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1. 发明申请

WO2005009323A2 A NEBULISER FOR THE PRODUCTION OF AEROSOLIZED MEDICATION 审中-公开
标题翻译：一种用于生产气溶胶药物的嗅觉器
公开(公告)号：WO2005009323A2
公开(公告)日：2005-02-03
申请号：PCT/US2004/021628
申请日：2004-07-06
申请人： AEROGEN, INC. , POWER, John , MORAN, Declan , DEVERY, Donal , O'SULLIVAN, Gavan , FINK, James , SMITH, Niall
发明人： POWER, John , MORAN, Declan , DEVERY, Donal , O'SULLIVAN, Gavan , FINK, James , SMITH, Niall
IPC分类号： A61J
CPC分类号： A61M15/0085 , A61M2205/8206 , A61M2205/8237 , B05B17/0607
摘要： A nebuliser to deliver a medicament that includes a housing having a reservoir for the medicament, an aerosol generator that can be supplied the medicament from the reservoir, where the generator aerosolizes at least a portion of the medicament into an aerosol, a gas venting inlet to permit a gas to enter the nebuliser and form a mixture with the aerosol, and a passage through which the mixture of the aerosol and the gas is delivered to an outlet port of the nebuliser.
摘要翻译：输送药物的雾化器，其包括具有用于药物的储存器的壳体，可从储存器供应药物的气雾剂发生器，其中发生器将药物的至少一部分雾化成气雾剂，允许气体进入雾化器并与气雾剂形成混合物的气体通气入口，以及气雾剂和气体的混合物通过该通道递送到雾化器的出口端口。

2. 发明申请

WO2006102345A2 METHODS AND SYSTEMS FOR OPERATING AN AEROSOL GENERATOR 审中-公开
标题翻译：用于操作气溶胶发生器的方法和系统
公开(公告)号：WO2006102345A2
公开(公告)日：2006-09-28
申请号：PCT/US2006/010278
申请日：2006-03-22
申请人： AEROGEN, INC. , FINK, James, B. , POWER, John , IVRI, Ehud , SMITH, Niall , DUNNE, Paul , O'SULLIVAN, Gavan , MORAN, Declan
发明人： FINK, James, B. , POWER, John , IVRI, Ehud , SMITH, Niall , DUNNE, Paul , O'SULLIVAN, Gavan , MORAN, Declan
IPC分类号： A61K9/12 , A61K9/72 , A61K47/02 , A61K31/7036 , A61M15/00 , A61M16/00
CPC分类号： A61M16/20 , A61K9/0078 , A61K31/7036 , A61M11/00 , A61M11/005 , A61M16/0833 , A61M16/0858 , A61M16/1065 , A61M16/208 , A61M2016/0021 , A61M2016/0027 , A61M2205/3561 , A61M2205/3569
摘要： A method of treating a patient with a pulmonary disease, where the method includes delivering a dose of aerosolized medicament intermittently to a ventilator circuit coupled to the respiratory system of the patient. Also, a method of treating a patient with a pulmonary disease, where the method includes taking the patient off a ventilator, and administering to the patient, a nebulized aerosol comprising from about 100 μg to about 500 mg of a medicament. Additionally, an aerosolized medicament for the treatment of a pulmonary disease, where the medicament includes amikacin mixed with an aqueous solution having an adjusted pH from about 5.5 to about 6.3. The pH is adjusted by adding hydrochloric acid and sodium hydroxide to the aqueous solution.
摘要翻译：一种治疗患有肺部疾病的患者的方法，其中所述方法包括将一定剂量的雾化药物间歇地递送至与患者呼吸系统相连的通气机回路。另外，一种治疗患有肺部疾病的患者的方法，其中所述方法包括使患者脱离呼吸机，并向患者施用包含约100μg至约500mg药物的雾化气雾剂。另外，一种用于治疗肺部疾病的雾化药物，其中药物包含与调节pH约5.5至约6.3的水溶液混合的阿米卡星。通过向水溶液中加入盐酸和氢氧化钠来调节pH。

3. 发明申请

WO2007024812A1 SELF-SEALING T-PIECE AND VALVED T-PIECE 审中-公开
标题翻译：自密封T型和阀门T型
公开(公告)号：WO2007024812A1
公开(公告)日：2007-03-01
申请号：PCT/US2006/032677
申请日：2006-08-21
申请人： AEROGEN, INC. , FINK, James, B. , O'SULLIVAN, Gavan , DUNNE, Paul , MORAN, Declan , POWER, John , SMITH, Niall
发明人： FINK, James, B. , O'SULLIVAN, Gavan , DUNNE, Paul , MORAN, Declan , POWER, John , SMITH, Niall
IPC分类号： A61M16/08
CPC分类号： A61M16/0833 , A61M11/00 , A61M15/009 , A61M16/0057 , A61M16/08 , A61M16/0875 , A61M16/14 , A61M16/20
摘要： Apparatus (500) and components for coupling fluid or gas conducting elements, such as apparatus and components for connecting a nebulizer (501) with a gas flow system. In particular, the apparatus (500) and components are useful for connecting, in a gas-tight and quick release manner, a nebulizer (501) to a pressure-assisted breathing system, such as a mechanical ventilator or a continuous positive airway pressure ("CPAP") system.
摘要翻译：用于耦合流体或气体传导元件的装置（500）和用于将雾化器（501）与气体流动系统连接的装置和部件。特别地，装置（500）和部件可用于以气密和快速释放的方式将雾化器（501）连接到诸如机械呼吸机或持续正压通气压力（例如， “CPAP”）系统。

4. 发明申请

WO2010035252A2 A NEBULISER SYSTEM 审中-公开
标题翻译： NEBULISER系统
公开(公告)号：WO2010035252A2
公开(公告)日：2010-04-01
申请号：PCT/IE2009/000068
申请日：2009-09-28
申请人： STAMFORD DEVICES LIMITED , POWER, John , DUFFY, Conor , SMITH, Niall , CLANCY, Dermot, Joseph , HYLAND, Kieran
发明人： POWER, John , DUFFY, Conor , SMITH, Niall , CLANCY, Dermot, Joseph , HYLAND, Kieran
IPC分类号： A61M11/00 , A61M15/00
CPC分类号： A61M11/005 , A61M15/0028 , A61M15/003 , A61M15/0031 , A61M15/0035 , A61M15/0085 , A61M2205/6045 , B05B12/081 , B05B17/0646
摘要： A nebuliser 1 particularly for home use comprises a housing 2 having an aerosol generator 3 mounted therein. The housing is closed by a hinged cap 4 and has an outlet 5 through which aerosol generated by the generator 3 is delivered. A suitable connector such as a mouthpiece 6 may be connected to the outlet 5. The housing 2 has a receiver for receiving a nebule 8. The receiver comprises a slot 7 which is sized and/or shaped to accommodate only a nebule 8 of predetermined shape and/or size. The nebuliser cap 4 has a nebule opening means which may be in the form of a puncture pin 10 projecting therefrom to pierce the nebule 8 when the cap is moved to the closed position. The pin 10 is hollow or splined to regulate flow from the nebule. The nebuliser 1 also has a switch means for enabling operation of the aerosol generator 3 when the nebule 8 is opened. The switch means comprises a microswitch 12 on the housing which is engageable by a trigger 13 on the cap 4 when the cap is moved to the closed position. Aerosol generated by the aerosol generator 3 is delivered into a chamber defined by the nebuliser housing 2. Air passes into the chamber through air inlets 30. The air entrains the aerosolised medicament and the entrained aerosolised medicament is delivered from the nebuliser through the outlet 5.
摘要翻译：特别用于家庭使用的雾化器1包括其中安装有气溶胶发生器3的壳体2。壳体由铰接盖4封闭，并且具有出口5，由发生器3产生的气雾通过该出口5被输送。诸如接口管6的合适的连接器可以连接到出口5.壳体2具有用于接收氖8的接收器。接收器包括槽7，槽7的尺寸和/或形状仅适于具有预定形状的氖8 和/或尺寸。雾化器盖4具有ne形开口装置，其可以是当帽移动到关闭位置时从其突出的穿刺销10的形式刺穿氖8。销10是中空的或花键的，以调节来自星云的流动。雾化器1还具有开关装置，用于当氖8打开时能使气溶胶发生器3工作。开关装置包括壳体上的微型开关12，当盖子移动到关闭位置时，该开关装置可由盖子4上的触发器13接合。由气溶胶发生器3产生的气雾剂被输送到由雾化器壳体2限定的室中。空气通过空气入口30进入室。空气夹带雾化的药物，并且夹带的雾化的药物从喷雾器通过出口5输送。

5. 发明申请

WO2009118718A1 ΗUMIDIFICATION IN BREATHIN CIRCUITS 审中-公开
标题翻译：呼吸回路中的呼吸
公开(公告)号：WO2009118718A1
公开(公告)日：2009-10-01
申请号：PCT/IE2009/000011
申请日：2009-03-27
申请人： STAMFORD DEVICES LIMITED , CLANCY, Dermot, Joseph , DUFFY, Conor , GIBBONS, Keith , POWER, John , SMITH, Niall
发明人： CLANCY, Dermot, Joseph , DUFFY, Conor , GIBBONS, Keith , POWER, John , SMITH, Niall
IPC分类号： A61B17/34 , A61M16/16 , B05B17/06 , A61M15/00
CPC分类号： A61B17/3474 , A61M11/005 , A61M11/042 , A61M15/0085 , A61M15/025 , A61M16/0833 , A61M16/147 , A61M16/16 , B05B12/081 , B05B17/0646 , B05B17/0669
摘要： A method for humidifying gas in a ventilator circuit 100, 101, 102, 105. 106 comprises aerosolising a humidifying agent such as water or saline using aerosol generator 2 and delivering the aerosolised humidifying agent, to the inspiration line 101 of the ventilator circuit coupled to the respiratory system of a patient. The aerosol generator 2 comprises a vibratable member 40 having a plurality of apertures extending between a first surface and a second surface. A controller 3 controls the operation of aerosol generator 2, for example in response to the flow of air in the inspiration line 101 as detected by a sensor11.
摘要翻译：用于使呼吸器回路100,101,102,105,106中的气体增湿的方法包括使用气溶胶发生器2将诸如水或盐水的增湿剂雾化并且将雾化的增湿剂递送至吸气器呼吸机回路的管线101连接到患者的呼吸系统。气雾发生器2包括具有在第一表面和第二表面之间延伸的多个孔的可振动构件40。控制器3例如响应于由传感器11检测到的吸气管线101中的空气流动来控制气雾发生器2的操作。

6. 发明申请

WO2003097126A2 APPARATUS FOR PROVIDING AEROSOL FOR MEDICAL TREATMENT AND METHODS 审中-公开
标题翻译：用于医疗治疗和方法提供气溶胶的装置
公开(公告)号：WO2003097126A2
公开(公告)日：2003-11-27
申请号：PCT/US2003/015891
申请日：2003-05-20
申请人： AEROGEN, INC.
发明人： POWER, John , REGAN, Des , SMITH, Niall
IPC分类号： A61M
CPC分类号： A61M15/0085 , A61M11/005 , B05B17/0646
摘要： Embodiments of the present invention include apparatus and methods for aerosolizing liquid. One embodiment of the invention provides an apparatus for generating an aerosol. The apparatus includes an actuator having a first face and a second face and defining an opening therethrough, as well as a vibratory element in mechanical communication with the actuator, and a sealing member configured to isolate the vibratory element from a surrounding environment. In accordance with certain embodiments, the apparatus further comprises an aerosolization element mounted on the actuator and disposed substantially over the opening, wherein the aerosolization element defines at least one aperture therethrough. Hence, the vibratory element may be operated to vibrate to cause movement of the aerosolization element in such a manner that a liquid at the first face of the aerosolization element can be dispensed as an aerosol through the at least one aperture. Some embodiments feature an electrode coupled to the vibratory element.
摘要翻译：本发明的实施例包括用于使液体雾化的装置和方法。本发明的一个实施例提供了一种用于产生气溶胶的装置。该装置包括具有第一面和第二面并且限定穿过其中的开口的致动器以及与致动器机械连通的振动元件，以及构造成将振动元件与周围环境隔离的密封构件。根据某些实施例，该装置还包括安装在致动器上并基本上设置在开口上方的雾化元件，其中雾化元件限定穿过其中的至少一个孔。因此，振动元件可以被操作以振动以引起雾化元件的移动，使得雾化元件的第一面处的液体可以通过至少一个孔分配为气溶胶。一些实施例的特征在于耦合到振动元件的电极。

7. 发明申请

WO2003097126A3 AEROSOL FOR MEDICAL TREATMENT AND METHODS 审中-公开
公开(公告)号：WO2003097126A3
公开(公告)日：2003-11-27
申请号：PCT/US2003/015891
申请日：2003-05-20
申请人： AEROGEN, INC.
发明人： POWER, John , REGAN, Des , SMITH, Niall
IPC分类号： B05B1/00
摘要： Embodiments of the present invention include apparatus and methods for aerosolizing liquid. One embodiment of the invention provides an apparatus for generating an aerosol. The apparatus includes an actuator having a first face and a second face and defining an opening therethrough, as well as a vibratory element in mechanical communication with the actuator, and a sealing member configured to isolate the vibratory element from a surrounding environment. In accordance with certain embodiments, the apparatus further comprises an aerosolization element mounted on the actuator and disposed substantially over the opening, wherein the aerosolization element defines at least one aperture therethrough. Hence, the vibratory element may be operated to vibrate to cause movement of the aerosolization element in such a manner that a liquid at the first face of the aerosolization element can be dispensed as an aerosol through the at least one aperture. Some embodiments feature an electrode coupled to the vibratory element.

8. 发明申请

WO2003059424A1 METHODS AND SYSTEMS FOR OPERATING AN AEROSOL GENERATOR 审中-公开
标题翻译：用于操作气溶胶发生器的方法和系统
公开(公告)号：WO2003059424A1
公开(公告)日：2003-07-24
申请号：PCT/US2003/001516
申请日：2003-01-15
申请人： AEROGEN, INC.
发明人： SMITH, Niall , POWER, John , FINK, James, B. , KLIMOWICZ, Michael
IPC分类号： A61M15/00
CPC分类号： A61J1/065 , A61J2205/10 , A61J2205/60 , A61M15/00 , A61M15/0028 , A61M15/0031 , A61M15/0033 , A61M15/0085 , A61M16/024 , A61M16/04 , A61M16/06 , A61M16/08 , A61M2016/0021 , A61M2016/0024 , A61M2205/52 , A61M2205/6045 , A61M2205/6054 , A61M2205/6072 , A61M2205/8206 , A61M2205/8262 , A61M2209/082 , B05B17/0646 , B65D1/095 , B65D2203/00
摘要： A nebule (28) having an identification marker/label (35) which is adapted to engage an aerosol generator (22). The marker/label (35) can be sensed by a sensing device (34) on the aerosol generator (22) so as to identify the contents of the nebule (28) for use by the aerosol controller (30). The controller (30) can then control the aerosol generator (22) based upon the identity of the contents of the nebule.
摘要翻译：具有适于接合气溶胶发生器（22）的识别标记/标签（35）的氖（28）。标记/标签（35）可以由气溶胶发生器（22）上的感测装置（34）感测，以便识别用于气溶胶控制器（30）的氖（28）的内容物。然后，控制器（30）可以基于氖气内容物的身份来控制气溶胶发生器（22）。

9. 发明公开

EP1474196A1 METHODS AND SYSTEMS FOR OPERATING AN AEROSOL GENERATOR 有权转让
标题翻译：方法和系统操作气溶胶发生器
公开(公告)号：EP1474196A1
公开(公告)日：2004-11-10
申请号：EP03702161.5
申请日：2003-01-15
申请人： AeroGen, Inc.
发明人： SMITH, Niall , POWER, John , FINK, James, B. , KLIMOWICZ, Michael
IPC分类号： A61M15/00 , A61M16/10
CPC分类号： A61J1/065 , A61J2205/10 , A61J2205/60 , A61M15/00 , A61M15/0028 , A61M15/0031 , A61M15/0033 , A61M15/0085 , A61M16/024 , A61M16/04 , A61M16/06 , A61M16/08 , A61M2016/0021 , A61M2016/0024 , A61M2205/52 , A61M2205/6045 , A61M2205/6054 , A61M2205/6072 , A61M2205/8206 , A61M2205/8262 , A61M2209/082 , B05B17/0646 , B65D1/095 , B65D2203/00
摘要： A nebule (28) having an identification marker/label (35) which is adapted to engage an aerosol generator (22). The marker/label (35) can be sensed by a sensing device (34) on the aerosol generator (22) so as to identify the contents of the nebule (28) for use by the aerosol controller (30). The controller (30) can then control the aerosol generator (22) based upon the identity of the contents of the nebule.

10. 发明公开

EP1509259A2 APPARATUS FOR PROVIDING AEROSOL FOR MEDICAL TREATMENT AND METHODS 有权转让
标题翻译：装置，提供油漆和医疗，程序
公开(公告)号：EP1509259A2
公开(公告)日：2005-03-02
申请号：EP03753105.0
申请日：2003-05-20
申请人： AeroGen, Inc.
发明人： POWER, John , REGAN, Des , SMITH, Niall
IPC分类号： A61M1/00
CPC分类号： A61M15/0085 , A61M11/005 , B05B17/0646
摘要： Embodiments of the present invention include apparatus and methods for aerosolizing liquid. One embodiment of the invention provides an apparatus for generating an aerosol. The apparatus includes an actuator having a first face and a second face and defining an opening therethrough, as well as a vibratory element in mechanical communication with the actuator, and a sealing member configured to isolate the vibratory element from a surrounding environment. In accordance with certain embodiments, the apparatus further comprises an aerosolization element mounted on the actuator and disposed substantially over the opening, wherein the aerosolization element defines at least one aperture therethrough. Hence, the vibratory element may be operated to vibrate to cause movement of the aerosolization element in such a manner that a liquid at the first face of the aerosolization element can be dispensed as an aerosol through the at least one aperture. Some embodiments feature an electrode coupled to the vibratory element.

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