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2. 发明公开

EP2657244A1 GLYCOSIDE COMPOUND 有权
标题翻译： GLYCOSIDVERBINDUNGEN ALS MITTEL ZURFÖRDERUNGDER SEKRETION VON GLP-1
公开(公告)号：EP2657244A1
公开(公告)日：2013-10-30
申请号：EP11850476.0
申请日：2011-12-22
申请人： Ajinomoto Co., Inc.
发明人： KUROSAWA, Wataru , TOYODA, Takuya , UBAGAI, Risa , NOGUSA, Yoshihito , OYAMA, Kana , AMINO, Yusuke
IPC分类号： C07H15/203 , A23L1/29 , A61K8/60 , A61K8/97 , A61K31/7034 , A61P3/04
CPC分类号： C07H15/207 , A23L33/10 , C07H15/203 , C12P19/46
摘要： The present invention provides a compound represented by the formula (I")

wherein R 11 , R 12 , R 13 , R 14 and R 15 are each independently a hydrogen atom, a hydroxyl group, a C 1-6 alkyl group, a C 1-6 alkoxy group, a C 1-6 alkyl-carbonyloxy group or a G-O- group, and at least one of R 11 , R 12 , R 13 , R 14 and R 15 is a G-O- group, wherein G is a saccharide residue,
X 1 is a single bond, or a methylene group, an ethylene group, a trimethylene group, a vinylene group or -CH=CH-CH 2 -,
X 2 is -CO-O- or -O-CO-,
p and q are each an integer of 0 to 7, which satisfy a relationship of p + q = 0 to 8,
Y 1 is a methylene group, an ethylene group or an alkenylene group having a carbon number of 2 to 15 and 1 to 3 double bonds, and
R 16 and R 17 are each independently a hydrogen atom, a methyl group or an ethyl group, or R 16 and R 17 form a C 3-6 cycloalkane,
a production method thereof, a GLP-1 secretion promoting agent containing same, and the like.
摘要翻译：本发明提供由式（I“）表示的化合物，其中R 11，R 12，R 13，R 14和R 15各自独立地为氢原子，羟基，C 1-6烷基，C 1-6烷氧基，C 1-6烷基 - 羰基氧基或GO-基团，并且R 11，R 12，R 13，R 14和R 15中的至少一个是GO-基团，其中G是糖残基，X 1为单键，亚甲基，亚乙基，三亚甲基，亚乙烯基或-CH = CH-CH 2 - ，X 2为-CO-O-或-O-CO- ，p和q各自为0〜7的整数，其满足p + q = 0〜8的关系，Y 1为亚甲基，亚乙基或碳数为2〜15的亚烯基，1 至3个双键，R 16和R 17各自独立地为氢原子，甲基或乙基，或R 16和R 17形成C 3-6环烷烃，其制备方法，GLP-1分泌含有它的促进剂等。

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