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1. 发明申请

WO2010059135A1 ANTI-CANCER MICROPARTICLE 审中-公开
标题翻译：抗癌微生物
公开(公告)号：WO2010059135A1
公开(公告)日：2010-05-27
申请号：PCT/SG2009/000447
申请日：2009-11-24
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , KHIN, Yin Win , YE, Enyi , HAN, Mingyong
发明人： KHIN, Yin Win , YE, Enyi , HAN, Mingyong
IPC分类号： A61K9/14 , A61K39/00 , A61K47/34 , A61K31/00 , A61K47/32
CPC分类号： A61K31/00 , A61K9/1647 , A61K9/5031
摘要： The present invention relates to a microparticle and its use. The microparticle has a width of at least about 1 micron. The microparticle includes a biocompatible polymer, a nanoparticle, and an anti-cancer agent.
摘要翻译：本发明涉及一种微粒及其用途。微粒具有至少约1微米的宽度。微粒包括生物相容性聚合物，纳米颗粒和抗癌剂。

2. 发明申请

WO2009045177A1 METHODS OF FORMING A NANOCRYSTAL 审中-公开
标题翻译：形成纳米晶的方法
公开(公告)号：WO2009045177A1
公开(公告)日：2009-04-09
申请号：PCT/SG2008/000381
申请日：2008-10-03
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , YE, Enyi , KHIN, Yin Win , HAN, Mingyong
发明人： YE, Enyi , KHIN, Yin Win , HAN, Mingyong
IPC分类号： C30B28/04 , B82B3/00 , C30B29/00
CPC分类号： C30B7/00 , B82Y30/00 , C09K11/54 , C09K11/602 , C09K11/605 , C09K11/883 , C30B29/40 , C30B29/48 , C30B29/60
摘要： Methods of forming a nanocrystal are provided. The nanocrystal may be a binary nanocrystal of general formula M1A or of general formula M1O, a ternary nanocrystal of general formula M1M2A, of general formula M1AB or of general formula M1M2O or a quaternary nanocrystal of general formula M1M2AB. M1 is a metal of Groups II - IV, Group VII or Group VIII of the PSE. A is an element of Group VI or Group V of the PSE. O is oxygen. A homogenous reaction mixture in a non-polar solvent of low boiling point is formed, that includes a metal precursor containing the metal M1 and, where applicable M2. For an oxygen containing nanocrystal the metal precursor contains an oxygen donor. Where applicable, A is also included in the homogenous reaction mixture. The homogenous reaction mixture is under elevated pressure brought to an elevated temperature that is suitable for forming a nanocrystal.
摘要翻译：提供了形成纳米晶体的方法。纳米晶体可以是通式M1A或通式M1O的二元纳米晶体，通式M1M2A的三元纳米晶体，通式M1AB或通式M1M2O或通式M1M2AB的季纳米晶体。 M1是PSE的II-IV族，VII族或VIII族的金属。 A是PSE的第VI组或第V组的要素。 O是氧气。在低沸点的非极性溶剂中形成均匀的反应混合物，其包括含有金属M1的金属前体，以及适用的M2。对于含氧纳米晶体，金属前体含有氧供体。在适用的情况下，A也包含在均匀的反应混合物中。均匀的反应混合物在升高的压力下达到适于形成纳米晶体的升高的温度。

3. 发明申请

WO2009038544A1 AMPHIPHILIC POLYMER AND PROCESSES OF FORMING THE SAME 审中-公开
标题翻译：聚合物及其制备方法
公开(公告)号：WO2009038544A1
公开(公告)日：2009-03-26
申请号：PCT/SG2008/000356
申请日：2008-09-19
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , JANCZEWSKI, Dominik , TOMCZAK, Nikodem , KHIN, Yin Win , HAN, Mingyong , VANCSO, Julius
发明人： JANCZEWSKI, Dominik , TOMCZAK, Nikodem , KHIN, Yin Win , HAN, Mingyong , VANCSO, Julius
IPC分类号： C08F2/02 , C08F2/10 , C08F2/08 , C08F22/06
CPC分类号： C08F8/00 , C08F222/06
摘要： Disclosed are an amphiphilic polymer, its synthesis and uses thereof. The polymer has a hydrocarbon backbone with -COOH side groups. It further has first aliphatic moieties with a main chain of about 3 to about 20 carbon atoms and 0 to about 3 heteroatoms, and second aliphatic moieties that have a main chain of about 3 to about 80 carbon atoms and about 2 to about 40 heteroatoms. The second aliphatic moieties have a copolymerisable group. In the synthesis a maleic anhydride polymer of formula (I) where n is an integer from about 10 to about 10000 and R1 is H or methyl, is reacted with a monofunctional compound with an alkyl chain of about 3 to about 20 carbon atoms and 0 to about 2 heteroatoms, and with an at least bifunctional compound with an alkyl chain of about 3 to about 80 carbon atoms and 0 to about 40 heteroatoms. The functional group of the monofunctional compound and one functional group of the at least bifunctional compound can form a linkage with an anhydride. Another functional group of the at least bifunctional compound, which is not allowed to react with the maleic anhydride polymer, is copolymerisable.
摘要翻译：公开了两亲性聚合物，其合成和用途。聚合物具有-COOH侧基的烃骨架。它还具有主链约3至约20个碳原子和0至约3个杂原子的第一脂族部分和具有约3至约80个碳原子和约2至约40个杂原子的主链的第二脂族部分。第二脂族部分具有可共聚基团。在合成中，其中n为约10至约10000的整数并且R 1为H或甲基的式（I）的马来酸酐聚合物与具有约3至约20个碳原子的烷基链的单官能化合物反应，并且0 至少约2个杂原子，以及至少具有约3至约80个碳原子的烷基链和0至约40个杂原子的双官能化合物。单官能化合物的官能团和至少双官能化合物的一个官能团可以与酸酐形成连接。不允许与马来酸酐聚合物反应的至少双官能化合物的另一官能团是可共聚的。

4. 发明申请

WO2006118543A1 NOVEL WATER-SOLUBLE NANOCRYSTALS COMPRISING A LOW MOLECULAR WEIGHT COATING REAGENT, AND METHODS OF PREPARING THE SAME 审中-公开
标题翻译：包含低分子量涂层试剂的新型水溶性纳米晶体及其制备方法
公开(公告)号：WO2006118543A1
公开(公告)日：2006-11-09
申请号：PCT/SG2005/000138
申请日：2005-05-04
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , HAN, Mingyong , WANG, Fuke
发明人： HAN, Mingyong , WANG, Fuke
IPC分类号： G01N33/58 , G01N33/533 , G01N21/64 , C07C323/25 , B82B1/00
CPC分类号： G01N33/588 , B82Y15/00 , B82Y30/00 , C01B19/007 , C01P2004/64 , C01P2004/80 , C09K11/02 , C09K11/025 , C09K11/565 , C09K11/883 , Y10T428/2982
摘要： The invention relates to a water soluble nanocrystal with a nanocrystal core comprising at least one metal M1 selected form an element of main group II, VIIA, subgroup VIIA, subgroup IB, subgroup IIB, main group III or main group IV of the periodic system of the elements (PSE), at least one element A selected from main group V or main group VI of the PSE, a capping reagent attached to the surface of the core of the nanocrystal, said capping reagent having at least two coupling groups, and a second layer comprising a low molecular weight coating reagent having at least two coupling moieties covalently coupled with the coating reagent, and at least one water soluble group for conferring water solubility to the second layer.
摘要翻译：本发明涉及具有纳米晶核的水溶性纳米晶体，其包含至少一种金属M1，其选自主要组II，VIIA，亚组VIIA，亚组IB，亚组IIB，主要组III或主要IV族的元素元素（PSE），选自主要组V或PSE的主组VI中的至少一种元素A，附着到纳米晶体核心表面的封端剂，所述封端剂具有至少两个偶联基团，和第二层包含具有与涂覆试剂共价偶联的至少两个偶联部分的低分子量涂覆试剂和至少一种用于赋予第二层水溶性的水溶性基团。

5. 发明申请

WO2006075974A1 WATER-SOLUBLE NANOCRYSTALS AND METHODS OF PREPARING THEM 审中-公开
标题翻译：水溶性纳米晶体及其制备方法
公开(公告)号：WO2006075974A1
公开(公告)日：2006-07-20
申请号：PCT/SG2005/000009
申请日：2005-01-17
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , HAN, Mingyong , WANG, Fuke
发明人： HAN, Mingyong , WANG, Fuke
IPC分类号： G01N33/52 , C08B37/16
CPC分类号： C09K11/025 , B82Y15/00 , C08B37/0012 , C08B37/0015 , C09K11/565 , C09K11/883 , G01N33/588
摘要： Disclosed is a water soluble nanocrystal having a core comprising at least one metal M1 selected from an element of subgroup IIb, subgroup VIIa, subgroup VIlla, subgroup lb, subgroup IV, main group II or main group III of the periodic system of the elements (PSE), at least one element A selected from an element of the main group V or VI of the periodic system of the elements, wherein a capping reagent is attached to the surface of the core of the nanocrystal, and wherein the capping reagent forms a host guest complex with a water soluble host molecule. Also disclosed is a water soluble nanocrystal having a core comprising at least one metal M1 selected from an element of subgroup Ilb, subgroup VIla, subgroup VIlla, subgroup lb, subgroup IV, main group II or main group III of the periodic system of the elements (PSE), and at least one element A selected from an element of the main group V or VI of the periodic system of the elements, wherein a capping reagent is attached to the surface of the core of the nanocrystal, and wherein the capping reagent is covalently linked to a water soluble host molecule. Also disclosed is a water soluble nanocrystal having a core comprising at least one metal M1 selected from an element of subgroup Ilb, subgroup VIla, subgroup VIlla, subgroup lb, subgroup IV, main group II or main group III of the periodic system of the elements (PSE), wherein a capping reagent is attached to the surface of the core of the nanocrystal, and wherein the capping reagent forms a host guest complex with a water soluble host molecule. Finally, compositions and uses of such nanocrystals are disclosed.
摘要翻译：公开了一种水溶性纳米晶体，其具有包含选自元素周期系统的亚组IIb，亚组VIIa，亚组VIlla，亚组1b，亚组IV，主要组II或主要III族的元素中的至少一种金属M1的核心（ PSE），至少一种元素A，其选自元素周期系统的主族V或VI的元素，其中封端剂附着到纳米晶体的芯的表面，并且其中封端剂形成主要客体复合物与水溶性主体分子。还公开了一种水溶性纳米晶体，其具有包含至少一种金属M1的核心，所述金属M1选自元素周期系统的亚组IIb，亚组VIla，亚组VIlla，亚组1b，亚组IV，主要组II或主要组III的元素（PSE）和选自元素周期性系统的主族V或VI的元素中的至少一种元素A，其中封端剂附着到纳米晶体的芯的表面，并且其中封端剂与水溶性主体分子共价连接。还公开了一种水溶性纳米晶体，其具有包含至少一种金属M1的核心，所述金属M1选自元素周期系统的亚组IIb，亚组VIla，亚组VIlla，亚组1b，亚组IV，主要组II或主要组III的元素（PSE），其中封端剂附着在纳米晶体的芯的表面上，并且其中封端剂与水溶性主体分子形成宿主客体络合物。最后，公开了这种纳米晶体的组成和用途。

6. 发明申请

WO2009020436A1 PROCESS OF FORMING A CADMIUM AND SELENIUM CONTAINING NANOCRYSTALLINE COMPOSITE AND NANOCRSTALLINE COMPOSITE OBTAINED THEREFROM 审中-公开
标题翻译：形成包含纳米复合材料的纳米复合材料和纳米复合材料的方法
公开(公告)号：WO2009020436A1
公开(公告)日：2009-02-12
申请号：PCT/SG2008/000290
申请日：2008-08-06
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , ZONG, Yun , HAN, Mingyong , KNOLL, Wolfgang
发明人： ZONG, Yun , HAN, Mingyong , KNOLL, Wolfgang
IPC分类号： B82B3/00 , C09K11/54 , C09K11/88
CPC分类号： C09K11/565 , C09K11/883
摘要： Provided is a process of forming a Cd and Se containing nanocrystalline composite. The nanocrystalline composite has a composition of one of (a) Cd, M, Se, (b) Cd, Se, A, and (c) Cd, M, Se, A, with M being an element of group (12) of the PSE other than Cd and A being an element of group (16) of the PSE other than O and Se. In one embodiment in a suitable solvent a solution of the element Cd, or a precursor thereof, and, where applicable, of M, or a precursor thereof is formed. To the solution the element Se and, where applicable, A is added and thereby a reaction mixture formed. The reaction mixture is heated for a sufficient period of time at a temperature suitable for forming the Cd and Se containing nanocrystalline composite and then the reaction mixture is allowed to cool. Finally the Cd and Se containing nanocrystalline composite isolated. In another embodiment the reaction mixture is formed by adding into a suitable solvent the element Cd, or a precursor thereof, Se, where applicable M and where applicable A. In this embodiment the reaction mixture is heated and water formed during the process is being removed.
摘要翻译：提供了形成含Cd和Se的纳米晶复合材料的方法。纳米晶复合物具有（a）Cd，M，Se，（b）Cd，Se，A和（c）Cd，M，Se，A中的一种的组成，M是组（12）的元素除了Cd和A之外的PSE是除了O和Se之外的PSE的组（16）的元素。在一个实施方案中，在合适的溶剂中，形成元素Cd或其前体，以及适用的M或其前体的溶液。向溶液中加入元素Se和（如适用）A，形成反应混合物。将反应混合物在适于形成含Cd和Se的纳米晶复合材料的温度下加热足够的时间，然后使反应混合物冷却。最后分离Cd和Se纳米晶复合物。在另一个实施方案中，反应混合物通过在合适的溶剂中加入元素Cd或其前体Se，在适用的情况下，在适用的情况下加入A.在该实施方案中，反应混合物被加热并且在该过程中形成的水被除去。

7. 发明申请

WO2009020430A2 METHOD OF FORMING A CADMIUM CONTAINING NANOCRYSTAL 审中-公开
标题翻译：形成含镉纳米晶体的方法
公开(公告)号：WO2009020430A2
公开(公告)日：2009-02-12
申请号：PCT/SG2007/000235
申请日：2007-08-06
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , ZONG, Yun , HAN, Mingyong , KNOLL, Wolfgang
发明人： ZONG, Yun , HAN, Mingyong , KNOLL, Wolfgang
CPC分类号： C30B29/60 , C30B7/00 , C30B29/48 , C30B29/50
摘要： The present invention provides a method of forming a nanocrystal of the composition CdA, with A being S or Se. The method includes forming in a suitable solvent a solution of cadmium, or a compound thereof, in a form suitable for the generation of a nanocrystal. The solvent includes a compound selected from an ether and an amine. The method further includes bringing the solution to a temperature selected in the range from about 20 °C to about 200 °C. The method also includes adding at the temperature selected in the range from about 20 °C to about 200 °C the element A in a form suitable for the generation of a nanocrystal. Thereby the forming of a nanocrystal of the composition CdA is allowed.
摘要翻译：本发明提供了形成组合物CdA的纳米晶体的方法，其中A是S或Se。该方法包括在合适的溶剂中形成适合于产生纳米晶体的镉或其化合物的溶液。溶剂包括选自醚和胺的化合物。该方法还包括使溶液达到在约20℃至约200℃范围内选择的温度。该方法还包括以适合于产生纳米晶体的形式在约20℃至约200℃范围内选择的温度添加元素A. 从而允许形成组合物CdA的纳米晶体。

8. 发明申请

WO2006118542A1 NOVEL WATER-SOLUBLE NANOCRYSTALS COMPRISING A POLYMERIC COATING REAGENT, AND METHODS OF PREPARING THE SAME 审中-公开
标题翻译：包含聚合物涂层试剂的新型水溶性纳米晶体及其制备方法
公开(公告)号：WO2006118542A1
公开(公告)日：2006-11-09
申请号：PCT/SG2005/000136
申请日：2005-05-04
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , HAN, Mingyong , WANG, Fuke
发明人： HAN, Mingyong , WANG, Fuke
IPC分类号： G01N33/58
CPC分类号： C08G83/001 , B82Y5/00 , B82Y10/00 , B82Y20/00 , B82Y30/00 , C08F292/00 , C08G83/003 , C08L53/00 , C08L2666/02
摘要： Disclosed is a water soluble nanocrystal comprising a nanocrystal core comprising at least one metal M1 selected from an element of main group II, subgroup VIIA, subgroup VIIIA, subgroup IB, subgroup IIB, main group III or main group IV of the periodic system of the elements (PSE), at least one element A selected from main group V or main group VI of the PSE, a capping reagent attached to the surface of the core of the nanocrystal, and a water soluble polymer covalently coupled with the capping reagent to form a water soluble polymer shell over the nanocrystal core. Also disclosed are compositions comprising such nanocrystals and uses of such nanocrystals.
摘要翻译：公开了一种水溶性纳米晶体，其包含纳米晶核，其包含至少一种金属M1，所述金属M1选自第II族，第VIIA族，亚组VIIIA，亚组IB，亚组IIB，主要III族或第IV族的元素的元素元素（PSE），选自主要组V或PSE主组VI中的至少一种元素A，连接到纳米晶体核心表面的封端剂和与封端剂共价偶联的水溶性聚合物以形成纳米晶核上的水溶性聚合物壳。还公开了包含这种纳米晶体的组合物和这种纳米晶体的用途。

9. 发明申请

WO2004054923A1 TERNARY AND QUATERNARY NANOCRYSTALS, PROCESSES FOR THEIR PRODUCTION AND USES THEREOF 审中-公开
标题翻译：第三季度和第四季度纳米晶体，其生产工艺及其用途
公开(公告)号：WO2004054923A1
公开(公告)日：2004-07-01
申请号：PCT/SG2003/000286
申请日：2003-12-16
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , NATIONAL UNIVERSITY OF SINGAPORE , HAN, Mingyong , ZHONG, Xinhua , KNOLL, Wolfgang
发明人： HAN, Mingyong , ZHONG, Xinhua , KNOLL, Wolfgang
IPC分类号： B82B1/00
CPC分类号： C30B7/00 , C30B29/48 , C30B29/605
摘要： The present invention relates to nanocrystals consisting of a homogeneous ternary or quaternary alloy having the composition M1 1-x M2 x A y B 1-y , respectively, a process for its production, as well as to uses of such nonocrystals such as short wavelength light-emitting devices, and in the detection of analytes, in particular biomolecules.
摘要翻译：本发明涉及由具有组成M11-xM2xAyB1-y的均匀三元或四元合金组成的纳米晶体，其生产方法，以及这些非晶体如短波长发光器件的使用，以及检测分析物，特别是生物分子。

10. 发明公开

EP2178790A1 PROCESS OF FORMING A CADMIUM AND SELENIUM CONTAINING NANOCRYSTALLINE COMPOSITE AND NANOCRSTALLINE COMPOSITE OBTAINED THEREFROM 审中-公开
标题翻译：形成含镉和硒的纳米晶体复合材料和由此获得的纳米复合材料的方法
公开(公告)号：EP2178790A1
公开(公告)日：2010-04-28
申请号：EP08794195.1
申请日：2008-08-06
申请人： Agency for Science, Technology and Research
发明人： ZONG, Yun , HAN, Mingyong , KNOLL, Wolfgang
IPC分类号： B82B3/00 , C09K11/54 , C09K11/88
CPC分类号： C09K11/565 , C09K11/883
摘要： Provided is a process of forming a Cd and Se containing nanocrystalline composite. The nanocrystalline composite has a composition of one of (a) Cd, M, Se, (b) Cd, Se, A, and (c) Cd, M, Se, A, with M being an element of group (12) of the PSE other than Cd and A being an element of group (16) of the PSE other than O and Se. In one embodiment in a suitable solvent a solution of the element Cd, or a precursor thereof, and, where applicable, of M, or a precursor thereof is formed. To the solution the element Se and, where applicable, A is added and thereby a reaction mixture formed. The reaction mixture is heated for a sufficient period of time at a temperature suitable for forming the Cd and Se containing nanocrystalline composite and then the reaction mixture is allowed to cool. Finally the Cd and Se containing nanocrystalline composite isolated. In another embodiment the reaction mixture is formed by adding into a suitable solvent the element Cd, or a precursor thereof, Se, where applicable M and where applicable A. In this embodiment the reaction mixture is heated and water formed during the process is being removed.
摘要翻译：提供了一种形成含Cd和Se的纳米晶复合物的方法。（a）Cd，M，Se，（b）Cd，Se，A和（c）Cd，M，Se，A中的一种的组成成分，其中M为除Cd以外的PSE和A是除O和Se之外的PSE组（16）的元素。在一个实施方案中，在合适的溶剂中，形成元素Cd或其前体，和如果适用的话，M的溶液或其前体。向该溶液中加入元素Se和（如果适用的话）A，由此形成反应混合物。将反应混合物在适于形成含Cd和Se的纳米晶复合物的温度下加热足够的时间，然后使反应混合物冷却。最后分离出含Cd和Se的纳米晶复合物。在另一个实施方案中，反应混合物通过将元素Cd或其前体Se（在适用的情况下M和适用的情况下）加入合适的溶剂中而形成。在该实施方案中，反应混合物被加热并且在该过程中形成的水被去除。

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