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    • 1. 发明申请
    • METHOD OF TREATING DIABETES
    • 治疗糖尿病的方法
    • WO03061551A2
    • 2003-07-31
    • PCT/IB0300597
    • 2003-01-23
    • AEGERA THERAPEUTICS INCUNIV BRITISH COLUMBIAVERCHERE BRUCETAN RUSUNGLISTON PETERKORNELUK ROBERT G
    • VERCHERE BRUCETAN RUSUNGLISTON PETERKORNELUK ROBERT G
    • A61K48/00A61P3/10A61K
    • A61K48/0075A61K48/005
    • The invention features methods for the treatment of diabetes by administering a IAP nucleic acid sequence to a subject. One methodincludes the steps of. (a) providing one or more insulin-producing cells or one or more precursor cells capable of producing progeny cells tha tproduce insulin; (b) transducing the cells with a nucleic acid sequence encoding an IAP plypeptide, the nucleic acid sequence postioned for expression of the IAP polypeptide in the cells, wherein expression of the IAP polypeptide increases survival of the cells relative to untreated control cells; and (c)transplanting the cells from step (b) that have been transduced with anucleic acid sequence encoding an IAP polypeptide into the individual, wherein the cells produce insulin in amounts sufficient to treat diabetes in the individual.
    • 本发明的特征在于通过向受试者施用IAP核酸序列来治疗糖尿病的方法。 一种方法包括以下步骤。 (a)提供一种或多种产生胰岛素的细胞或能够产生产生胰岛素的子代细胞的一种或多种前体细胞; (b)用编码IAP多肽的核酸序列转导细胞,所述核酸序列用于在细胞中表达IAP多肽,其中IAP多肽的表达增加了细胞相对于未处理的对照细胞的存活; 和(c)将已经用编码IAP多肽的核酸序列转导的来自步骤(b)的细胞移植到个体中,其中所述细胞以足以治疗个体中的糖尿病的量产生胰岛素。