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1. 发明申请

WO2012106634A1 USE OF AN ANTI-CD200 ANTIBODY FOR PROLONGING THE SURVIVAL OF ALLOGRAFTS 审中-公开
标题翻译：使用抗CD200抗体来促进ALLOGRAFTS生存
公开(公告)号：WO2012106634A1
公开(公告)日：2012-08-09
申请号：PCT/US2012/023831
申请日：2012-02-03
申请人： ALEXION PHARMACEUTICALS, INC. , WANG, Yi , FAAS MCKNIGHT, Susan , YU, Zhao, Xue , WANG, Hao
发明人： WANG, Yi , FAAS MCKNIGHT, Susan , YU, Zhao, Xue , WANG, Hao
IPC分类号： A61P37/06 , A61K39/395
CPC分类号： C07K16/2803 , A61K9/0019 , A61K31/365 , A61K31/436 , A61K31/439 , A61K31/5377 , A61K38/13 , A61K39/39533 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2300/00 , C07K2317/52 , C07K2317/71 , C07K2317/76 , G01N33/6893 , G01N2333/70596 , G01N2800/245 , G01N2800/347 , G01N2800/56
摘要： The present disclosure provides methods useful for prolonging the survival of an allograft organ in a recipient mammal. The methods include administration of an anti-CD200 antibody or a CD200-binding fragment of the antibody. The disclosure also provides biomarkers, a change in one or more of which indicates that an anti- CD200 antibody has produced a desired immunomodulatory effect in a mammal. Also featured are pharmaceutical compositions, kits, and solutions that contain at least one anti-CD200 antibody and are useful in the methods described herein.
摘要翻译：本公开提供了用于延长受体哺乳动物中同种异体移植器官的存活的方法。所述方法包括施用抗CD200抗体或抗体的CD200结合片段。本公开还提供了生物标志物，其中一个或多个的变化表明抗CD200抗体已经在哺乳动物中产生了所需的免疫调节作用。还特征在于含有至少一种抗CD200抗体的药物组合物，试剂盒和溶液，并且可用于本文所述的方法。

2. 发明申请

WO2007103134A2 PROLONGATION OF SURVIVAL OF AN ALLOGRAFT BY INHIBITING COMPLEMENT ACTIVITY 审中-公开
标题翻译：通过抑制补充活动来扩大合成酶的活性
公开(公告)号：WO2007103134A2
公开(公告)日：2007-09-13
申请号：PCT/US2007/005290
申请日：2007-03-02
申请人： ALEXION PHARMACEUTICALS, INC. , ROTHER, Russell, P. , WANG, Hao , ZHONG, Zhen
发明人： ROTHER, Russell, P. , WANG, Hao , ZHONG, Zhen
CPC分类号： C07K16/18 , A61K31/16 , A61K31/365 , A61K31/573 , A61K38/13 , A61K2039/505
摘要： Methods of prolonging survival of allotransplanted cells, tissues or organs are presented. These methods are directed to administering to the allograft recipient an inhibitor of complement activity together with one or more immunosuppressants and/or immunosuppressive methods. The inhibitor of complement activity is administered chronically. These methods have been determined to aid in preventing chronic rejection of allografts. These methods can additionally be used in cases in which the recipient has been presensitized to the allograft or in which there is an ABO mismatch between the allograft and the recipient.
摘要翻译：提出了延长移植细胞，组织或器官存活的方法。这些方法涉及向同种异体移植受体施用补体活性的抑制剂以及一种或多种免疫抑制剂和/或免疫抑制方法。补体活性抑制剂长期施用。已经确定了这些方法以帮助预防同种异体移植物的慢性排斥反应。这些方法可以另外用于接受者已经被同化异体移植或同种异体移植物与受体之间存在ABO不匹配的情况。

3. 发明申请

WO2005110481A3 PROLONGATION OF SURVIVAL OF AN ALLOGRAFT BY INHIBITING COMPLEMENT ACTIVITY 审中-公开
公开(公告)号：WO2005110481A3
公开(公告)日：2005-11-24
申请号：PCT/US2005/017048
申请日：2005-05-16
申请人： ALEXION PHARMACEUTICALS, INC. , THE UNIVERSITY OF WESTERN ONTARIO , ROTHER, Russell, P. , WANG, Hao , ZHONG, Zhen
发明人： ROTHER, Russell, P. , WANG, Hao , ZHONG, Zhen
IPC分类号： A61K39/395 , C07K16/18 , A61M5/28 , C12N5/08
摘要： Methods of prolonging survival of allotransplanted cells, tissues or organs are presented. These methods are directed to administering to the allotransplant recipient an inhibitor of complement activity together with one or more immunosuppressants. The inhibitor of complement activity is administered chronically. These methods have been determined to aid in preventing chronic rejection of allografts. These methods can additionally be used in cases in which the recipient has been presensitized to the allograft or in which there is an ABO mismatch between the allograft and the recipient.

4. 发明申请

WO2012129771A1 METHOD AND APPARATUS FOR CREATING AN EPHEMERAL SOCIAL NETWORK 审中-公开
标题翻译：创造一个社会网络的方法和装置
公开(公告)号：WO2012129771A1
公开(公告)日：2012-10-04
申请号：PCT/CN2011/072234
申请日：2011-03-29
申请人： NOKIA CORPORATION , CHIN, Alvin , WANG, Hao , WANG, Hao
发明人： CHIN, Alvin , WANG, Hao , WANG, Hao
IPC分类号： H04W4/02 , H04W4/04
CPC分类号： H04L67/18 , G06Q50/01 , H04W4/02 , H04W4/21
摘要： An approach is provided for creating a connection between users of a social network. The approach involves determining location information associated with a user and other location information associated with one or more other users. The approach also includes processing the location information and the other location information to cause, at least in part, identification of one or more encounters, one or more encounter patterns, or a combination thereof with respect to the user and the one or more other users. The approach further includes determining to generate at least one recommendation to create at least one social network, at least one social networking relationship, or a combination thereof between the user and at least one of the one or more other users based, at least in part, on the one or more encounters, the one or more encounter patterns, one or more meetings and/or events, or a combination thereof.
摘要翻译：提供了一种用于在社交网络的用户之间建立连接的方法。该方法涉及确定与用户相关联的位置信息和与一个或多个其他用户相关联的其他位置信息。该方法还包括处理位置信息和其他位置信息，以至少部分地使得相对于用户和一个或多个其他用户的一个或多个遭遇，一个或多个遭遇模式或其组合的识别。该方法进一步包括至少部分地确定生成至少一个建议以至少创建至少一个社交网络，至少一个社交网络关系或其组合，所述用户与所述一个或多个其他用户中的至少一个之间一次或多次遭遇，一个或多个遭遇模式，一个或多个会议和/或事件或其组合。

5. 发明申请

WO2013131278A1 METHOD AND APPARATUS FOR PERFORMING AN INCREMENTAL UPDATE OF A RECOMMENDATION MODEL 审中-公开
标题翻译：用于执行建议模型更新更新的方法和装置
公开(公告)号：WO2013131278A1
公开(公告)日：2013-09-12
申请号：PCT/CN2012/072142
申请日：2012-03-09
申请人： NOKIA CORPORATION , WANG, Hao , CHIN, Alvin , WANG, Hao , BRAHMAKAL, Hrishikesh , AARNIO, Ari
发明人： WANG, Hao , CHIN, Alvin , WANG, Hao , BRAHMAKAL, Hrishikesh , AARNIO, Ari
IPC分类号： G06F17/30
CPC分类号： G06F17/30174 , G06F17/30598 , G06F17/30867
摘要： An approach is provided for determining one or more recommendations based on an incremental update of a recommendation model. An incremental platform causes, at least in part, a categorization of activity information into a plurality of subsets based, at least in part, on one or more user groups, one or more item groups, at least one update time for at least one recommendation model associated with the activity information, or a combination thereof. The incremental platform further processes and/or facilitates a processing of the activity information based, at least in part, on the categorization to determine whether to perform an incremental update of the at least one recommendation model. The incremental platform also determines one or more recommendations based, at least in part, on the at least one recommendation model, the incremental update, or a combination thereof.
摘要翻译：提供了一种基于推荐模型的增量更新来确定一个或多个建议的方法。至少部分地，至少部分地基于一个或多个用户组，一个或多个项目组，至少一个建议的至少一个更新时间，至少部分地将活动信息分类为多个子集与活动信息相关联的模型，或其组合。至少部分地，所述增量平台进一步处理和/或促进对所述活动信息的处理，所述至少部分地基于所述分类以确定是否执行所述至少一个推荐模型的增量更新。增量平台还至少部分地基于至少一个推荐模型，增量更新或其组合来确定一个或多个推荐。

6. 发明授权

EP1755674B1 PROLONGATION OF SURVIVAL OF AN ALLOGRAFT BY INHIBITING COMPLEMENT ACTIVITY 有权
标题翻译： VERLÄNGERTELEBENSDAUER EINES ALLOTRANSPLANTATS MITTELS HEMMUNG VONKOMPLEMENTAKTVITÄT
公开(公告)号：EP1755674B1
公开(公告)日：2014-11-19
申请号：EP05779924.9
申请日：2005-05-16
申请人： ALEXION PHARMACEUTICALS, INC.
发明人： ROTHER, Russell, P. , WANG, Hao , ZHONG, Zhen
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , A61K2039/505
摘要： Methods of prolonging survival of allotransplanted cells, tissues or organs are presented. These methods are directed to administering to the allotransplanted recipient an inhibitor of complement activity together with one or more immunosuppressants. The inhibitor of complement activity is administered chronically. These methods have been determined to aid in preventing chronic rejection of allografts. These methods can additionally be used in cases in which the recipient has been presensitized to the allograft or in which there is an ABO mismatch between the allograft and the recipient.
摘要翻译：提出了延长移植细胞，组织或器官存活的方法。这些方法涉及向同种异体移植受体施用补体活性抑制剂以及一种或多种免疫抑制剂。补体活性的抑制剂是长期施用的。已经确定了这些方法以帮助预防同种异体移植物的慢性排斥反应。这些方法可以另外用于接受者已经被同化异体移植或同种异体移植物和受体之间存在ABO不匹配的情况。

7. 发明公开

EP1988882A2 PROLONGATION OF SURVIVAL OF AN ALLOGRAFT BY INHIBITING COMPLEMENT ACTIVITY 无效
标题翻译：寿命延长同种异体移植物通过抑制KOMPLEMENTAKTVITÄT
公开(公告)号：EP1988882A2
公开(公告)日：2008-11-12
申请号：EP07752018.7
申请日：2007-03-02
申请人： ALEXION PHARMACEUTICALS, INC.
发明人： ROTHER, Russell P. , WANG, Hao , ZHONG, Zhen
IPC分类号： A61K31/00 , A61K31/573 , A61K31/365 , A61K38/00 , A61K38/13 , A61K39/395 , A61K45/06 , A61P37/06 , A61K31/16
CPC分类号： C07K16/18 , A61K31/16 , A61K31/365 , A61K31/573 , A61K38/13 , A61K2039/505
摘要： Methods of prolonging survival of allotransplanted cells, tissues or organs are presented. These methods are directed to administering to the allograft recipient an inhibitor of complement activity together with one or more immunosuppressants and/or immunosuppressive methods. The inhibitor of complement activity is administered chronically. These methods have been determined to aid in preventing chronic rejection of allografts. These methods can additionally be used in cases in which the recipient has been presensitized to the allograft or in which there is an ABO mismatch between the allograft and the recipient.

8. 发明授权

EP2670487B1 USE OF AN ANTI-CD200 ANTIBODY FOR PROLONGING THE SURVIVAL OF ALLOGRAFTS 有权
公开(公告)号：EP2670487B1
公开(公告)日：2019-09-04
申请号：EP12741568.5
申请日：2012-02-03
申请人： Alexion Pharmaceuticals, Inc.
发明人： WANG, Yi , FAAS MCKNIGHT, Susan , YU, Zhao, Xue , WANG, Hao
IPC分类号： C07K16/28 , A61K39/395 , A61P37/06

9. 发明公开

EP3056218A1 PROLONGATION OF SURVIVAL OF AN ALLOGRAFT BY INHIBITING COMPLEMENT ACTIVITY 审中-公开
标题翻译： VERLÄNGERUNGDER LEBENSDAUER EINES ALLOTRANSPLANTATS MITTELS HEMMUNG VONKOMPLEMENTAKTIVITÄT
公开(公告)号：EP3056218A1
公开(公告)日：2016-08-17
申请号：EP16160321.2
申请日：2005-05-16
申请人： Alexion Pharmaceuticals, Inc.
发明人： ROTHER, Russell P. , WANG, Hao , ZHONG, Zhen
IPC分类号： A61K39/395 , C07K16/18
CPC分类号： C07K16/18 , A61K2039/505
摘要： An antibody specific to C5, which inhibits the cleavage of C5, for use in prolonging survival of an allograft in a recipient mammal, wherein said antibody to C5 is to be administered chronically and said antibody to C5 is administered in conjunction with more than one immunosuppressive drug.
摘要翻译：一种针对C5抑制C5切割的抗体，用于延长受体哺乳动物中同种异体移植物的存活，其中所述针对C5的抗体将被长期施用，并且所述针对C5的抗体与多于一种免疫抑制剂药物。

10. 发明授权

EP1988882B1 PROLONGATION OF SURVIVAL OF AN ALLOGRAFT BY INHIBITING COMPLEMENT ACTIVITY 无效
标题翻译：通过抑制补充活动延长异体移植的存活时间
公开(公告)号：EP1988882B1
公开(公告)日：2014-12-17
申请号：EP07752018.7
申请日：2007-03-02
申请人： ALEXION PHARMACEUTICALS, INC.
发明人： ROTHER, Russell P. , WANG, Hao , ZHONG, Zhen
IPC分类号： C07K16/18 , A61K39/00 , A61P37/06 , A61K38/13 , A61K31/16 , A61K31/365 , A61K31/573
CPC分类号： C07K16/18 , A61K31/16 , A61K31/365 , A61K31/573 , A61K38/13 , A61K2039/505

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