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1. 发明专利

DK1175257T4 未知
公开(公告)号：DK1175257T4
公开(公告)日：2008-10-27
申请号：DK00928391
申请日：2000-04-26
申请人： ACUSPHERE INC
发明人： KEEGAN MARK J , CHICKERING DONALD E , RANDALL GREG , BERNSTEIN HOWARD , STRAUB JULIE
IPC分类号： B01J2/04 , F26B3/06 , A61K9/16 , B01D1/18 , F26B17/10 , F26B17/16 , F26B23/10
摘要： Improved spray drying apparati, and methods of use thereof, have been developed. The spray drying equipment includes a primary drying chamber and a secondary drying apparatus which includes tubing having a length sufficient to increase the contact time between the drying gas and the droplets/particles to dry the particles to the extent desired, at a drying rate and temperature which would be too low to provide adequate drying without the secondary drying apparatus. The secondary drying apparatus increases the drying efficiency of the spray dryer system without increasing the drying rate, while minimizing loss in yield The ratio of the length of tubing to the length of the primary drying chamber is at least 2:1. The tubing diameter is substantially smaller than the diameter of the primary drying chamber, such that the particles move at higher velocity through the tubing to minimize product losses. The ratio of the cross-sectional area of the primary drying chamber to the cross-sectional area of the tubing most preferably is about 16:1. The tubing preferably is in a compact coil design, which can more easily be transported and which has minimum space requirements, and may optionally include a jacket to control the temperature of the secondary drying process. A preferred application for the spray drying process and equipment is in the production of polymeric microparticles, between about 1 and 200 mum in diameter, which can be used to deliver therapeutic and diagnostic agents.

2. 发明专利

NO321912B1 未知
公开(公告)号：NO321912B1
公开(公告)日：2006-07-17
申请号：NO20015351
申请日：2001-11-01
申请人： ACUSPHERE INC
发明人： STRAUB JULIE ANN , CHICKERING DONALD E , KEEGAN MARK J , RANDALL GREG , BERNSTEIN HOWARD
IPC分类号： B01J2/04 , F26B3/06 , A61K9/16 , B01D1/18 , F26B17/10 , F26B17/16 , F26B23/10
摘要： Improved spray drying apparati, and methods of use thereof, have been developed. The spray drying equipment includes a primary drying chamber and a secondary drying apparatus which includes tubing having a length sufficient to increase the contact time between the drying gas and the droplets/particles to dry the particles to the extent desired, at a drying rate and temperature which would be too low to provide adequate drying without the secondary drying apparatus. The secondary drying apparatus increases the drying efficiency of the spray dryer system without increasing the drying rate, while minimizing loss in yield The ratio of the length of tubing to the length of the primary drying chamber is at least 2:1. The tubing diameter is substantially smaller than the diameter of the primary drying chamber, such that the particles move at higher velocity through the tubing to minimize product losses. The ratio of the cross-sectional area of the primary drying chamber to the cross-sectional area of the tubing most preferably is about 16:1. The tubing preferably is in a compact coil design, which can more easily be transported and which has minimum space requirements, and may optionally include a jacket to control the temperature of the secondary drying process. A preferred application for the spray drying process and equipment is in the production of polymeric microparticles, between about 1 and 200 mum in diameter, which can be used to deliver therapeutic and diagnostic agents.

3. 发明专利

NZ515684A Spray drying apparatus and methods of use 未知
公开(公告)号：NZ515684A
公开(公告)日：2003-05-30
申请号：NZ51568400
申请日：2000-04-26
申请人： ACUSPHERE INC
发明人： CHICKERING DONALD E , KEEGAN MARK J , RANDALL GREG , BERNSTEIN HOWARD , STRAUB JULIE
IPC分类号： F26B3/06 , A61K9/16 , B01D1/18 , B01J2/04 , F26B17/10 , F26B17/16 , F26B23/10
摘要： Improved spray drying apparati, and methods of use thereof, have been developed. The spray drying equipment includes a primary drying chamber and a secondary drying apparatus which includes tubing having a length sufficient to increase the contact time between the drying gas and the droplets/particles to dry the particles to the extent desired, at a drying rate and temperature which would be too low to provide adequate drying without the secondary drying apparatus. The secondary drying apparatus increases the drying efficiency of the spray dryer system without increasing the drying rate, while minimizing loss in yield The ratio of the length of tubing to the length of the primary drying chamber is at least 2:1. The tubing diameter is substantially smaller than the diameter of the primary drying chamber, such that the particles move at higher velocity through the tubing to minimize product losses. The ratio of the cross-sectional area of the primary drying chamber to the cross-sectional area of the tubing most preferably is about 16:1. The tubing preferably is in a compact coil design, which can more easily be transported and which has minimum space requirements, and may optionally include a jacket to control the temperature of the secondary drying process. A preferred application for the spray drying process and equipment is in the production of polymeric microparticles, between about 1 and 200 micro-metres in diameter, which can be used to deliver therapeutic and diagnostic agents.

4. 发明专利

ES2216889T5 APARATO DE SECADO POR PULVERIZACION Y SUS PROCEDIMIENTOS DE UTILIZACION. 未知
公开(公告)号：ES2216889T5
公开(公告)日：2009-03-01
申请号：ES00928391
申请日：2000-04-26
申请人： ACUSPHERE INC
发明人： CHICKERING DONALD E , KEEGAN MARK J , RANDALL GREG , BERNSTEIN HOWARD , STRAUB JULIE
IPC分类号： B01J2/04 , F26B3/06 , A61K9/16 , B01D1/18 , F26B17/10 , F26B17/16 , F26B23/10
摘要： Un aparato de secado por pulverización que comprende: una cámara de secado primaria que tiene un espacio de flujo interno que termina en una salida de descarga, y una cámara de secado secundaria que comprende una tubería que tiene una entrada en comunicación fluida con la salida de descarga de la cámara de secado, donde la relación del área de sección transversal de la cámara de secado primaria con respecto al área de sección transversal de la tubería es al menos 4:3, y donde la relación de la longitud de la tubería con respecto a la longitud de la cámara de secado primaria es al menos 2:1.

5. 发明专利

BR0011226A 未知
公开(公告)号：BR0011226A
公开(公告)日：2002-05-07
申请号：BR0011226
申请日：2000-04-26
申请人： ACUSPHERE INC
发明人： CHICKERING DONALD E , KEEGAN MARK J , RANDALL GREG , BERNSTEIN HOWARD , STRAUB JULIE
IPC分类号： F26B3/06 , A61K9/16 , B01D1/18 , B01J2/04 , F26B17/10 , F26B17/16 , F26B23/10
摘要： Improved spray drying apparati, and methods of use thereof, have been developed. The spray drying equipment includes a primary drying chamber and a secondary drying apparatus which includes tubing having a length sufficient to increase the contact time between the drying gas and the droplets/particles to dry the particles to the extent desired, at a drying rate and temperature which would be too low to provide adequate drying without the secondary drying apparatus. The secondary drying apparatus increases the drying efficiency of the spray dryer system without increasing the drying rate, while minimizing loss in yield The ratio of the length of tubing to the length of the primary drying chamber is at least 2:1. The tubing diameter is substantially smaller than the diameter of the primary drying chamber, such that the particles move at higher velocity through the tubing to minimize product losses. The ratio of the cross-sectional area of the primary drying chamber to the cross-sectional area of the tubing most preferably is about 16:1. The tubing preferably is in a compact coil design, which can more easily be transported and which has minimum space requirements, and may optionally include a jacket to control the temperature of the secondary drying process. A preferred application for the spray drying process and equipment is in the production of polymeric microparticles, between about 1 and 200 mum in diameter, which can be used to deliver therapeutic and diagnostic agents.

6. 发明专利

NO20015351A 未知
公开(公告)号：NO20015351A
公开(公告)日：2001-01-02
申请号：NO20015351
申请日：2001-11-01
申请人： ACUSPHERE INC
发明人： CHICKERING DONALD E , KEEGAN MARK J , RANDALL GREG , BERNSTEIN HOWARD , STRAUB JULIE
IPC分类号： F26B3/06 , A61K9/16 , B01D1/18 , B01J2/04 , F26B17/10 , F26B17/16 , F26B23/10
CPC分类号： B01J2/04 , B01D1/18

7. 发明专利

ZA200109553B Spray drying apparatus and methods of use. 未知
公开(公告)号：ZA200109553B
公开(公告)日：2003-06-06
申请号：ZA200109553
申请日：2001-11-20
申请人： ACUSPHERE INC
发明人： CHICKERING DONALD E , KEEGAN MARK J , RANDALL GREG , BERNSTEIN HOWARD , STRAUB JULIE
IPC分类号： F26B3/06 , A61K9/16 , B01D1/18 , B01J2/04 , F26B17/10 , F26B17/16 , F26B23/10 , B01D , B01J
摘要： Improved spray drying apparati, and methods of use thereof, have been developed. The spray drying equipment includes a primary drying chamber and a secondary drying apparatus which includes tubing having a length sufficient to increase the contact time between the drying gas and the droplets/particles to dry the particles to the extent desired, at a drying rate and temperature which would be too low to provide adequate drying without the secondary drying apparatus. The secondary drying apparatus increases the drying efficiency of the spray dryer system without increasing the drying rate, while minimizing loss in yield The ratio of the length of tubing to the length of the primary drying chamber is at least 2:1. The tubing diameter is substantially smaller than the diameter of the primary drying chamber, such that the particles move at higher velocity through the tubing to minimize product losses. The ratio of the cross-sectional area of the primary drying chamber to the cross-sectional area of the tubing most preferably is about 16:1. The tubing preferably is in a compact coil design, which can more easily be transported and which has minimum space requirements, and may optionally include a jacket to control the temperature of the secondary drying process. A preferred application for the spray drying process and equipment is in the production of polymeric microparticles, between about 1 and 200 mum in diameter, which can be used to deliver therapeutic and diagnostic agents.

8. 发明专利

NO20015351D0 未知
公开(公告)号：NO20015351D0
公开(公告)日：2001-11-01
申请号：NO20015351
申请日：2001-11-01
申请人： ACUSPHERE INC
发明人： CHICKERING DONALD E , KEEGAN MARK J , RANDALL GREG , BERNSTEIN HOWARD , STRAUB JULIE
IPC分类号： F26B3/06 , A61K9/16 , B01D1/18 , B01J2/04 , F26B17/10 , F26B17/16 , F26B23/10 , B01J
摘要： Improved spray drying apparati, and methods of use thereof, have been developed. The spray drying equipment includes a primary drying chamber and a secondary drying apparatus which includes tubing having a length sufficient to increase the contact time between the drying gas and the droplets/particles to dry the particles to the extent desired, at a drying rate and temperature which would be too low to provide adequate drying without the secondary drying apparatus. The secondary drying apparatus increases the drying efficiency of the spray dryer system without increasing the drying rate, while minimizing loss in yield The ratio of the length of tubing to the length of the primary drying chamber is at least 2:1. The tubing diameter is substantially smaller than the diameter of the primary drying chamber, such that the particles move at higher velocity through the tubing to minimize product losses. The ratio of the cross-sectional area of the primary drying chamber to the cross-sectional area of the tubing most preferably is about 16:1. The tubing preferably is in a compact coil design, which can more easily be transported and which has minimum space requirements, and may optionally include a jacket to control the temperature of the secondary drying process. A preferred application for the spray drying process and equipment is in the production of polymeric microparticles, between about 1 and 200 mum in diameter, which can be used to deliver therapeutic and diagnostic agents.

9. 发明专利

NO20015351L 未知
公开(公告)号：NO20015351L
公开(公告)日：2001-01-02
申请号：NO20015351
申请日：2001-11-01
申请人： ACUSPHERE INC
发明人： CHICKERING DONALD E , KEEGAN MARK J , RANDALL GREG , BERNSTEIN HOWARD , STRAUB JULIE
IPC分类号： F26B3/06 , A61K9/16 , B01D1/18 , B01J2/04 , F26B17/10 , F26B17/16 , F26B23/10
摘要： Improved spray drying apparati, and methods of use thereof, have been developed. The spray drying equipment includes a primary drying chamber and a secondary drying apparatus which includes tubing having a length sufficient to increase the contact time between the drying gas and the droplets/particles to dry the particles to the extent desired, at a drying rate and temperature which would be too low to provide adequate drying without the secondary drying apparatus. The secondary drying apparatus increases the drying efficiency of the spray dryer system without increasing the drying rate, while minimizing loss in yield The ratio of the length of tubing to the length of the primary drying chamber is at least 2:1. The tubing diameter is substantially smaller than the diameter of the primary drying chamber, such that the particles move at higher velocity through the tubing to minimize product losses. The ratio of the cross-sectional area of the primary drying chamber to the cross-sectional area of the tubing most preferably is about 16:1. The tubing preferably is in a compact coil design, which can more easily be transported and which has minimum space requirements, and may optionally include a jacket to control the temperature of the secondary drying process. A preferred application for the spray drying process and equipment is in the production of polymeric microparticles, between about 1 and 200 mum in diameter, which can be used to deliver therapeutic and diagnostic agents.

10. 发明专利

ES2216889T3 未知
公开(公告)号：ES2216889T3
公开(公告)日：2004-11-01
申请号：ES00928391
申请日：2000-04-26
申请人： ACUSPHERE INC
发明人： CHICKERING DONALD E , KEEGAN MARK J , RANDALL GREG , BERNSTEIN HOWARD , STRAUB JULIE
IPC分类号： F26B3/06 , A61K9/16 , B01D1/18 , B01J2/04 , F26B17/10 , F26B17/16 , F26B23/10
摘要： Improved spray drying apparati, and methods of use thereof, have been developed. The spray drying equipment includes a primary drying chamber and a secondary drying apparatus which includes tubing having a length sufficient to increase the contact time between the drying gas and the droplets/particles to dry the particles to the extent desired, at a drying rate and temperature which would be too low to provide adequate drying without the secondary drying apparatus. The secondary drying apparatus increases the drying efficiency of the spray dryer system without increasing the drying rate, while minimizing loss in yield The ratio of the length of tubing to the length of the primary drying chamber is at least 2:1. The tubing diameter is substantially smaller than the diameter of the primary drying chamber, such that the particles move at higher velocity through the tubing to minimize product losses. The ratio of the cross-sectional area of the primary drying chamber to the cross-sectional area of the tubing most preferably is about 16:1. The tubing preferably is in a compact coil design, which can more easily be transported and which has minimum space requirements, and may optionally include a jacket to control the temperature of the secondary drying process. A preferred application for the spray drying process and equipment is in the production of polymeric microparticles, between about 1 and 200 mum in diameter, which can be used to deliver therapeutic and diagnostic agents.

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