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    • 3. 发明申请
    • EPSTEIN-BARR VIRUS PEPTIDES AND ANTIBODIES AGAINST THESE PEPTIDES
    • EPSTEIN-BARR病毒肽和抗体对抗这些肽
    • WO1994006912A1
    • 1994-03-31
    • PCT/EP1993002478
    • 1993-09-13
    • AKZO N.V.MIDDELDORP, Jaap, Michiel
    • AKZO N.V.
    • C12N15/38
    • C07K16/087C07K14/005C12N2710/16222
    • The invention relates to a peptide or fragment thereof which is immunochemically reactive with Epstein-Barr Virus (EBV) antibodies. A new monoclonal antibody directed to said peptide or fragment thereof is also part of the invention. The invention also relates to a method for the detection of EBV or anti-EBV antibodies in a test fluid and also to an immunochemical reagent comprising a peptide, a fragment or a polypeptide according to the invention and a test kit to be used when applying the said detection methods. Detection of EBV in a test fluid or tissue specimen using antibodies, monoclonal and polyclonal, directed to the said peptide, which have the characteristics of detecting both native and denatured intact, functional EBNA-1 protein is also part of said invention.
    • 本发明涉及与爱泼斯坦 - 巴尔病毒(EBV)抗体免疫化学反应的肽或其片段。 针对所述肽或其片段的新单克隆抗体也是本发明的一部分。 本发明还涉及一种用于在测试流体中检测EBV或抗EBV抗体的方法,还涉及包含根据本发明的肽,片段或多肽的免疫化学试剂以及当应用本发明时使用的测试试剂盒 说检测方法。 使用具有检测天然和变性完整的功能性EBNA-1蛋白的特征的针对所述肽的抗体(单克隆抗体和多克隆抗体)检测试验液或组织标本中的EBV也是所述发明的一部分。