXANDRE VASILIEVICH , DEMIN ALEXANDRE VIKTOROVICH
IPC分类号： A61K31/137 , A61J3/07 , A61J3/10 , A61K9/20 , A61K9/48 , A61K47/26 , A61K47/32 , A61K47/34 , A61P25/28 , A61P31/18 , A61P37/06
CPC分类号： A61K47/36 , A61J3/074 , A61K9/4858 , A61K9/4866 , A61K31/135 , A61K47/10 , A61K47/32
摘要： The invention relates to the field of pharmaceuticals, specifically to solid pharmaceutical compositions containing 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol or a pharmaceutically acceptable salt thereof, a stabiliser, a lubricant and a filler, and also to methods for producing said pharmaceutical composition and to medicinal agents for suppressing the immune system and treating multiple sclerosis. 2-Amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol is an immunomodulator which causes a redistribution of lymphocytes from the blood flow to the secondary lymphatic tissue, thus leading to immunosuppression. The invention provides a uniform distribution of the active component in a solid composition, high stability and the improved flowability of a solid pharmaceutical composition. This improved flowability allows for the use of the compositions proposed in the invention in conjunction with automatic equipment.
摘要翻译：本发明涉及药物领域，具体涉及含有2-氨基-2- [2-（4-辛基苯基）乙基]丙烷-1,3-二醇或其药学上可接受的盐，稳定剂，润滑剂和填充剂，以及制备所述药物组合物的方法和用于抑制免疫系统和治疗多发性硬化症的药物。 2-氨基-2- [2-（4-辛基苯基）乙基]丙烷-1,3-二醇是引起淋巴细胞从血流再次分布到次级淋巴组织的免疫调节剂，从而导致免疫抑制。本发明提供活性组分在固体组合物中的均匀分布，高稳定性和固体药物组合物的改善的流动性。这种改进的流动性允许结合自动设备使用本发明中提出的组合物。

4. 发明申请

WO2012091628A3 SUBSTITUTED HYDROGENATED THIENO-PYRROLO[3,2-C]PYRIDINE, LIGANDS, A PHARMACEUTICAL COMPOSITION AND A METHOD FOR USING THE ABOVE 审中-公开
标题翻译：取代的氢化噻吩并吡咯[3,2-C]吡啶，配体，药物组合物和使用上述方法
公开(公告)号：WO2012091628A3
公开(公告)日：2012-09-13
申请号：PCT/RU2011000980
申请日：2011-12-13
申请人： IVACHTCHENKO ALEXANDRE VASILIEVICH , ALLA CHEM LLC , MITKIN OLEG DMITRIEVICH
发明人： IVACHTCHENKO ALEXANDRE VASILIEVICH , MITKIN OLEG DMITRIEVICH
IPC分类号： C07D495/14 , A61K31/4365 , A61K31/439 , A61K31/46 , A61P25/24 , A61P25/28 , C07D451/02 , C07D495/22
CPC分类号： C07D495/14 , C07D471/04 , C07D495/22
摘要： The invention relates to novel substituted tetrahydro-4H-thieno-pyrrolo[3,2-c]pyridines of general formula 1, geometric isomers thereof, mixtures of the geometric isomers thereof, and pharmaceutically acceptable salts thereof, where Th is an annulated thiene ring; W is a single bond (in this case R3 is bonded directly to the nitrogen atom of the pyrrole ring), a methylene, 1,2-ethane, 1,2-ethylene, 1,2-acetylene, 1,3-propane or 1,3-allyl bridge optionally substituted by a hydroxyl group; R1 and R2 are hydrogen, C1-C4alkyl, halogen or -??2??; R3 is hydrogen, optionally substituted phenyl, optionally substituted azaheteroaryl; R4 is C1-C4alkyl, ??2?2?5 or ??2?(??3)3; R5, R6, R7, independently of one another, are hydrogen or C1-C4alkyl, or R5 and R6 together form an ethylene bridge and R7 is a hydrogen atom, or R5 and R7 together form an ethylene bridge and R6 is a hydrogen atom; and also to the synthesis of novel chemical substances, novel physiologically active substances, "molecular instruments", a pharmaceutical composition, methods for producing same and a method for treating and preventing the development of various diseases, including diseases of the central nervous system.
摘要翻译：本发明涉及通式1的新的取代的四氢-4H-噻吩并 - 吡咯并[3,2-c]吡啶，其几何异构体，其几何异构体的混合物及其药学上可接受的盐，其中Th是稠合的噻吩环 ; W是单键（在这种情况下R3直接键合到吡咯环的氮原子上），亚甲基，1,2-乙烷，1,2-亚乙基，1,2-乙炔，1,3-丙烷或任选被羟基取代的1,3-烯丙基桥; R 1和R 2是氢，C 1 -C 4烷基，卤素或-α2δ; R3是氢，任选取代的苯基，任选取代的氮杂杂芳基; R4是C1-C4烷基，α2→2α5或β2β（αβ3）3; R5，R6，R7彼此独立地为氢或C1-C4烷基，或R5和R6一起形成亚乙基桥，并且R7为氢原子，或R5和R7一起形成亚乙基桥，R6为氢原子; 并且还涉及新化学物质，新型生理活性物质，“分子仪器”的合成，药物组合物，其制备方法以及治疗和预防包括中枢神经系统疾病在内的各种疾病发展的方法。

5. 发明申请

WO2012074437A3 SUBSTITUTED AZOLES, ANTI-VIRAL ACTIVE INGREDIENT, PHARMACEUTICAL COMPOSITION, METHOD FOR THE PRODUCTION AND USE THEREOF 审中-公开
标题翻译：取代的偶氮唑，抗病毒活性成分，药物组合物，其生产方法和用途
公开(公告)号：WO2012074437A3
公开(公告)日：2012-09-13
申请号：PCT/RU2011000932
申请日：2011-11-28
申请人： IVACHTCHENKO ALEXANDRE VASILIEVICH , ALLA CHEM LLC , BICHKO VADIM VASILIEVICH , MITKIN OLEG DMITRIEVICH
发明人： IVACHTCHENKO ALEXANDRE VASILIEVICH , BICHKO VADIM VASILIEVICH , MITKIN OLEG DMITRIEVICH
IPC分类号： C07D403/04 , A61K31/12 , A61K31/4178 , A61K31/422 , A61K31/427 , C07D403/14 , C07D405/10 , C07D405/14 , C07D409/10 , C07D409/14 , C07D413/14
CPC分类号： C07D403/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present invention relates to novel azoles, novel anti-viral active ingredients of general formula 1A and 1B, a pharmaceutical composition, an anti-viral drug and a method for preventing and treating viral diseases, particularly those caused by hepatitis C viruses (HCV). In the general formula 1A and 1B, in which the continuous lines accompanied by dotted lines (---) represent a single or double bond, X and Y assume different meanings, one being nitrogen and the other being oxygen, sulphur or an NH group; R1 and R2 are optionally identical radicals selected from 2-(R) and (S)-substituted N-acyl pyrrolidine derivatives; N-MeTmi-N-[2-(R) and (S)-substituted 2,2-disubstituted acetamides; methyl [2-(R) and (S)-substituted (((methyl)amino)-(1-oxo-butan-2-yl)-2-(11)-] and (?)-isopropyl)-carbamates. ? stands for an aliphatic ?2-?8 biradical; dioxane, cycloaliphatic, bicycloaliphatic, alkyloxyalkyl, alkyloxyalkyleneoxyalkyl, alkenyloxyalkyl, alkynyloxyalkyl biradicals and thia analogues thereof; aryl and thiophenyl, alkynylcycloalkyl, alkynyldioxane, alkynylaryl, alkylthiophene, alkenylthiophene and alkynylthiophene, alkyloxyaryl, alkenyloxyaryl, alkynyloxyaryl, alkylthiaaryl, alkenylthiaaryl, alkynylthiaaryl, cycloalkylthiophene, aryldioxane and thiophenyldioxane biradicals. ? stands for: an aliphatic ?2-?8 radical comprising 1, 2 or 3 triple ?=? bonds; aryl and thiophenyl, alkynylcycloalkyl, alkynyldioxane, alkynylaryl, alkylthiophene, alkenylthiophene and alkynylthiophene, cycloalkylbenzene, 4-cycloalkylbiphenyl, bicycloalkylbenzene, 4-bicycloalkylbiphenyl, cycloalkylthiophene, aryldioxane and thiophenyldioxane radicals.
摘要翻译：本发明涉及新的唑类，通式1A和1B的新型抗病毒活性成分，药物组合物，抗病毒药物以及预防和治疗病毒疾病，特别是由丙型肝炎病毒（HCV）引起的病毒疾病的方法，。在由虚线（---）表示单键或双键的连续线表示单键或双键的通式1A和1B中，X和Y具有不同的含义，一个是氮，另一个是氧，硫或NH基团 ; R1和R2任选地是选自2-（R）和（S） - 取代的N-酰基吡咯烷衍生物的相同的基团; N-MeTmi-N- [2-（R）和（S） - 取代的2,2-二取代乙酰胺; （2-（R）和（S） - 取代的（（（甲基）氨基） - （1-氧代 - 丁烷-2-基）-2-（11） - ]和（ - ） - 异丙基）？代表脂族α2→8双基; 环烷基，二环脂族基，烷氧基烷基，烷氧基亚烷氧基烷基，烯氧基烷基，炔氧基烷基双基和它们的硫杂类似物; 烯基噻吩和炔基噻吩，烷氧基芳基，烯氧基芳基，炔氧基芳基，烷基硫杂芳基，烯硫基芳基，炔基硫杂芳基，环烷基噻吩，芳基二氧杂环己烷和噻吩基二恶烷双基。？代表：包含1,2或3个三重α=β的脂族α2→8基团。债券; 炔基环烷基，炔基二恶烷，炔基芳基，烷基噻吩，烯基噻吩和炔基噻吩，环烷基苯，4-环烷基联苯，双环烷基苯，4-双环烷基联苯，环烷基噻吩，芳基二恶烷和噻吩基二恶烷。

10. 发明专利

ES2652170T3 Azoles sustituidos, ingrediente activo antiviral, composición farmacéutica, método para la producción y uso de los mismos 未知
公开(公告)号：ES2652170T3
公开(公告)日：2018-01-31
申请号：ES14002393
申请日：2011-11-28
申请人： ALLA CHEM LLC , IVACHTCHENKO ALEXANDRE VASILIEVICH , IVASHCHENKO ANDREY ALEXANDROVICH , SAVCHUK NIKOLAY FILIPPOVICH
发明人： IVACHTCHENKO ALEXANDRE VASILIEVICH , BICHKO VADIM VALILIEVICH , MITKIN OLEG DMITRIEVICH
IPC分类号： C07D403/04 , A61K31/4178 , A61K31/422 , A61K31/454 , A61P31/12
摘要： Azoles sustituidos de la fórmula general 1A y sales farmacéuticamente aceptables de los mismos,**Fórmula** en donde: las líneas sólidas con líneas discontinuas adjuntas (---) representan un enlace sencillo o un doble enlace, con la condición que si uno de ellos es un enlace sencillo, entonces el otro sea un doble enlace; X e Y tienen significados opcionalmente diferentes y representan un átomo de nitrógeno o un grupo NH; R1 y R2 - representan radicales opcionalmente idénticos 2.1-2.20, en los que un asterisco (*) indica la posición de ligazón del fragmento azólico;**Fórmula** A representa: - un birradical alquinilarílico o alquiniltiofénico seleccionado de los birradicales de fórmulas 3.96, 3.100 y 3.112, en donde un asterisco (*) indica las posición de ligazón a los fragmentos azólicos;**Fórmula**

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