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1. 发明申请

WO2006050730A1 NOVEL SALTS OF FUMARIC ACID MONOALKYLESTERS AND THEIR PHARMACEUTICAL USE 审中-公开
标题翻译：新型单糖单酯及其药物用途
公开(公告)号：WO2006050730A1
公开(公告)日：2006-05-18
申请号：PCT/DK2005/000717
申请日：2005-11-09
申请人： ADITECH PHARMA AB , NILSSON, Henrik , ANDERSEN, Jens, E.T. , MÜLLER, Bernd, W. , ROBINSON, Joseph, R.
发明人： NILSSON, Henrik , ANDERSEN, Jens, E.T. , MÜLLER, Bernd, W. , ROBINSON, Joseph, R.
IPC分类号： C07C69/60 , A61K31/28 , A61P17/06
CPC分类号： C07C69/60 , C07C67/30
摘要： The present invention relates to novel strontium salts of fumaric acid monoalkylesters. The salts are suitable for use as active subtances in the treatment of e.g. psoriasis or other hyperproliferative, inflammatory or autoimmune disorders either alone or in combination with another fumaric acid ester.
摘要翻译：本发明涉及富马酸单烷基酯的新型锶盐。这些盐适合用作例如治疗中的活性偶氮。牛皮癣或其他过度增生，炎性或自身免疫性疾病，单独或与另一种富马酸酯组合。

2. 发明申请

WO2007006307A2 NOVEL SALTS OF FUMARIC ACID MONOALKYLESTERS AND THEIR PHARMACEUTICAL USE 审中-公开
标题翻译：富马酸单烷基酯的新盐及其药物用途
公开(公告)号：WO2007006307A2
公开(公告)日：2007-01-18
申请号：PCT/DK2006/000402
申请日：2006-07-07
申请人： ADITECH PHARMA AB , NILSSON, Henrik , ANDERSEN, Jens E.T. , MÜLLER, Bernd, W.
发明人： NILSSON, Henrik , ANDERSEN, Jens E.T. , MÜLLER, Bernd, W.
IPC分类号： C07C55/02 , C07C69/593 , A61K31/194 , A61K31/195
CPC分类号： C07C69/60 , C07C229/08 , C07C229/22 , C07C229/24 , C07C229/26 , C07C279/14 , C07C323/58 , C07D207/16 , C07D207/337
摘要： The present invention relates to novel amino acid salts of fumaric acid monoalkylesters. The salts are suitable for use as active substances in the treatment of e.g. psoriasis or other hyperproliferative, inflammatory or autoimmune disorders.
摘要翻译：本发明涉及富马酸单烷酯的新型氨基酸盐。这些盐适合用作活性物质来处理例如牛皮癣或其他过度增殖，炎症或自身免疫性疾病。

3. 发明申请

WO2006037342A3 CONTROLLED RELEASE PHARMACEUTICAL COMPOSITIONS COMPRISING A FUMARIC ACID ESTER 审中-公开
公开(公告)号：WO2006037342A3
公开(公告)日：2006-04-13
申请号：PCT/DK2005/000648
申请日：2005-10-07
申请人： ADITECH PHARMA AB , NILSSON, Henrik , SCHÖNHARTING, Florian , MÜLLER, Bernd, W. , ROBINSON, Joseph, R.
发明人： NILSSON, Henrik , SCHÖNHARTING, Florian , MÜLLER, Bernd, W. , ROBINSON, Joseph, R.
IPC分类号： A61K9/20
摘要： The present invention relates to controlled release pharmaceutical compositions comprising fumaric acid ester(s) as active substance(s). The compositions are suitable for use in the treatment of e.g. psoriasis or other hyperproliferative, inflammatory or autoimmune disorders and are designated to release the fumaric acid ester in a controlled manner so that local high concentrations of the active substance within the gastrointestinal tract upon oral administration can be avoided and, thereby, enabling a reduction in gastro-intestinal related side-effects.

4. 发明申请

WO2007006308A1 NOVEL GLUCOPYRANOSE ESTERS AND GLUCOFURANOSE ESTERS OF ALKYL- FU MARATES AND THEIR PHARMACEUTICAL USE 审中-公开
标题翻译：阿尔茨海默病的新型葡萄糖苷和葡萄糖醛酸苷及其药物使用
公开(公告)号：WO2007006308A1
公开(公告)日：2007-01-18
申请号：PCT/DK2006/000403
申请日：2006-07-07
申请人： ADITECH PHARMA AB , NILSSON, Henrik , ANDERSEN, Jens E.T.
发明人： NILSSON, Henrik , ANDERSEN, Jens E.T.
IPC分类号： C07H13/04 , C07D309/06 , A61K31/351 , A61K31/341 , A61K31/7028 , A61K31/7024
CPC分类号： C07H13/04
摘要： The present invention relates to novel glucofuranose esters and glucopyranose esters of alkyl-fumarates. The esters are suitable for use as active substances in the treatment of e.g. psoriasis or other hyperproliferative, inflammatory or autoimmune disorders.
摘要翻译：本发明涉及烷基富马酸盐的新颖的呋喃葡萄糖酯和吡喃葡萄糖酯。所述酯适合用作例如治疗中的活性物质。牛皮癣或其他过度增生，炎症或自身免疫性疾病。

5. 发明申请

WO2007042034A1 CONTROLLED RELEASE PHARMACEUTICAL COMPOSITIONS COMPRISING A FUMARIC ACID ESTER 审中-公开
标题翻译：受控释放的含有酸性酯的药物组合物
公开(公告)号：WO2007042034A1
公开(公告)日：2007-04-19
申请号：PCT/DK2006/000561
申请日：2006-10-06
申请人： ADITECH PHARMA AB , NILSSON, Henrik , MÜLLER, Bernd, W.
发明人： NILSSON, Henrik , MÜLLER, Bernd, W.
IPC分类号： A61K9/28 , A61K9/20 , A61K31/215 , A61P17/06
CPC分类号： A61K9/2846 , A61K9/2013 , A61K9/2027 , A61K9/2054 , A61K9/4891 , A61K9/5047 , A61K31/215 , A61K31/225 , A61K45/06 , A61K2300/00
摘要： The present invention relates to controlled release pharmaceutical compositions comprising fumaric acid ester(s) as active substance(s). The compositions are suitable for use in the treatment of e.g. psoriasis or other hyperproliferative, inflammatory or autoimmune disorders and are designed to release the fumaric acid ester in a controlled manner so that local high concentrations of the active substance within the gastrointestinal tract upon oral administration can be avoided and, thereby, enabling a reduction in gastro-intestinal related side-effects.
摘要翻译：本发明涉及包含富马酸酯作为活性物质的控释药物组合物。该组合物适合用于治疗例如儿童。牛皮癣或其他过度增生，炎症或自身免疫性疾病，并且被设计为以受控的方式释放富马酸酯，使得可以避免在口服给药时胃肠道内的活性物质的局部高浓度，从而能够减少胃 - 肠道相关副作用。

6. 发明申请

WO2007042035A3 COMBINATION THERAPY WITH FUMARIC ACID ESTERS FOR THE TREATMENT OF AUTOIMMUNE AND/OR INFLAMMATORY DISORDERS 审中-公开
公开(公告)号：WO2007042035A3
公开(公告)日：2007-04-19
申请号：PCT/DK2006/000563
申请日：2006-10-06
申请人： ADITECH PHARMA AB , NILSSON, Henrik
发明人： NILSSON, Henrik
IPC分类号： A61K31/225 , A61P17/00 , A61P17/06 , A61P25/28 , A61P29/00
摘要： The present invention relates to compositions, kits and methods for administration of a first component of fumaric acid ester(s), or a pharmaceutically acceptable salt thereof, and a second component which is a substance that reduces or eliminates flushing.

7. 发明申请

WO2005110454A2 PROTECTIVE BINDING MEMBERS OF PYY FOR THE TREATMENT OF METABOLIC DISORDERS 审中-公开
标题翻译： PYY保护性结合成分治疗代谢性疾病
公开(公告)号：WO2005110454A2
公开(公告)日：2005-11-24
申请号：PCT/DK2005/000329
申请日：2005-05-18
申请人： ADITECH PHARMA AB , NILSSON, Henrik , HANSEN, Christian
发明人： NILSSON, Henrik , HANSEN, Christian
IPC分类号： A61K38/02
CPC分类号： C07K14/57545 , C07K14/72
摘要： The present invention relates to a binding member of PYY or a functional equivalent thereof for use in pharmaceutical compositions. The pharmaceutical compositions are in particular useful in the treatment of metabolic disorders e.g. obesity, eating disorders, such as disorders characterised by cravings and binges and functional gastrointestinal disorders such as irritable bowel syndrome and functional dyspepsia. The invention further relates to methods of treatment using said compositions. Further included is the combination of a binding member of PYY or a functional equivalent thereof with a secondary active ingredient such as PYY or functional equivalents thereof. The invention further describes the use of a binding member of PYY or a functional equivalent thereof for diagnostic purposes.
摘要翻译：本发明涉及用于药物组合物的PYY的结合成员或其功能等同物。该药物组合物特别适用于治疗代谢紊乱，例如肥胖症，进食障碍，如以渴望和暴食为特征的疾病和功能性胃肠疾病如肠易激综合征和功能性消化不良。本发明还涉及使用所述组合物的治疗方法。还包括PYY的结合成员或其功能等同物与第二活性成分例如PYY或其功能等同物的组合。本发明进一步描述了PYY的结合成员或其功能等价物用于诊断目的的用途。

8. 发明申请

WO2005110457A2 TREATMENT OF EATING DISORDERS AND INDUCTION OF LIPOLYSIS 审中-公开
标题翻译：治疗排卵障碍和感染的诱导
公开(公告)号：WO2005110457A2
公开(公告)日：2005-11-24
申请号：PCT/DK2005/000328
申请日：2005-05-18
申请人： ADITECH PHARMA AB , HANSEN, Christian , NILSSON, Henrik , SCHÖNHARTING, Florian , SCHAMBYE, Hans T.
发明人： HANSEN, Christian , NILSSON, Henrik , SCHÖNHARTING, Florian , SCHAMBYE, Hans T.
IPC分类号： A61K38/17
CPC分类号： C07K14/575 , A61K38/00
摘要： The present invention relates to PYY or functional equivalents thereof for use in pharmaceutical compositions. The pharmaceutical compositions are in particular useful in the treatment of eating disorders, such as disorders characterised by cravings and binges. The invention further discloses the use of said composition for regulation of lipolysis, e.g. stimulation of lipolysis for the treatment of obesity. The invention further relates to methods of treatment using said compositions. Further included is the combination of PYY or functional equivalents thereof with a secondary active ingredient such as an anti-emetic drug.
摘要翻译：本发明涉及用于药物组合物的PYY或其功能等同物。药物组合物特别可用于治疗进食障碍，例如以渴求和叮咬为特征的病症。本发明进一步公开了所述组合物用于调节脂肪分解的用途。刺激脂肪分解治疗肥胖症。本发明还涉及使用所述组合物的治疗方法。还包括PYY或其功能等同物与次级活性成分如抗呕吐药物的组合。

9. 发明申请

WO2005110467A1 A COMPOSITION COMPRISING PYY FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS 审中-公开
标题翻译：包含PYY治疗胃肠疾病的组合物
公开(公告)号：WO2005110467A1
公开(公告)日：2005-11-24
申请号：PCT/DK2005/000327
申请日：2005-05-18
申请人： ADITECH PHARMA AB , NILSSON, Henrik
发明人： NILSSON, Henrik
IPC分类号： A61K38/22
CPC分类号： A61K38/22 , A61K45/06 , A61K2300/00
摘要： The present invention relates to PYY or functional equivalents thereof for use in pharmaceutical compositions. The pharmaceutical compositions are in particular useful in the treatment of functional gastrointestinal disorders, such as irritable bowel disease and functional dyspepsia. The invention further relates to methods of treatment using said compositions. Further included is the combination of PYY or functional equivalents thereof with a secondary active ingredient such as an anti-emetic drug.
摘要翻译：本发明涉及用于药物组合物的PYY或其功能等同物。药物组合物特别可用于治疗功能性胃肠道疾病，例如肠易激综合征和功能性消化不良。本发明还涉及使用所述组合物的治疗方法。还包括PYY或其功能等同物与次级活性成分如抗呕吐药物的组合。

10. 发明申请

WO2006063596A2 A COMPOSITION COMPRISING PP FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS 审中-公开
标题翻译：含PP的组合物用于治疗胃肠道病症
公开(公告)号：WO2006063596A2
公开(公告)日：2006-06-22
申请号：PCT/DK2005/000796
申请日：2005-12-15
申请人： ADITECH PHARMA AB , NILSSON, Henrik
发明人： NILSSON, Henrik
CPC分类号： A61K38/22 , A61K2300/00
摘要： The present invention relates to PP or functional equivalents thereof for use in pharmaceutical compositions. The pharmaceutical compositions are in particular useful in the treatment of functional gastrointestinal disorders, such as irritable bowel disease and functional dyspepsia. The invention further relates to methods of treatment using said compositions. Further included is the combination of PP or functional equivalents thereof with a secondary active ingredient such as an anti-emetic drug.
摘要翻译：本发明涉及用于药物组合物的PP或其功能等同物。该药物组合物特别可用于治疗功能性胃肠病症，如过敏性肠病和功能性消化不良。本发明还涉及使用所述组合物的治疗方法。还包括PP或其功能等同物与第二活性成分例如止吐药的组合。

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