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1. 发明专利

JP2004000479A Modular type home dialysis system 有权
公开(公告)号：JP2004000479A
公开(公告)日：2004-01-08
申请号：JP2003029641
申请日：2003-02-06
申请人： Aksys Ltd , アクシスリミテッドAksys, Ltd.
发明人： KENLEY RODNEY S , MATTHEWS DAWN , WILKERSON DOUGLAS L , TREU DENNIS M , PETER JR FREDERICK H , BROSE TOM L , BELL ERIC , FELDSEIN THOMAS M , PAWLAK KENNETH E , WALKER DONALD C , MINNS H GORDON , ADOLF WAYNE F
IPC分类号： A61M1/14 , A61L2/04 , A61L2/18 , A61M1/16 , A61M1/34 , A61M1/36 , A61M39/16 , B01D17/00 , B01D17/09 , B01D61/02 , B01D61/04 , B01D61/12 , B01D61/24 , B01D61/32 , B01D65/02 , B01D65/10 , C02F1/28 , C02F1/44 , C02F1/68 , F16K17/04
CPC分类号： B01D65/102 , A61L2/04 , A61L2/18 , A61M1/16 , A61M1/1607 , A61M1/1609 , A61M1/1649 , A61M1/165 , A61M1/1656 , A61M1/1658 , A61M1/166 , A61M1/1662 , A61M1/1666 , A61M1/1668 , A61M1/1672 , A61M1/1682 , A61M1/1684 , A61M1/1686 , A61M1/1688 , A61M1/169 , A61M1/1692 , A61M1/1694 , A61M1/288 , A61M1/3434 , A61M1/3437 , A61M1/3465 , A61M1/3468 , A61M1/3609 , A61M1/3626 , A61M1/3627 , A61M1/3629 , A61M1/3639 , A61M1/3641 , A61M1/3643 , A61M1/3644 , A61M1/3646 , A61M1/3647 , A61M1/3649 , A61M1/365 , A61M39/16 , A61M2205/12 , A61M2205/15 , A61M2205/17 , A61M2205/18 , A61M2205/3317 , A61M2205/3324 , A61M2205/3331 , A61M2205/3344 , A61M2205/3368 , A61M2205/3382 , A61M2205/3386 , A61M2205/502 , A61M2205/505 , A61M2205/6072 , A61M2205/705 , A61M2205/707 , A61M2205/7554 , A61M2205/7581 , A61M2206/11 , A61M2230/65 , B01D61/02 , B01D61/025 , B01D61/04 , B01D61/12 , B01D61/32 , B01D65/022 , B01D65/104 , B01D2311/04 , B01D2321/04 , B01D2321/16 , B01D2321/32 , C02F1/441 , F16K17/0453 , Y10S210/929 , Y10S215/03 , Y10T137/7722 , Y10T137/7794 , Y10T137/7796 , Y10T137/7799 , B01D2311/10 , B01D2311/25 , B01D2311/2626
摘要： PROBLEM TO BE SOLVED: To provide a water pre-processing apparatus for an artificial kidney machine having a feed water port in a home blood dialysis system which requires just minimum patient's labor and is automated, advantageous in costs, movable, simplified and reliable. SOLUTION: Water is guided from a water source through the water pre-processing apparatus 20, and the modular type home dialysis system is provided with: a liquid path 46 arranged with a carbon filter 44, a polyphosphate water quality regulating agent 43 and a water pressure regulator 38 for controlling a pressure to be supplied to the artificial kidney machine 22; a liquid drain conduit 58 for supply to the water pre-processing apparatus 20; and a water put-in route 54 for connecting a water put-in connection to a feed water port 52 of the artificial kidney machine 22. The liquid drain conduit 58 is connected between a water drain outlet of the artificial kidney machine 22 and a drain put-in connection of the water pre-processing apparatus 20, and the artificial kidney machine 22 is equipped with a user interface 25 for periodically calling periodical switching of the water put-in route 54 and the liquid drain conduit 58. Besides, in the liquid drain conduit 58, the water put-in connection is connected to a water intake 56, and in the water put-in route 54, the liquid drain outlet 50 is connected to the drain put-in connection. COPYRIGHT: (C)2004,JPO

2. 发明专利

JP2003199819A MODULAR TYPE HOME DIALYZING SYSTEM 审中-公开
公开(公告)号：JP2003199819A
公开(公告)日：2003-07-15
申请号：JP2003030963
申请日：2003-02-07
申请人： AKSYS LTD
发明人： KENLEY RODNEY S , MATTHEWS DAWN , WILKERSON DOUGLAS L , TREU DENNIS M , PETER FREDERICK H JR , BROSE TOM L , BELL ERIC , FELDSEIN THOMAS M , PAWLAK KENNETH E , WALKER DONALD C , MINNS GORDON H , ADOLF WAYNE F
IPC分类号： A61M1/14 , A61L2/04 , A61L2/18 , A61M1/16 , A61M1/34 , A61M1/36 , A61M39/16 , B01D17/00 , B01D17/09 , B01D61/02 , B01D61/04 , B01D61/12 , B01D61/24 , B01D61/32 , B01D65/02 , B01D65/10 , C02F1/28 , C02F1/44 , C02F1/68 , F16K17/04
摘要： PROBLEM TO BE SOLVED: To provide artificial kidney equipment in a simple and extremely reliable modular type home dialyzing system automating all of processes, requiring only the minimum labor of a patient, advantageous from an aspect of cost and made movable. SOLUTION: The artificial kidney equipment has a dialyzer having a dialyzing membrane for discriminating between a blood side and a dialyzing fluid side and the extracorporeal circulation circuit comprising the artery and vein side circuits connected to the dialyzer to become a route for mainly guiding the blood of a patient to the dialyzer and subsequently returning the same to patient. The extracorporeal circulation circuit has a reversibly rotatable blood pump and a dialyzing fluid circuit including a dialyzing fluid supply flow channel for supplying a dialyzing fluid to the dialyzer and a dialyzing fluid drain flow channel for draining the dialyzing fluid from the dialyzer. The dialyzing fluid circuit has a dialyzing fluid pump for circulating the dialyzing fluid and communicates with an ultrafiltration tank through a reversibly rotatable ultrafiltration pump to perform the liquid transport from the blood side to the dialyzing fluid side through the dialyzing membrane and the liquid transport from the dialyzing fluid side to the blood side. COPYRIGHT: (C)2003,JPO

3. 发明专利

JP2003235966A MODULAR TYPE AT-HOME ARTIFICIAL DIALYSIS SYSTEM 审中-公开
公开(公告)号：JP2003235966A
公开(公告)日：2003-08-26
申请号：JP2003029462
申请日：2003-02-06
申请人： AKSYS LTD
发明人： KENLEY RODNEY S , MATTHEWS DAWN , WILKERSON DOUGLAS L , TREU DENNIS M , PETER FREDERICK H JR , BROSE TOM L , BELL ERIC , FELDSEIN THOMAS M , PAWLAK KENNETH E , WALKER DONALD C , MINNS GORDON H , ADOLF WAYNE F
IPC分类号： A61M1/14 , A61L2/04 , A61L2/18 , A61M1/16 , A61M1/34 , A61M1/36 , A61M39/16 , B01D17/00 , B01D17/09 , B01D61/02 , B01D61/04 , B01D61/12 , B01D61/24 , B01D61/32 , B01D65/02 , B01D65/10 , C02F1/28 , C02F1/44 , C02F1/68 , F16K17/04
摘要： PROBLEM TO BE SOLVED: To provide a method for deciding necessity for exchanging a dialysis device by testing clearance of the dialysis device in a simple and reliable at- home blood dialysis system requiring minimum labor of a patient by automating all processes. SOLUTION: The method contains a step for repeating a step for roughly estimating a urea clearance of the dialysis device in the new condition by measuring conductivity of a dialysis solution before and after circulation of the dialysis solution through a dialysis solution side of the dialysis device and a step for roughly estimating the urea clearance of the dialysis device after a dialysis session by measuring conductivity of the second dialysis solution before and after circulation of the second dialysis solution through the dialysis solution side of the dialysis device and deciding a new coefficient of clearance of the dialysis device, and a step for comparing K init with K i , and a step for pressing a user of an artificial kidney machine to exchange the dialysis device when K i init by using a predetermined quantity of threshold. COPYRIGHT: (C)2003,JPO

4. 发明专利

JP2003235961A MODULAR TYPE AT-HOME ARTIFICIAL DIALYSIS SYSTEM 审中-公开
公开(公告)号：JP2003235961A
公开(公告)日：2003-08-26
申请号：JP2003029320
申请日：2003-02-06
申请人： AKSYS LTD
发明人： KENLEY RODNEY S , MATTHEWS DAWN , WILKERSON DOUGLAS L , TREU DENNIS M , PETER FREDERICK H JR , BROSE TOM L , BELL ERIC , FELDSEIN THOMAS M , PAWLAK KENNETH E , WALKER DONALD C , MINNS GORDON H , ADOLF WAYNE F
IPC分类号： A61M1/14 , A61L2/04 , A61L2/18 , A61M1/16 , A61M1/34 , A61M1/36 , A61M39/16 , B01D17/00 , B01D17/09 , B01D61/02 , B01D61/04 , B01D61/12 , B01D61/24 , B01D61/32 , B01D65/02 , B01D65/10 , C02F1/28 , C02F1/44 , C02F1/68 , F16K17/04
摘要： PROBLEM TO BE SOLVED: To provide a device for eliminating bubbles from the blood in a low- priced, movable, simple and reliable at-home blood dialysis system requiring minimum labor of a patient by automating all processes. SOLUTION: This system is provided with a front cover 1002, a rear cover 1008 and a liquid circuit board 1004 provided between the front cover and the rear cover and having opposite surfaces of a front part and a rear part facing to the front cover and the rear cover. In this liquid circuit board, a blood chamber 1014 and an air chamber are formed, and a fine porous film separates the blood chamber from the air chamber. The system is also provided with a fine porous film support means, a pressure sensor, a blood inlet port 1022, a blood outlet port 1020 and an air port communicating with the air chamber so that gas passes for discharge from the blood chamber through the fine porous film. COPYRIGHT: (C)2003,JPO

5. 发明专利

JP2003245344A MODULAR TYPE DIALYSIS SYSTEM AT HOME 审中-公开
公开(公告)号：JP2003245344A
公开(公告)日：2003-09-02
申请号：JP2003029402
申请日：2003-02-06
申请人： AKSYS LTD
发明人： KENLEY RODNEY S , MATTHEWS DAWN , WILKERSON DOUGLAS L , TREU DENNIS M , PETER FREDERICK H JR , BROSE TOM L , BELL ERIC , FELDSEIN THOMAS M , PAWLAK KENNETH E , WALKER DONALD C , MINNS GORDON H , ADOLF WAYNE F
IPC分类号： A61M1/14 , A61L2/04 , A61L2/18 , A61M1/16 , A61M1/34 , A61M1/36 , A61M39/16 , B01D17/00 , B01D17/09 , B01D61/02 , B01D61/04 , B01D61/12 , B01D61/24 , B01D61/32 , B01D65/02 , B01D65/10 , C02F1/28 , C02F1/44 , C02F1/68 , F16K17/04
摘要： PROBLEM TO BE SOLVED: To provide an apparatus which establishes liquid connections between an extracorporeal circulation circuit and microbicide liquid sources in a blood dialysis system at home that is simple and reliable by automating the entire process and allows it move by the minimum labor of patients. SOLUTION: This system is provided with a microbicidal path for conveying microbicide liquids to the extracorporeal circulation circuit 28 in an extracorporeal circulation circuit unit having an artery side circuit and a vein side circuit, a microbicidal manifold which receives an artery side circuit connector into a first port thereof and a vein side circuit connector into a second port thereof, a microbicidal manifold which provides a sufficient amount of a peripheral space on each of the external surfaces of the artery side and vein side circuit connectors when the artery side and vein side circuit connectors are received into the first and second ports of the microbicidal manifold so that liquids can be circulated around the external surfaces of the artery side and vein side circuit connectors, and a return path for establishing the liquid connections between the microbicidal manifolds and the microbicide liquid sources from the extracorporeal circulation circuit. COPYRIGHT: (C)2003,JPO

6. 发明专利

JP2003235965A MODULAR TYPE AT-HOME ARTIFICIAL DIALYSIS SYSTEM 审中-公开
公开(公告)号：JP2003235965A
公开(公告)日：2003-08-26
申请号：JP2003029540
申请日：2003-02-06
申请人： AKSYS LTD
发明人： KENLEY RODNEY S , MATTHEWS DAWN , WILKERSON DOUGLAS L , TREU DENNIS M , PETER FREDERICK H JR , BROSE TOM L , BELL ERIC , FELDSEIN THOMAS M , PAWLAK KENNETH E , WALKER DONALD C , MINNS GORDON H , ADOLF WAYNE F
IPC分类号： A61M1/14 , A61L2/04 , A61L2/18 , A61M1/16 , A61M1/34 , A61M1/36 , A61M39/16 , B01D17/00 , B01D17/09 , B01D61/02 , B01D61/04 , B01D61/12 , B01D61/24 , B01D61/32 , B01D65/02 , B01D65/10 , C02F1/28 , C02F1/44 , C02F1/68 , F16K17/04
摘要： PROBLEM TO BE SOLVED: To provide a method for automatically testing reliability of a dialysis device in an at-home blood dialysis system. SOLUTION: Blood is transported by a pump from a patient to the dialysis device through an artery side circuit, and returned to the patient through a vein side circuit. This dialysis device is provided with a film having a blood side and a dialysis liquid side. The testing method contains a step for practically eliminating the liquid existing in the blood side of the film, a step for pressurizing the dialysis device by transporting air to the blood side of the film, a step for measuring the pressurization of the dialysis device, a step for measuring attenuation of the pressurization when the dialysis device is pressurized, and a step for showing reliability of the film of the dialysis device with the pressurization and the attenuation. COPYRIGHT: (C)2003,JPO

7. 发明专利

JP2003235963A MODULAR TYPE AT-HOME ARTIFICIAL DIALYSIS SYSTEM 审中-公开
公开(公告)号：JP2003235963A
公开(公告)日：2003-08-26
申请号：JP2003029601
申请日：2003-02-06
申请人： AKSYS LTD
发明人： KENLEY RODNEY S , MATTHEWS DAWN , WILKERSON DOUGLAS L , TREU DENNIS M , PETER FREDERICK H JR , BROSE TOM L , BELL ERIC , FELDSEIN THOMAS M , PAWLAK KENNETH E , WALKER DONALD C , MINNS GORDON H , ADOLF WAYNE F
IPC分类号： A61M1/14 , A61L2/04 , A61L2/18 , A61M1/16 , A61M1/34 , A61M1/36 , A61M39/16 , B01D17/00 , B01D17/09 , B01D61/02 , B01D61/04 , B01D61/12 , B01D61/24 , B01D61/32 , B01D65/02 , B01D65/10 , C02F1/28 , C02F1/44 , C02F1/68 , F16K17/04
摘要： PROBLEM TO BE SOLVED: To provide a method for maintaining separation of old dialysis liquid and new dialysis liquid from each other in a batch dialysis liquid adjusting tank of an at-home blood dialysis system. SOLUTION: The method contains a step for storing the new dialysis liquid in the tank at a first temperature, a step for taking the new dialysis liquid from a bottom part of the tank, a step for returning the old dialysis liquid to the tank through a top part of the tank at a second temperature higher than the first temperature, while practically preventing the generation of turbulence of the old dialysis liquid when returning the old dialysis liquid to the tank. Temperature difference of the dialysis liquid between the first temperature and the second temperature and the way of returning the old dialysis liquid practically maintain the new dialysis liquid and the old dialysis liquid in separate zones, and the old dialysis liquid in the first zone is maintained at a higher position than the new dialysis liquid in the second zone, and a boundary exists between them. The boundary is lowered with a progress of the dialysis of a patient. COPYRIGHT: (C)2003,JPO

8. 发明专利

JP2003199821A MODULAR TYPE HOME DIALYZING SYSTEM 审中-公开
公开(公告)号：JP2003199821A
公开(公告)日：2003-07-15
申请号：JP2003029352
申请日：2003-02-06
申请人： AKSYS LTD
发明人： KENLEY RODNEY S , MATTHEWS DAWN , WILKERSON DOUGLAS L , TREU DENNIS M , PETER FREDERICK H JR , BROSE TOM L , BELL ERIC , FELDSEIN THOMAS M , PAWLAK KENNETH E , WALKER DONALD C , MINNS GORDON H , ADOLF WAYNE F
IPC分类号： A61M1/14 , A61L2/04 , A61L2/18 , A61M1/16 , A61M1/34 , A61M1/36 , A61M39/16 , B01D17/00 , B01D17/09 , B01D61/02 , B01D61/04 , B01D61/12 , B01D61/24 , B01D61/32 , B01D65/02 , B01D65/10 , C02F1/28 , C02F1/44 , C02F1/68 , F16K17/04
摘要： PROBLEM TO BE SOLVED: To provide a method for automatically priming the dialyzer of the extracorporeal circulation circuit in a simple and extremely reliable modular type home dialyzing system automating all of processes, requiring only the minimum labor of a patient, advantageous from an aspect of cost and made movable. SOLUTION: In the method for automatically priming the dialyzer of the extracorporeal circulation circuit, the dialyzer has a membrane and the blood side and dialyzing fluid side thereof. This priming method is performed in artificial kidney equipment as it is and includes a step for substantially filling the extracorporeal circulation circuit and the blood side of the dialyzer with a liquid, a step being a step inducing a plurality of short pressure pulses in the liquid of the extracorporeal circulation circuit and the blood side of the dialyzer and removing the air bubbles of the membrane on the blood side of the dialyzer from the blood side of the membrane by a plurality of the short pressure pulses and a step for guiding air bubbles from the blood side of the dialyzer to remove them from the extracorporeal circulation circuit. COPYRIGHT: (C)2003,JPO

9. 发明专利

JPH09618A ARTIFICIAL KIDNEY APPARATUS 失效
公开(公告)号：JPH09618A
公开(公告)日：1997-01-07
申请号：JP2570596
申请日：1996-02-13
申请人： AKSYS LTD , AKUSHISU LTD
发明人： KENLEY RODNEY S , MATTHEWS DAWN , WILKERSON DOUGLAS L , TREU DENNIS M , PETER FREDERICK H JR , BROSE TOM L , BELL ERIC , FELDSEIN THOMAS M , PAWLAK KENNETH E , WALKER DONALD C , MINNS GORDON H , ADOLF WAYNE F
IPC分类号： A61M1/14 , A61L2/04 , A61L2/18 , A61M1/16 , A61M1/34 , A61M1/36 , A61M39/16 , B01D17/00 , B01D17/09 , B01D61/02 , B01D61/04 , B01D61/12 , B01D61/24 , B01D61/32 , B01D65/02 , B01D65/10 , C02F1/28 , C02F1/44 , C02F1/68 , F16K17/04
摘要： PROBLEM TO BE SOLVED: To conduct a hemodialysis in a shortened time for a patient, by communicating the outlet of a temperature regulating mixing valve to a water filtrating unit and by supplying water to a liquid path from the water filtrating unit to a water supply inlet of an artificial kidney. SOLUTION: A water pretreatment module 20 equipped with a demountable circuit is connected to a home water supply source which supplies hot water and cooling water. Hot water and cooling water are supplied from the home water supply source to a temperature regulating valve 36, the water is mixed here, kept at a given temperature in an outlet path 37 and sent to a water filtrating unit 40 through a water pressure regulating valve 38 and a manual operating valve 39. The filtrated water is supplied from the water filtrating unit 40 through an outlet 50 to a supplying inlet 52 of the artificial kidney through a demountable hose 54. The effluent from the artificial kidney apparatus 22 is sent to a drainage 60 of the home apparatus through a drain path 62 and a check valve CV3. By this apparatus, a hemodialysis to a patient can be conducted in a short time, and a labor and a cost of consumable can be reduced.

10. 发明专利

DE19655230B4 未知
公开(公告)号：DE19655230B4
公开(公告)日：2009-04-02
申请号：DE19655230
申请日：1996-02-13
申请人： AKSYS LTD
发明人： KENLEY RODNEY S , MATTHEWS DAWN , WILKERSON DOUGLAS L , TREU DENNIS M , PETER JUN FREDERICK H , BROSE TOM L , BELL ERIC , FELDSEIN THOMAS M , PAWLAK KENNETH E , WALKER DONALD C , MINNS H GORDON , ADOLF WAYNE F
IPC分类号： A61M1/14 , A61L2/04 , A61M1/16 , A61L2/18 , A61M1/34 , A61M1/36 , A61M39/16 , B01D17/00 , B01D17/09 , B01D61/02 , B01D61/04 , B01D61/12 , B01D61/24 , B01D61/32 , B01D65/02 , B01D65/10 , C02F1/28 , C02F1/44 , C02F1/68 , F16K17/04
摘要： Dialysis apparatus which includes water pre-treatment (20), dialysate preparation (26) and an extra corporeal circuit (28), for circulating blood from a patient through a dialysis circuit and back to the patient is described in detail and the following different inventions in, or for, a dialysis machine are claimed: (a) a water pre-treatment apparatus in which hot and cold water is fed to a thermostatically controlled mixing valve which feeds water at controlled temperature through a filter to the water inlet of the dialysis machine; (b) methods of disinfecting a dialysis machine by placing the patient ends of the arterial and venous blood lines into communication with a source of hot water which is circulated through the lines, the water treatment module and the dialysate circuit; (c) as (b) with the hot water being filtered in a reverse osmosis unit in the water treatment module (24) before it is heated; (d) a connector for establishing connection of disinfection fluid line to the arterial and venous blood lines, in which the connector has a space about the blood line ends to provide disinfection of the exterior surfaces of the ends; (e) apparatus for supply of chemicals to a dialysate tank form three vessels via a housing having two ports for passage of chemicals from two of the vessels and a third port to which the third vessel, which contains dialysate chemical, salt, nutritional supplement, medication, cleaning agent or disinfecting agent, is attached; (f) a dialysate preparation apparatus including a dialysate preparation tank and a vessel containing a batch of chemical with a device which automatically introduces the batch of chemical into the tank; (g) a bottle for a unit batch of medical chemical and a machine readable indicator attached to the bottle carrying cooled information of the bottle contents; (h) a system for applying chemicals to a dialysis tank which accepts a bottle as in (g) and has a vertically movable spike and a device for removing the machine readable indicator; (i) system as in (h) in which the indicator is read prior to applying the chemical to the tank and the patient alerted if the information does not correspond to appropriate stored information; (j) method of separating old and new dialysate in a tank by conditioning the two types to two different temperatures; (k) method of operating the dialyser by periodically pumping fluid through the dialysis membrane from the dialysis side to remove blood products from the blood side; (l) method of dialysis in which priming fluid and blood are pumped through respective circuits of the membrane to prevent priming fluid reaching the patient; (m) a method of testing the integrity of a dialysate filter by pressurising the membrane with air and monitoring the rate of decrease of pressure; (n) a method of approximating the sodium clearance of a dialyser by circulating sodium solution and water on respective sides of the membrane and measuring the sodium solution conductivity once conditions have stabilised; (o) apparatus for in-situ cleaning of dialyser and tubing set after dialysis without exposing the dialyser or tubing set to airborne contaminants; and (p) cleaning a reusable extra corporeal circuit installed in a dialyser by back flushing and cyclically changing flow rate and direction of flow of cleaning fluid.

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