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1. 发明申请

WO2010065079A3 ANTIBODIES TO IL-6 AND USE THEREOF 审中-公开
标题翻译：抗IL-6的抗体及其用途
公开(公告)号：WO2010065079A3
公开(公告)日：2010-07-29
申请号：PCT/US2009006274
申请日：2009-11-24
申请人： ALDER BIOPHARMACEUTICALS INC , GARCIA-MARTINEZ LEON , JENSEN ANNE ELISABETH CARVALHO , OLSON KATIE , DUTZAR BEN , LATHAM JOHN , KOVACEVICH BRIAN , SMITH JEFFREY T L , LITTON MARK , SCHATZMAN RANDALL
发明人： GARCIA-MARTINEZ LEON , JENSEN ANNE ELISABETH CARVALHO , OLSON KATIE , DUTZAR BEN , LATHAM JOHN , KOVACEVICH BRIAN , SMITH JEFFREY T L , LITTON MARK , SCHATZMAN RANDALL
IPC分类号： A61K39/395 , C07H21/04 , C07K16/24
CPC分类号： C07K16/248 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C07K2317/92
摘要： Disclosed are therapeutic methods using IL-6 antagonists such as an Ab 1 antibody or antibody fragment having binding specificity for IL-6 to prevent or treat disease or to improve survivability or quality of life of a patient in need thereof Patients will preferably comprise those exhibiting (or at psk of developing) an elevated serum C-reactive protein level, reduced serum albumin level, elevated D-dimer or other coagulation cascade related prote?n(s), cachexia, fever, weakness and/or fatigue prior to treatment The subject therapies also may include the administration of other actives such as chemotherapeutics, anti-coagulants, statins, and others
摘要翻译：公开了使用IL-6拮抗剂如Ab1抗体或对IL-6具有结合特异性的抗体片段来治疗疾病或改善有需要的患者的生存能力或生活质量的治疗方法。患者优选包括那些展现（或发展中的psk）升高的血清C-反应蛋白水平，降低的血清白蛋白水平，升高的D-二聚体或其他凝血级联相关的蛋白质，恶病质，发热，无力和/或疲劳治疗前主题疗法还可以包括其他活性物质的施用，例如化学治疗剂，抗凝血剂，他汀类药物和其他活性物质

2. 发明申请

WO2011066371A3 ANTIBODIES TO IL-6 AND USE THEREOF 审中-公开
标题翻译： IL-6的抗体及其用途
公开(公告)号：WO2011066371A3
公开(公告)日：2011-10-20
申请号：PCT/US2010057981
申请日：2010-11-24
申请人： ALDER BIOPHARMACEUTICALS INC , GARCIA-MARTINEZ LEON , JENSEN ANNE ELISABETH CARVALHO , OLSON KATIE , DUTZAR BEN , LATHAM JOHN , KOVACEVICH BRIAN , SMITH JEFFREY T L , LITTON MARK , SCHATZMAN RANDALL
发明人： GARCIA-MARTINEZ LEON , JENSEN ANNE ELISABETH CARVALHO , OLSON KATIE , DUTZAR BEN , LATHAM JOHN , KOVACEVICH BRIAN , SMITH JEFFREY T L , LITTON MARK , SCHATZMAN RANDALL
IPC分类号： A61K39/395 , A61K38/16 , A61P25/00 , A61P29/00 , A61P35/00
CPC分类号： A61K39/3955 , A61K31/454 , A61K38/2013 , A61K38/208 , A61K45/06 , A61K2039/505 , A61K2039/545 , C07K16/248 , C07K16/462 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/565 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94
摘要： The present invention is directed to therapeutic methods using IL-6 antagonists such as an Ab1 antibody or antibody fragment having binding specificity for IL-6 to prevent or treat disease or to improve survivability or quality of life of a patient in need thereof. In preferred embodiments these patients will comprise those exhibiting (or at risk of developing) an elevated serum C-reactive protein level, reduced serum albumin level, elevated D-dimer or other coagulation cascade related protein(s), cachexia, fever, weakness and/or fatigue prior to treatment. The subject therapies also may include the administration of other actives such as chemotherapeutics, anti-coagulants, statins, and others. Additional preferred embodiments of the subject invention relate to therapeutic compositions and methods treating or preventing rheumatoid arthritis, especially subcutaneous and intravenous formulations and dosage regimens using IL-6 antagonists according to the invention, as well as methods for preventing or treating GVHD or leukemia relapse in subjects receiving transplanted cells, tissue or organs, use thereof in the treatment or prevention of mucositis, and use thereof to potentiate the cytotoxic, apoptotic, and anti-metastatic or anti-invasive effects of chemotherapeutics and radiation on cancers, especially cancers that have developed a resistance to radiation or chemotherapy, such as an EGFR inhibitor.
摘要翻译：本发明涉及使用IL-6拮抗剂例如Ab1抗体或对IL-6具有结合特异性的抗体片段来预防或治疗疾病或改善有需要的患者的生存能力或生活质量的治疗方法。在优选的实施方案中，这些患者将包括显示（或处于发展中）升高的血清C-反应蛋白水平，降低的血清白蛋白水平，升高的D-二聚体或其他凝血级联相关蛋白，恶病质，发热，虚弱和 /或治疗前疲劳。主题疗法还可包括施用其他活性物质，例如化学治疗剂，抗凝血剂，他汀类药物等。本发明的另外优选实施方案涉及治疗或预防类风湿性关节炎，特别是使用根据本发明的IL-6拮抗剂的皮下和静脉内制剂和剂量方案的治疗组合物和方法，以及预防或治疗GVHD或白血病复发的方法接受移植的细胞，组织或器官的受试者，其在治疗或预防粘膜炎中的应用，以及其用于增强化学治疗剂和辐射对癌症尤其是癌症的细胞毒性，细胞凋亡和抗转移或抗侵袭作用对辐射或化学疗法的抗性，如EGFR抑制剂。

3. 发明申请

WO2008144763A3 ANTIBODIES TO IL-6 AND USE THEREOF 审中-公开
标题翻译：抗IL-6的抗体及其用途
公开(公告)号：WO2008144763A3
公开(公告)日：2009-01-22
申请号：PCT/US2008064432
申请日：2008-05-21
申请人： ALDER BIOPHARMACEUTICALS INC , GARCIA-MARTINEZ LEON , JENSEN ANNE ELISABETH CARVALHO , OLSON KATIE , DUTZAR BEN , OJALA ETHAN , LATHAM JOHN , KOVACEVICH BRIAN , SMITH JEFFREY T L
发明人： GARCIA-MARTINEZ LEON , JENSEN ANNE ELISABETH CARVALHO , OLSON KATIE , DUTZAR BEN , OJALA ETHAN , LATHAM JOHN , KOVACEVICH BRIAN , SMITH JEFFREY T L
IPC分类号： A61K39/395
CPC分类号： C07K16/248 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/20 , C07K2317/24 , C07K2317/34 , C07K2317/41 , C07K2317/76 , C07K2317/94
摘要： The present invention is directed to antibodies and fragments thereof having binding specificity for IL-6. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-IL-6 antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-IL-6 antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-IL-6 antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with IL-6. These antibodies may bind at least one of soluble IL-6, cell surface expressed IL-6, IL-6/IL-6R and/or prevent the association of IL-6 and IL-6R, the association of IL-6/IL-6R and gp130 and or the formation of IL-6/IL-6R/gp130 multimers and thereby inhibit a biological effect associated with any of the foregoing.
摘要翻译：本发明涉及对IL-6具有结合特异性的抗体及其片段。本发明的另一个实施方案涉及本文所述的抗体及其结合片段，其包含本文所述的VH，VL和CDR多肽的序列，以及编码它们的多核苷酸。本发明还涉及抗IL-6抗体及其与一个或多个功能或可检测部分缀合的结合片段的缀合物。本发明还考虑制备所述抗IL-6抗体及其结合片段的方法。本发明的实施方案还涉及抗IL-6抗体及其结合片段用于诊断，评估和治疗与IL-6相关的疾病和病症的用途。这些抗体可以结合可溶性IL-6，细胞表面表达的IL-6，IL-6 / IL-6R中的至少一种和/或阻止IL-6和IL-6R的结合，IL-6 / IL -6R和gp130，或者形成IL-6 / IL-6R / gp130多聚体，从而抑制与前述任何相关的生物学作用。

4. 发明申请

WO2008144753A3 ANTIBODIES TO TNF ALPHA AND USE THEREOF 审中-公开
标题翻译：抗TNF抗体及其用途
公开(公告)号：WO2008144753A3
公开(公告)日：2009-01-29
申请号：PCT/US2008064414
申请日：2008-05-21
申请人： ALDER BIOPHARMACEUTICALS INC , GARCIA-MARTINEZ LEON , JENSEN ANNE ELISABETH CARVALHO , OLSON KATIE , DUTZAR BEN , OJALA ETHAN , LATHAM JOHN
发明人： GARCIA-MARTINEZ LEON , JENSEN ANNE ELISABETH CARVALHO , OLSON KATIE , DUTZAR BEN , OJALA ETHAN , LATHAM JOHN
IPC分类号： A61K39/395
CPC分类号： C07K16/241 , A61K39/3955 , A61K45/06 , A61K47/6815 , A61K47/6845 , A61K49/0002 , A61K49/001 , A61K51/1021 , C07K2317/34 , C07K2317/41 , C07K2317/622
摘要： The present invention is directed to antibodies and fragments thereof having binding specificity for TNF-a. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-TNF-a antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-TNF-a antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-TNF-a antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with TNF-a.
摘要翻译：本发明涉及对TNF-α具有结合特异性的抗体及其片段。本发明的另一个实施方案涉及本文所述的抗体及其结合片段，其包含本文所述的VH，VL和CDR多肽的序列，以及编码它们的多核苷酸。本发明还考虑了与一种或多种功能或可检测部分缀合的抗TNF-α抗体及其结合片段的缀合物。本发明还考虑制备所述抗TNF-α抗体及其结合片段的方法。本发明的实施方案还涉及抗TNF-α抗体及其结合片段用于诊断，评估和治疗与TNF-α相关的疾病和病症的用途。

5. 发明申请

WO2012162243A3 ANTI-CGRP COMPOSITIONS AND USE THEREOF 审中-公开
标题翻译：抗CGRP组合物及其用途
公开(公告)号：WO2012162243A3
公开(公告)日：2013-01-17
申请号：PCT/US2012038844
申请日：2012-05-21
申请人： ALDERBIO HOLDINGS LLC , KOVACEVICH BRIAN ROBERT , GARCIA-MARTINEZ LEON F , OLSON KATIE , DUTZAR BENJAMIN H , BILLGREN JENS J , LATHAM JOHN A , MITCHELL DANIELLE M , MCNEILL PATRICIA DIANNE , JANSON NICOLE M , LOOMIS MARIA-CRISTINA
发明人： KOVACEVICH BRIAN ROBERT , GARCIA-MARTINEZ LEON F , OLSON KATIE , DUTZAR BENJAMIN H , BILLGREN JENS J , LATHAM JOHN A , MITCHELL DANIELLE M , MCNEILL PATRICIA DIANNE , JANSON NICOLE M , LOOMIS MARIA-CRISTINA
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00 , C12N15/13
CPC分类号： C07K16/18 , A61K31/485 , A61K39/3955 , A61K49/00 , A61K2039/505 , C07K16/26 , C07K2317/24 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76
摘要： The present invention is directed to antibodies and fragments thereof having binding specificity for CGRP. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-CGRP antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-CGRP antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-CGRP antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with CGRP.
摘要翻译：本发明涉及对CGRP具有结合特异性的抗体及其片段。本发明的另一个实施方案涉及本文所述的抗体及其结合片段，其包含本文所述的VH，VL和CDR多肽的序列，以及编码它们的多核苷酸。本发明还考虑了抗CGRP抗体和与一个或多个功能或可检测部分缀合的结合片段的缀合物。本发明还考虑制备所述抗CGRP抗体及其结合片段的方法。本发明的实施方案还涉及抗CGRP抗体及其结合片段用于诊断，评估和治疗与CGRP相关的疾病和病症的用途。

6. 发明专利

MX2012005927A ANTICUERPOS PARA IL-6 USO DE LOS MISMOS. 未知
公开(公告)号：MX2012005927A
公开(公告)日：2012-11-23
申请号：MX2012005927
申请日：2010-11-24
申请人： ALDER BIOPHARMACEUTICALS INC
发明人： LATHAM JOHN , KOVACEVICH BRIAN , OLSON KATIE , JENSEN ANNE ELISABETH CARVALHO , DUTZAR BEN , SMITH JEFFREY T L , LITTON MARK , SCHATZMAN RANDALL , GARCIA-MARTINEZ LEON
IPC分类号： A61K39/395 , A61K38/16 , A61P25/00 , A61P29/00 , A61P35/00
摘要： La presente invención se dirige a métodos terapéuticos que usan antagonistas de IL-6 tal como un anticuerpo Ab1 o fragmento de anticuerpo que tiene especificidad de enlace para IL-6 para prevenir o tratar una enfermedad o para mejorar la supervivencia o calidad de vida de un paciente en necesidad de los mismos. En modalidades preferidas estos pacientes comprenderán aquellos que exhiben (o están en riesgo de desarrollar) un nivel de proteína C-reactiva en el suero elevado, nivel de albúmina en el suero reducido, D-dímero elevado u otra(s) proteína(s) relacionada(s) con la cascada de coagulación, caquexia, fiebre, debilidad y/o fatiga antes del tratamiento. Las presentes terapias también pueden incluir la administración de otros activos tales como quimioterapéuticos, anticoagulantes, estatinas y otros. Las modalidades preferidas adicionales de la presente invención se relacionan a composiciones terapéuticas y métodos para tratar o prevenir la artritis reumatoide, especialmente formulaciones subcutáneas e intravenosas y regimenes de dosificación que usan los antagonistas de IL-6 de acuerdo con la invención, así como métodos para prevenir o tratar GVHD o recaída de leucemia en sujetos que reciben células, tejido u órganos transplantados, uso de los mismos en el tratamiento o prevención de mucositis, y uso de los mismos para aumentar en potencia los efectos citotóxicos, apoptóticos y antimetastáticos o anti-invasivos de los quimioterapéuticos y radiación sobre cánceres, especialmente cánceres que han desarrollado una resistencia a la radiación o quimioterapia, tal como un inhibidor de EGFR.

7. 发明专利

MX2009012492A ANTICUERPOS PARA IL-6 Y SUS USOS. 未知
公开(公告)号：MX2009012492A
公开(公告)日：2010-01-20
申请号：MX2009012492
申请日：2008-05-21
申请人： ALDER BIOPHARMACEUTICALS INC
发明人： LATHAM JOHN , KOVACEVICH BRIAN , GARCIA-MARTINEZ LEON , OLSON KATIE , JENSEN ANNE ELISABETH CARVALHO , DUTZAR BEN , OJALA ETHAN , SMITH JEFFREY T L
IPC分类号： A61K39/395
摘要： La presente invención se dirige a anticuerpos y fragmentos de los mismos que tienen especificidad de enlace para IL-6. Otra modalidad de esta invención se relaciona a los anticuerpos descritos en la presente, y fragmentos de enlace de los mismos, que comprenden las secuencias de los polipéptidos VH, VL y CDR descritos en la presente, y los polinucleótidos que los codifican. La invención también contempla conjugados de anticuerpos anti-IL-6 y fragmentos de enlace de los mismos conjugados con una o más porciones funcionales o detectables. La invención también contempla métodos para hacer los anticuerpos anti-IL-6 y fragmentos de enlace de los mismos. Las modalidades de la invención también pertenecen al uso de anticuerpos anti-IL-6, y fragmentos de enlace de los mismos, para la diagnosis, estimación y tratamiento de enfermedades y desórdenes asociados con IL-6. Estos anticuerpos pueden enlazar por lo menos uno de IL-6 soluble, IL-6 expresado en la superficie celular, IL-6/IL-6R y/o prevenir la asociación de IL-6 e IL-6R, la asociación de IL-6/IL-6R y gp130 y/o la formación de multimeros IL-6/IL- 6R/gp130 y de esta manera inhibir un efecto biológico asociado con cualquiera de lo anterior.

8. 发明专利

NO20093387A 未知
公开(公告)号：NO20093387A
公开(公告)日：2010-01-15
申请号：NO20093387
申请日：2009-11-20
申请人： ALDER BIOPHARMACEUTICALS INC
发明人： LATHAM JOHN , OJALA ETHAN , KOVACEVICH BRIAN , GARCIA-MARTINEZ LEON , JENSEN ANNE ELISABETH CARVALHO , OLSON KATIE , DUTZAR BEN , SMITH JEFFREY T L
IPC分类号： C07K16/24 , A61K39/395 , A61P37/02 , C07K16/18 , C12P21/08
CPC分类号： C07K16/248 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/20 , C07K2317/24 , C07K2317/34 , C07K2317/41 , C07K2317/76 , C07K2317/94
摘要： The present invention is directed to antibodies and fragments thereof having binding specificity for IL-6. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the V H , V L and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-IL-6 antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-IL-6 antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-IL-6 antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with IL-6. These antibodies may bind at least one of soluble IL-6, cell surface expressed IL-6, IL-6/IL-6R and/or prevent the association of IL-6 and IL-6R, the association of IL-6/IL-6R and gp130 and or the formation of IL-6/IL-6R/gp130 multimers and thereby inhibit a biological effect associated with any of the foregoing.

9. 发明专利

CA2688146A1 ANTIBODIES TO IL-6 AND USE THEREOF 未知
公开(公告)号：CA2688146A1
公开(公告)日：2008-11-27
申请号：CA2688146
申请日：2008-05-21
申请人： ALDER BIOPHARMACEUTICALS INC
发明人： OLSON KATIE , KOVACEVICH BRIAN , LATHAM JOHN , JENSEN ANNE ELISABETH CARVALHO , DUTZAR BEN , SMITH JEFFREY T L , OJALA ETHAN , GARCIA-MARTINEZ LEON
IPC分类号： C12N15/13 , A61K39/395 , A61K47/48 , A61K49/00 , A61K51/10 , C07K16/24 , C12N1/19 , C12P21/08
摘要： The present invention is directed to antibodies and fragments thereof hav ing binding specificity for IL-6. Another embodiment of this invention relat es to the antibodies described herein, and binding fragments thereof, compri sing the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugate s of anti-IL-6 antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates met hods of making said anti-IL-6 antibodies and binding fragments thereof. Embo diments of the invention also pertain to the use of anti-IL-6 antibodies, an d binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with IL-6. These antibodies may bind at le ast one of soluble IL-6, cell surface expressed IL-6, IL-6/IL-6R and/or prev ent the association of IL-6 and IL-6R, the association of IL-6/IL-6R and gp1 30 and or the formation of IL-6/IL-6R/gp130 multimers and thereby inhibit a biological effect associated with any of the foregoing.

10. 发明专利

ZA201103803B ANTIBODIES TO IL-6 AND USE THEREOF 未知
公开(公告)号：ZA201103803B
公开(公告)日：2022-03-30
申请号：ZA201103803
申请日：2011-05-24
申请人： ALDER BIOPHARMACEUTICALS INC
发明人： LATHAM JOHN , GARCIA-MARTINEZ LEON , OLSON KATIE , SMITH JEFFREY T L , SCHATZMAN RANDALL , JENSEN ANNE ELISABETH CARVALHO , DUTZAR BEN , KOVACEVICH BRIAN , LITTON MARK
IPC分类号： A61K39/00
摘要： The present invention is directed to therapeutic methods using IL-6 antagonists such as an Abl antibody or antibody fragment having binding specificity for IL-6 to prevent or treat disease or to improve survivability or quality of life of a patient in need thereof. In preferred embodiments these patients will comprise those exhibiting (or at risk of developing) an elevated serum C-reactive protein level, reduced serum albumin level, elevated D-dimer or other coagulation cascade related protein(s), cachexia, fever, weakness and/or fatigue prior to treatment. The subject therapies also may include the administration of other actives such as chemotherapeutics, anti-coagulants, statins, and others.

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