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1. 发明申请

WO2007116336A9 METHOD AND APPARATUS FOR MONITORING ALTERATION OF FLOW CHARACTERISTICS IN A LIQUID SAMPLE 审中-公开
标题翻译：用于监测液体样品中流动特性变化的方法和装置
公开(公告)号：WO2007116336A9
公开(公告)日：2008-11-27
申请号：PCT/IB2007051129
申请日：2007-03-29
申请人： AGAMATRIX INC , HARDING IAN , IYENGAR SRIDHAR G , NGUYEN HA , WILLIAMS RICHARD
发明人： HARDING IAN , IYENGAR SRIDHAR G , NGUYEN HA , WILLIAMS RICHARD
IPC分类号： G01N33/49
CPC分类号： G01N27/26 , G01N33/4905 , G01N33/86
摘要： A device for measuring blood coagulation time is formed from a first substrate; a second substrate; a spacer layer disposed between the first and second substrates, said spacer layer having an opening formed therein defining a sample receiving chamber, a vented sink chamber, and an elongated reservoir forming a conduit for liquid movement between the sample receiving chamber and the sink chamber; a first electrode disposed on the first substrate, said first electrode being exposed in the reservoir portion through a first opening in the spacer layer; and a second electrode disposed on the second substrate, said second electrode being exposed in the reservoir portion through a second opening in the spacer layer. The device of the invention is used in combination with an apparatus that is connected to the first and second electrodes for measuring current flow between the first and second electrodes. Changes in observed current are indicative of flow through the device, and a cessation of flow indicates coagulation.
摘要翻译：用于测量凝血时间的装置由第一基底形成; 第二基板; 间隔层，其设置在所述第一和第二基板之间，所述间隔层具有形成在其中的开口，所述隔离件限定了样品接收室，通气的宿室和形成用于液体在样品接收室和宿室之间移动的导管的细长储存器; 设置在所述第一基板上的第一电极，所述第一电极通过所述间隔层中的第一开口暴露在所述储存部分中; 以及设置在所述第二基板上的第二电极，所述第二电极通过所述间隔层中的第二开口暴露在所述储存部分中。本发明的装置与连接到第一和第二电极的装置结合使用，用于测量第一和第二电极之间的电流。观察到的电流的变化表示通过该装置的流动，并且停止流动表示凝结。

2. 发明申请

WO2007116336A2 METHOD AND APPARATUS FOR MONITORING ALTERATION OF FLOW CHARACTERISTICS IN A LIQUID SAMPLE 审中-公开
标题翻译：用于监测液体样品中流动特性改变的方法和设备
公开(公告)号：WO2007116336A2
公开(公告)日：2007-10-18
申请号：PCT/IB2007051129
申请日：2007-03-29
申请人： AGAMATRIX INC , HARDING IAN , IYENGAR SRIDHAR G , NGUYEN HA , WILLIAMS RICHARD
发明人： HARDING IAN , IYENGAR SRIDHAR G , NGUYEN HA , WILLIAMS RICHARD
IPC分类号： G01N33/49
CPC分类号： G01N27/26 , G01N33/4905 , G01N33/86
摘要： A device for measuring blood coagulation time is formed from a first substrate; a second substrate; a spacer layer disposed between the first and second substrates, said spacer layer having an opening formed therein defining a sample receiving chamber, a vented sink chamber, and an elongated reservoir forming a conduit for liquid movement between the sample receiving chamber and the sink chamber; a first electrode disposed on the first substrate, said first electrode being exposed in the reservoir portion through a first opening in the spacer layer; and a second electrode disposed on the second substrate, said second electrode being exposed in the reservoir portion through a second opening in the spacer layer. The device of the invention is used in combination with an apparatus that is connected to the first and second electrodes for measuring current flow between the first and second electrodes. Changes in observed current are indicative of flow through the device, and a cessation of flow indicates coagulation.
摘要翻译：用于测量凝血时间的装置由第一基底形成; 第二衬底; 设置在所述第一和第二基板之间的间隔层，所述间隔层具有形成在其中的开口，所述开口限定样品接收室，排气式吸收室和形成用于在所述样品接收室和所述吸收室之间的液体移动的导管的细长储存器; 设置在所述第一基板上的第一电极，所述第一电极通过所述间隔层中的第一开口暴露在所述储存部分中; 以及设置在第二基板上的第二电极，所述第二电极通过间隔层中的第二开口暴露在储存部分中。本发明的装置与连接到第一和第二电极的设备结合使用，用于测量第一和第二电极之间的电流。观察到的电流的变化指示通过装置的流动，并且停止流动指示凝结。

3. 发明申请

WO2006109274A3 ERROR DETECTION IN ANALYTE MEASUREMENTS BASED ON MEASUREMENT OF SYSTEM RESISTANCE 审中-公开
标题翻译：基于测量系统电阻的分析测量中的错误检测
公开(公告)号：WO2006109274A3
公开(公告)日：2007-01-11
申请号：PCT/IB2006051177
申请日：2006-04-15
申请人： AGAMATRIX INC , HARDING IAN , WILLIAMS RICHARD , DIAMOND STEVEN
发明人： HARDING IAN , WILLIAMS RICHARD , DIAMOND STEVEN
IPC分类号： G01N27/416 , C12Q1/00 , G01N33/487
CPC分类号： C12Q1/006 , G01N27/3273
摘要： Measurement of the voltage drop at open circuit due to the series resistance of a working and counter electrode pair in an electrochemical test strip provides error detection for multiple variations in the quality of the test strip, as well as the operation of strip in the test meter. In particular, a single measurement of voltage drop can be used to detect and generate an error message when an incorrect reading is likely to result due to (1) damaged electrode tracks, (2) fouled electrode surfaces, (3) dirty strip contacts, or (4) short circuit between the electrodes.
摘要翻译：由于电化学测试条中工作电极对和对电极对的串联电阻，开路电压的测量提供了对测试条质量的多种变化以及测试仪中条带的操作的误差检测。特别地，当由于（1）损坏的电极轨迹，（2）污染的电极表面，（3）脏的带状接触，或者（3）的脏带接触而导致不正确的读数时，可以使用单个的电压降测量来检测并产生错误信息，或（4）电极之间的短路。

4. 发明申请

WO2008049075A2 ELECTROCHEMICAL DETERMINATION OF ANALYTES 审中-公开
标题翻译：分析仪的电化学测定
公开(公告)号：WO2008049075A2
公开(公告)日：2008-04-24
申请号：PCT/US2007081831
申请日：2007-10-18
申请人： AGAMATRIX INC , DIAMOND STEVEN , HARDING IAN , IYENGAR SRIDHAR , WILLIAMS RICHARD
发明人： DIAMOND STEVEN , HARDING IAN , IYENGAR SRIDHAR , WILLIAMS RICHARD
IPC分类号： G01N33/48 , G01N33/49 , G01N35/00
CPC分类号： G01N27/3274
摘要： Determination of an analyte with increased accuracy is achieved by electrochemically determining an initial analyte concentration, performing a plurality of amperometric/ potentiometric switching cycles, observing a characteristic of the signal during each of the plurality of switching cycles, determining an averaged value for the characteristic of the signal, and correcting the initial measurement value to arrive at a final measurement value of analyte concentration or rejecting the initial measurement value depending on the averaged value of the characteristic of the signal. The characteristic of the signal that is observed is not per se indicative of the amount of analyte present in a sample. Rather, it is a characteristic of the signal that reflects the quality of the electrodes, the extent of fill of the electrochemical cell or characteristics of the sample other than analyte concentration such as oxygen levels or hematocrit.
摘要翻译：通过电化学测定初始分析物浓度，执行多个电流/电位开关周期，观察多个开关周期中的每一个期间的信号特性，确定分析物的特性的平均值，信号，并且校正初始测量值以获得分析物浓度的最终测量值或者根据信号的特性的平均值来拒绝初始测量值。观察到的信号的特征本身并不表示样品中存在的分析物的量。而是反映电极的质量，电化学电池的填充程度或样品的特性，而不是分析物浓度如氧水平或血细胞比容的信号的特征。

5. 发明申请

WO2008049074A3 ERROR DETECTION IN ANALYTE MEASUREMENTS BASED ON MEASUREMENT OF SYSTEM RESISTANCE 审中-公开
标题翻译：基于系统电阻测量的分析测量误差检测
公开(公告)号：WO2008049074A3
公开(公告)日：2008-06-05
申请号：PCT/US2007081830
申请日：2007-10-18
申请人： AGAMATRIX INC , DIAMOND STEVEN , HARDING IAN , WILLIAMS RICHARD
发明人： DIAMOND STEVEN , HARDING IAN , WILLIAMS RICHARD
IPC分类号： G01F1/64 , G01N27/26
CPC分类号： G01N27/3274
摘要： Measurement of the series track resistance of a working and counter electrode pair in an electrochemical test strip provide error detection for multiple variations in the quality of the test strip, as well as the operation of strip in the test meter. In particular, a single measurement of series resistance can be used to detect and generate an error message when an incorrect reading is likely to result due to (1) damaged electrode tracks, (2) fouled electrode surfaces, (3) dirty strip contacts, or (4) short circuit between the electrodes.
摘要翻译：测量电化学测试条中工作电极和反电极对的串联电阻电阻，可以检测测试条质量的多种变化以及测试仪中条的操作。特别是，当由于（1）电极轨迹受损，（2）电极表面污染，（3）条带接触不良，或（4）电极之间短路。

6. 发明申请

WO2006109277A3 DETERMINATION OF PARTIAL FILL IN ELECTROCHEMICAL STRIPS 审中-公开
标题翻译：电化学条中部分填充物的测定
公开(公告)号：WO2006109277A3
公开(公告)日：2007-02-22
申请号：PCT/IB2006051180
申请日：2006-04-15
申请人： AGAMATRIX INC , HARDING IAN , DIAMOND STEVEN , WILLIAMS RICHARD , IYENGAR SRIDHAR
发明人： HARDING IAN , DIAMOND STEVEN , WILLIAMS RICHARD , IYENGAR SRIDHAR
IPC分类号： G01N33/487
CPC分类号： G01N27/327
摘要： Partial fill of an electrochemical test strip is determined by making a DC determination of double layer capacitance from charging or discharging charge on a test strip containing sample, for example a blood sample to be tested for glucose. The measured double layer capacitance is compared to a reference value. The double layer capacitance may be determined as an integral or differential capacitance. Double layer capacitance may also be used for quality control to monitor the quality of electrode formation, particularly in strips using screen printed electrodes.
摘要翻译：电化学测试条的部分填充通过在包含样本的测试条（例如待测试葡萄糖的血液样本）上进行充电或放电电荷的双层电容的DC测定来确定。测量的双层电容与参考值进行比较。双层电容可以被确定为积分或微分电容。双层电容也可用于质量控制，以监测电极形成的质量，特别是在使用丝网印刷电极的条中。

7. 发明申请

WO2006109280A2 METHOD AND APPARATUS FOR DETECTION OF ABNORMAL TRACES DURING ELECTROCHEMICAL ANALYTE DETECTION 审中-公开
标题翻译：电化学分析仪检测异常检测方法及装置
公开(公告)号：WO2006109280A2
公开(公告)日：2006-10-19
申请号：PCT/IB2006051189
申请日：2006-04-17
申请人： AGAMATRIX INC , HARDING IAN , WILLIAMS RICHARD
发明人： HARDING IAN , WILLIAMS RICHARD
IPC分类号： G01N33/487 , C12Q1/00
CPC分类号： G01N33/5438 , C12Q1/006 , G01N27/3273
摘要： Detection of abnormal signal traces in electrochemical measurements generated using an electrochemical test strip to which a potential is applied allows for an indication of an erroneous analyte determination. The current trace has an expected shape in which a peak current is observed a time tpeak after which there is a decrease in current. To detect abnormal signal traces, the time tpeak is determined experimentally and compared with an expected value, t'peak, and if the difference between the two values to over a predetermined threshold, an error message is provided to the user instead of a test result. The value of t'peak is determined as a function of a mobility term that is determined during a potentiometry phase following the amperometric measurements.
摘要翻译：使用电化学测试条产生的电化学测量中异常信号迹线的检测可以用于指示错误的分析物确定。当前迹线具有预期的形状，其中观察到峰值电流在时间tpeak之后，其中电流降低。为了检测异常信号迹线，通过实验确定时间tpeak，并将其与期望值t'peak进行比较，并且如果两个值之间的差异超过预定阈值，则向用户提供错误消息而不是测试结果。 t'peak的值被确定为在电流计测量之后的电位计相位期间确定的迁移项的函数。

8. 发明申请

WO2006109277B1 DETERMINATION OF PARTIAL FILL IN ELECTROCHEMICAL STRIPS 审中-公开
标题翻译：电化学工业部分填充物的测定
公开(公告)号：WO2006109277B1
公开(公告)日：2007-04-12
申请号：PCT/IB2006051180
申请日：2006-04-15
申请人： AGAMATRIX INC , HARDING IAN , DIAMOND STEVEN , WILLIAMS RICHARD , IYENGAR SRIDHAR
发明人： HARDING IAN , DIAMOND STEVEN , WILLIAMS RICHARD , IYENGAR SRIDHAR
IPC分类号： G01N33/487
CPC分类号： G01N27/327
摘要： Partial fill of an electrochemical test strip is determined by making a DC determination of double layer capacitance from charging or discharging charge on a test strip containing sample, for example a blood sample to be tested for glucose. The measured double layer capacitance is compared to a reference value. The double layer capacitance may be determined as an integral or differential capacitance. Double layer capacitance may also be used for quality control to monitor the quality of electrode formation, particularly in strips using screen printed electrodes.
摘要翻译：电化学测试条的部分填充通过在含有样品的测试条（例如要测试葡萄糖的血液样品）上进行充电或放电电荷的双层电容的DC测定来确定。将测量的双层电容与参考值进行比较。双层电容可以被确定为积分或差分电容。双层电容也可用于质量控制，以监测电极形成的质量，特别是使用丝网印刷电极的条带。

9. 发明申请

WO2006109279A3 ANALYTE DETERMINATION METHOD AND ANALYTE METER 审中-公开
标题翻译：分析测定方法和分析仪
公开(公告)号：WO2006109279A3
公开(公告)日：2007-03-08
申请号：PCT/IB2006051188
申请日：2006-04-17
申请人： AGAMATRIX INC , HARDING IAN , WILLIAMS RICHARD , IYENGAR SRIDHAR
发明人： HARDING IAN , WILLIAMS RICHARD , IYENGAR SRIDHAR
IPC分类号： G01N33/487 , C12Q1/00
CPC分类号： G01N27/3274 , C12Q1/006 , G01N27/307 , G01N27/327 , G01N27/3272 , G01N27/3273
摘要： The presence of oxygen or red blood cells in a sample applied to an electrochemical test strip that makes use of a reduced mediator is corrected for by an additive correction factor that is determined as a function of the temperature of the sample and a measurement that reflects the oxygen carrying capacity of the sample. The measured oxygen carrying capacity can also be used to determine hematocrit and to distinguish between blood samples and control solutions applied to a test strip.
摘要翻译：在施加到使用还原介体的电化学测试条的样品中的氧或红细胞的存在通过作为样品的温度的函数确定的添加剂校正因子来校正，并且反映样品的氧气承载能力。测量的氧气承载能力也可用于确定血细胞比容并区分血液样本和应用于测试条的对照溶液。

10. 发明公开

EP2174135A4 ELECTROCHEMICAL ANALYTE DETECTION APPARATUS AND METHOD 有权转让
标题翻译：用于检测电化学分析的装置和方法
公开(公告)号：EP2174135A4
公开(公告)日：2010-08-25
申请号：EP08782340
申请日：2008-07-24
申请人： AGAMATRIX INC
发明人： HARDING IAN , IYENGAR SRIDHAR , WILLIAMS RICHARD
IPC分类号： G01N33/53 , C12Q1/04
CPC分类号： G01N33/573 , C12Q1/001 , G01N27/4166 , G01N33/5438 , G01N2333/90 , G01N2333/902
摘要： A method and apparatus for electrochemical detection of analyte in a sample makes use of a binding interaction and relies on the discovery that asymmetric distribution of a redox enzyme between two electrodes that occurs when a redox enzyme-containing reagent is immobilized at the surface of one electrode can be detected as a chemical potential gradient arising from an asymmetry in the distribution of oxidized or reduced redox substrate. This chemical potential gradient can be detected potentiometrically by observing the potential difference between the electrodes in an open circuit, or amperometrically by observing the current flow between the electrodes when the circuit is closed. In both cases, the observation of asymmetry can be done without the application of an external potential or current to the electrodes.

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