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4. 发明申请

WO2013021409A8 PROCESS FOR THE PRODUCTION BY PLASMA OF NANOMETRIC THICKNESS COATINGS ALLOWING CONTROLLED RELEASE OF SILVER IONS OF OTHER ELEMENTS, OR OF MOLECULES OF BIOMEDICAL INTEREST, FROM SOLID PRODUCTS, AND PRODUCTS THUS COATED 审中-公开
标题翻译：使用等离子体厚度涂层的等离子体生产方法，允许控制释放其他元素的银离子，或生物医学利益的分子，固体产品和包装产品
公开(公告)号：WO2013021409A8
公开(公告)日：2013-04-04
申请号：PCT/IT2012000255
申请日：2012-08-10
申请人： UNIV BARI , MEDIPLASMA S R L DIPARTIMENTO DI SCIENZE PER LA SALUTE DELL UNI DEL MOLISE UNIMOL , PLASMA SOLUTION S R L , D AGOSTINO RICCARDO , FAVIA PIETRO , FRACASSI FRANCESCO , SARDELLA ELOISA , COSTAGLIOLA CIRO , MANGONE ANNAROSA
发明人： D AGOSTINO RICCARDO , FAVIA PIETRO , FRACASSI FRANCESCO , SARDELLA ELOISA , COSTAGLIOLA CIRO , MANGONE ANNAROSA
IPC分类号： A61L27/34 , A61L27/54 , A61L31/10 , A61L31/16
CPC分类号： A61L31/16 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/104 , A61L2300/404 , A61L2300/602 , A61L2300/624 , A61L2400/18 , A61L2420/04 , A61L2420/08 , C08L71/02
摘要： Process for the production by plasmochemical deposition of a film having a nanometric thickness, optionally multilayered, permitting carrying out in a controlled, uniform and long lasting way, release of substances of interest in a surrounding medium containing liquids, from a substrate including the substance to be released as micro/nano particles, or from a layer deposited on the substrate including the substance to be released as micro/nano particles, or from a layer of the substance to be released deposited on the substrate, or from a substrate that is the substance to be released optionally in the form of particles. The substances to be released can be metals, compounds having anti-bacterial properties, biologically active molecules such as drugs, hormones, vegetable extracts, peptides, lipids, protides and glucides. The layer with the substance to be released, be it organic or inorganic, is obtained by plasmochemical deposition optionally having a structure similar to polyethylene oxide (PEO) or polyethylene glycol (PEG), called PEO-like polymers, constituted, in a variable percentage da ethylene oxide units (-CH2CH2O-, EO); barrier film is obtained by depositing by plasma at least one organic or inorganic layer, optionally with a PEO-like structure, wherein chemical composition, degree of crosslinking and thickness are adjustable by the plasmo chemical deposition process parameters, and allow to adjust the release of the active substance according to specific needs. The structures on which the above said films can be deposited are: medical-surgical devices, common handworks, structures known as scaffolds, and the above defined substances to be released themselves. The invention also relates to medical-surgical devices, common handworks and scaffolds coated by a substrate and barrier layer, as well as to biologically active substances coated by at least one barrier layer.
摘要翻译：通过等离子体化学沉积生产的方法，其具有纳米厚度的膜，任选地多层，允许以受控的，均匀的和持久的方式进行，将感兴趣的物质从包含该物质的底物释放到含有液体的周围介质中，作为微/纳米颗粒或从包含要作为微/纳米颗粒释放的物质的沉积在基底上的层或从要沉积在基底上的待释放物质的层或从作为任选以颗粒形式释放的物质。要释放的物质可以是金属，具有抗菌性质的化合物，生物活性分子如药物，激素，植物提取物，肽，脂质，胶原和糖苷。具有待释放物质的层（无论是有机还是无机）通过任选具有类似于聚氧乙烯（PEO）或聚乙二醇（PEG），称为PEO样聚合物的结构的等离子体化学沉积获得，以可变百分比构成环氧乙烷单元（-CH 2 CH 2 O-，EO）; 通过等离子体沉积至少一种有机或无机层，任选地具有PEO样结构，其中化学组成，交联度和厚度可通过等离子体化学沉积工艺参数调节，并且允许调节活性物质根据具体需要。上述薄膜可以沉积的结构是：医用手术装置，普通手工工具，称为支架的结构，以及要释放的上述定义的物质。本发明还涉及由衬底和阻挡层涂覆的医用手术装置，普通手工工具和支架以及由至少一个阻挡层涂覆的生物活性物质。

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