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1. 发明申请

WO2010010382A3 METHOD OF STIFFENING A RIB DURING ASSEMBLY 审中-公开
标题翻译：在组装过程中加固RIB的方法
公开(公告)号：WO2010010382A3
公开(公告)日：2010-05-06
申请号：PCT/GB2009050889
申请日：2009-07-20
申请人： AIRBUS OPERATIONS LTD , WILLIAMS STEPHEN
发明人： WILLIAMS STEPHEN
IPC分类号： B64C3/18 , B64F5/00
CPC分类号： B64C3/187 , B64F5/10 , Y10T29/49622
摘要： A method of stiffening a rib (19, 20) during the assembly of an aircraft wing is described. A stiffener panel (40, 41) is attached to a face of the rib (19, 20). The rib is aligned with one or more wing components with the stiffener panel (40, 41) attached. An assembly operation such as drilling (16) is performed with the rib aligned and the stiffener panel attached. The stiffener panel (40, 41) is removed from the rib after the assembly operation. The stiffener panel has a resilient external sealing ring which is mounted on a face of the panel and forms an external perimeter of a vacuum cavity; and at least one resilient internal sealing ring which is mounted on the panel (20, 21) within the perimeter defined by the external sealing ring and forms an internal perimeter of the vacuum cavity. The stiffener can be attached to the rib by a vacuum clamping force, the vacuum being sealed by the external and internal sealing rings. The internal sealing ring(s) seal any holes which are present in the rib. The stiffener (40, 41) can support the rib (20, 21) during alignment to give it the required flatness.
摘要翻译：描述了在飞行器机翼的组装期间加强肋（19,20）的方法。加强板（40,41）附接到肋（19,20）的表面。肋与一个或多个机翼部件对准，并且加强板（40,41）连接在一起。执行诸如钻孔（16）的组装操作，其中肋对准并且加强板连接。在组装操作之后，加强板（40,41）从肋上移除。加强板具有弹性的外部密封环，其安装在面板的表面上并形成真空腔的外周; 以及至少一个弹性内部密封环，其安装在由外部密封环限定的周边内的面板（20,21）上并形成真空腔的内部周边。加强件可以通过真空夹紧力连接到肋上，真空由外部和内部密封环密封。内密封环密封肋中存在的任何孔。加强件（40,41）可以在对准期间支撑肋（20,21），以使其成为所需的平整度。

2. 发明专利

JP2013240882A Composite structural body 有权
标题翻译：复合结构体
公开(公告)号：JP2013240882A
公开(公告)日：2013-12-05
申请号：JP2012035125
申请日：2012-02-21
申请人： Airbus Operations Ltd , エアバスオペレーションズリミテッドAirbus Operations Limited
发明人： SANDERSON TIMOTHY , WILLIAMS STEPHEN
IPC分类号： B29C70/06 , B29C70/10 , B29K105/08 , B29L31/30 , B32B5/00 , B32B5/28 , B64C1/00 , B64C3/20
CPC分类号： B64C3/185 , B29C70/207 , B29C70/222 , B29L2031/3082 , B29L2031/3085 , B64C3/24 , B64C3/26 , Y02T50/43 , Y02T50/433 , Y10T428/24124 , Y10T428/24132 , Y10T428/24174 , Y10T428/24612 , Y10T428/24752
摘要： PROBLEM TO BE SOLVED: To provide a structural body including a curved corner part when a first section and a second section are connected with each other.SOLUTION: A structural body includes a stack of fiber-reinforced ply. The stack includes: a first outside plies 20 and 21 extending to a second section from an inside of a corner part from the first section; and second outside plies 22-27 extending to the second section curved the outside of a corner part from the first section. The inside plies 22-27 are placed between the outside plies 20 and 21, and from the first section and curved the corner part of the first section and extends to the second section, and it is interrupted in the second section, and from the inside plies 22-27 are many positioned in the first section many than in the second section. In the structural body, the thickness are increased where the inside plies are overlapped.
摘要翻译：要解决的问题：提供一种当第一部分和第二部分彼此连接时包括弯曲角部的结构体。解决方案：结构体包括纤维增强层的堆叠。该堆叠包括：从第一部分的拐角部分的内部延伸到第二部分的第一外部帘布层20和21; 并且延伸到第二部分的第二外层22-27从第一部分弯曲角部的外侧。内层22-27被放置在外层20和21之间，并且从第一部分放置并弯曲第一部分的角部并且延伸到第二部分，并且在第二部分中断，并且从内部层22-27在第一部分中比第二部分多。在结构体中，内层重叠时厚度增加。

3. 发明专利

JP2012176614A Composite structure 审中-公开
标题翻译：复合结构
公开(公告)号：JP2012176614A
公开(公告)日：2012-09-13
申请号：JP2012036099
申请日：2012-02-22
申请人： Airbus Operations Ltd , エアバスオペレーションズリミテッドAirbus Operations Limited
发明人： SANDERSON TIMOTHY J , WILLIAMS STEPHEN
IPC分类号： B32B1/04 , B29C70/06 , B29C70/10 , B29K105/08 , B29L31/30 , B32B3/10 , B32B5/12 , B64C3/00
CPC分类号： B64C3/24 , B29C70/207 , B29C70/222 , B29L2031/3082 , B29L2031/3085 , B64C3/185 , B64C3/26 , Y02T50/43 , Y02T50/433 , Y10T428/24174 , Y10T428/24628 , Y10T428/24752
摘要： PROBLEM TO BE SOLVED: To provide a composite structure which is used suitably for an airfoil in aircraft wings and allows effective transmission of a load in a corner part.SOLUTION: A composite structure includes a first section, a second section and a curved corner joining the first and second sections. The structure has a stack of fiber-reinforced plies including a first external ply which runs from the first section into the second section curving around the outside of the corner and a second external ply which runs from the first section into the second section curving around the outside of the corner. A discontinuous first internal ply is sandwiched between the first and second external plies so that it is interrupted inside the structure and many of the first internal plies are located within the first section than within the second section. A second internal ply is sandwiched between the first and second external plies.
摘要翻译：要解决的问题：提供一种适合用于飞机机翼中的翼型的复合结构，并且允许有效地传递角部中的载荷。解决方案：复合结构包括第一部分，第二部分和连接第一和第二部分的弯曲角。该结构具有堆叠的纤维增强层，包括第一外层，从第一部分延伸到围绕角部弯曲的第二部分和从第一部分延伸到第二部分的第二部分，第二部分围绕在角落之外不连续的第一内部层被夹在第一和第二外层之间，使得其在结构内部被中断，并且许多第一内部层位于第一区段内而不是在第二区段内。第二内层夹在第一和第二外层之间。版权所有（C）2012，JPO＆INPIT

4. 发明申请

WO02069232A2 METHOD FOR IDENTIFICATION OF T-CELL EPITOPES AND USE FOR PREPARING MOLECULES WITH REEDUCED IMMUNOGENICITY 审中-公开
标题翻译：用于鉴定T细胞外膜的方法和用于制备具有免疫原性的分子的用途
公开(公告)号：WO02069232A2
公开(公告)日：2002-09-06
申请号：PCT/EP0201688
申请日：2002-02-18
申请人： MERCK PATENT GMBH , CARR FRANCIS J , CARTER GRAHAM , JONES TIM , WILLIAMS STEPHEN , HAMILTON ANITA
发明人： CARR FRANCIS J , CARTER GRAHAM , JONES TIM , WILLIAMS STEPHEN , HAMILTON ANITA
IPC分类号： G01N33/50 , A61K9/70 , A61K38/00 , A61K38/11 , A61K47/02 , A61K47/12 , C07K14/00 , C07K14/285 , C07K14/415 , C07K14/47 , C07K14/475 , C07K14/50 , C07K14/525 , C07K14/535 , C07K14/54 , C07K14/545 , C07K14/575 , C07K14/59 , C07K14/725 , C07K16/00 , C07K16/18 , C07K16/28 , C07K16/30 , C07K16/46 , C07K19/00 , C12N9/24 , C12N9/54 , C12N9/64 , C12N15/09 , G01N33/15 , G01N33/48 , G06F19/16 , G06F19/18 , G06F19/00
CPC分类号： G06F19/16 , A61K9/7015 , A61K38/00 , A61K47/02 , A61K47/12 , C07K14/54 , C07K16/18 , C07K16/2866 , C07K16/2896 , C07K16/30 , C07K16/3046 , C07K16/464 , C07K16/465 , C07K2319/00 , G06F19/18
摘要： This invention relates to a novel approach for identification of T-cell epitopes, that give rise to an immune reaction in a living host. By means of this novel method biological compounds can be generated which have a no or at least a reduced immunogenicity when exposed to the immune system of a given species and compared with the relevant non-modified entity. Thus the invention relates also to novel biological molecules, especially proteins and antibodies, obtained by the method according to the invention.
摘要翻译：本发明涉及用于鉴定在宿主中产生免疫反应的T细胞表位的新方法。通过这种新方法，可以产生当暴露于给定物种的免疫系统且与相关未修饰实体相比较时具有或至少具有降低的免疫原性的生物化合物。因此，本发明还涉及通过根据本发明的方法获得的新型生物分子，特别是蛋白质和抗体。

5. 发明专利

CA2728509C METHOD OF STIFFENING A RIB 未知
公开(公告)号：CA2728509C
公开(公告)日：2015-03-24
申请号：CA2728509
申请日：2009-07-20
申请人： AIRBUS OPERATIONS LTD
发明人： WILLIAMS STEPHEN
IPC分类号： B64C3/18 , B64F5/00
摘要： A method of stiffening a rib (19, 20) during the assembly of an aircraft wing is described. A stiffener panel (40, 41) is attached to a face of the rib (19, 20). The rib is aligned with one or more wing components with the stiffener panel (40, 41) attached. An assembly operation such as drilling (16) is performed with the rib aligned and the stiffener panel attached. The stiffener panel (40, 41) is removed from the rib after the assembly operation. The stiffener panel has a resilient external sealing ring which is mounted on a face of the panel and forms an external perimeter of a vacuum cavity; and at least one resilient internal sealing ring which is mounted on the panel (20, 21) within the perimeter defined by the external sealing ring and forms an internal perimeter of the vacuum cavity. The stiffener can be attached to the rib by a vacuum clamping force, the vacuum being sealed by the external and internal sealing rings. The internal sealing ring(s) seal any holes which are present in the rib. The stiffener (40, 41) can support the rib (20, 21) during alignment to give it the required flatness.

6. 发明专利

BRPI0916856A2 método de reforçar uma nervura 未知
公开(公告)号：BRPI0916856A2
公开(公告)日：2016-02-10
申请号：BRPI0916856
申请日：2009-07-20
申请人： AIRBUS OPERATIONS LTD
发明人： WILLIAMS STEPHEN
IPC分类号： B64C3/18 , B64F5/00

7. 发明专利

GB2516830A Aircraft Structure 未知
公开(公告)号：GB2516830A
公开(公告)日：2015-02-11
申请号：GB201313636
申请日：2013-07-31
申请人： AIRBUS OPERATIONS LTD
发明人： PRICE JONATHAN , MEAKIN ALASTAIR , EDEN JAMES , KORYA CHETAN , WILLIAMS STEPHEN , BURLEIGH CHRISTOPHER , BAKER PETER
IPC分类号： B64C1/26
摘要： An aircraft structure or wing extending from a root to a tip having the root arranged to be joined to an aircraft fuselage at a wing box 20. The structure has upper and lower covers with an aerodynamic outer surface and an inner surface. The structure also includes a plurality of stiffeners 8 and a plurality of ribs 13. The ribs include an inboard rib 10 and a plurality of further ribs between the inboard rib and the tip. Each of the stiffeners has a stiffener flange joined to the inner surface of the cover and a stiffener web extending away from the stiffener flange. One of the further ribs has a rib web and a plurality of rib feet. Each rib foot includes a first rib foot flange joined to the web of a respective one of the stiffeners, a second rib foot flange joined to the inner surface of the cover or to the flange of the respective one of the stiffeners and a rib foot web joined to the rib web. The joint between the first rib foot flange and the stiffener flange provides an efficient path for transmitting load from the cover into the rib web. Typically each first rib foot flange is joined to the stiffener web by a joint which can transmit load in shear from the stiffener web to the first rib foot flange.

8. 发明专利

CA2728509A1 METHOD OF STIFFENING A RIB 未知
公开(公告)号：CA2728509A1
公开(公告)日：2010-01-28
申请号：CA2728509
申请日：2009-07-20
申请人： AIRBUS OPERATIONS LTD
发明人： WILLIAMS STEPHEN
IPC分类号： B64C3/18 , B64F5/00
摘要： A method of stiffening a rib (19, 20) during the assembly of an aircraft wing is described. A stiffener panel (40, 41) is attached to a face of the rib (19, 20). The rib is aligned with one or more wing components with the stiffener panel (40, 41) attached. An assembly operation such as drilling (16) is performed with the rib aligned and the stiffener panel attached. The stiffener panel (40, 41) is removed from the rib after the assembly operation. The stiffener panel has a resilient external sealing ring which is mounted on a face of the panel and forms an external perimeter of a vacuum cavity; and at least one resilient internal sealing ring which is mounted on the panel (20, 21) within the perimeter defined by the external sealing ring and forms an internal perimeter of the vacuum cavity. The stiffener can be attached to the rib by a vacuum clamping force, the vacuum being sealed by the external and internal sealing rings. The internal sealing ring(s) seal any holes which are present in the rib. The stiffener (40, 41) can support the rib (20, 21) during alignment to give it the required flatness.

9. 发明申请

WO2012106389A3 DISTRIBUTED ENERGY STORAGE SYSTEM AND METHOD OF DISTRIBUTING ENERGY 审中-公开
标题翻译：分布式能源储存系统和分配能源的方法
公开(公告)号：WO2012106389A3
公开(公告)日：2012-11-29
申请号：PCT/US2012023422
申请日：2012-02-01
申请人： S & C ELECTRIC CO , BERKOWITZ DONALD S , PORTER DAVID , BELLEI TERRENCE , SEMBER JAMES W , WILLIAMS STEPHEN
发明人： BERKOWITZ DONALD S , PORTER DAVID , BELLEI TERRENCE , SEMBER JAMES W , WILLIAMS STEPHEN
IPC分类号： H02J3/28 , H02J3/16
CPC分类号： H02J3/32 , G05B15/02 , H02J3/1807 , Y02E40/30
摘要： This patent describes embodiments of systems, apparatus and methods to provide improved control and coordination of a multiplicity of electric distribution grid-connected, energy storage units deployed over a geographically-dispersed area.
摘要翻译：该专利描述了系统，装置和方法的实施例，以提供在地理上分散的区域上部署的多个配电并网的能量存储单元的改进的控制和协调。

10. 发明申请

WO02066514A3 ARTIFICIAL FUSION PROTEINS WITH REDUCED IMMUNOGENICITY 审中-公开
标题翻译：具有降低免疫原性的人造融合蛋白
公开(公告)号：WO02066514A3
公开(公告)日：2003-02-13
申请号：PCT/EP0201690
申请日：2002-02-18
申请人： MERCK PATENT GMBH , GILLIES STEPHEN , CARR FRANCIS J , JONES TIM , CARTER GRAHAM , HAMILTON ANITA , WILLIAMS STEPHEN , HANLON MARIAN , WATKINS JOHN , BAKER MATTHEW , WAY JEFFREY C
发明人： GILLIES STEPHEN , CARR FRANCIS J , JONES TIM , CARTER GRAHAM , HAMILTON ANITA , WILLIAMS STEPHEN , HANLON MARIAN , WATKINS JOHN , BAKER MATTHEW , WAY JEFFREY C
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61P43/00 , C07K14/47 , C07K16/00 , C07K16/18 , C07K16/28 , C07K16/30 , C07K19/00 , C12P21/02 , C12N15/62
CPC分类号： C07K16/30 , C07K16/28 , C07K16/2863 , C07K2317/24 , C07K2317/34 , C07K2319/00 , C07K2319/30
摘要： The invention relates to artificial modified proteins, preferably fusion proteins, having a reduced immunogenicity compared to the parent non-modified molecule when exposed to a species in vivo. The invention relates, above all, to novel immunoglobulin fusion proteins which essentially consist of an immunoglobulin molecule or a fragment thereof covalently fused via its C-terminus to the N-terminus of a biologically active non-immunoglobulin molecule, preferably a polypeptide or protein or a biologically active fragment thereof. In a specific embodiment, the invention relates to fusion proteins consisting of an Fc portion of an antibody which is fused as mentioned to the non-immunological target molecule which elicits biological or pharmacological efficacy. The molecules of the invention have amino acid sequences which are altered in one or more amino acid residue positions but have in principal the same biological activity as compared with the non-altered molecules. The changes are made in regions of the molecules which are identified as T-cell epitopes, which contribute to an immune reaction in a living host. Thus, the invention also relates to a novel method of making such fusion proteins by identifying said epitopes comprising calculation of T-cell epitope values for MHC Class II molecule binding sites in a peptide by computer-aided methods.
摘要翻译：本发明涉及人体修饰蛋白，优选融合蛋白，当与体内物种暴露时，与亲本非修饰分子相比具有降低的免疫原性。本发明首先涉及新的免疫球蛋白融合蛋白，其基本上由免疫球蛋白分子或其通过C末端与生物活性非免疫球蛋白分子，优选多肽或蛋白质的N末端共价融合的片段组成，或其生物活性片段。在一个具体的实施方案中，本发明涉及由抗体的Fc部分组成的融合蛋白，所述Fc部分如提及的非免疫靶标分子融合而引起生物学或药理学功效。本发明的分子具有氨基酸序列，其在一个或多个氨基酸残基位置被改变，但与未改变的分子相比具有相同的生物学活性。在被鉴定为T细胞表位的分子的区域中进行改变，其有助于在宿主中的免疫反应。因此，本发明还涉及通过鉴定所述表位来制备此类融合蛋白的新方法，包括通过计算机辅助方法计算肽中MHC II类分子结合位点的T细胞表位值。

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