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1. 发明专利

CA2434569A1 ROBOTIC AUTOSAMPLER FOR AUTOMATED ELECTROSPRAY FROM A MICROFLUIDIC CHIP 未知
公开(公告)号：CA2434569A1
公开(公告)日：2002-08-01
申请号：CA2434569
申请日：2002-01-28
申请人： ADVION BIOSCIENCES INC
发明人： PROSSER SIMON J , RULE GEOFFREY S , SCHULTZ GARY A , CORSO THOMAS N
IPC分类号： G01N27/62 , G01N1/00 , G01N35/00 , G01N35/04 , G01N35/10 , H01J49/04 , B01D59/44 , H01J49/00
摘要： A robotic autosampler (1) provides for automated manipulation of microfluidi c chips having multiple electrospray devices and/or sample inlets (113) for interface to a mass spectrometer (111) or other detection device. The autosampler also provides for connection of control voltages to the electrospray device to facilitate enablement, control and steering of charge d droplets and ions. The autosampler further provides a method of fluid delive ry that may be disposable or reusable. The delivery device may contain material s for component separation or sample purification. The delivery device may contain preloaded sample or the sample may be loaded by the autosampler. A method for automated manipulation of multiple electrosprays (115) in communication with a detector, includes: providing a robot autosampler havin g an electrospray chip (80); electrospraying at least one analyte from at leas t one electrospray device on the electrospray chip; and manipulating the electrospray chip in communication with a detector in a manner to detect analyte from the electrospray.

2. 发明专利

AU2002240143A1 Robotic autosampler for automated electrospray from a microfluidic chip 未知
公开(公告)号：AU2002240143A1
公开(公告)日：2002-08-06
申请号：AU2002240143
申请日：2002-01-28
申请人： ADVION BIOSCIENCES INC
发明人： SCHULTZ GARY A , CORSO THOMAS N , PROSSER SIMON J , RULE GEOFFREY S
IPC分类号： G01N27/62 , G01N1/00 , G01N35/00 , G01N35/04 , G01N35/10 , H01J49/04 , B01D59/44 , H01J49/00
摘要： A robotic autosampler provides for automated manipulation of microfluidic chips having multiple electrospray devices and/or sample inlets for interface to a mass spectrometer or other detection device. The autosampler also provides for connection of control voltages to the electrospray device to facilitate enablement, control and steering of charged droplets and ions. The autosampler further provides a method of fluid delivery that may be disposable or reusable. The delivery device may contain materials for component separation or sample purification. The delivery device may contain preloaded sample or the sample may be loaded by the autosampler. A method for automated manipulation of multiple electrosprays in communication with a detector, includes: providing a robot autosampler having an electrospray chip; electrospraying at least one analyte from at least one electrospray device on the electrospray chip; and manipulating the electrospray chip in communication with a detector in a manner to detect analyte from the electrospray.

3. 发明申请

WO02059563A3 ROBOTIC AUTOSAMPLER FOR AUTOMATED ELECTROSPRAY FROM A MICROFLUIDIC CHIP 审中-公开
标题翻译：用于微流控芯片的自动电动机的机动自动控制器
公开(公告)号：WO02059563A3
公开(公告)日：2002-09-26
申请号：PCT/US0202467
申请日：2002-01-28
申请人： ADVION BIOSCIENCES INC
发明人： PROSSER SIMON J , RULE GEOFFREY S , SCHULTZ GARY A , CORSO THOMAS N
IPC分类号： G01N27/62 , G01N1/00 , G01N35/00 , G01N35/04 , G01N35/10 , H01J49/04 , B01D59/44 , H01J49/00
CPC分类号： G01N35/10 , G01N35/0099 , G01N35/04 , G01N2035/00158 , G01N2035/0491 , G01N2035/1034 , H01J49/0413 , H01J49/165
摘要： A robotic autosampler (1) provides for automated manipulation of microfluidic chips having multiple electrospray devices and/or sample inlets (113) for interface to a mass spectrometer (111) or other detection device. The autosampler also provides for connection of control voltages to the electrospray device to facilitate enablement, control and steering of charged droplets and ions. The autosampler further provides a method of fluid delivery that may be disposable or reusable. The delivery device may contain materials for component separation or sample purification. The delivery device may contain preloaded sample or the sample may be loaded by the autosampler. A method for automated manipulation of multiple electrosprays (115) in communication with a detector, includes: providing a robot autosampler having an electrospray chip (80); electrospraying at least one analyte from at least one electrospray device on the electrospray chip; and manipulating the electrospray chip in communication with a detector in a manner to detect analyte from the electrospray.
摘要翻译：机器人自动进样器（1）提供具有多个电喷雾装置和/或样品入口（113）的微流体芯片的自动操作，用于与质谱仪（111）或其它检测装置的接口。自动进样器还提供了将控制电压连接到电喷雾装置，以便于带电液滴和离子的启用，控制和转向。自动进样器还提供可以是一次性的或可重复使用的流体输送方法。输送装置可以含有用于组分分离或样品纯化的材料。输送装置可以包含预加载的样品，或者样品可以由自动进样器装载。一种用于与检测器通信的多个电喷雾（115）的自动操作的方法，包括：提供具有电喷雾芯片（80）的机器人自动进样器; 从电喷雾芯片上的至少一个电喷雾装置电喷雾至少一种分析物; 以及以检测来自电喷雾的分析物的方式操纵与检测器通信的电喷雾芯片。

4. 发明公开

EP1383592A4 ROBOTIC AUTOSAMPLER FOR AUTOMATED ELECTROSPRAY FROM A MICROFLUIDIC CHIP 审中-公开
标题翻译：用于自动电的机器人自动取样装置喷射从一个微电子芯片的油液
公开(公告)号：EP1383592A4
公开(公告)日：2007-02-21
申请号：EP02706034
申请日：2002-01-28
申请人： ADVION BIOSCIENCES INC
发明人： PROSSER SIMON J , RULE GEOFFREY S , SCHULTZ GARY A , CORSO THOMAS N
IPC分类号： G01N27/62 , G01N1/00 , G01N35/00 , G01N35/04 , G01N35/10 , H01J49/04 , B01D59/44 , H01J49/00
CPC分类号： G01N35/10 , G01N35/0099 , G01N35/04 , G01N2035/00158 , G01N2035/0491 , G01N2035/1034 , H01J49/0413 , H01J49/165
摘要： A robotic autosampler (1) provides for automated manipulation of microfluidic chips having multiple electrospray devices and/or sample inlets (113) for interface to a mass spectrometer (111) or other detection device. The autosampler also provides for connection of control voltages to the electrospray device to facilitate enablement, control and steering of charged droplets and ions. The autosampler further provides a method of fluid delivery that may be disposable or reusable. The delivery device may contain materials for component separation or sample purification. The delivery device may contain preloaded sample or the sample may be loaded by the autosampler. A method for automated manipulation of multiple electrosprays (115) in communication with a detector, includes: providing a robot autosampler having an electrospray chip (80); electrospraying at least one analyte from at least one electrospray device on the electrospray chip; and manipulating the electrospray chip in communication with a detector in a manner to detect analyte from the electrospray.

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