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1. 发明申请

WO2003088897A3 FAB I INHIBITORS 审中-公开
公开(公告)号：WO2003088897A3
公开(公告)日：2003-10-30
申请号：PCT/US2002/010332
申请日：2002-04-03
申请人： AFFINIUM PHARMACEUTICALS, INC. , BURGESS, Walter, J. , JAKAS, Dalia , HUFFMAN, William, F. , MILLER, William, H. , NEWLANDER, Kenneth, A. , SEEFELD, Mark, A. , UZINSKAS, Irene, N.
发明人： BURGESS, Walter, J. , JAKAS, Dalia , HUFFMAN, William, F. , MILLER, William, H. , NEWLANDER, Kenneth, A. , SEEFELD, Mark, A. , UZINSKAS, Irene, N.
IPC分类号： A61K31/4439
摘要： Compounds are disclosed which are Fab I inhibitors and are useful in the treatment of bacterial infections.

2. 发明申请

WO2003088897A2 FAB I INHIBITORS 审中-公开
标题翻译： FAB I抑制剂
公开(公告)号：WO2003088897A2
公开(公告)日：2003-10-30
申请号：PCT/US2002/010332
申请日：2002-04-03
申请人： AFFINIUM PHARMACEUTICALS, INC. , BURGESS, Walter, J. , JAKAS, Dalia , HUFFMAN, William, F. , MILLER, William, H. , NEWLANDER, Kenneth, A. , SEEFELD, Mark, A. , UZINSKAS, Irene, N.
发明人： BURGESS, Walter, J. , JAKAS, Dalia , HUFFMAN, William, F. , MILLER, William, H. , NEWLANDER, Kenneth, A. , SEEFELD, Mark, A. , UZINSKAS, Irene, N.
IPC分类号： A61K
CPC分类号： C07D213/73 , A61K31/16 , A61K31/381 , A61K31/416 , A61K31/47 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D471/04 , C07D487/04 , C07D491/04
摘要： Compounds are disclosed which are Fab I inhibitors and are useful in the treatment of bacterial infections.
摘要翻译：公开了作为Fab I抑制剂并且可用于治疗细菌感染的化合物。

3. 发明授权

EP1226138B1 FAB I INHIBITORS 有权
标题翻译： FAB I抑制剂
公开(公告)号：EP1226138B1
公开(公告)日：2004-12-29
申请号：EP00968895.3
申请日：2000-10-06
申请人： Affinium Pharmaceuticals, Inc.
发明人： MILLER, William, H. , NEWLANDER, Kenneth, A. , SEEFELD, Mark, A. , UZINSKAS, Irene, N. , DeWOLF, Walter, E., Jr. , JAKAS, Dalia, R.
IPC分类号： A61P31/04 , C07D401/12 , C07D405/12 , C07D209/14 , C07D215/38 , C07D221/02 , C07D265/36 , C07D498/02 , C07D471/02 , A61K31/495 , A61K31/381 , C07D403/12 , C07D409/12 , C07D213/73 , C07D498/04 , C07D471/04 , C07D495/04
CPC分类号： C07D213/75 , A61K31/381 , A61K31/4436 , A61K31/4439 , A61K31/47 , A61K31/495 , A61K31/506 , A61K31/5365 , C07D209/14 , C07D209/52 , C07D239/42 , C07D401/12 , C07D405/12 , C07D471/04 , C07D487/04 , C07D495/04 , Y02A50/473
摘要： Compounds of the formula (I) are disclosed which are Fab I inhibitors and are useful in the treatment of bacterial infections.

4. 发明授权

EP1560584B1 FAB I INHIBITORS 有权
标题翻译： FAB I抑制剂
公开(公告)号：EP1560584B1
公开(公告)日：2009-01-14
申请号：EP02807262.7
申请日：2002-04-03
申请人： Affinium Pharmaceuticals, Inc.
发明人： BURGESS, Walter, J. , JAKAS, Dalia , HUFFMAN, William, F. , MILLER, William, H. , NEWLANDER, Kenneth, A. , SEEFELD, Mark, A. , UZINSKAS, Irene, N.
IPC分类号： A61K31/4439 , A61K31/4436 , A61K31/443 , A61K31/437 , A61K31/44 , C07D401/12 , C07D405/12 , C07D409/12 , C07D471/04 , C07D213/72 , C07D487/04 , C07D498/04 , C07D403/12 , C07D401/14
CPC分类号： C07D213/73 , A61K31/16 , A61K31/381 , A61K31/416 , A61K31/47 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D471/04 , C07D487/04 , C07D491/04
摘要： Compounds are disclosed which are Fab I inhibitors and are useful in the treatment of bacterial infections.

5. 发明授权

EP1225894B1 FAB I INHIBITORS 有权
标题翻译： FAB-I-缝边
公开(公告)号：EP1225894B1
公开(公告)日：2006-07-05
申请号：EP00968801.1
申请日：2000-10-06
申请人： Affinium Pharmaceuticals, Inc.
发明人： MILLER, William, H. , NEWLANDER, Kenneth, A. , SEEFELD, Mark, A. , UZINSKAS, Irene, N.
IPC分类号： A61K31/40 , A61K31/44 , A61K31/405 , A61K31/415 , A61K31/445 , C07D209/16 , C07D231/56 , C07D401/00 , C07D409/12
CPC分类号： C07D401/12 , C07D209/14 , C07D231/56
摘要： Compounds of formula (I) and (II) are disclosed which are Fab I inhibitors and are useful in the treatment of bacterial infections wherein R1 is H or C¿1-4?alkyl; R?2¿ is C¿1-4?alkyl; R?3¿ is (a) or (b); Q is a single bond, -O-, -S-, -NH-, -CH¿2?-, or -CH2CH2-; R?4¿ is C¿1-6?alkyl, OC1-6alkyl, OH, CF3 or piperidinyl; (c) is a five- or six-membered heteroaromatic ring or a six-membered aromatic ring unsubstituted or substituted by R?5¿; (d) is a five- or six-membered heteroaromatic ring or a six-membered aromatic ring unsubstituted or substituted by R6; (e) is a five- or six-membered heteroaromatic ring or a six-membered aromatic ring unsubstituted or substituted by R6; R5 is OR' or NR'C(O)R'; R6 is OR' or N(R')¿2?; X is H, C1-4alkyl, OR', SR', CN, N(R')2, CH2N(R')2, NO2, CF3, CO2R', CON(R')2, COR', NR'C(O)R', F, Cl, Br, I or -S(O)rCF3; R' is H, C1-6alkyl or -C0-6alkyl-Ar; and r is 0, 1 or 2; or a pharmaceutically acceptable salt thereof.

6. 发明公开

EP1560584A2 FAB I INHIBITORS 有权
标题翻译： FAB I抑制剂
公开(公告)号：EP1560584A2
公开(公告)日：2005-08-10
申请号：EP02807262.7
申请日：2002-04-03
申请人： Affinium Pharmaceuticals, Inc.
发明人： BURGESS, Walter, J. , JAKAS, Dalia , HUFFMAN, William, F. , MILLER, William, H. , NEWLANDER, Kenneth, A. , SEEFELD, Mark, A. , UZINSKAS, Irene, N.
IPC分类号： A61K31/4439 , A61K31/4436 , A61K31/443 , A61K31/437 , A61K31/44 , C07D401/12 , C07D405/12 , C07D409/12 , C07D471/04 , C07D213/72
CPC分类号： C07D213/73 , A61K31/16 , A61K31/381 , A61K31/416 , A61K31/47 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D471/04 , C07D487/04 , C07D491/04
摘要： Compounds are disclosed which are Fab I inhibitors and are useful in the treatment of bacterial infections.

7. 发明授权

EP1171428B1 FAB I INHIBITORS 有权
标题翻译： FAB I抑制剂
公开(公告)号：EP1171428B1
公开(公告)日：2009-06-17
申请号：EP00928259.1
申请日：2000-04-19
申请人： Affinium Pharmaceuticals, Inc.
发明人： MILLER, William, H. , NEWLANDER, Kenneth, A. , SEEFELD, Mark, A.
IPC分类号： C07D243/14 , C07D403/12 , C07D405/12 , C07D417/12 , A61K31/5513 , A61P31/04
CPC分类号： C07D403/12
摘要： Compounds of formula (I) are disclosed which are Fab I inhibitors and are useful in the treatment of bacterial infections: wherein R1 is H, C¿1-6?alkyl or Ar-C0-6alkyl; R?2¿ is H, C¿1-6?alkyl, Ar-C0-6alkyl, HO-(CH2)n- or R'OC(O)-(CH2)n-; R?3¿ is A-C¿0-4?alkyl, A-C2-4alkenyl, A-C2-4alkynyl, A-C3-4oxoalkenyl, A-C3-4oxoalkynyl, A-C1-4aminoalkyl, A-C3-4aminoalkenyl, A-C3-4aminoalkynyl, optionally substituted by any accessible combination of one or more of R?10 or R7; R4¿ is (a), (b), (c), or (d); R5 is H, C¿1-6?alkyl, Ar-C0-6alkyl or C3-6cycloalkyl-C0-6alkyl; A is H, C3-6cycloalkyl, Het or Ar; R?7 is-COR8¿, -COCR'¿2R?9, -C(S)R8, -S(O)¿k?OR', -S(O)kNR'R'', -PO(OR'),-PO(OR')2, -B(OR')2, -NO2, or tetrazolyl; R?8¿ is -OR', -NR'R'', -NR'SO2R', or -NR'OR', -OCR'¿2?CO(O)R'; R?9¿ is -OR', -CN, -S(O)¿r?R', -S(O)kNR'2, -C(O)R', C(O)NR'2, or -CO2R'; R?10¿ is H, halo, -OR11, -CN, -NR'R11, -NO2, -CF3, CF3S(O)r-, -CO2R', -CONR'2, A-C0-6alkyl-, A-C1-6oxoalkyl-, A-C2-6alkenyl-, A-C2-6alkynyl-, A-C0-6alkyloxy-, A-C0-6alkylamino- or A-C0-6alkyl-S(O)r-; R11 is R', -C(O)R', -C(O)NR'¿2?, -C(O)OR', -S(O)kR', or -S(O)kNR'2; R' is H, C1-6alkyl, Ar-C0-6alkyl or C3-6cycloalkyl-C0-6alkyl; R'' is R', -C(O)R' or -C(O)OR'; R''' is H, C1-6alkyl, Ar-C0-6alkyl, HO-(CH2)2-, R'C(O)-, (R')2NC(O)CH2- or R'S(O)2-; X is H, C1-4alkyl, OR', SR', C1-4alkylsulfonyl, C1-4alkylsulfoxyl, -CN, N(R')2, CH2N(R')2,-NO2,-CF3, -CO2R', -CON(R')2, -COR', -NR'C(O)R', F, C1, Br, I, or CF3S(O)r-; k is 1 or 2; m is 1, 2 or 3; n is 1 to 6; and r is 0, 1 or 2; or a pharmaceutically acceptable salt thereof.

8. 发明授权

EP1180030B1 ANTIBACTERIAL COMPOUNDS 有权
标题翻译：抗菌化合物
公开(公告)号：EP1180030B1
公开(公告)日：2004-11-24
申请号：EP00936459.7
申请日：2000-06-01
申请人： Affinium Pharmaceuticals, Inc.
发明人： MILLER, William, H. , NEWLANDER, Kenneth, A. , SEEFELD, Mark
IPC分类号： A61K31/437 , A61P31/04 , C07D471/04
CPC分类号： C07D471/04
摘要： Compounds of formula (I) are disclosed which are Fab I inhibitors and are useful in the treatment bacterial infections, wherein: R1 is Ar or Het; R2 is H, C¿1-6?alkyl or Ar-C0-6alkyl; X is H, C1-4alkyl, OR', SR', C1-4alkylsulfonyl, C1-4alkylsulfoxyl, CN, N(R')2, CH2N(R')2, NO2, CF3, CO2R', CON(R')2, COR', NR'C(O)R', F, Cl, Br, I, or CF3S(O)r-; R' is H, C1-6alkyl or Ar-C0-6alkyl; and r is 0, 1 or 2; or a pharmaceutically acceptable salt thereof.

9. 发明授权

EP1225895B1 FAB I INHIBITORS 有权
标题翻译： FAB I HEMMER
公开(公告)号：EP1225895B1
公开(公告)日：2005-05-04
申请号：EP00973420.3
申请日：2000-10-06
申请人： Affinium Pharmaceuticals, Inc.
发明人： MILLER, William, H. , NEWLANDER, Kenneth, A. , SEEFELD, Mark, A.
IPC分类号： A61K31/4045 , C07D209/14 , A61P31/04
CPC分类号： C07D209/14

10. 发明申请

WO2012005805A1 AZAINDAZOLES 审中-公开
标题翻译：氮杂吲唑
公开(公告)号：WO2012005805A1
公开(公告)日：2012-01-12
申请号：PCT/US2011/035344
申请日：2011-05-05
申请人： GLAXOSMITHKLINE LLC , BURGESS, Joelle, Lorraine , JOHNSON, Neil , KNIGHT, Steven, D. , LAFRANCE, Louis , MILLER, William, H. , NEWLANDER, Kenneth , ROMERIL, Stuart , ROUSE, Meagan, B. , TIAN, Xinrong , VERMA, Sharad, Kumar , SUAREZ, Dominic
发明人： BURGESS, Joelle, Lorraine , JOHNSON, Neil , KNIGHT, Steven, D. , LAFRANCE, Louis , MILLER, William, H. , NEWLANDER, Kenneth , ROMERIL, Stuart , ROUSE, Meagan, B. , TIAN, Xinrong , VERMA, Sharad, Kumar , SUAREZ, Dominic
IPC分类号： A61K31/497
CPC分类号： C07D471/04 , C07D519/00
摘要： Herein are disclosed azaindazoles of formula (I) where the various groups are defined herein, and which are useful for treating cancer.
摘要翻译：本文公开了式（I）的氮杂吲唑，其中各种基团在本文中定义，并且其可用于治疗癌症。

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