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1. 发明申请

WO2020044384A1 IMMUNOFLUORIMETRIC METHOD FOR BIOLOGICAL CLINICAL ANALYSIS 审中-公开
公开(公告)号：WO2020044384A1
公开(公告)日：2020-03-05
申请号：PCT/IT2019/050193
申请日：2019-08-30
申请人： ALIFAX S.R.L. , UNIVERSITA' DEGLI STUDI DI PADOVA
发明人： GALIANO, Paolo , AMENDOLA, Vincenzo , BRAVIN, Carlo , DI COLA, Giovanni
IPC分类号： G01N33/542
摘要： Immunofluorometric method for biological clinical analysis, in particular for detecting antigens that need to be evaluated over a wide concentration range, based on fluorescence "quenching" using antibodies or aptamers functionalized with fluorescent or luminescent substances and nanoparticles, having the capacity to extend the dynamic measuring range avoiding the prozone effect and maintaining high sensitivity even at low analyte concentrations.

2. 发明申请

WO2021205483A1 METHOD AND SYSTEM TO DETECT AND CLASSIFY BACTERIA AND OTHER CELLS IN A URINE SAMPLE 审中-公开
公开(公告)号：WO2021205483A1
公开(公告)日：2021-10-14
申请号：PCT/IT2020/000033
申请日：2020-04-08
申请人： ALIFAX S.R.L. , CONSIGLIO NAZIONALE DELLE RICERCHE
发明人： GALIANO, Paolo , COJOC, Danut Adrian , DO REGO BARROS FERNANDES DE LIMA, Maria Augusta
IPC分类号： G01N21/45 , G01N15/14 , G01N33/493
摘要： The current invention concerns a method and a system to detect and classify bacteria and other cells, in primary urine samples and classify the samples. The method comprises providing a liquid urine sample; obtaining optical phase information from the liquid urine sample by digital holographic (DHM) and speckle microscopy (SM); localizing and tracking of the cells flowing in fluidic cell sample; deriving cellular parameters (e.g. size, shape, volume, aspect ratio) from optical phase information, and classifying the cells on the base of the extracted cellular parameters.

3. 发明申请

WO2019150408A1 METHOD TO IDENTIFY MICROORGANISMS USING SPECTROSCOPIC TECHNIQUE 审中-公开
公开(公告)号：WO2019150408A1
公开(公告)日：2019-08-08
申请号：PCT/IT2019/050025
申请日：2019-01-31
申请人： ALIFAX S.R.L.
发明人： GALIANO, Paolo
IPC分类号： C12Q1/04 , G01N21/552 , G01N21/35
摘要： Method to classify and identify microorganisms that provides to classify and identity microorganisms using the FTIR ATR technique.

4. 发明申请

WO2018007939A1 INTEGRATED APPARATUS FOR DIAGNOSTIC ANALYSES 审中-公开
标题翻译：用于诊断分析的集成设备
公开(公告)号：WO2018007939A1
公开(公告)日：2018-01-11
申请号：PCT/IB2017/054022
申请日：2017-07-04
申请人： ALIFAX S.R.L.
发明人： GALIANO, Paolo
IPC分类号： G01N35/00 , G01N35/02 , G01N35/10 , G01N35/04
摘要： Integrated apparatus for diagnostic analyses, comprising a support structure (11) inside which are positioned a first refrigerated container (26) to house at least one panel of antibiotics ( n ) contained in ampoules or phials (27), reconstituted with liquid to allow them to be dispensed in a liquid phase, and to be tested according to a plurality of molecules which can be selected by an operator and possibly also according to a plurality of concentrations ( m ), in order to carry out a modulatable antibiogram and MIC (Minimal Inhibitory Concentration) tests for each antibiotic chosen; an analysis area (32) in which a plurality of microplates (35) is positioned with a plurality of receptacles or wells (36) in which a portion of a primary sample is inserted; a samples removal and delivery unit (20) configured to remove a portion of a primary sample from respective test tubes (13) and deliver it into the wells (36) of the microplates (35); a temperature control area (30) of the microplates (35) containing the primary samples; and a robotic head (14) configured to interact with said samples removal and delivery unit (20) so as to transfer the primary samples taken from the test tubes (13) in the microplates (35) of the analysis area (32) and to transfer the microplates (35) to the temperature control area (30) and configured to insert, into each of the wells (36) of the microplates (35), the sample where a bacterial growth has been identified, a portion of one of the antibiotics ( n ) in liquid form according to a choice at the discretion of the operator directed as a function of the type of species identified.
摘要翻译：一种用于诊断分析的集成设备，包括支撑结构（11），在该支撑结构（11）内放置第一冷藏集装箱（26）以容纳至少一个抗生素板（n）包含在安瓿或小玻璃瓶（27）中，用液体重构以允许它们以液相分配，并且根据可由操作者选择的多个分子进行测试，并且还可能根据多个浓度（为了对所选择的每种抗生素进行可调整的抗菌谱和MIC（最小抑制浓度）测试; 分析区域（32），其中多个微孔板（35）定位有多个容器或孔（36），主要样本的一部分插入其中; 样品移除和递送单元（20），其被配置为从相应的试管（13）移除一部分主要样品并将其递送到微孔板（35）的孔（36）中; 包含主样品的微孔板（35）的温度控制区域（30）和配置成与所述样品去除和递送单元（20）相互作用的机器人头部（14），以便将从分析区域（32）的微板（35）中的试管（13）取得的原始样本转移到将微孔板（35）转移到温度控制区域（30），并将微孔板（35）的每个孔（36）中的细菌生长已被鉴定的样品插入微孔板（35）根据操作者的判断选择液体形式的抗生素（n）作为所鉴定的物种类型的函数。

5. 发明申请

WO2017090015A1 METHOD TO DETECT BACTERIAL ACTIVITY IN A BIOLOGICAL SAMPLE AND CORRESPONDING DETECTION UNIT 审中-公开
标题翻译：检测生物样本和相应检测单元中细菌活性的方法
公开(公告)号：WO2017090015A1
公开(公告)日：2017-06-01
申请号：PCT/IB2016/057162
申请日：2016-11-28
申请人： ALIFAX S.R.L.
发明人： GALIANO, Paolo
IPC分类号： G01N33/569
CPC分类号： C12Q1/04
摘要： Method and corresponding detection unit to detect bacterial activity in biological sample (14), in particular, but not only, blood samples contained in test tube (12) with a stopper (16).
摘要翻译：用于检测生物样品（14）中的细菌活性的方法和相应的检测单元，特别是但不仅限于包含在具有塞子（16）的试管（12）中的血液样品。

6. 发明申请

WO2022013895A1 METHOD TO COLLECT AND ANALYZE BIOLOGICAL SAMPLES AND CORRESPONDING KIT 审中-公开
公开(公告)号：WO2022013895A1
公开(公告)日：2022-01-20
申请号：PCT/IT2021/050170
申请日：2021-06-01
申请人： ALIFAX S.R.L.
发明人： GALIANO, Paolo
IPC分类号： A61B10/00
摘要： The invention concerns a kit and a method to collect and analyze a biological sample, in particular saliva, obtained by means of voluntary expulsion from a human or animal organism. The invention can advantageously be used by a user who needs to know in a simple and rapid way the presence of antigens or antibodies of a specific virus causing a particular infection, in particular of the respiratory tract.

7. 发明申请

WO2022009237A1 PORTABLE ELECTROMAGNETIC EMISSION DEVICE TO INACTIVATE MICRO-ORGANISMS 审中-公开
公开(公告)号：WO2022009237A1
公开(公告)日：2022-01-13
申请号：PCT/IT2020/000056
申请日：2020-07-09
申请人： ALIFAX S.R.L.
发明人： GALIANO, Paolo , LAZZARINO, Marco
IPC分类号： A61N1/40 , A61B18/18 , A61N5/06
摘要： The current invention concerns a portable electromagnetic emission device to inactivate a microorganism comprising an emission group to emit electromagnetic waves of an inactivating microorganism wavelength.

8. 发明申请

WO2021210031A1 METHOD FOR DETECTION OF VIRUSES AND ANTIBODIES IN BIOLOGICAL SAMPLES 审中-公开
公开(公告)号：WO2021210031A1
公开(公告)日：2021-10-21
申请号：PCT/IT2020/000034
申请日：2020-04-15
申请人： ALIFAX S.R.L.
发明人： GALIANO, Paolo , SINIGAGLIA, Milena , DI COLA, Giovanni
IPC分类号： C12Q1/6851 , B01L3/00
摘要： Dual test which includes disposable cartridges, of the type developed with MEMS (Micro Electro-Mechanical Systems) technology, suitable for containing reagents and acquiring fluorescent signals, including at least one specific reaction mixture suitable for performing molecular biology tests and/or one specific reaction mixture for immunological analysis, which said tests are carried out through the use of a single instrument starting from biological samples isolated from virus infected or potentially infected patients.

9. 发明申请

WO2021130794A1 PERFECTED METHOD FOR THE ANALYSIS OF A LIQUID WITH SUSPENDED BODIES 审中-公开
公开(公告)号：WO2021130794A1
公开(公告)日：2021-07-01
申请号：PCT/IT2020/050321
申请日：2020-12-22
申请人： ALIFAX S.R.L.
发明人： GALIANO, Paolo
IPC分类号： G01N15/05 , G01N11/00 , G01N33/49 , G01N35/08 , G01N21/00 , G01N2011/008 , G01N2015/055 , G01N2021/0346 , G01N21/05 , G01N33/491 , G01N33/492
摘要： The invention concerns a method for the analysis of a liquid with suspended bodies, such as blood. The purposed of the present invention is specifically to analyze the behavior of a liquid containing suspended bodies subjected to stress, in order to obtain cognitive factors connected to the liquid itself and to the suspended bodies. In particular, the purpose of present invention is to carry out analysis of the balances reached, in said liquid, by the suspended bodies. The present invention finds application in a wide form of fluids.

10. 发明申请

WO2021186486A1 METHOD FOR IDENTIFYING MICROORGANISMS AND/OR THEIR RESISTANCE TO DRUGS, CARTRIDGE AND RELATED CARTRIDGE PANEL TO PERFORM THE METHOD 审中-公开
公开(公告)号：WO2021186486A1
公开(公告)日：2021-09-23
申请号：PCT/IT2021/050073
申请日：2021-03-18
申请人： ALIFAX S.R.L.
发明人： GALIANO, Paolo
IPC分类号： C12Q1/689 , B01L3/00 , C12Q1/6895
摘要： Embodiments described here concern a disposable cartridge suitable to carry out molecular biology tests starting from biological samples positive for microorganisms, comprising at least one specific reaction mixture for RT-PCR (Real Time Polymerase Chain Reaction) suitable for typing particular microorganisms and/or for providing information on relative resistance to antimicrobial and antifungal drugs, a panel comprising a plurality of cartridges and a method to identify at least one microorganism and/or its resistance to antimicrobial or antifungal drugs responsible for a systemic inflammatory state.

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