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1. 发明公开

EP3054005A4 HEPAROSAN-PRODUCING BACTERIUM AND HEPAROSAN MANUFACTURING METHOD 有权
标题翻译：乙肝疫苗
公开(公告)号：EP3054005A4
公开(公告)日：2017-09-13
申请号：EP14850420
申请日：2014-10-02
申请人： AJINOMOTO KK
发明人： YAMAZAKI SHUNSUKE , SHIMIZU TOMOKO , MORI KENICHI , TONOUCHI NAOTO
IPC分类号： C12N1/21 , C07K14/245 , C08B37/00 , C08B37/10 , C12N15/09 , C12P19/04 , C12P19/26
CPC分类号： C07K14/245 , C08B37/0075 , C12N15/70 , C12P19/04 , C12P19/26
摘要： A method for producing heparosan is provided. Heparosan is produced by culturing an Escherichia bacterium having a heparosan-producing ability and modified so that expression of one or more kinds of genes selected from the group consisting of rbsR, rbsK, rbsB, hsrA, glgB, glgX, micF, rcsD, rcsB, ybiX, ybiI, ybiJ, ybiC, ybiB, rfaH, nusG, pcoR, pcoS, pcoE, yhcN, yhcO, aaeB, aaeA, aaeX, g1455, alpA, g1453, yrbA, mlaB, mlaC, mlaD, mlaE, mlaF, yrbG, norW, ybjI, ybjJ, ybjK, rybB, yjjY, yjtD, thrL, thrA, thrB, fruA, psuK, ytfT, yjfF, fbp, yagU, paoA, paoB, gsiC, gsiD, yliE, irp2, irp1, bhsA, ycfS, lepB, rnc, era, dapA, gcvR, bcp, hyfA, rpoE, nadB, yfiC, srmB, g1414, g1413, nuoE, nuoF, nuoG, glmZ, hemY, hemX, hemD, rlmL, artQ, artM, artJ, rlmC, YbjO, yejO, yejM, yejL, rpoS, ygbN, ygbM, ygbL, g3798, g3797, g3796, g3795, g3794, g3793, g3792, ryjA, soxR, soxS, yjcC, yjcB, efeU, and efeO genes is increased in a medium, and collecting heparosan from the medium.
摘要翻译：提供了一种生产肝素的方法。通过培养具有产生肝素生成能力的埃希氏菌属细菌并使其变性，使得选自rbsR，rbsK，rbsB，hsrA，glgB，glgX，micF，rcsD，rcsB， ybiX，ybiI，ybiJ，ybiC，ybiB，rfaH，nusG，pcoR，pcoS，pcoE，yhcN，yhcO，aaeB，aaeA，aaeX，g1455，alpA，g1453，yrbA，mlaB，mlaC，mlaD，mlaE，mlaF， nw，ybjI，ybjJ，ybjK，rybB，yjjY，yjtD，thrL，thrA，thrB，fruA，psuK，ytfT，yjfF，fbp，yagU，paoA，paoB，gsiC，gsiD，yliE，irp2，irp1，bhsA，ycfS， lepB，rnc，era，dapA，gcvR，bcp，hyfA，rpoE，nadB，yfiC，srmB，g1414，g1413，nuoE，nuoF，nuoG，glmZ，hemY，hemX，hemD，rlmL，artQ，art，artJ，rlmC， YbjO，yejO，yejM，yejL，rpoS，ygbN，ygbM，ygbL，g3798，g3797，g3796，g3795，g3794，g3793，g3792，ryjA，soxR，soxS，yjcC，yjcB，efeU和efeO基因在培养基，并从培养基中收集肝素。

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