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1. 发明申请

WO2007100464A3 BONE MARROW ASPIRATION DEVICE 审中-公开
标题翻译：骨髓吸引装置
公开(公告)号：WO2007100464A3
公开(公告)日：2008-02-21
申请号：PCT/US2007003465
申请日：2007-02-09
申请人： ADVANCED CARDIOVASCULAR SYSTEM , COX DANIEL L , MICHAL EUGENE T , AINSWORTH ROBERT D , CHAN GREGORY W , LEE JEONG S , CHIN ALBERT K , WILLIS GEOFF , YIP PHILIP S
发明人： COX DANIEL L , MICHAL EUGENE T , AINSWORTH ROBERT D , CHAN GREGORY W , LEE JEONG S , CHIN ALBERT K , WILLIS GEOFF , YIP PHILIP S
IPC分类号： A61B10/02
CPC分类号： A61B10/025 , A61B10/0283 , A61B34/20 , A61B2010/0208 , A61B2010/0258
摘要： A bone marrow aspiration device is described. In one embodiment, the bone marrow aspiration device includes a central body portion having a proximal end and a distal end, and an outer shaft portion coupled to the distal end of the central body portion. The outer shaft portion also has a distal opening. A first lumen is formed by the central body portion and the outer shaft portion, and the first lumen extends from the proximal end to the distal opening. An aspiration needle is disposed within the first lumen. The aspiration needle has a substantially linear configuration when positioned within the first lumen, and a substantially curved configuration when extended from die distal opening. The aspiration needle is adapted to aspirate liquid bone marrow from a first region of a bone cavity.
摘要翻译：描述骨髓抽吸装置。在一个实施例中，骨髓抽吸装置包括具有近端和远端的中心主体部分，以及联接到中心主体部分的远端的外轴部分。外轴部分还具有远端开口。第一管腔由中心主体部分和外轴部分形成，并且第一内腔从近端延伸到远端开口。抽吸针设置在第一管腔内。当定位在第一内腔内时，抽吸针具有基本上线性的构型，并且当从模具远端开口延伸时具有基本弯曲的构造。抽吸针适于从骨腔的第一区域吸出液体骨髓。

2. 发明申请

WO2007111908A2 METHOD AND APPARATUS FOR TREATING VULNERABLE PLAQUE 审中-公开
标题翻译：用于处理易损碎屑的方法和装置
公开(公告)号：WO2007111908A2
公开(公告)日：2007-10-04
申请号：PCT/US2007007040
申请日：2007-03-20
申请人： ADVANCED CARDIOVASCULAR SYSTEM , MANDRUSOV EVGENIA , MICHAL EUGENE T , CHOW MINA , HOSSAINY SYED FAIYEZ AHMED , KILPATRICK DEBORAH , SIMHAMBHATLA MURTHY , CHIU JESSICA G , CLAUDE CHARLES D , WEBLER WILLIAM E
发明人： MANDRUSOV EVGENIA , MICHAL EUGENE T , CHOW MINA , HOSSAINY SYED FAIYEZ AHMED , KILPATRICK DEBORAH , SIMHAMBHATLA MURTHY , CHIU JESSICA G , CLAUDE CHARLES D , WEBLER WILLIAM E
IPC分类号： A61B17/22 , A61F2/82 , A61F2/86 , A61M29/02
CPC分类号： A61F2/07 , A61B5/02007 , A61B2017/22077 , A61F2/82 , A61F2/86 , A61F2/90 , A61F2/958 , A61F2002/077 , A61F2220/0058 , A61F2250/0067 , A61M1/3613 , A61M25/104 , A61M2025/105 , A61M2025/1056 , A61M2025/107 , A61M2025/1086 , A61M2025/1095
摘要： Various apparatuses and methods are described to treat vulnerable plaque with the use of combination drug therapy. In one embodiment, the apparatus has an elongated catheter body adapted for insertion in a body lumen, with a drug delivery device attached near a distal portion of the elongated body. The drug delivery device is configured to deliver a therapeutic or biologically active agent to stabilize a vulnerable plaque. In another embodiment, a drug eluting stent is delivered and deployed in conjunction with a second apparatus that delivers drug in pressurized retrograde perfusion. Still another embodiment uses a uniquely shaped balloon to deploy a stent while utilizing a drug infusion needle to inject drug into the vessel wall through a hollow guide wire.
摘要翻译：描述了使用组合药物治疗来治疗易损斑块的各种装置和方法。在一个实施例中，该装置具有适于插入体腔中的细长导管体，其中药物递送装置附接在细长体的远侧部分附近。药物递送装置被配置为递送治疗或生物活性剂以稳定易损斑块。在另一个实施方案中，药物洗脱支架与在加压逆行灌注中递送药物的第二装置一起递送和展开。另一个实施例使用独特形状的气囊来展开支架，同时利用药物输注针将药物通过空心导丝将药物注入血管壁。

3. 发明申请

WO2006076121A3 TISSUE REGENERATION 审中-公开
标题翻译：组织再生
公开(公告)号：WO2006076121A3
公开(公告)日：2007-01-11
申请号：PCT/US2005045627
申请日：2005-12-16
申请人： ADVANCED CARDIOVASCULAR SYSTEM , MANDRUSOV EVGENIA , CLAUDE CHARLES , MICHAL EUGENE T
发明人： MANDRUSOV EVGENIA , CLAUDE CHARLES , MICHAL EUGENE T
IPC分类号： A61L27/38 , A61L27/54
CPC分类号： A61L27/3873 , A61L27/54 , A61L2300/414 , A61L2300/602 , A61L2300/622
摘要： A method including positioning a delivery device at a location in a vessel within a mammalian body, introducing a first treatment agent including a cellular component through the delivery device, and introducing a different second treatment agent disposed in a carrier through the delivery device. A method including identifying an infarct region within myocardial tissue and a border region of perfused tissue adjacent the infarct region, introducing a treatment agent including a cellular component to the border region, and introducing a plurality of microparticles to the infarct region. A kit including a treatment agent including a cellular component in a form suitable for percutaneous delivery, and a separate amount of a plurality of microparticles in a form suitable for percutaneous delivery.
摘要翻译：一种方法，包括将输送装置定位在哺乳动物体内的血管中的位置，通过输送装置引入包括细胞组分的第一处理剂，以及通过输送装置引入设置在载体中的不同的第二处理剂。一种方法，包括鉴定心肌组织内的梗死区域和与梗塞区域相邻的灌注组织的边界区域，将包括细胞组分的治疗剂引入边界区域，以及将多个微粒引入梗塞区域。一种试剂盒，其包括包含适于经皮递送形式的细胞成分的处理剂，以及适合于经皮递送形式的分开量的多个微粒。

4. 发明申请

WO2005011770A3 BIOLOGICALLY ABSORBABLE COATINGS FOR IMPLANTABLE DEVICES 审中-公开
标题翻译：用于可植入设备的生物吸收性涂料
公开(公告)号：WO2005011770A3
公开(公告)日：2005-08-18
申请号：PCT/US2004022018
申请日：2004-07-08
申请人： ADVANCED CARDIOVASCULAR SYSTEM , HOSSAINY SYED F A , MICHAL EUGENE T , TANG YIWEN
发明人： HOSSAINY SYED F A , MICHAL EUGENE T , TANG YIWEN
IPC分类号： A61L31/10 , A61L31/16
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/114 , A61L2300/606 , C08L67/04 , C08L71/02
摘要： Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings comprising a biologically degradable, biologically erodable, and/or biologically resorbable ABA or AB block copolymer. A biologically active agent can be conjugated to the block copolymer.
摘要翻译：公开了用于可植入医疗装置的涂层及其制造方法，所述涂层包含生物可降解，生物可侵蚀和/或生物可再吸收的ABA或AB嵌段共聚物。生物活性剂可以与嵌段共聚物缀合。

5. 发明申请

WO2007112048A3 METHODS AND APPARATUSES FOR COATING A LESION 审中-公开
标题翻译：用于涂层的方法和装置
公开(公告)号：WO2007112048A3
公开(公告)日：2008-08-14
申请号：PCT/US2007007343
申请日：2007-03-22
申请人： ADVANCED CARDIOVASCULAR SYSTEM , MICHAL EUGENE T , TROLLSAS MIKAEL , TANG EVELEEN , GLAUSER THIERRY , HOSSAINY SYED FAIYEZ AHMED
发明人： MICHAL EUGENE T , TROLLSAS MIKAEL , TANG EVELEEN , GLAUSER THIERRY , HOSSAINY SYED FAIYEZ AHMED
IPC分类号： A61L31/12 , A61L27/44 , A61L27/50 , A61L31/14 , C07K14/78
CPC分类号： A61L31/043 , A61L2430/36
摘要： A method and apparatus to treat regions of a vessel is described. A protein elastin-based polymer is released from the apparatus to coat the vessel lining as a primary therapy or an adjunct therapy with the delivery and deployment of a stent with or without drug coating. The protein elastin-based polymer may include a triblock structure having an elastin pentapeptide as the flanking block and a hydrophilic variant of the pentapeptide as the middle block. Both the flanking and middle blocks can be modified to change the structural and chemical properties of the polymer. In particular, the protein elastin based polymer is adapted to perform at least one of controlling release of a treatment agent, stimulating endothelial cell growth and stabilizing the vulnerable plaque to prevent rupture of the vulnerable plaque.
摘要翻译：描述了一种处理容器区域的方法和装置。将蛋白质弹性蛋白基聚合物从装置中释放出来，作为主要疗法或辅助治疗来涂覆血管衬里，随着具有或不具有药物涂层的支架的递送和展开。基于蛋白质弹性蛋白的聚合物可以包括具有弹性蛋白五肽作为侧翼嵌段的三嵌段结构和作为中间嵌段的五肽的亲水性变体。可以改变侧面和中间嵌段以改变聚合物的结构和化学性质。特别地，基于蛋白质弹性蛋白的聚合物适于执行控制治疗剂释放，刺激内皮细胞生长和稳定易损斑块中的至少一种，以防止脆弱斑块的破裂。

6. 发明申请

WO2007100475A2 HYDROGEL BIOSCAFFOLDINGS AND BIOMEDICAL DEVICE COATINGS 审中-公开
标题翻译： HYDROGEL生物医药和生物医疗器械涂料
公开(公告)号：WO2007100475A2
公开(公告)日：2007-09-07
申请号：PCT/US2007003614
申请日：2007-02-09
申请人： ADVANCED CARDIOVASCULAR SYSTEM , MICHAL EUGENE T
发明人： MICHAL EUGENE T
IPC分类号： A61L27/38 , A61L27/26 , A61L27/52 , A61L27/54
CPC分类号： A61L27/52 , A61L27/20 , A61L27/225 , A61L27/24 , A61L27/26 , A61L27/3826 , A61L27/383 , A61L27/3834 , A61L27/3873 , C08L89/06 , C08L5/04
摘要： Bioscaffoldings formed of hydrogels that are crosslinked in situ in an infarcted region of the heart (myocardium) by a Michael's addition reaction or by a disulfide bond formed by an oxidative process are described. Each of the bioscaffoldings described includes hyaluronan as one of the hydrogel components and the other component is selected from collagen, collagen-laminin, poly-1-lysine, and fibrin. The bioscaffolding may further include an alginate component. The bioscaffoldings may have biofunctional groups such as angiogenic factors and stem cell homing factors bound to the collagen, collagen-laminin, poly-1-lysine, or fibrinogen hydrogel component. In particular, the biofunctional groups may be PRl 1, PR39, VEGF, bFGF, a polyarginine/DNA plasmid complex, or a DNA/polyethyleneimine (PEI) complex. Additionally, the hydrogel components may be injected into the infarct region along with stem cells and microspheres containing stem cell homing factors. The bioscaffolding may be formed on a stent or a cardiac medical device.
摘要翻译：描述了由水凝胶形成的生物支架，其通过迈克尔加成反应或通过氧化过程形成的二硫键在心脏（心肌）的梗死区域原位交联。所描述的每个生物支架包括透明质酸作为水凝胶组分之一，另一组分选自胶原，胶原 - 层粘连蛋白，聚-1-赖氨酸和纤维蛋白。生物支架还可包括藻酸盐组分。生物支架可具有诸如血管生成因子和结合于胶原，胶原 - 层粘连蛋白，聚-1-赖氨酸或纤维蛋白原水凝胶组分的干细胞归巢因子的生物功能组。特别地，生物功能基团可以是PR11，PR39，VEGF，bFGF，聚精氨酸/ DNA质粒复合物或DNA /聚乙烯亚胺（PEI）复合物。此外，水凝胶组分可以与含有干细胞归巢因子的干细胞和微球一起注入梗塞区域。生物支架可以形成在支架或心脏医疗装置上。

7. 发明申请

WO2010030995A2 LOCAL DELIVERY OF WATER-SOLUBLE OR WATER-INSOLUBLE THERAPEUTIC AGENTS TO THE SURFACE BODY LUMENS 审中-公开
标题翻译：将水溶性或水不溶性治疗剂局部输送到表面体液
公开(公告)号：WO2010030995A2
公开(公告)日：2010-03-18
申请号：PCT/US2009056842
申请日：2009-09-14
申请人： CV INGENUITY , MICHAL EUGENE T , LERNER DANIEL J , POLLMAN MATTHEW J
发明人： MICHAL EUGENE T , LERNER DANIEL J , POLLMAN MATTHEW J
IPC分类号： A61K47/02 , A61F2/958 , A61K31/337 , A61K31/4353 , A61K31/436 , A61L31/08 , A61L31/16
CPC分类号： A61L29/106 , A61K47/02 , A61L29/10 , A61L29/16 , A61L2300/114 , A61L2300/216 , A61L2300/41 , A61L2300/416
摘要： A method and device for local delivery of water-soluble or water-insoluble therapeutic agents to the surface of a normal or diseased body lumen is disclosed. An expandable structure of a medical disposable device, such as a balloon of a balloon catheter, is coated with an amphiphilic polymer coating comprising a therapeutic agent and an amphiphilic polymer or co-polymer. The medical disposable device is inserted into a body lumen, and expanded to contact the amphiphilic polymer coating against the body lumen. The total solubility of the polymer or co-polymer in vivo prevents any embolic hazard associated with the amphiphilic polymer coating.
摘要翻译：公开了一种将水溶性或水不溶性治疗剂局部递送到正常或患病体腔表面的方法和装置。医疗一次性装置（例如球囊导管的球囊）的可膨胀结构用包含治疗剂和两亲性聚合物或共聚物的两亲性聚合物涂层涂覆。将医疗一次性装置插入体腔中，并膨胀以使两亲性聚合物涂层抵靠体腔接触。聚合物或共聚物在体内的总溶解度可防止与两亲性聚合物涂层相关的任何栓塞危险。

8. 发明专利

AU745979B2 Hydrophilic coating for an intracorporeal medical device 未知
公开(公告)号：AU745979B2
公开(公告)日：2002-04-11
申请号：AU2567799
申请日：1999-01-29
申请人： ADVANCED CARDIOVASCULAR SYSTEM
发明人： MICHAL EUGENE T , BUCHKO CHRISTOPHER J , BIGUS STEPHEN J
IPC分类号： A61L29/00 , A61F2/04 , A61K31/04 , A61K31/196 , A61K31/21 , A61K31/5375 , A61K31/711 , A61K33/00 , A61K38/00 , A61L29/04 , A61L29/08 , A61L31/00 , A61L31/04 , A61L31/10

9. 发明专利

AT330646T 未知
公开(公告)号：AT330646T
公开(公告)日：2006-07-15
申请号：AT99905536
申请日：1999-01-29
申请人： ADVANCED CARDIOVASCULAR SYSTEM
发明人： MICHAL EUGENE T , BUCHKO CHRISTOPHER J , BIGUS STEPHEN J
IPC分类号： A61L29/00 , A61F2/04 , A61K31/04 , A61K31/196 , A61K31/21 , A61K31/5375 , A61K31/711 , A61K33/00 , A61K38/00 , A61L29/04 , A61L29/08 , A61L31/00 , A61L31/04 , A61L31/10

10. 发明专利

CA2316223A1 HYDROPHILIC COATING FOR AN INTRACORPOREAL MEDICAL DEVICE 未知
公开(公告)号：CA2316223A1
公开(公告)日：1999-08-05
申请号：CA2316223
申请日：1999-01-29
申请人： ADVANCED CARDIOVASCULAR SYSTEM
发明人： BUCHKO CHRISTOPHER J , MICHAL EUGENE T , BIGUS STEPHEN J
IPC分类号： A61L29/00 , A61F2/04 , A61K31/04 , A61K31/196 , A61K31/21 , A61K31/5375 , A61K31/711 , A61K33/00 , A61K38/00 , A61L29/04 , A61L29/08 , A61L31/00 , A61L31/04 , A61L31/10
摘要： It has been discovered that compositions which are blends or mixtures including a monomeric fatty acid component can serve as stable lubricity additives in distillate fuels, including gasoline. The compositions may include saturated or unsaturated, monomeric fatty acids having from 12 to 22 carbon atoms; a synthetic monomeric acid having from 12 to 40 carbon atoms; and saturated or unsaturated, oligomeric fatty acids having from 24 to 66 carbon atoms. Where a saturated monomeric fatty acid is used, a hindered and/or tertiary amine may be present as a stabilizer.

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