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1. 发明申请

WO2007112209A2 NOVEL HYBRID INTRAOCULAR LENS MATERIALS FOR SMALL INCISION SURGERY 审中-公开
标题翻译：用于小型手术的新型混合型眼科镜片材料
公开(公告)号：WO2007112209A2
公开(公告)日：2007-10-04
申请号：PCT/US2007/064039
申请日：2007-03-15
申请人： ADVANCED MEDICAL OPTICS, INC. , LOWERY, Michael, D. , MAKKER, Harish, C.
发明人： LOWERY, Michael, D. , MAKKER, Harish, C.
CPC分类号： A61F2/1616 , A61L27/18 , A61L2430/16 , C08F30/08 , C08F290/068 , C08G77/20 , C08L51/085 , G02B1/043 , C08L83/04 , C08L33/10 , C08L33/08 , C08L2666/02
摘要： Intraocular lenses comprised of an acrylic-silicone hybrid polymer are disclosed. The intraocular lenses described herein are suitable for insertion through incisions of 2 mm or less.
摘要翻译：公开了由丙烯酸 - 硅氧烷杂化聚合物组成的人造眼镜。本文所述的眼内透镜适合于通过2mm以下的切口插入。

2. 发明申请

WO2007030095A1 BIOCOMPATIBLE POLYMERIC COMPOSITIONS FOR USE IN MAKING ANTERIOR CHAMBER INTRAOCULAR LENSES 审中-公开
标题翻译：用于制造前房室内镜的生物成分聚合物组合物
公开(公告)号：WO2007030095A1
公开(公告)日：2007-03-15
申请号：PCT/US2005/031314
申请日：2005-09-01
申请人： ADVANCED MEDICAL OPTICS, INC. , MAKKER, Harish, C. , LOWERY, Michael, D. , HU, Can, B.
发明人： MAKKER, Harish, C. , LOWERY, Michael, D. , HU, Can, B.
IPC分类号： C08F220/10 , C08F220/22 , G02B1/04
CPC分类号： C08F220/18 , A61L27/16 , A61L2430/16 , C08L33/00
摘要： Biocompatible polymers useful for making anterior chamber intraocular lenses (AC-IOL) are provided. The biocompatible polymers are generally composed of one or more acrylate monomers, crosslinked with at least one diacrylate ester and may include one or more additional components such as ultraviolet light and/or blue-violate light absorbing dyes. The AC-IOLs made using the biocompatible polymers disclosed herein are suitable for placement in phakic or aphakic eyes and are intended for refractive correction including myopia, hyperopia, presbyopia and astigmatisms.
摘要翻译：提供了可用于制备前房人工晶状体（AC-IOL）的生物相容性聚合物。生物相容性聚合物通常由一种或多种丙烯酸酯单体组成，与至少一种二丙烯酸酯交联，并且可以包括一种或多种另外的组分，例如紫外线和/或蓝色的光吸收染料。使用本文公开的生物相容性聚合物制备的AC-IOL适合于放置在晶状体或无晶状体眼中，并且用于屈光矫正，包括近视，远视，老花眼和散光。

3. 发明申请

WO2005066662A1 INTRAOCULAR LENS MATERIALS SUITABLE FOR INSERTION THROUGH A SMALL BORE CARTRIDGE 审中-公开
标题翻译：内镜镜片材料适用于通过一个小孔卡盒进行插入
公开(公告)号：WO2005066662A1
公开(公告)日：2005-07-21
申请号：PCT/US2004/043846
申请日：2004-12-29
申请人： ADVANCED MEDICAL OPTICS, INC. , MAKKER, Harish, C. , LOWERY, Michael, D. , HU, Can, B.
发明人： MAKKER, Harish, C. , LOWERY, Michael, D. , HU, Can, B.
IPC分类号： G02B1/04
CPC分类号： G02B1/043 , C08L33/12 , C08L33/10
摘要： A polymer material useful for manufacturing an intraocular lens (IOL) suitable for insertion through an IOL inserter barrel having an inner diameter of less than 3 mm is provided. Specifically, acrylic-silicone hybrids having a tensile strength of approximately 100 psi to 400 psi and a percent elongation at break of between 50% and 400% are disclosed.
摘要翻译：提供了一种用于制造适于通过内径小于3mm的IOL插入筒插入的眼内透镜（IOL）的聚合物材料。具体地，公开了具有约100psi至400psi的拉伸强度和50％至400％的断裂伸长率的丙烯酸 - 硅氧烷杂化物。

4. 发明申请

WO2006110696A1 MEDICAL DEVICES HAVING SOFT, FLEXIBLE LUBRICIOUS COATINGS 审中-公开
标题翻译：具有柔软，柔性润滑剂涂层的医疗器械
公开(公告)号：WO2006110696A1
公开(公告)日：2006-10-19
申请号：PCT/US2006/013392
申请日：2006-04-10
申请人： ADVANCED MEDICAL OPTICS, INC. , HU, Can, B. , LOWERY, Michael, D. , MAKKER, Harish, C.
发明人： HU, Can, B. , LOWERY, Michael, D. , MAKKER, Harish, C.
IPC分类号： A61L27/34 , A61L29/08 , A61L31/10 , C09D175/04 , C08L39/06
CPC分类号： A61F2/1675 , A61L27/34 , C08G18/0823 , C08G18/833 , C08L39/06 , C09D175/04 , Y10T428/31536 , Y10T428/31551 , Y10T428/31663 , C08L5/08 , C08L2666/04
摘要： Soft, flexible highly lubricious coatings for polymeric IOL insertion cartridges that allow IOLs to be easily inserted through small bore cartridges suitable for use with small (less than 3mm) incisions are provided. These lubricious coatings allow IOLs to be inserted into the eye of a patient without the risk of lens damage or transfer of lubricants to the lens surface during implantation. Specifically, polymeric coatings comprising a matrix polymer having an equivalent weight greater than 5000 g/eq are used to form interpenetrating networks (IPN) on the surface of hydrophobic structural polymers. The IPNs thus formed entrap highly lubricious hydrophilic compounds within the IPN using multi-functional cross linkers.
摘要翻译：提供用于聚合物IOL插入盒的柔软，柔性高光泽的涂层，其允许IOL容易地插入适于与小（小于3mm）切口一起使用的小孔筒。这些光滑涂层允许IOL插入患者的眼睛，而不会在植入期间发生晶状体损伤或将润滑剂转移到镜片表面。具体地说，使用包含当量大于5000g / eq的基质聚合物的聚合物涂层在疏水结构聚合物的表面上形成互穿网络（IPN）。因此，IPNs使用多功能交联剂在IPN内捕获高度润滑的亲水性化合物。

5. 发明申请

WO2006060179A1 BIOCOMPATIBLE POLYMERIC COMPOSITIONS FOR USE IN MAKING POSTERIOR CHAMBER INTRAOCULAR LENSES 审中-公开
标题翻译：生物成分聚合物组合物，用于制造后置室内镜片
公开(公告)号：WO2006060179A1
公开(公告)日：2006-06-08
申请号：PCT/US2005/041776
申请日：2005-11-17
申请人： ADVANCED MEDICAL OPTICS, INC. , MAKKER, Harish, C. , GHAZIZADEH, Massoud , LOWERY, Michael, D.
发明人： MAKKER, Harish, C. , GHAZIZADEH, Massoud , LOWERY, Michael, D.
IPC分类号： A61F2/16
CPC分类号： A61L27/14 , A61F2/16 , A61L27/16 , A61L27/26 , A61L2430/16 , C08F220/18 , C08F220/28 , C08F222/1006 , C08L2312/00 , C08L33/08 , C08L33/10
摘要： Biocompatible polymers useful for making intraocular lenses are provided. The biocompatible polymers are generally composed of one or more acrylate monomers, crosslinked with at least one diacrylate ester and may include one or more additional components such as ultraviolet light and/or blue-violet light absorbing dyes. The posterior chamber IOLs made using the biocompatible polymers disclosed herein are suitable for placement in phakic or aphakic eyes and are intended for refractive correction including myopia, hyperopia, presbyopia, astigmatisms and for implantation after removal of the natural crystalline lens as warranted by medical conditions such as cataracts.
摘要翻译：提供了可用于制造眼内透镜的生物相容性聚合物。生物相容性聚合物通常由一种或多种丙烯酸酯单体组成，与至少一种二丙烯酸酯交联，并且可以包括一种或多种另外的组分，例如紫外光和/或蓝紫色光吸收染料。使用本文公开的生物相容性聚合物制备的后室IOL适合于放置在晶状体或无晶状体眼睛中，并且用于屈光矫正，包括近视，远视，老花眼，散光，以及在除去天然晶状体后，由医疗条件作为白内障。

6. 发明申请

WO2005062965A2 LUBRICIOUS, BIOCOMPATIBLE COATINGS FOR MEDICAL DEVICES 审中-公开
标题翻译：润滑剂，用于医疗器械的生物涂料
公开(公告)号：WO2005062965A2
公开(公告)日：2005-07-14
申请号：PCT/US2004/043497
申请日：2004-12-22
申请人： ADVANCED MEDICAL OPTICS, INC. , LOWERY, Michael, D. , MAKKER, Harish, C. , HU, Can, B.
发明人： LOWERY, Michael, D. , MAKKER, Harish, C. , HU, Can, B.
IPC分类号： A61F2/16 , A61F9/00 , A61L27/34 , A61L27/44 , A61L29/12 , A61L31/10 , A61L31/12 , B05D3/00
CPC分类号： A61L27/34 , A61F2/1662 , A61L31/10 , A61L2400/10 , C08L39/06
摘要： A lubricous coating composition and methods for using same are provided. Specifically, a composition suitable for providing hydrophobic polymer surfaces with lubricious coatings is described wherein a polyolefin surface is reiteratively treated with hydrophilic polymer solutions and cross-linking solutions. Methods for reiterative coating polymer surfaces are also provided including methods wherein the hydrophobic polymer surface is pretreated using plasma energy.
摘要翻译：提供了一种润滑涂料组合物及其使用方法。具体地，描述了适用于提供具有光滑涂层的疏水聚合物表面的组合物，其中聚合物表面用亲水性聚合物溶液和交联溶液反复处理。还提供了重复涂布聚合物表面的方法，包括其中使用等离子体能预处理疏水性聚合物表面的方法。

7. 发明申请

WO2007100979A2 LENS SURFACE ENHANCEMENT 审中-公开
标题翻译：镜头表面增强
公开(公告)号：WO2007100979A2
公开(公告)日：2007-09-07
申请号：PCT/US2007/062111
申请日：2007-02-14
申请人： ADVANCED MEDICAL OPTICS, INC. , LOWERY, Michael, D. , HOFFMANN, Laurent
发明人： LOWERY, Michael, D. , HOFFMANN, Laurent
CPC分类号： A61L27/50 , A61F2/16 , A61L27/34 , A61L2430/16 , C08L71/02
摘要： An intraocular lens with a hydrophilic polymer coating composition and methods for using same are provided. Specifically, a composition suitable for reducing tackiness in intraocular lens is provided wherein an acrylic intraocular lens is treated by vapor deposition with an alkoxy silyl terminated polyethylene glycol polymer composition. Methods for making an intraocular lens with a hydrophilic polymer coating are also provided.
摘要翻译：提供具有亲水性聚合物涂层组合物的人工晶状体及其使用方法。具体地说，提供一种适用于降低人工晶状体粘合性的组合物，其中丙烯酸类眼内透镜通过气相沉积用烷氧基甲硅烷基封端的聚乙二醇聚合物组合物进行处理。还提供了制备具有亲水性聚合物涂层的眼内透镜的方法。

8. 发明申请

WO2009045902A2 POLYMER COMPOSITIONS SUITABLE FOR INTRAOCULAR LENSES AND RELATED METHODS 审中-公开
标题翻译：适用于内镜的聚合物组合物及相关方法
公开(公告)号：WO2009045902A2
公开(公告)日：2009-04-09
申请号：PCT/US2008/077878
申请日：2008-09-26
申请人： ADVANCED MEDICAL OPTICS, INC. , HU, Can, B. , LOWERY, Michael, D.
发明人： HU, Can, B. , LOWERY, Michael, D.
IPC分类号： A61F2/16 , A61L27/18 , C08F230/08 , C08G77/38
CPC分类号： A61F2/16 , A61F2/15 , A61F2/1613 , A61F2002/1681 , A61F2002/1682 , A61F2250/0018 , A61L27/18 , A61L2430/16 , C08F230/08 , C08G77/20 , C08G77/70 , C08L83/04 , Y10T156/10
摘要： A polymeric material with a molecular response time that makes it suitable for use near fragile body tissues. The polymeric material is useful for both low modulus and high modulus applications thereby simplifying the multi-part polymeric article manufacturing process and creating better integrated multi-part polymeric articles. Cross-linked polymers with different moduli may be obtained utilizing the same or similar starting materials but modifying the amount of catalyst, the amount of cross-linking agent, and/or the amount of methyl vinyl cyclics.
摘要翻译：具有分子响应时间的聚合材料，使其适合在脆弱的身体组织附近使用。聚合物材料可用于低模量和高模量应用，从而简化了多部件聚合物制品的制造过程，并且形成了更好的集成的多部分聚合物制品。具有不同模量的交联聚合物可以利用相同或相似的起始材料获得，但改变催化剂的量，交联剂的量和/或甲基乙烯基环状的量。

9. 发明申请

WO2005066694A2 INTRAOCULAR LENSES HAVING A VISIBLE LIGHT-SELECTIVE-TRANSMISSIVE-REGION 审中-公开
标题翻译：具有可见光选择性传递区域的内窥镜
公开(公告)号：WO2005066694A2
公开(公告)日：2005-07-21
申请号：PCT/US2004/043627
申请日：2004-12-29
申请人： ADVANCED MEDICAL OPTICS, INC. , PAUL, Marlene, L. , LOWERY, Michael, D. , LAGUETTE, Stephen, W. , BANDHAUER, Mark, H.
发明人： PAUL, Marlene, L. , LOWERY, Michael, D. , LAGUETTE, Stephen, W. , BANDHAUER, Mark, H.
IPC分类号： G02C
CPC分类号： A61F2/1613 , A61F2/1659 , A61F2002/1696 , A61F2240/001
摘要： Intraocular lenses are provided having a visible-light selective transmissive zone defined therein. The visible light-selective transmissive zone can be located near the lens center and designed to reduce the transmission of any wave-length of visible light specifically light in the blue light region having wavelength between approximately 400 λ to 550 λ. In one embodiment he IOLs are made from acrylates and the light absorbing compound is a yellow dye.
摘要翻译：提供了具有限定在其中的可见光选择性透射区域的人造眼镜。可见光选择透射区域可以位于透镜中心附近，并被设计成在具有约400λ至550λ之间的波长的蓝色光区域中减少任何波长的可见光的透射率。在一个实施方案中，IOL由丙烯酸酯制成，并且光吸收化合物是黄色染料。

10. 发明申请

WO2007005692A1 INTRAOCULAR LENS INSERTION PLUNGER WITH LOW STIMULS SOFT TIP 审中-公开
标题翻译：内窥镜镜片插入式低频刺激软灯
公开(公告)号：WO2007005692A1
公开(公告)日：2007-01-11
申请号：PCT/US2006/025745
申请日：2006-06-29
申请人： ADVANCED MEDICAL OPTICS, INC. , MAKKER, Harish , HU, Can, B. , LOWERY, Michael, D.
发明人： MAKKER, Harish , HU, Can, B. , LOWERY, Michael, D.
IPC分类号： A61F2/16
CPC分类号： A61F2/1678 , A61F2/167
摘要： An intraocular lens (IOL) insertion apparatus for implanting IOLs through smaller incisions. The insertion apparatus includes an insertion cartridge that receives the IOL and cooperates with a handpiece. The cartridge includes a longitudinal lumen from al loading chamber to an open distal mouth that gradually narrows in dimension. A push rod having an extremely soft tip thereon urges the IOL through the cartridge and from the open distal mouth. The soft tip (130) is made of low-stimulus material having a minimum ultimate elongation of 400%. Because of the extremely soft material of the tip, the outside diameter of the open distal mouth can be reduced to no more than 2.00 mm, enabling passage through incisions of 2.2 mm or less. The soft tip may be a thermoplastic elastomer having a relatively high elongation and relatively low modulus at elongations of 100-300%.
摘要翻译：一种用于通过较小切口植入IOL的人工晶状体（IOL）插入装置。插入装置包括容纳IOL并与手持件配合的插入盒。药筒包括从装载室到开口的远端口的纵向腔，其逐渐变窄。具有非常软的尖端的推杆通过盒和从开放的远端口引导IOL。软尖端（130）由具有最小极限伸长率为400％的低刺激材料制成。由于尖端的材料非常柔软，所以开放的远端口的外径可以减小到不超过2.00mm，能够穿过2.2mm以下的切口。软尖端可以是在100-300％的伸长率下具有相对高的伸长率和相对低的模量的热塑性弹性体。

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