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1. 发明专利

JPH0585925A COSMETIC 失效
公开(公告)号：JPH0585925A
公开(公告)日：1993-04-06
申请号：JP25213891
申请日：1991-09-30
申请人： AGENCY IND SCIENCE TECHN , KANEBO LTD , HAKUTO KK
发明人： KURANE RYUICHIRO , OTA MASAKATSU , NOBATA YASUHIRO
IPC分类号： A61K8/72 , A61K8/00 , A61K8/34 , A61K8/73 , A61K8/96 , A61K8/99 , A61Q1/00 , A61Q1/12 , A61Q19/00
摘要： PURPOSE:To obtain a cosmetic having excellent moisture retention free from greasiness resulting from a water-soluble polyhydric alcohol by blending a water-soluble polyhydric alcohol with a specific polysaccharide. CONSTITUTION:A cosmetic comprising (a) a water-soluble polyhydric alcohol such as dipropylene glycol, polyglycerol or reducing saccharide and (B) a polysaccharide produced by a Gram-negative aerobic bacterium such as Alcaligenes latus B-16 strain (FERM-BP-2,015), capable of producing a polysaccharide, in a ratio of 3-40wt.% component A and 0.001-5.0wt.%, preferably 0.01-1.0wt.% component B based on the total amount of the final composition. The polysaccharide consists essentially of rhamnose, fucose, glucose, mannose and glucuronic acid, its constitution ratio by molecular ratio is (1-10):(2-10):(4-20):1-(1-5), the ratio of elemental analysis (wt.%) is C:40+ or -4, H:6+ or -1.0, O:54+ or -5, a carbonization temperature is 225-280 deg.C and solubility is slightly soluble in water, soluble in alkali and insoluble in methanol, ethanol and acetone.

2. 发明专利

JPH07109230A DERMAL AGENT COMPOSITION FOR EXTERNAL USE 失效
公开(公告)号：JPH07109230A
公开(公告)日：1995-04-25
申请号：JP27765293
申请日：1993-10-07
申请人： KANEBO LTD
发明人： OTA MASAKATSU , IKEMOTO TAKESHI
IPC分类号： A61K9/00 , A61K45/00 , A61K47/44 , C11B9/00
摘要： PURPOSE:To provide a dermal agent composition for external use, excellent in skin penetration properties of the bioactive substance and organoleptic properties. CONSTITUTION:This dermal agent composition for external use is prepared by blending an (A) component, a (B) component and one or more bioactive substances. The (A) component is composed of ethanol, a water-soluble polyvalent alcohol and/or a nonionic surfactant and the (B) component is composed of one or more kinds of essential oils of dlants selected from a cypress, an elemi, an oregano, an orange, a galbanum, a camphor tree, a grape fruit, a juniper berry, a Japan cedar, a pop, a mandarin, a tangerine, a lime, a labdanum, a lemon and a laurel or composed of a purified essential oil fraction obtained by purifying the essential oil components of plants selected from a cypress, an elemi, an oregano, an orange, a galbanum, a camphor tree, a grape fruit, a juniper berry, a Japan cedar, a pop, a mandarin, a tangerine, a lime, a labdanum, a lemon and a laurel according to the distillation method or the column purification method.

3. 发明专利

JPH06239735A ENZYME-INCLUDED GELATIN CAPSULE 失效
公开(公告)号：JPH06239735A
公开(公告)日：1994-08-30
申请号：JP5157393
申请日：1993-02-16
申请人： KANEBO LTD , FUJI CAPSULE KK
发明人： YOSHIDA KATSUHIKO , OTA MASAKATSU , KASHIWAGI TAKANORI , KONDO TAKASHI
IPC分类号： A61K8/00 , A61K8/11 , A61K8/31 , A61K8/65 , A61K8/66 , A61K8/89 , A61K8/891 , A61K9/48 , A61Q1/02 , A61Q1/14 , A61Q19/10 , A61K7/02 , A61K7/50
摘要： PURPOSE:To obtain an enzyme-included gelatin capsule for scrubbing agents capable of stably keeping an included enzyme for a long period even being blended with aqueous cleansing agents, causing no excess swelling of the capsule in a preparation and exhibiting a proper scrubbing effect in using. CONSTITUTION:This enzyme-included gelatin capsule for scrubbing agents having 0.1-3.0mm particle diameter is obtained by insolubilizing a gelatin capsule, obtained by blending 30-79.9 pts.wt. one or more substances among liquid paraffin, squalane and silicone with 0.1-10 pts.wt. enzyme selected from protease, lipase and muramidase and 20-60 pts.wt. gelatin, with 0.1-3wt.% acetaldehyde and/or propionic aldehyde based on the capsule weight.

4. 发明专利

JPH08133936A HAIR-GROWTH SUPPRESSING AGENT FOR EXTERNAL APPLICATION TO SKIN 失效
公开(公告)号：JPH08133936A
公开(公告)日：1996-05-28
申请号：JP29378794
申请日：1994-11-02
申请人： KANEBO LTD
发明人： TSUTSUMI CHIEMI , MIYAMOTO TATSU , OTA MASAKATSU
IPC分类号： A61K8/00 , A61Q5/00 , A61Q7/02 , A61Q9/04 , A61K7/155
摘要： PURPOSE: To obtain a hair-growth suppressing agent for external application to the skin, containing bisabolol which is a component of the essential oil of camomile flower as an active component, free from load on and stimulation of the skin and having excellent hair-regeneration retarding effect. CONSTITUTION: This hair-growth suppressing agent for external application, most suitable for the treatment of armpit hair contains bisabolol expressed by the formula C15 H26 O as an active component. The amount of bisabolol is preferably 0.001-3.0%, especially 0.01-1.0%. The external agent can be used in various forms such as face lotion, milky lotion, cream, pack, ointment, aerosol and powder. The components to be compounded to the external agent are properly selected, as necessary, from aqueous component, surfactant, oil, humectant, powder, alcohol, pH-modifier, preservative, antioxidant, thickener, colorant, pigment, perfume, etc.

5. 发明专利

JPH0873344A ENZYME-CONTAINING WAX CAPSULE 失效
公开(公告)号：JPH0873344A
公开(公告)日：1996-03-19
申请号：JP23409094
申请日：1994-09-02
申请人： KANEBO LTD
发明人： YOSHIDA KATSUHIKO , OTA MASAKATSU
IPC分类号： A61K9/48 , A61K8/00 , A61K8/11 , A61K8/31 , A61K8/97 , A61Q1/02 , A61Q1/14 , A61Q19/00 , A61Q19/10 , A61K7/00 , A61K7/02 , A61K7/48 , A61K7/50
摘要： PURPOSE: To obtain the subject capsule excellent in storage stability, effectively functioning as a scrubbing agent because of being collapsed with a proper physical stress, and useful as a face-washing agent by dispersing an enzyme in paraffin wax, candelilla wax or the like, cooling and filtering. CONSTITUTION: This capsule is prepared by dispersing an enzyme selected from (D) protease, lipase, and muramidase in the thermally melted mixture of (A) paraffin wax, (B) candelilla wax, and (C) carnauba wax, dispersing the dispersion in hot water, cooling the dispersion, and subsequently filtering the cooled dispersion. The components A, B and C are preferably used in amounts of 20-70wt.%, 10-50wt.% and 5-40wt.%, respectively, on the basis of the whole amount of the waxes, and the component D is preferably used in an amount of 0.1-10wt.% based on the final composition. The diameter of the capsule is preferably 0.2-1mm.

6. 发明专利

JPH07155182A PRODUCTION OF MODIFIED PROTEASE 失效
公开(公告)号：JPH07155182A
公开(公告)日：1995-06-20
申请号：JP33997193
申请日：1993-12-06
申请人： KANEBO LTD
发明人： NAKAYAMA HIROSHI , FUKUNAGA SHINICHI , MIZUNO MUTSUMI , OGINO KAZUO , OTA MASAKATSU
IPC分类号： C12N9/00 , A61K8/49 , A61K8/66 , A61K8/73 , A61K8/96 , A61K38/46 , C11D3/386 , C12N9/50
摘要： PURPOSE:To obtain a modified protease good in stability and safety and useful as cosmetics, detergents, medicines, etc., by activating polysaccharides with cyanuric chloride, then regulating the content of triazine rings in a reactional solution and reacting the activated polysaccharides with a protease. CONSTITUTION:This method for producing the objective modified protease is to add an acetone solution containing cyanuric chloride to an aqueous solution of polysaccharides (e.g. dextran) at ambient temperature while keeping the pH at 7.5-9.5, activate the polysaccharides, then add boric acid to a reactional solution, acidify the reactional solution, remove the unreacted cyanuric chloride from the solution according to the ultrafiltration or dialysis, regulate the content of triazine rings introduced into the polysaccharides to >=50mo1% based on the total content thereof present in the reactional solution, then add an alkalophilic protease derived from a bacterium of the genus Bacillus thereto and react the activated polysaccharides with the protease. Thereby, the modified protease is remarkably improved in operating efficiency and economical efficiency, good in stability and safety and useful for industrial applications such as medicines, cosmetics or detergents.

7. 发明专利

JPH07109229A PERCUTANEOUS ABSORPTION PROMETER AND DERMAL AGENT COMPOSITION FOR EXTERNAL USE 失效
公开(公告)号：JPH07109229A
公开(公告)日：1995-04-25
申请号：JP27765193
申请日：1993-10-07
申请人： KANEBO LTD
发明人： OTA MASAKATSU , NISHIO HIROYUKI
IPC分类号： A61K47/10 , A61K8/00 , A61K8/34 , A61Q19/00 , A61K7/00 , A61K7/48
摘要： PURPOSE:To obtain a percutaneous absorption promoter capable of promoting percutaneous absorption of a medicinal component in a dermal agent for external use in both a closed system and an open system and excellent in safety and stability. CONSTITUTION:A percutaneous absorption promoter composed of hydrogenated bisabol represented by the formula. The compound of the formula can be synthesized by hydrogenating natural alpha-bisabol. If 0.01 to 10wt.% compound of the formula is added to a dermal agent composition for external use containing a bioactive substance, a dermal agent composition for external use improved in the amount of the dermal medicinal component absorbed into the lower cutaneous tissue and in the amount of the systemically active component transferred into the systemic blood flow is prepared. In this composition, one of 5 to 60wt.% ethanol, 2 to 20wt.% water-soluble polyvalent alcohol (e.g. propylene glycol or glycerin), 0.01 to 2wt.% water-soluble polymer (e.g. PVA, xanthan gum or CMC) and 0.1 to 10wt.% nonionic surfactant (e.g. a polyoxyethylene sorbitan fatty acid ester) may be blended.

8. 发明专利

JPH07101850A HUMECTANT 失效
公开(公告)号：JPH07101850A
公开(公告)日：1995-04-18
申请号：JP26822993
申请日：1993-09-29
申请人： KANEBO LTD
发明人： OTA MASAKATSU
IPC分类号： A61K8/96 , A61K8/00 , A61K8/97 , A61Q5/00 , A61Q5/02 , A61Q7/00 , A61Q19/00 , A61Q19/10 , A61K7/48 , A61K7/00 , A61K7/06 , A61K7/50
摘要： PURPOSE:To provide a humectant used for cosmetics, excellent in moisture- retaining effect, good in functional characteristics when and after used, and high in general usefulness. CONSTITUTION:A humectant comprises the hydrophilic organic solvent extract of the leave of persimmons and/or the fruits of Hovenia dulcis Thunberg.

9. 发明专利

JPH06135821A HAIR TONIC 失效
公开(公告)号：JPH06135821A
公开(公告)日：1994-05-17
申请号：JP31578792
申请日：1992-10-30
申请人： KANEBO LTD
发明人： OTA MASAKATSU , IWAMOTO YOSHIMICHI , MINAMINO HIROMI
IPC分类号： A61K8/00 , A61K8/44 , A61K8/63 , A61K8/97 , A61Q5/00 , A61Q7/00 , A61K7/06
摘要： PURPOSE:To obtain a hair tonic exhibiting remarkable hair growth promoting effect and excellent in hair rearing effect and effects of prevention of alopecia and prevention of dander. CONSTITUTION:This hair tonic is obtained by blending (A) at least one kind of substance having hair growth effect with (B) a sesquiterpene-based compound having percutaneous absorption promoting effect in open system, e.g. a hydrocarbon such as bisabolene or zingiberene, an alcohol such as bisabolol or farnesol, ketones such as methyl ionone and methyl santalate, ketones such as methyl ionone or esters such as methyl santalate. The component B is preferably blended in an amount of 0.01-20wt.% based on weight of final composition. As the component A, glycyrrhizic acid and glycyrrhetic acid and their derivatives, amino acid or its derivative (e.g. L-methione or L-serine), female sex hormone (e.g. estradiol), anti-inflammatory agent (e.g. hydrocortisone), ingredient having blood circulation promoting action and/or hair matrix cell potentiating action (e.g. extract of Swertia jaonica Makino), vitamin B6 and its derivative, germicide, an keratolytic agent, an extract of galenical medicine, etc., is exemplified.

10. 发明专利

JPH06128120A DERMAL MEDICINE COMPOSITION FOR EXTERNAL USE 失效
公开(公告)号：JPH06128120A
公开(公告)日：1994-05-10
申请号：JP30188492
申请日：1992-10-13
申请人： KANEBO LTD
发明人： OTA MASAKATSU , IKEMOTO TAKESHI
IPC分类号： A61K8/30 , A61K8/00 , A61K8/34 , A61K47/06 , A61K47/08 , A61K47/10 , A61Q19/00 , A61K7/00 , A61K7/48
摘要： PURPOSE:To provide a dermal medicine for external use, excellent in dermal absorption of a bioactive substance. CONSTITUTION:A dermal medicine composition for external use, prepared by blending one or more kinds of bioactive substances with a sesquiterpene and a water-soluble polyvalent alcohol.

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