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1. 发明申请

WO2009086000A2 BIOMARKERS FOR TRICHOGENICITY 审中-公开
标题翻译：生物标志物的生物多样性
公开(公告)号：WO2009086000A2
公开(公告)日：2009-07-09
申请号：PCT/US2008087513
申请日：2008-12-18
申请人： ADERANS RES INST INC , STENN KURT , PARIMOO SATISH , YANG HONGHUA , HOMAN YING , CHEN WEI , ZHENG YING
发明人： STENN KURT , PARIMOO SATISH , YANG HONGHUA , HOMAN YING , CHEN WEI , ZHENG YING
IPC分类号： A61K48/00 , C12N15/11 , C12Q1/68 , G01N33/68
CPC分类号： C12Q1/6881 , C12Q2600/178 , G01N33/6881 , G01N33/6893 , G01N2500/10
摘要： Biomarkers for identifying trichogenic cells have been identified. The biomarkers include microRNA as wells as mRNA and proteins. Certain biomarkers are upregulated in trichogenic cells compared to non-trichogenic cells; whereas, other biomarkers are down-regulated in trichogenic cells compared to non-trichogenic cells. The cells can be dermal cells, epidermal cells, or a combination thereof. Preferably the cells are mammalian, more preferably the cells are human. One embodiment provides a method for selecting trichogenic cells by assaying the cells for expression of one or more biomarkers for trichogenicity, and selecting the cells having increased expression of the one or more biomarkers relative to a control, wherein increased expression of the a biomarker in the cells is indicative of trichogenicity. Preferably, the one or more biomarkers are selected from the group consisting of hsa-miR-200c, hsa-miR-205, hsa-miR-200a*, hsa-miR- 200a, hsa-miR-141, hsa-miR-182, DEPDC1, hFLEG1, ESM1, TOME-1, THBD and combinations thereof.
摘要翻译：已鉴定出用于鉴定发生细胞的生物标志物。生物标志物包括微RNA作为mRNA和蛋白质的孔。与非致毛细胞相比，某些生物标志物在致毛细胞中上调; 而与非致毛细胞相比，其它生物标志物在发育细胞中下调。细胞可以是真皮细胞，表皮细胞或其组合。优选地，细胞是哺乳动物，更优选细胞是人。一个实施方案提供了通过测定细胞用于表达一种或多种针刺性生物标志物并选择相对于对照而增加一种或多种生物标志物表达的细胞来选择发生细胞的方法，其中所述生物标志物在细胞表示毛发性。优选地，一种或多种生物标志物选自hsa-miR-200c，hsa-miR-205，hsa-miR-200a *，hsa-miR-200a，hsa-miR-141，hsa-miR-182 ，DEPDC1，hFLEG1，ESM1，TOME-1，THBD及其组合。

3. 发明专利

AU2010260063A1 Methods and compositions for increasing trichogenic potency of dermal cells 未知
公开(公告)号：AU2010260063A1
公开(公告)日：2012-02-02
申请号：AU2010260063
申请日：2010-06-16
申请人： ADERANS RES INST INC
发明人： ZHENG YING , BOUCHER MARYLENE , HOMAN YING , HOLLOW CHARLES , MAMONTOV POLINA , STENN KURT
IPC分类号： C07D409/00 , A61K31/381 , A61K31/4436 , C07D409/14
摘要： Methods and compositions for increasing trichogenicity of cells in culture are provided. One embodiment provides culturing dissociated mammalian dermal cells in vitro in the presence of an effective amount of one or more sonic hedgehog (Shh) pathway agonists to increase the trichogenicity of the dissociated mammalian dermal cells compared to untreated dissociated mammalian dermal cells. The cell culture optionally includes epidermal cells. Preferred Shh agonists include, but are not limited to CUR-0236715 and CUR-0201365 available from Curis, Inc. Trichogenicity is measured using the Aderans Hair Patch Assay.The cultured dermal cells can be maintained in culture in the presence of the one or more Shh agonists for at least 1 to 7 or more days prior to harvest. The treated, cultured dermal cells can be used to treat hair loss in a mammalian subject, preferably a human, by implanting them in an effective amount to induce hair follicle formation.

4. 发明专利

CA2765706A1 METHODS AND COMPOSITIONS FOR INCREASING TRICHOGENIC POTENCY OF DERMAL CELLS 未知
公开(公告)号：CA2765706A1
公开(公告)日：2010-12-23
申请号：CA2765706
申请日：2010-06-16
申请人： ADERANS RES INST INC
发明人： ZHENG YING , BOUCHER MARYLENE , HOMAN YING , HOLLOW CHARLES , MAMONTOV POLINA , STENN KURT
IPC分类号： A61K31/381 , A61K31/4436 , C07D409/00 , C07D409/14
摘要： Methods and compositions for increasing trichogenicity of cells in culture are provided. One embodiment provides culturing dissociated mammalian dermal cells in vitro in the presence of an effective amount of one or more sonic hedgehog (Shh) pathway agonists to increase the trichogenicity of the dissociated mammalian dermal cells compared to untreated dissociated mammalian dermal cells. The cell culture optionally includes epidermal cells. Preferred Shh agonists include, but are not limited to CUR-0236715 and CUR-0201365 available from Curis, Inc. Trichogenicity is measured using the Aderans Hair Patch AssayTM.The cultured dermal cells can be maintained in culture in the presence of the one or more Shh agonists for at least 1 to 7 or more days prior to harvest. The treated, cultured dermal cells can be used to treat hair loss in a mammalian subject, preferably a human, by implanting them in an effective amount to induce hair follicle formation.

5. 发明申请

WO9641623A2 TRICOT-LIKE POUCH FOR THE DELIVERY OF TOPICAL DRUGS AND COSMETICS 审中-公开
标题翻译： TRICOT-LIKE POUCH用于输送局部药物和化妆品
公开(公告)号：WO9641623A2
公开(公告)日：1996-12-27
申请号：PCT/US9608979
申请日：1996-06-05
申请人： JOHNSON & JOHNSON CONSUMER , VERDICCHIO ROBERT J , YANG MORRIS C , CARASSO SAMUEL E , STENN KURT
发明人： VERDICCHIO ROBERT J , YANG MORRIS C , CARASSO SAMUEL E , STENN KURT
IPC分类号： A61K8/02 , A61K9/70 , A61Q19/00
CPC分类号： A61K9/703 , A61K8/0208 , A61K9/70 , A61Q1/12 , A61Q5/02 , A61Q17/005 , A61Q19/00 , A61Q19/10 , Y10T428/31913
摘要： This invention relates to pouch or pledget delivery system having an apertured film or fabric covering which assists in evenly and safely distributing topical medicaments.
摘要翻译：本发明涉及具有有助于均匀和安全地分布局部药物的多孔膜或织物覆盖物的袋或药物输送系统。

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