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1. 发明申请

WO2009022985A1 SENSOR CHIP FOR USE IN OPTICAL SPECTROSCOPY 审中-公开
标题翻译：传感器芯片用于光学光谱
公开(公告)号：WO2009022985A1
公开(公告)日：2009-02-19
申请号：PCT/SG2007/000255
申请日：2007-08-14
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , ZHANG, Nan , KNOLL, Wolfgang , DHARMATILLEKE, Saman , LIU, Hong
发明人： ZHANG, Nan , KNOLL, Wolfgang , DHARMATILLEKE, Saman , LIU, Hong
IPC分类号： G01N21/55
CPC分类号： G01N21/554 , B01L3/502707 , B01L2300/0654 , B01L2300/0816 , B01L2300/12 , B01L2300/168 , G01N21/7743
摘要： A grating-coupled surface plasmon resonance sensor chip having a substrate body comprising at least one fluid channel integrally formed on the surface thereof by imprinting stamp, and a reflective material layer being integrally transferred to at least part of said fluid channel at the same time of the imprinting step.
摘要翻译：一种光栅耦合表面等离子体共振传感器芯片，其具有衬底主体，该衬底主体包括通过压印而在其表面上整体形成的至少一个流体通道，以及反射材料层，其一体地转移到所述流体通道的至少一部分，同时印记步骤。

2. 发明申请

WO2010014045A1 METHOD OF MODIFYING A SUBSTRATE FOR DEPOSITION OF CHARGED PARTICLES THEREON 审中-公开
标题翻译：修饰用于沉积其中的颗粒的基材的方法
公开(公告)号：WO2010014045A1
公开(公告)日：2010-02-04
申请号：PCT/SG2009/000270
申请日：2009-08-03
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , NANYANG TECHNOLOGICAL UNIVERSITY , ZHOU, Xiaodong , LIU, Kai Yu , ZHANG, Nan , OH, Su Yin, Sharon Roslyn , PAN, Jisheng
发明人： ZHOU, Xiaodong , LIU, Kai Yu , ZHANG, Nan , OH, Su Yin, Sharon Roslyn , PAN, Jisheng
IPC分类号： B82B3/00 , B32B7/10 , G01N21/62
CPC分类号： G01N21/554 , Y10T428/24372
摘要： A method of modifying a substrate for deposition of charged particles thereon, the method comprising the steps of: providing a substrate that is incapable of bonding to a polyelectrolyte coating that has a charge that is opposite to the charge of the particles that are to be deposited thereon; modifying the surface of the substrate to provide a layer of silicon thereon or therein; and coating the silicon layered surface of the substrate with the polyelectrolyte coating, the polyelectrolyte coating containing functional groups that are capable of forming bonds with said silicon layer and wherein said polyelectrolyte coating enables a substantially even distribution of said charged particles to be deposited thereon.
摘要翻译：一种用于在其上沉积带电粒子的基底的方法，所述方法包括以下步骤：提供不能与聚电解质涂层结合的基底，所述聚电解质涂层具有与要沉积的颗粒的电荷相反的电荷在其上; 改变衬底的表面以在其上或其中提供硅层; 以及用所述聚电解质涂层涂覆所述基底的所述硅层状表面，所述聚电解质涂层含有能够与所述硅层形成键的官能团，并且其中所述聚电解质涂层能够使所述带电粒子基本均匀地分布在其上。

3. 发明申请

WO2020130942A1 A NON-DESTRUCTIVE SYSTEM AND METHOD FOR DETERMINING THE QUALITY OF CHINESE HERB USING TERAHERTZ TIME-DOMAIN SPECTROSCOPY 审中-公开
公开(公告)号：WO2020130942A1
公开(公告)日：2020-06-25
申请号：PCT/SG2019/050619
申请日：2019-12-17
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
发明人： KE, Lin , LIU, Hongwei , ZHANG, Nan , GU, Haiwen
IPC分类号： G01N21/3586
摘要： The present invention provides a system and a method for non-destructively determining the quality of Chinese herb housed in packaging using terahertz time-domain spectroscopy. The system comprises a femtosecond laser source (102), a transmitter (104), an optical system (106), a digital optical phase conjugation system (108), a detector (110) and a signal processing system (112). The method comprises illuminating THz radiation onto a surface of the Chinese herb housed in packaging, and collecting and measuring the THz radiation reflected from the surface of the Chinese herb. The THz radiation is then defocused onto at least one sub-interface of the Chinese herb housed in packaging and the THz radiation reflected from the sub-interface is collected and measured. The signals measured are subjected to Fast Fourier Transform and the data obtained is corrected by time domain delay. Spectral analysis and/or dielectric and absorption spectral analysis is performed to determine the quality of the Chinese herb housed in packaging.

4. 发明申请

WO2020013762A1 SYSTEMS AND METHODS FOR CORNEAL PROPERTY ANALYSIS USING TERAHERTZ RADIATION 审中-公开
公开(公告)号：WO2020013762A1
公开(公告)日：2020-01-16
申请号：PCT/SG2019/050337
申请日：2019-07-10
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , SINGAPORE HEALTH SERVICES PTE LTD
发明人： KE, Lin , LIU, Hongwei , ZHANG, Nan , MEHTA, Jod S , LIU, Yu Chi
IPC分类号： A61B3/10 , A61B5/05
摘要： Methods and systems for analysing a property of a cornea of an eye using terahertz (THz) radiation are provided. The method includes projecting a first THz wave onto a surface of the cornea and detecting a first reflected wave being a reflection of the first THz wave reflected from the surface of the cornea. The method further includes deforming the cornea by projecting visible light or puffing air to the surface of the cornea, projecting a second THz wave onto the surface of the cornea after the deforming, and detecting a second reflected wave being a reflection of the second THz wave reflected from the surface of the cornea after the deforming. Finally, the method includes calculating the property of the cornea based on the first reflected wave and the second reflected wave. The invention particularly relates to systems and methods for corneal elasticity and/or rigidity analysis using terahertz (THz) time-domain spectroscopy.

5. 发明申请

WO2023043379A2 PAINT THICKNESS MEASURING DEVICE AND COMPUTER-IMPLEMENTED METHOD FOR MEASURING PAINT THICKNESS 审中-公开
公开(公告)号：WO2023043379A2
公开(公告)日：2023-03-23
申请号：PCT/SG2022/050670
申请日：2022-09-20
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
发明人： LEONG, Hai Sheng , KE, Lin , ZHANG, Nan , WU, Qing Yang, Steve , GORELIK, Sergey , LIU, Hong , NGO, Chun Yong, Andrew
摘要： A paint thickness measuring device (10) and a computer-implemented method (50) for measuring paint thickness using the same are provided. The paint thickness measuring device (10) includes a first continuous-wave (cw) laser (12), a second continuous-wave laser (14), a photomixer (15), one or more computer processors (22), and a non-transitory computer-readable memory (24). The photomixer (15) includes an optical coupler (26) configured to mix laser lights emitted by the first and second continuous-wave lasers (12, 14) and generate a terahertz (THz) wave, a photomixer emitter (16) configured to emit the terahertz wave, and a photomixer receiver (18) configured to detect the terahertz wave reflected off a painted surface (20). The non-transitory computer-readable memory (24) stores computer program instructions executable by the one or more computer processors (22) to perform operations for paint thickness measurement. The operations include: comparing (52) the detected terahertz wave (54) to simulation results (56), identifying (58) a minimum difference between the detected terahertz wave (54) and the simulation results (56), and determining (60) a paint thickness of the painted surface (20) from the simulation results (56) with the minimum difference.

6. 发明申请

WO2020013763A1 SYSTEMS AND METHODS FOR DRY EYE ANALYSIS USING TERAHERTZ RADIATION 审中-公开
公开(公告)号：WO2020013763A1
公开(公告)日：2020-01-16
申请号：PCT/SG2019/050338
申请日：2019-07-10
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , SINGAPORE HEALTH SERVICES PTE LTD
发明人： KE, Lin , LIU, Hongwei , ZHANG, Nan , MEHTA, Jod S , LIU, Yu Chi
IPC分类号： A61B3/10 , A61B5/05
摘要： Methods and systems for dry eye analysis using terahertz (THz) radiation. The method includes projecting a THz wave onto a surface of an eye and detecting a reflected wave being a reflection of the THz wave reflected from the surface of the eye. The method further includes analysing properties of the eye in response to the THz wave reflected from the surface of the eye, the properties of the eye including thickness of the eye's cornea and ambient tissues, and analyzing the properties of the eye comprises measuring the thickness of the cornea and/or the ambient tissues and/or measuring an amount of chemical components of one or more of the eye's layers.

7. 发明申请

WO2019045653A1 NON-DESTRUCTIVE SYSTEMS AND METHODS FOR IDENTIFICATION OF PACKAGED MEDICINE 审中-公开
公开(公告)号：WO2019045653A1
公开(公告)日：2019-03-07
申请号：PCT/SG2018/050447
申请日：2018-09-04
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
发明人： KE, Lin , LIU, Hongwei , ZHANG, Nan
IPC分类号： G01N21/3586 , G01N21/95 , G01N33/15
摘要： Systems and methods for non-destructive packaged tablet, capsule and liquid medicine identification is provided. The system also includes a digital optical phase conjugation system configured to THz time domain system sampling of the sample while defocusing the THz radiation to a sub-interface of packaging of the packaged tablet, capsule or liquid medicine, in order to avoid the direct reflection of the THz radiation. The method includes measuring THz radiation reflected from a surface of a sample of packaged tablet, capsule or liquid medicine and shifting a focal point of the THz radiation from the surface of the sample through the packaging until the focal point focuses the THz radiation on a container/medicine interface of the sample of packaged tablet, capsule or liquid medicine. The method also includes measuring THz radiation reflected from the container/medicine interface of the sample of packaged tablet, capsule or liquid medicine, calculating an absorption spectra of the measured THz radiation, and auto-identifying by a processing device in response to the absorption spectra of the measured THz radiation a type of medicine within the sample of packaged tablet, capsule or liquid medicine in response to cluster analysis to group the type of medicine within the sample of packaged tablet, capsule or liquid medicine with respect to a database of THz reflectance spectra information for a plurality of medicines.

8. 发明申请

WO2017007426A1 METHOD AND SYSTEM FOR ISOLATING ADIPOSE-DERIVED STEM CELLS 审中-公开
标题翻译：用于分离ADIPOSE衍生的干细胞的方法和系统
公开(公告)号：WO2017007426A1
公开(公告)日：2017-01-12
申请号：PCT/SG2016/050311
申请日：2016-07-04
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
发明人： KE, Lin , ZHANG, Nan
IPC分类号： C12N5/0775
CPC分类号： C12N5/0667 , C12N13/00 , C12N2529/00 , C12N2529/10
摘要： The present invention refers to a non -invasive method for isolating adipose-derived stem cells from adipose tissue by illuminating the adipose tissue with at least one laser having a wavelength of between 360nm to 480nm or between 800nm to 2pm for a predetermined time for dissociating fat cells and blood vessels of the adipose tissue to release intact stem cells from the adipose tissue while maintaining the viability of the stem cells. In the preferred embodiment, the adipose tissue is illuminated with pulsed near infra-red (NIR) laser and a continuous wave (CW) diode blue laser. The present invention also contains a system adapted for isolating adipose -derived stem cells from adipose tissue using the method of the present invention.
摘要翻译：本发明涉及通过用波长为360nm至480nm或800nm至2pm之间的至少一种激光照射脂肪组织一段预定时间以解离脂肪来从脂肪组织分离脂肪来源的干细胞的非侵入性方法。细胞和血管，以从脂肪组织释放完整的干细胞，同时保持干细胞的活力。在优选实施例中，用脉冲近红外（NIR）激光和连续波（CW）二极管蓝色激光照射脂肪组织。本发明还包含适于使用本发明的方法从脂肪组织分离脂肪来源的干细胞的系统。

9. 发明申请

WO2017171650A1 A SYSTEM AND METHOD FOR FLUID ANALYSIS 审中-公开
标题翻译：流体分析的系统和方法
公开(公告)号：WO2017171650A1
公开(公告)日：2017-10-05
申请号：PCT/SG2017/050174
申请日：2017-03-30
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
发明人： LAI, Szu Cheng , KE, Lin , ZHANG, Nan
IPC分类号： G01N21/51 , G01N21/01 , G01N21/25
CPC分类号： G01N21/51 , G01N33/04 , G01N33/14 , G01N2201/061 , G01N2201/0633
摘要： In a first aspect, a system for analysing a fluid sample is provided, comprises: a container configured to receive the fluid sample; a first light source optically coupled to the container and configured to project a first light having a first wavelength; a second light source optically coupled to the container and configured to project a second light having a second wavelength different from the first wavelength; one or more photo-sensors optically coupled to the container and configured to analyse the fluid sample in response to a first scattered light generated in response to projecting the fluid sample with the first light source and a second scattered light generated in response to projecting the fluid sample with the second light source. In a preferred embodiment, the nutritious compositions (such as the concentration of fats and protein) of milk samples are identified based on the scattering of the first and second light source by the milk sample.
摘要翻译：在第一方面，提供了一种用于分析流体样本的系统，包括：容器，被配置为接收流体样本; 第一光源，光学耦合到所述容器并且被配置为投射具有第一波长的第一光; 第二光源，其光学耦合到所述容器并且被配置为投射具有不同于所述第一波长的第二波长的第二光; 一个或多个光学传感器，其光学耦合到所述容器并被配置为响应于响应于使用第一光源投射流体样本而产生的第一散射光以及响应于投射流体而产生的第二散射光来分析流体样本用第二个光源进行采样。在一个优选的实施方案中，牛奶样品的营养组合物（例如脂肪和蛋白质的浓度）基于第一和第二光源在牛奶样品上的散射来识别。

10. 发明公开

EP2185918A1 SENSOR CHIP FOR USE IN OPTICAL SPECTROSCOPY 审中-公开
标题翻译：传感器芯片在使用光学光谱
公开(公告)号：EP2185918A1
公开(公告)日：2010-05-19
申请号：EP07794265.4
申请日：2007-08-14
申请人： Agency for Science, Technology And Research
发明人： ZHANG, Nan , KNOLL, Wolfgang , DHARMATILLEKE, Saman , LIU, Hong
IPC分类号： G01N21/55
CPC分类号： G01N21/554 , B01L3/502707 , B01L2300/0654 , B01L2300/0816 , B01L2300/12 , B01L2300/168 , G01N21/7743
摘要： A grating-coupled surface plasmon resonance sensor chip having a substrate body comprising at least one fluid channel integrally formed on the surface thereof by imprinting stamp, and a reflective material layer being integrally transferred to at least part of said fluid channel at the same time of the imprinting step.

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