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1. 发明申请

WO2012074784A3 NOVEL FLUORINATED SULFAMIDES EXHIBITING NEUROPROTECTIVE ACTION AND THEIR METHOD OF USE 审中-公开
标题翻译：展示神经保护作用的新型氟化磺胺及其使用方法
公开(公告)号：WO2012074784A3
公开(公告)日：2014-04-03
申请号：PCT/US2011061341
申请日：2011-11-18
申请人： ADVANCED NEURAL DYNAMICS INC , FOX CHASE CHEMICAL DIVERSITY CT INC , SMITH GARRY ROBERT , BRENNEMAN DOUGLAS E , REITZ ALLEN B , ZHANG YAN , DU YANMING
发明人： SMITH GARRY ROBERT , BRENNEMAN DOUGLAS E , REITZ ALLEN B , ZHANG YAN , DU YANMING
IPC分类号： A61K31/16
CPC分类号： C07C307/06 , C07D261/20 , C07D263/56 , C07D333/58
摘要： Pharmaceutical compositions of the invention include fluorinated sulfamide derivatives having a disease-modifying action in the treatment of diseases associated with excitotoxicity and accompanying oxidative stress that include epilepsy, Alzheimer's disease, Parkinson's disease, Huntington's disease, heavy metal toxicity and any neurodegenerative disease involving glutamate toxicity.
摘要翻译：本发明的药物组合物包括在治疗与兴奋性毒性相关的疾病和伴随的氧化应激中具有疾病改变作用的氟化磺酰胺衍生物，其包括癫痫，阿尔茨海默病，帕金森病，亨廷顿病，重金属毒性和任何涉及谷氨酸毒性的神经变性疾病。

2. 发明专利

IL291891A Prodrugs of myeloperoxidase inhibitors 未知
公开(公告)号：IL291891A
公开(公告)日：2022-06-01
申请号：IL29189122
申请日：2022-04-03
申请人： BIOHAVEN THERAPEUTICS LTD , DUBOWCHIK GENE M , LUNDQUIST JOSEPH THEODORE IV , MCWHERTER MELODY A , PELLETIER JEFFREY C , REITZ ALLEN B , STROBEL ERIC , ZHANG YAN
发明人： DUBOWCHIK GENE M , LUNDQUIST JOSEPH THEODORE IV , MCWHERTER MELODY A , PELLETIER JEFFREY C , REITZ ALLEN B , STROBEL ERIC , ZHANG YAN
摘要： Disclosed are prodrugs of myeloperoxidase (MPO) inhibitors, methods of treating MPO related disorders, e.g., multiple system atrophy, amyotrophic lateral sclerosis, and Huntingtons disease, and methods of neuroprotection, which include administering to a patient in need thereof the prodrugs, pharmaceutical compositions including the prodrugs, and kits including the pharmaceutical compositions and instructions for use.

3. 发明专利

IL291891D0 Prodrugs of myeloperoxidase inhibitors 未知
公开(公告)号：IL291891D0
公开(公告)日：2022-06-01
申请号：IL29189122
申请日：2022-04-03
申请人： BIOHAVEN THERAPEUTICS LTD , DUBOWCHIK GENE M , LUNDQUIST JOSEPH THEODORE IV , MCWHERTER MELODY A , PELLETIER JEFFREY C , REITZ ALLEN B , STROBEL ERIC , ZHANG YAN
发明人： DUBOWCHIK GENE M , LUNDQUIST JOSEPH THEODORE IV , MCWHERTER MELODY A , PELLETIER JEFFREY C , REITZ ALLEN B , STROBEL ERIC , ZHANG YAN
IPC分类号： A61P25/28
摘要： Disclosed are prodrugs of myeloperoxidase (MPO) inhibitors, methods of treating MPO related disorders, e.g., multiple system atrophy, amyotrophic lateral sclerosis, and Huntingtons disease, and methods of neuroprotection, which include administering to a patient in need thereof the prodrugs, pharmaceutical compositions including the prodrugs, and kits including the pharmaceutical compositions and instructions for use.

4. 发明公开

EP1546121A4 SUBSTITUTED TRIAZINE KINASE INHIBITORS 有权
标题翻译：取代三嗪激酶抑制剂
公开(公告)号：EP1546121A4
公开(公告)日：2007-08-15
申请号：EP03765676
申请日：2003-07-18
申请人： JANSSEN PHARMACEUTICA NV , KUO GEE HONG , DEANGELIS ALAN , WANG AIHUA , ZHANG YAN , EMANUEL STUART L
发明人： KUO GEE-HONG , DEANGELIS ALAN , WANG AIHUA , ZHANG YAN , EMANUEL STUART L , MIDDLETON STEVE A
IPC分类号： A61K31/53 , A61P19/02 , A61P35/00 , A61P35/02 , C07D401/04 , C07D403/04 , C07D405/14 , C07D251/22 , C07D401/14 , C07D403/12 , C07D405/04
CPC分类号： C07D401/04 , A61K31/53 , C07D403/04 , C07D405/14

5. 发明专利

CA2999292A1 SAND SENSOR SYSTEM 未知
公开(公告)号：CA2999292A1
公开(公告)日：2019-09-26
申请号：CA2999292
申请日：2018-03-26
申请人： ZHANG YAN
发明人： ZHANG YAN
IPC分类号： G01V9/00 , E21B47/11

6. 发明专利

AU2015267228A1 Improvements in using blood culture platforms for commercial sterility tests 未知
公开(公告)号：AU2015267228A1
公开(公告)日：2017-01-12
申请号：AU2015267228
申请日：2015-05-26
申请人： BECTON DICKINSON HOLDINGS PTE LTD , ZHANG YAN , LIU JIANWEI , LI XIAO
发明人： LI XIAO , ZHANG YAN , LIU JIANWEI
IPC分类号： G01N33/02 , G01N33/00 , G01N33/04
摘要： A system that indicates the presence or absence of microorganisms in fluid food products. The system has a bottle for receiving sample to be tested. The bottle has a sensor that will monitor and detect changes in at least one sample parameter, but no additives that contain nutrients that support microbial growth. The bottle is placed in an incubator and the sensor in the bottle is monitored for changes. The incubator is programed so that, if the sensor detects that the value of the monitored parameter has reached a certain value, then the sample is determined to be positive for microbial growth.

7. 发明专利

AU2003259153A1 SUBSTITUTED TRIAZINE KINASE INHIBITORS 未知
公开(公告)号：AU2003259153A1
公开(公告)日：2004-02-09
申请号：AU2003259153
申请日：2003-07-18
申请人： JANSSEN PHARMACEUTICA NV , KUO GEE HONG , DEANGELIS ALAN , WANG AIHUA , ZHANG YAN , EMANUEL STUART L , MIDDLETON STEVE A
发明人： KUO GEE-HONG , DEANGELIS ALAN , WANG AIHUA , ZHANG YAN , EMANUEL STUART L , MIDDLETON STEVE A
IPC分类号： A61K31/53 , A61P19/02 , A61P35/00 , A61P35/02 , C07D401/04 , C07D403/04 , C07D405/14 , C07D251/22 , C07D401/14 , C07D403/12 , C07D405/04
摘要： The present invention provides substituted 1,3,5-triazine compounds of Formula (I): wherein X, Y and Z are independently selected from the group consisting of CH and N; wherein m is an integer from 2 to 5; wherein X, Y and Z include at least one CH atom and at least one N atom; and, wherein a N atom may simultaneously occupy only the X and Z positions; R 1 is selected from the group consisting of hydrogen and NH 2 ; and, R 2 is selected from the group consisting of phenyl (wherein phenyl is substituted with one substituent selected from the group consisting of halogen and heterocyclyl) and 1,4-benzodioxinyl; and pharmaceutically acceptable salts thereof as kinase inhibitors and a method for treating or ameliorating a kinase mediated disorder.

8. 发明专利

ZA202208842B A COMPOUND FOR PREVENTING AND TREATING MYOPIA 未知
公开(公告)号：ZA202208842B
公开(公告)日：2022-12-21
申请号：ZA202208842
申请日：2022-08-08
申请人： ZHANG YAN , WANG SHUQING
发明人： ZHANG YAN , WANG SHUQING

9. 发明专利

CA3096187A1 FILM ROLLER SYSTEM 未知
公开(公告)号：CA3096187A1
公开(公告)日：2022-04-28
申请号：CA3096187
申请日：2020-10-28
申请人： ZHANG YAN
发明人： ZHANG YAN
IPC分类号： E06B7/16 , A47H23/00
摘要： The Invention provides a rapid system to seal a window, or separate a divided and sealed space. The system includes film roller and holder assembly, rail assemblies, catch assembly, and optional corner assemblies. There are two parts of sealing provided with the system. During the initial installation, the sealing elements on the frame are squeezed against the mounting surfaces, hence forming the seal. With the frames installed, the film can be pulled out from the roller, and locked in the catch assembly. Once the film is deployed, the sealing elements on the frame are pressed by the film, hence forming the seal. Also, optional corner assemblies are provided and can be installed on the frame, which seal off possible minor leaks at the corners. The Invention provides an improved rapid system to seal windows or other openings; also serves as an improved rapid system to separate, and seal a room. The present invention relates to efficiently and effectively deploy a sealed and divided chamber. In particular, to a sealed window to control thermal efficiency, or to divide a room into two separate sections to control air-exchange. Heat loss and heat gain through windows and doors accounts for a significant part of a building's total energy need. These heat exchanges occur during the heating and cooling season as a consequence of the window's low insulating rating. Commonly used solution is the "window insulation film kit" that contains Min and double-sided tape, where the film is glued on around the window to form a seal. Common installation method also involves blowing hot air at the file to shrink the film and apply tension. Comparing the novel film roller system to the "insulation kit", a few advantages are: - The film roller system does not require glue during deployment; - The Min roller system is not a "single use" product, it can be efficiently open and closed as needed. - In the film roller system, in the event of film damage, the film roll can be efficiently swapped out, without redoing the entire installation.

10. 发明专利

ES2392426T3 Inhibidores de quinasas con triazina sustituida 未知
公开(公告)号：ES2392426T3
公开(公告)日：2012-12-10
申请号：ES03765676
申请日：2003-07-18
申请人： JANSSEN PHARMACEUTICA NV , KUO GEE HONG , DEANGELIS ALAN , WANG AIHUA , ZHANG YAN , EMANUEL STUART L
发明人： KUO GEE-HONG , DEANGELIS ALAN , WANG AIHUA , ZHANG YAN , EMANUEL STUART , MIDDLETON STEVE
IPC分类号： C07D251/22 , A61K31/53 , A61P19/02 , A61P35/00 , A61P35/02 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/14
摘要： Un compuesto de fórmula (I):en la que:X, Y y Z son independientemente CH o N;m es un número entero de 2 a 5;X, Y y Z incluyen al menos un átomo de CH y al menos un átomo de N;un átomo de N sólo puede ocupar simultáneamente las dos posiciones de X y Z;R1 es NH2; yR2 es fenilo (en el que el fenilo está sustituido con un sustituyente de halógeno o heterociclilo) o 1,4-benzodioxinilo;o una de sus sales farmacéuticamente aceptables.

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