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1. 发明申请

WO2007053374A3 HAPTIC FOR ACCOMMODATING INTRAOCULAR LENS 审中-公开
标题翻译：适合摄入镜片
公开(公告)号：WO2007053374A3
公开(公告)日：2007-10-11
申请号：PCT/US2006041500
申请日：2006-10-23
申请人： ADVANCED MEDICAL OPTICS INC , BRADY DANIEL G , WEEBER HENK A
发明人： BRADY DANIEL G , WEEBER HENK A
IPC分类号： A61F2/16
CPC分类号： A61F2/1635 , A61F2/1613 , A61F2/1624 , A61F2002/1682 , A61F2002/1683 , A61F2002/1686 , A61F2002/169
摘要： A haptic (30, 50, 59, 69, 89) is provided for use in an accommodating intraocular lens. The haptic has multiple filaments, each connected to the edge of the optic (28,48,58,68,88,98,108) at one end. Each filament has a shape that conforms to an equatorial region of the capsular bag (18). The haptic couples the forces exerted by the capsular bag of the eye (10) during accommodation radially to the edge of the optic, produce a diametric expansion or compression of the optic. This diametric motion distorts the optic, producing a change in any or all of the anterior radius, the posterior radius, and the thickness. These changes affect the power of the lens and/or location of the image. The haptic may optionally have a thin membrane (66) joining the filaments at the optic end, and may optionally have a connecting ring (62) that joins the filaments at the end opposite that of the optic.
摘要翻译：提供用于容纳人工晶状体的触觉（30,50,59,69,89）。触觉具有多个细丝，每个细丝在一端连接到光学元件的边缘（28,48,58,68,88,98,108）。每个细丝具有符合囊袋（18）的赤道区域的形状。触觉件将由眼睛（10）的囊袋施加的力在径向地放置到光学器件的边缘处，产生光学器件的直径膨胀或压缩。该直径运动扭曲光学元件，产生前半径，后半径和厚度中的任何或全部的变化。这些变化影响镜头的功率和/或图像的位置。触觉件可以可选地具有在光学端处连接细丝的薄膜（66），并且可以可选地具有连接环（62），所述连接环在与光学元件相对的端部连接长丝。

2. 发明申请

WO2008082853A3 PRE-STRESSED HAPTIC FOR ACCOMMODATING INTRAOCULAR LENS 审中-公开
标题翻译：预先配合眼科镜片
公开(公告)号：WO2008082853A3
公开(公告)日：2008-10-30
申请号：PCT/US2007086832
申请日：2007-12-07
申请人： ADVANCED MEDICAL OPTICS INC , BRADY DANIEL G , WOODS RANDALL L , BUMBALOUGH TIMOTHY R , GERAGHTY EDWARD P
发明人： BRADY DANIEL G , WOODS RANDALL L , BUMBALOUGH TIMOTHY R , GERAGHTY EDWARD P
IPC分类号： A61F2/16
CPC分类号： A61F2/1635 , A61F2002/1682
摘要： An intraocular lens is disclosed, with an optic (21,28,43,63,82,111,130,200,230) that changes shape in response to a deforming force exerted by the zonules of the eye. A haptic (23,30,42,62,81,112,120,190,220) supports the optic around its equator and couples the optic to the capsular bag of the eye. The haptic may be pre-stressed before the optic is placed within it. After such placement, the pre-stress may be relieved, and the haptic may produce stress in the optic. The pre-stress may produce a radial tension or a radial compression in the optic. Alternatively, once the optic is placed within the haptic, both may undergo a process that changes the size and/or shape of one with respect to the other, causing a stress within the optic. This process may produce a radial tension or a radial compression in the optic. The haptic may include an annular ring having outer and inner diameters that may depend on the stiffness of the haptic.
摘要翻译：公开了一种眼内透镜，其具有响应于由眼睛的小区施加的变形力而改变形状的光学元件（21,28,43,63,82,111,130,200,230）。触觉（23,30,42,62,81,112,120,190,220）支撑其赤道周围的光学元件，并将光学元件耦合到眼睛的囊袋。在光学元件放置在其中之前，触觉可以被预应力。在这种放置之后，预应力可以减轻，并且触觉可能在视神经中产生应力。预应力可能在光学元件中产生径向张力或径向压缩。或者，一旦将光学元件放置在触觉件内，则两者都可以经历一种相对于另一个改变尺寸和/或形状的过程，从而导致光学元件内的应力。该过程可能在光学元件中产生径向张力或径向压缩。触觉件可以包括具有取决于触觉件的刚度的外部和内部直径的环形环。

3. 发明申请

WO2005082287A3 FOLDABLE UNITARY INTRAOCULAR LENS 审中-公开
标题翻译：可折叠的单位镜片
公开(公告)号：WO2005082287A3
公开(公告)日：2006-06-08
申请号：PCT/US2005005352
申请日：2005-02-22
申请人： ADVANCED MEDICAL OPTICS INC , BRADY DANIEL G
发明人： BRADY DANIEL G
IPC分类号： A61F2/00 , A61F2/16
CPC分类号： A61F2/16 , A61F2/1616 , A61F2/1618 , A61F2002/009 , A61F2002/1681 , A61F2002/16905 , A61F2002/1699 , A61F2250/0036 , A61F2250/0073
摘要： An intraocular lens (10) has an optic (12) made of a foldable material and at least two haptics (14) integrally formed with the optic. The optic comprises an optical element (18) with optical power, a transition region (20) disposed around the entire perimeter of the optical element, and a support (22) disposed about at least a portion of the transition region, the thickness of the support (ts) being greater than the thickness of the transition region (te). The transition region advantageously has a thickness of between at least about 0.07 mm and about 0.40 mm.
摘要翻译：眼内透镜（10）具有由可折叠材料制成的光学元件（12）和与光学元件整体形成的至少两个襻（14）。光学元件包括具有光学功率的光学元件（18），围绕光学元件的整个周边设置的过渡区域（20）和围绕过渡区域的至少一部分设置的支撑件（22）支撑（ts）大于过渡区域（te）的厚度。过渡区有利地具有至少约0.07mm至约0.40mm之间的厚度。

4. 发明申请

WO2008083283A3 MULTIFOCAL ACCOMMODATING INTRAOCULAR LENS 审中-公开
标题翻译：多功能摄影镜片
公开(公告)号：WO2008083283A3
公开(公告)日：2011-10-13
申请号：PCT/US2007089060
申请日：2007-12-28
申请人： ADVANCED MEDICAL OPTICS INC , GERAGHTY EDWARD , BRADY DANIEL G , BUMBALOUGH TIMOTHY R , CALI DOUGLAS S
发明人： GERAGHTY EDWARD , BRADY DANIEL G , BUMBALOUGH TIMOTHY R , CALI DOUGLAS S
IPC分类号： A61F2/16
CPC分类号： A61F2/1613 , A61F2/1618 , A61F2/1624 , A61F2/1635 , A61F2/164 , A61F2/1645 , A61F2/1654 , A61F2002/1681 , A61F2250/0014
摘要： An intraocular lens for providing accommodative visions to a subject includes an adjustable optic and a haptic that is operably coupled to the optic. The adjustable optic comprises an optical axis, a central zone disposed about the optical axis, and an annular zone surrounding the central zone. The optic may also comprise additional annular zones disposed about the central zone and the first annular zone. The haptic comprises a transparent portion protruding into the adjustable optic. The intraocular lens has a disaccommodative configuration in which the central zone has a base optical power and an accommodative configuration in which the central zone has an add optical power that is at least about 1 Diopter greater than the base optical power, preferably at least about 2 Diopters greater than the base optical power. In some embodiments, the add optical power is at least 3 Diopters, or even 4 Diopters, greater than the base optical power. The central zone and the annular zone have different optical powers when the adjustable intraocular lens is in the accommodative configuration and/or when the adjustable intraocular lens is in the disaccommodative configuration.
摘要翻译：用于向受试者提供调节视力的眼内透镜包括可操作地连接到光学元件的可调光学元件和触觉件。可调节光学元件包括光轴，围绕光轴设置的中心区域和围绕中心区域的环形区域。光学元件还可以包括围绕中心区域和第一环形区域设置的附加环形区域。触觉包括突出到可调节光学元件中的透明部分。眼内透镜具有不利的配置，其中中心区域具有基本光焦度和调节结构，其中中心区域具有比基本光功率大至少约1屈光度的添加光焦度，优选至少约2 屈光度大于基础光功率。在一些实施例中，添加光功率大于基本光功率的至少3屈光度，或甚至4屈光度。当可调节眼内透镜处于调节构型时和/或当可调节眼内透镜处于不利配置时，中心区域和环形区域具有不同的光焦度。

5. 发明申请

WO2005011531A3 PRIMARY AND SUPPLEMENTAL INTRAOCULAR LENS SYSTEM 审中-公开
标题翻译：主要和补充性眼内镜系统
公开(公告)号：WO2005011531A3
公开(公告)日：2005-06-16
申请号：PCT/US2004024399
申请日：2004-07-28
申请人： ADVANCED MEDICAL OPTICS INC , BRADY DANIEL G , ROCKLEY PAUL
发明人： BRADY DANIEL G , ROCKLEY PAUL
IPC分类号： A61F2/16
CPC分类号： A61F2/1654 , A61F2/1602 , A61F2/1648 , A61F2250/0036
摘要： An intraocular lens system includes a primary intraocular lens configured to correct vision in a patient, and a supplemental intraocular lens configured to modify the correction provided by the primary intraocular lens. The supplemental intraocular lens, which is substantially completely diffractive, is preferably ultrathin. The two lenses may be connected to, or separate from, one another. The supplemental intraocular lens may be implanted at the same time as the primary intraocular lens, or added later.
摘要翻译：眼内透镜系统包括被配置为校正患者视力的初级眼内透镜和被配置为修改由初级眼内透镜提供的校正的补充眼内透镜。基本上完全衍射的补充眼内透镜优选为超薄膜。两个透镜可以彼此连接或分离。补充眼内透镜可以与主要眼内透镜同时植入，或者稍后加入。

6. 发明申请

WO2008082855A3 HAPTIC FOR ACCOMMODATING INTRAOCULAR LENS 审中-公开
标题翻译：适合摄入镜片
公开(公告)号：WO2008082855A3
公开(公告)日：2009-09-11
申请号：PCT/US2007086840
申请日：2007-12-07
申请人： ADVANCED MEDICAL OPTICS INC , CALI DOUGLAS S , NGUYEN TUYET HOC , BRADY DANIEL G , WEEBEER HENDRIK A
发明人： CALI DOUGLAS S , NGUYEN TUYET HOC , BRADY DANIEL G , WEEBEER HENDRIK A
IPC分类号： A61F2/16
CPC分类号： A61F2/1635 , A61F2002/1681 , A61F2002/169 , A61F2230/0095 , A61F2250/0018
摘要： An intraocular lens is disclosed, with an optic that changes shape in response to a deforming force exerted by the zonules of the eye. A haptic (120) supports the optic around its equator and couples the optic to the capsular bag of the eye. The region of contact between the optic and the haptic extends into the edge of the optic (130), similar to the interface between a bicycle tire and the rim that holds it in place. The haptic may be stiffer than the optic. The haptic may have the same refractive index as the optic. The haptic may include a saddle-shaped portion in contact with the adjustable optic, with a convex profile along an optical axis; and a concave profile in a plane perpendicular to the optical axis.
摘要翻译：公开了一种眼内透镜，其具有响应于由眼睛的小环施加的变形力而改变形状的光学元件。触觉（120）支撑其赤道附近的光学器件，并将光学元件耦合到眼睛的囊袋。光学元件和触觉件之间的接触区域延伸到光学元件（130）的边缘，类似于自行车轮胎和将其保持在适当位置的边缘之间的界面。触觉可能比光学元件更硬。触觉可以具有与光学元件相同的折射率。触觉件可以包括与可调节光学元件接触的鞍形部分，具有沿着光轴的凸形轮廓; 以及在垂直于光轴的平面中的凹形轮廓。

7. 发明申请

WO02058596A3 APPARATUS AND METHOD FOR MULTIPLY FOLDING AND INSERTING AN INTRAOCULAR LENS IN AN EYE 审中-公开
标题翻译：用于在眼中多次折叠和插入眼内晶状体的装置和方法
公开(公告)号：WO02058596A3
公开(公告)日：2002-10-10
申请号：PCT/US0202217
申请日：2002-01-21
申请人： ADVANCED MEDICAL OPTICS INC , BRADY DANIEL G
发明人： BRADY DANIEL G
IPC分类号： A61F9/007 , A61F2/16
CPC分类号： A61F2/1664
摘要： An intraocular lens (IOL) insertion system, cartridge and/or combination cartridge and folding member that facilitates multiply folding an IOL within a load chamber of the cartridge prior to insertion in an eye. In the system embodiment, a folding member is provided in a handpiece that interacts with the cartridge to multiply fold the IOL therewithin. Alternatively, the cartridge may incorporate the folding member in its structure, or a separate folding member that interacts with the cartridge may be provided in a combination. The folding member may be a planar element that extends through a slot in the wall of the load chamber ot displace a midportion of the IOL away from the inner wall of the load chamber. Desirably, the multiply folded configuration that results is an M-shape or a W-shape, depending on orientation. The cartridge may further include structure that retains the multiply folded configuration of the IOL as it passes through an injection tube and into the eye.
摘要翻译：眼内透镜（IOL）插入系统，盒和/或组合盒和折叠构件，其有助于在插入眼中之前在盒的装载室内多次折叠IOL。在该系统实施例中，折叠构件被设置在与盒相互作用以在其中多倍折叠IOL的手持件中。可选地，盒可以将折叠构件结合在其结构中，或者可以以组合的方式提供与盒相互作用的单独的折叠构件。折叠构件可以是平面元件，其延伸穿过装载室的壁中的狭槽以使IOL的中间部分远离装载室的内壁移位。理想地，取决于取向，产生的多重折叠配置是M形或W形。药筒可进一步包括当IOL穿过注射管并进入眼睛时保持IOL的多重折叠构型的结构。

8. 发明申请

WO2008008627A2 OPHTHALMIC LENS COMBINATIONS 审中-公开
标题翻译：眼底镜组合
公开(公告)号：WO2008008627A2
公开(公告)日：2008-01-17
申请号：PCT/US2007072275
申请日：2007-06-27
申请人： ADVANCED MEDICAL OPTICS INC , GLICK ROBERT E , BRADY DANIEL G
发明人： GLICK ROBERT E , BRADY DANIEL G
IPC分类号： G02C7/02 , A61F2/16
CPC分类号： A61F2/1648 , A61F2/1602 , A61F2/1613 , A61F2/1629 , A61F2/1635 , A61F2002/009 , A61F2250/0053 , G02C7/00
摘要： An ophthalmic device is provided for a patient that has a basic prescription for distant vision, the ophthalmic device including a primary optic and a supplemental optic. The primary optic is configured for placement in the eye and has a base optical power configured to substantially provide the basic prescription. The supplemental optic has an optical power that is less than the optical power of the primary optic and is configured to provide, in combination with the primary optic, a combined optical power that provides the basic prescription of the patient. In addition, at least one surface of the primary optic is configured to deform in response to an ocular force so as to modify the combined optical power by at least 1 Diopter. The ophthalmic device may further include a movement assembly operably coupled to the primary optic that is structured to cooperate with the eye to effect accommodating deformation of the primary optic in response to an ocular force produced by the eye. The movement assembly may also be configured to provide accommodating axial movement of the primary optic.
摘要翻译：为具有远视力的基本处方的患者提供眼科装置，该眼科装置包括主光学元件和辅助光学元件。主要光学元件被配置为放置在眼睛中并且具有被配置为基本上提供基本处方的基本光功率。辅助光学器件具有小于主光学器件的光功率的光功率，并且被配置为与主光学器件组合提供提供患者的基本处方的组合光功率。此外，主光学元件的至少一个表面被配置为响应于眼睛的力而变形，以便将组合光焦度修改至少1屈光度。眼科装置还可以包括可操作地连接到主要光学元件的运动组件，其被构造成与眼睛配合以响应于眼睛产生的眼睛力量来实现主要光学元件的变形。运动组件还可以被配置为提供容纳主要光学元件的轴向运动。

9. 发明申请

WO2005055875A3 FOLDABLE INTRAOCULAR LENS AND METHOD OF MAKING 审中-公开
标题翻译：可折叠内镜透镜及其制作方法
公开(公告)号：WO2005055875A3
公开(公告)日：2005-09-09
申请号：PCT/US2004041511
申请日：2004-12-09
申请人： ADVANCED MEDICAL OPTICS INC , DEACON JIM , SHEPHERD DAVID J , BRADY DANIEL G , PAUL MARLENE L
发明人： DEACON JIM , SHEPHERD DAVID J , BRADY DANIEL G , PAUL MARLENE L
IPC分类号： A61F2/00 , A61F2/16
CPC分类号： A61F2/16015 , A61F2/1613 , A61F2002/009 , A61F2002/1681 , A61F2002/1689 , A61F2002/1696 , Y10T29/49
摘要： A foldable intraocular lens(10) for providing vision contains an optic body (11) that includes an optical zone(12) and a peripheral zone (13) entirely surrounding the optical zone. The optic body has an anterior face (14), a substantially opposing posterior face (18), an optic edge (20), and an optical axis (22). The anterior face comprises a central face (24), a peripheral face (28), and a recessed annular face (30) therebetween that is disposed posterior to the peripheral face. The intraocular lens further comprises at least one haptic (32) that is integrally formed with the peripheral zone. The haptic comprises a distal posterior face (34), a proximal prosterior face (38), and a step edge (39) disposed at a boundary therebetween. The haptic further comprises a side edge (40) disposed between the optic edge and the step edge. The proximal posterior face and the posterior face of the optic body form a continuous surface (48). An edge corner (50) is formed by the intersection of the continuous surface with the optic edge, the side edge, and the step edge.
摘要翻译：用于提供视觉的可折叠眼内透镜（10）包含光学主体（11），其包括完全围绕光学区域的光学区域（12）和周边区域（13）。光学主体具有前表面（14），基本相对的后表面（18），光学边缘（20）和光轴（22）。前表面包括中心面（24），周边面（28）和位于其之间的凹入的环形面（30）。眼内透镜还包括与周边区域整体形成的至少一个触觉（32）。触觉件包括远侧后表面（34），近侧砧座面（38）和设置在其间边界处的台阶边缘（39）。触觉装置还包括设置在光学边缘和台阶边缘之间的侧边缘（40）。光学主体的近侧后表面和后表面形成连续表面（48）。边缘角（50）由连续表面与光学边缘，侧边缘和台阶边缘的交点形成。

10. 发明申请

WO03020170A3 IRIS-SUPPORTED INTRAOCULAR LENSES 审中-公开
标题翻译： IRIS支持的内窥镜
公开(公告)号：WO03020170A3
公开(公告)日：2003-05-22
申请号：PCT/US0225634
申请日：2002-08-12
申请人： ADVANCED MEDICAL OPTICS INC , BRADY DANIEL G
发明人： BRADY DANIEL G
IPC分类号： A61F2/16
CPC分类号： A61F2/1602 , A61F2/16 , A61F2/1608 , A61F2002/1681
摘要： An iris-supported intraocular lens having an optic portion 50 and a plurality of fixation members 52a,52b coupled thereto. Each fixation member has a pair of pincer arms 58a,58b that separate outward of the optic and converge toward one another at aligned end tips 64. One or both of the end tips are covered with a soft sleeve 70a,70b or cap. The IOL is fixed in the anterior chamber of the eye by pinching the iris tissue between the end tips of each pair of pincer arms. The soft sleeves eliminate damage to the iris tissue.
摘要翻译：具有光学部分50和耦合到其上的多个固定构件52a，52b的虹膜支撑的眼内透镜。每个固定构件具有一对夹持臂58a，58b，该对夹臂58a，58b分离出光学器件的外部并且在对准的端部尖端64处朝向彼此会聚。一个或两个端部尖端被软套筒70a，70b或盖子覆盖。 IOL通过在每对钳手臂的末端之间夹紧虹膜组织固定在眼前房中。柔软的袖子消除了虹膜组织的损伤。

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