专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2013001505A2 SULPHONAMIDE DERIVATIVES OF ALICYCLIC AMINES FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISEASES 审中-公开
标题翻译：用于治疗中枢神经系统疾病的亚胺胺磺酰胺衍生物
公开(公告)号：WO2013001505A2
公开(公告)日：2013-01-03
申请号：PCT/IB2012/053318
申请日：2012-06-29
申请人： ADAMED SP. Z O.O. , KOŁACZKOWSKI, Marcin , MARCINKOWSKA, Monika , BUCKI, Adam , PAWŁOWSKI, Maciej , KRUKOWSKI, Andrzej , RUSIECKI, Rafał , SIWEK, Agata Magdalena , WOLAK, Małgorzata Anna
发明人： KOŁACZKOWSKI, Marcin , MARCINKOWSKA, Monika , BUCKI, Adam , PAWŁOWSKI, Maciej , KRUKOWSKI, Andrzej , RUSIECKI, Rafał , SIWEK, Agata Magdalena , WOLAK, Małgorzata Anna
IPC分类号： C07D403/06
CPC分类号： C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
摘要： Sulphonamide derivatives of alicyclic amines of formula (I), wherein A represents naphthyl or 9- or 10-membered bicyclic group, consisting of benzene ring fused with -or 6-membered heterocyclic ring; D represents phenyl, naphthyl, 5-membered aromatic heterocyclic group, bicyclic group consisting of a ring selected from benzene and pyridine, fused with aromatic or non-aromatic 5-membered heterocyclic ring; r represents 0 or 1; x, z independently represent 1 or 2; n represents 3 and p represents 0, or n represents 2 and p represents 1;and enantiomers, pharmaceutically acceptable salts and solvates thereof. The compounds may be useful for the treatment and/or prevention of the central nervous system disorders (Formula I).
摘要翻译：式（I）脂环族胺的磺酰胺衍生物，其中A代表萘基或9-或10-元双环基团，由与6-或6-元杂环稠合的苯环组成; D代表苯基，萘基，5元芳族杂环基团，由选自苯和吡啶的环组成的双环基团，与芳族或非芳族5-元杂环稠合; r代表0或1; x，z独立地表示1或2; n表示3且p表示0，或者n表示2且p表示1;以及其对映异构体，可药用盐和溶剂合物。该化合物可用于治疗和/或预防中枢神经系统疾病（式I）。

2. 发明申请

WO2013001499A1 INDOLEAMINE DERIVATIVES FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISEASES 审中-公开
标题翻译：用于治疗中枢神经系统疾病的吲哚胺衍生物
公开(公告)号：WO2013001499A1
公开(公告)日：2013-01-03
申请号：PCT/IB2012/053309
申请日：2012-06-28
申请人： ADAMED SP. Z O.O. , KOŁACZKOWSKI, Marcin , MARCINKOWSKA, Monika , BUCKI, Adam , PAWŁOWSKI, Maciej , KAZEK, Grzegorz , BEDNARSKI, Marek , WESOŁOWSKA, Anna
发明人： KOŁACZKOWSKI, Marcin , MARCINKOWSKA, Monika , BUCKI, Adam , PAWŁOWSKI, Maciej , KAZEK, Grzegorz , BEDNARSKI, Marek , WESOŁOWSKA, Anna
IPC分类号： C07D209/30 , C07D403/04 , C07D413/04 , A61K31/404
CPC分类号： C07D401/12 , C07D209/08 , C07D209/30 , C07D403/04 , C07D413/04
摘要： Indoleamine derivatives of formula (IA), wherein R 1 represents benzyl unsubstituted or substituted with halogen atom, -OH, or C 1 -C 3 -alkyl; phenylsulphonyl unsubstituted or substituted in the phenyl ring with halogen atom, -OH or C 1 -C 3 -alkyl; G 1 represents phenoxyalkyl, heteroaryloxyalkyl- or heterocyclyloxyalkyl-piperazine moiety; and pharmaceutically acceptable salts and solvates thereof. The compounds may be useful for the treatment and/or prevention of the central nervous system disorders.
摘要翻译：式（IA）的吲哚胺衍生物，其中R 1表示未取代或被卤素原子取代的苄基，-OH或C 1 -C 3 - 烷基; 在苯环中未被取代或取代的苯基磺酰基与卤素原子，-OH或C 1 -C 3 - 烷基; G1表示苯氧基烷基，杂芳氧基烷基或杂环基烷基 - 哌嗪部分; 及其药学上可接受的盐和溶剂化物。所述化合物可用于治疗和/或预防中枢神经系统疾病。

3. 发明申请

WO2012035123A1 ARYLOSULFONAMIDES FOR THE TREATMENT OF CNS DISEASES 审中-公开
标题翻译：用于治疗CNS疾病的ARYLOSULFONAMIDES
公开(公告)号：WO2012035123A1
公开(公告)日：2012-03-22
申请号：PCT/EP2011/066054
申请日：2011-09-16
申请人： ADAMED SP. Z O.O. , KOŁACZKOWSKI, Marcin , KOWALSKI, Piotr , JAŚKOWSKA, Jolanta , MARCINKOWSKA, Monika , MITKA, Katarzyna , BUCKI, Adam , WESOŁOWSKA, Anna , PAWŁOWSKI, Maciej
发明人： KOŁACZKOWSKI, Marcin , KOWALSKI, Piotr , JAŚKOWSKA, Jolanta , MARCINKOWSKA, Monika , MITKA, Katarzyna , BUCKI, Adam , WESOŁOWSKA, Anna , PAWŁOWSKI, Maciej
IPC分类号： C07D209/40 , C07D235/30 , C07D275/04 , C07D319/20 , C07D413/12 , A61K31/496 , A61P25/00
CPC分类号： C07D401/04 , C07D209/40 , C07D235/30 , C07D263/58 , C07D275/04 , C07D277/82 , C07D319/20 , C07D401/02 , C07D403/02 , C07D405/12 , C07D409/02 , C07D409/12 , C07D409/14 , C07D413/02 , C07D413/04 , C07D413/12 , C07D417/02 , C07D417/12 , C07D417/14 , C07D471/04
摘要： Arylsulphonamide derivatives of formula (I) and pharmaceutically acceptable salts thereof. The compounds may be useful for the treatment and/or prevention of disorders of the central nervous system.
摘要翻译：式（I）的芳基磺酰胺衍生物及其药学上可接受的盐。所述化合物可用于治疗和/或预防中枢神经系统疾病。

4. 发明申请

WO2013140347A1 SULPHONAMIDE DERIVATIVES OF BENZYLAMINE FOR THE TREATMENT OF CNS DISEASES 审中-公开
标题翻译：苯甲酰胺用于治疗CNS疾病的磺酰胺衍生物
公开(公告)号：WO2013140347A1
公开(公告)日：2013-09-26
申请号：PCT/IB2013/052204
申请日：2013-03-20
申请人： ADAMED SP. Z O.O.
发明人： KOŁACZKOWSKI, Marcin , MARCINKOWSKA, Monika , BUCKI, Adam , ŁYSAKOWSKI, Tomasz , PAWŁOWSKI, Maciej
IPC分类号： C07C311/21 , C07D403/12 , C07D413/14 , C07D319/18 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D261/20 , C07D487/04 , C07D209/08 , C07D307/79 , A61K31/18 , A61P25/00
CPC分类号： C07D487/04 , C07C311/21 , C07D209/08 , C07D261/20 , C07D307/79 , C07D319/18 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12
摘要： Sulphonamide derivatives of benzylamine of formula (I), wherein A represents phenyl unsubstituted or substituted;or 9-or 10-membered bicyclic group, linked to –(O) x - (CH 2 ) y -through one of its aromatic carbon atoms,consisting of benzene ring fused with -membered heteroaromatic ring containing 1 or 2 heteroatoms independently selected from the group consisting of N and O, wherein such bicyclic group is unsubstituted or substituted or with 5-or 6-membered non-aromaticheterocyclic ring having 1 or 2 O atoms, wherein heterocyclic ring is unsubstituted or substituted with one or more C 1 -C 3 - alkyls; D represents a group selected from:phenyl unsubstituted or substituted; naphthyl unsubstituted or substituted;thiophene unsubstituted or substituted;bicyclic group consisting of imidazolering fused with5-membered non-aromatic carbocyclic ring; bicyclic group consisting of benzene ring fused with 5-membered heteroaromatic ring, having 1 or 2heteroatoms independently selected from the group consisting of N, O and S, unsubstituted or substituted and linked to sulphonamide moiety through one of carbon atoms of benzene ring;and bicyclic group consisting of benzene ring fused with -or 6-membered non-aromatic heterocyclic ring having 1 or 2heteroatoms independently selected from the group consisting of N and O, unsubstituted or substituted, and linked to sulphonamide moiety through one of carbon atoms of benzene ring;R represents H or –CH 3;x is 0 or 1;yis 2 or 3;and pharmaceutically acceptable salts and solvates thereof, with the provisos that if x is 0 and y is 2, then D is naphthyl unsubstituted or substituted with one halogen atom, and if R represents –CH 3, then A is not unsubstituted or substituted phenyl. The compounds can be used in the treatment and/or prophylaxis of central nervous system disorders.
摘要翻译：式（I）的苄胺的磺酰胺衍生物，其中A表示未取代或取代的苯基;或与 - （O）x - （CH 2）y连接的9或10元双环，通过其芳族碳原子之一，由含有1或2个独立地选自N和O的杂原子的含有杂芳环的苯环稠合，其中这样的双环基团是未取代的或取代的，或具有1或2个的5-或6-元非芳族杂环 O原子，其中杂环是未取代的或被一个或多个C 1 -C 3 - 烷基取代; D表示选自以下的基团：未取代或取代的苯基; 未取代或取代的萘基;未取代或取代的噻吩;由5元非芳族碳环稠合的咪唑啉组成的双环; 由与5-元杂芳环稠合的苯环组成的双环基团，具有独立地选自N，O和S的1或2个杂原子，未取代或取代并通过苯环的碳原子连接到磺酰胺部分;和双环由具有1或2个独立选自N和O的未取代或取代的杂原子的6元非芳香杂环稠合的苯环，和通过苯环的碳原子与磺酰胺部分连接的苯环; R表示H或-CH 3; x为0或1; yis 2或3;及其药学上可接受的盐和溶剂合物，条件是如果x为0且y为2，则D为未取代的或被一个卤素取代的萘基原子，如果R表示-CH 3，则A不是未取代的或取代的苯基。所述化合物可用于治疗和/或预防中枢神经系统疾病。

5. 发明授权

EP2828238B1 SULPHONAMIDE DERIVATIVES OF BENZYLAMINE FOR THE TREATMENT OF CNS DISEASES 有权
标题翻译：磺胺苄胺中枢神经系统疾病的治疗
公开(公告)号：EP2828238B1
公开(公告)日：2016-05-25
申请号：EP13721084.5
申请日：2013-03-20
申请人： Adamed Sp. z o.o.
发明人： KOLACZKOWSKI, Marcin , MARCINKOWSKA, Monika , BUCKI, Adam , LYSAKOWSKI, Tomasz , PAWLOWSKI, Maciej
IPC分类号： C07C311/21 , C07D403/12 , C07D413/14 , C07D319/18 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D261/20 , C07D487/04 , C07D209/08 , C07D307/79 , A61K31/18 , A61P25/00
CPC分类号： C07D487/04 , C07C311/21 , C07D209/08 , C07D261/20 , C07D307/79 , C07D319/18 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12

6. 发明公开

EP2726476A2 SULPHONAMIDE DERIVATIVES OF ALICYCLIC AMINES FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISEASES 审中-公开
标题翻译：中枢神经系统的疾病治疗的脂环族胺的磺酰胺衍生物
公开(公告)号：EP2726476A2
公开(公告)日：2014-05-07
申请号：EP12762391.6
申请日：2012-06-29
申请人： Adamed sp. z o.o.
发明人： KOLACZKOWSKI, Marcin , MARCINKOWSKA, Monika , BUCKI, Adam , PAWLOWSKI, Maciej , KRUKOWSKI, Andrzej , RUSIECKI, Rafa , SIWEK, Agata Magdalena , WOLAK, Malgorzata Anna
IPC分类号： C07D403/06
CPC分类号： C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
摘要： Sulphonamide derivatives of alicyclic amines of formula (I), wherein A represents naphthyl or 9- or 10-membered bicyclic group, consisting of benzene ring fused with -or 6-membered heterocyclic ring; D represents phenyl, naphthyl, 5-membered aromatic heterocyclic group, bicyclic group consisting of a ring selected from benzene and pyridine, fused with aromatic or non-aromatic 5-membered heterocyclic ring; r represents 0 or 1; x, z independently represent 1 or 2; n represents 3 and p represents 0, or n represents 2 and p represents 1;and enantiomers, pharmaceutically acceptable salts and solvates thereof. The compounds may be useful for the treatment and/or prevention of the central nervous system disorders (Formula I).

7. 发明公开

EP2828238A1 SULPHONAMIDE DERIVATIVES OF BENZYLAMINE FOR THE TREATMENT OF CNS DISEASES 有权
标题翻译：磺胺苄胺中枢神经系统疾病的治疗
公开(公告)号：EP2828238A1
公开(公告)日：2015-01-28
申请号：EP13721084.5
申请日：2013-03-20
申请人： Adamed Sp. z o.o.
发明人： KOLACZKOWSKI, Marcin , MARCINKOWSKA, Monika , BUCKI, Adam , LYSAKOWSKI, Tomasz , PAWLOWSKI, Maciej
IPC分类号： C07C311/21 , C07D403/12 , C07D413/14 , C07D319/18 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D261/20 , C07D487/04 , C07D209/08 , C07D307/79 , A61K31/18 , A61P25/00
CPC分类号： C07D487/04 , C07C311/21 , C07D209/08 , C07D261/20 , C07D307/79 , C07D319/18 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12
摘要： Sulphonamide derivatives of benzylamine of formula (I), wherein A represents phenyl unsubstituted or substituted;or 9-or 10-membered bicyclic group, linked to –(O)
x - (CH 2 )
y -through one of its aromatic carbon atoms,consisting of benzene ring fused with -membered heteroaromatic ring containing 1 or 2 heteroatoms independently selected from the group consisting of N and O, wherein such bicyclic group is unsubstituted or substituted or with 5-or 6-membered non-aromaticheterocyclic ring having 1 or 2 O atoms, wherein heterocyclic ring is unsubstituted or substituted with one or more C
1 -C
3 - alkyls; D represents a group selected from:phenyl unsubstituted or substituted; naphthyl unsubstituted or substituted;thiophene unsubstituted or substituted;bicyclic group consisting of imidazolering fused with5-membered non-aromatic carbocyclic ring; bicyclic group consisting of benzene ring fused with 5-membered heteroaromatic ring, having 1 or 2heteroatoms independently selected from the group consisting of N, O and S, unsubstituted or substituted and linked to sulphonamide moiety through one of carbon atoms of benzene ring;and bicyclic group consisting of benzene ring fused with -or 6-membered non-aromatic heterocyclic ring having 1 or 2heteroatoms independently selected from the group consisting of N and O, unsubstituted or substituted, and linked to sulphonamide moiety through one of carbon atoms of benzene ring;R represents H or –CH 3;x is 0 or 1;yis 2 or 3;and pharmaceutically acceptable salts and solvates thereof, with the provisos that if x is 0 and y is 2, then D is naphthyl unsubstituted or substituted with one halogen atom, and if R represents –CH 3, then A is not unsubstituted or substituted phenyl. The compounds can be used in the treatment and/or prophylaxis of central nervous system disorders.

8. 发明公开

EP2726457A1 INDOLEAMINE DERIVATIVES FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISEASES 审中-公开
标题翻译： INDOLAMINDERIVATE为中央神经系统疾病的治疗
公开(公告)号：EP2726457A1
公开(公告)日：2014-05-07
申请号：EP12762390.8
申请日：2012-06-28
申请人： Adamed sp. z o.o.
发明人： KOLACZKOWSKI, Marcin , MARCINKOWSKA, Monika , BUCKI, Adam , PAWLOWSKI, Maciej , KAZEK, Grzegorz , BEDNARSKI, Marek , WESOLOWSKA, Anna
IPC分类号： C07D209/30 , C07D403/04 , C07D413/04 , A61K31/404
CPC分类号： C07D401/12 , C07D209/08 , C07D209/30 , C07D403/04 , C07D413/04
摘要： Indoleamine derivatives of formula (IA), wherein R
1 represents benzyl unsubstituted or substituted with halogen atom, -OH, or C
1 -C
3 -alkyl; phenylsulphonyl unsubstituted or substituted in the phenyl ring with halogen atom, -OH or C
1 -C
3 -alkyl; G
1 represents phenoxyalkyl, heteroaryloxyalkyl- or heterocyclyloxyalkyl-piperazine moiety; and pharmaceutically acceptable salts and solvates thereof. The compounds may be useful for the treatment and/or prevention of the central nervous system disorders.

9. 发明公开

EP3530651A1 INDOLE AND BENZIMIDAZOLE DERIVATIVES AS DUAL 5-HT2A AND 5-HT6 RECEPTOR ANTAGONISTS 审中-公开
公开(公告)号：EP3530651A1
公开(公告)日：2019-08-28
申请号：EP18461519.3
申请日：2018-02-21
申请人： Adamed sp. z o.o.
发明人： KOLACZKOWSKI, Marcin , BUCKI, Adam , SNIECIKOWSKA, Joanna , MARCINKOWSKA, Monika
IPC分类号： C07D209/10 , C07D235/10 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61K31/496
摘要： The invention relates to new 4-(piperazin-1-yl)-2-(trifluoromethyl)-1H-indoles and 4-(piperazin-1-yl)-2-(trifluoromethyl)-1H-benzimidazoles represented by formula (I), wherein all symbols and variables are as defined in the description. The compounds can find use in a method of prevention and/or treatment of diseases selected from the group consisting of Alzheimer's disease, Parkinson's disease, Levy body dementia, dementia-related psychosis, schizophrenia, delusional syndromes and other psychotic conditions related and not related to taking psychoactive substances, depression, anxiety disorders of various aetiology, sleep disorders of various aetiology.

10. 发明公开

EP2616440A1 ARYLOSULFONAMIDES FOR THE TREATMENT OF CNS DISEASES 审中-公开
标题翻译： ARYLOSULFONAMIDE为中央神经系统疾病的治疗
公开(公告)号：EP2616440A1
公开(公告)日：2013-07-24
申请号：EP11767950.6
申请日：2011-09-16
申请人： Adamed sp. z o.o.
发明人： KOLACZKOWSKI, Marcin , KOWALSKI, Piotr , JASKOWSKA, Jolanta , MARCINKOWSKA, Monika , MITKA, Katarzyna , BUCKI, Adam , WESOLOWSKA, Anna , PAWLOWSKI, Maciej
IPC分类号： C07D209/40 , C07D235/30 , C07D275/04 , C07D319/20 , C07D413/12 , A61K31/496 , A61P25/00
CPC分类号： C07D401/04 , C07D209/40 , C07D235/30 , C07D263/58 , C07D275/04 , C07D277/82 , C07D319/20 , C07D401/02 , C07D403/02 , C07D405/12 , C07D409/02 , C07D409/12 , C07D409/14 , C07D413/02 , C07D413/04 , C07D413/12 , C07D417/02 , C07D417/12 , C07D417/14 , C07D471/04
摘要： Arylsulphonamide derivatives of formula (I) and pharmaceutically acceptable salts thereof. The compounds may be useful for the treatment and/or prevention of disorders of the central nervous system.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式