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1. 发明申请

WO2010115184A3 HYDROXYTHIENOQUINOLONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS 审中-公开
标题翻译：羟肟酸和相关化合物作为抗感染剂
公开(公告)号：WO2010115184A3
公开(公告)日：2011-03-24
申请号：PCT/US2010029938
申请日：2010-04-05
申请人： ACHILLION PHARMACEUTICALS INC , BRADBURY BARTON JAMES , DESHPANDE MILIND , HASHIMOTO AKIHIRO , KIM HA YOUNG , LUCIEN EDLAINE , PAIS GODWIN , PUCCI MICHAEL , WANG QIUPING , WILES JASON ALLAN , PHADKE AVINASH
发明人： BRADBURY BARTON JAMES , DESHPANDE MILIND , HASHIMOTO AKIHIRO , KIM HA YOUNG , LUCIEN EDLAINE , PAIS GODWIN , PUCCI MICHAEL , WANG QIUPING , WILES JASON ALLAN , PHADKE AVINASH
IPC分类号： C07D495/04 , A61P29/00 , C07D495/14 , C07D495/16
CPC分类号： A61K31/4743 , A61K31/496 , C07D495/04 , C07D498/16 , C07D519/00
摘要： Disclosed herein are hydroxythienoquinolones and related compounds and their pharmaceutically acceptable salts useful as antiviral agents and having the general formula (I) in which the variables R2, R6, and R7 are defined herein. Certain compounds provided herein possess potent antibacterial, antiprotozoal, or antifungal activity and are particularly efficacious for the treatment of MRSA infections. The invention also provides pharmaceutical compositions, pharmaceutical compositions containing a hydroxythienoquinolone in combination with one or more other active agent, and methods of treating microbial infections in animals by administering an effective amount of a hydroxythienoquinolone or related compound to an animal suffering from a microbial infection.
摘要翻译：本文公开了羟基噻吩并喹啉酮及其可药用盐，其可用作抗病毒剂并具有通式（I），其中变量R2，R6和R7在本文中定义。本文提供的某些化合物具有有效的抗细菌，抗原生动物或抗真菌活性，并且对于治疗MRSA感染特别有效。本发明还提供药物组合物，含有羟基噻吩并喹啉酮与一种或多种其它活性剂的药物组合物，以及通过向有微生物感染的动物施用有效量的羟基噻吩并喹啉酮或相关化合物来治疗动物微生物感染的方法。

2. 发明申请

WO2008036420A3 9-(HETEROARYL)-ISOTHIAZOLO[5,4-B]QUINOLINE-3,4-DIONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS 审中-公开
标题翻译： 9-（杂芳基） - 异噻唑并[5,4-B]喹啉-3,4-二酮及作为抗感染剂的相关化合物
公开(公告)号：WO2008036420A3
公开(公告)日：2008-05-22
申请号：PCT/US2007020611
申请日：2007-09-21
申请人： ACHILLION PHARMACEUTICALS INC , BRADBURY BARTON JAMES , WANG QIUPING , WILES JASON ALLAN , HASHIMOTO AKIHIRO , LUCIEN EDLAINE , PAIS GODWIN CLARENCE GILROY , KIM HA YOUNG
发明人： BRADBURY BARTON JAMES , WANG QIUPING , WILES JASON ALLAN , HASHIMOTO AKIHIRO , LUCIEN EDLAINE , PAIS GODWIN CLARENCE GILROY , KIM HA YOUNG
IPC分类号： C07D513/04 , A61K31/428 , A61P31/04
CPC分类号： C07D513/04
摘要： The invention provides compounds and salts of Formula (I) and Formula (II); which possess antimicrobial activity. The invention also provides novel synthetic intermediates useful in making compounds of Formula (I) and Formula (II). The variables R 2 , R 3 , R 5 , R 6 , R 7 , A 8 and R 9 are defined herein. Certain compounds of Formula (I) and Formula (II) disclosed herein are potent and/or selective inhibitors of bacterial DNA synthesis and bacterial replication. The invention also provides antimicrobial compositions, including pharmaceutical compositions, containing one or more compounds of Formula (I) or Formula (II) and one or more carriers, excipients, or diluents. Such compositions may contain a compound of Formula (I) or Formula (II) as the only active agent or may contain a combination of a compound of Formula (I) or Formula (II) and one or more other active agents. The invention also provides methods for treating microbial infections in animals.
摘要翻译：本发明提供了式（I）和式（II）的化合物和盐; 具有抗菌活性。本发明还提供了用于制备式（I）和式（II）化合物的新型合成中间体。变量R _{2 ，R _{3 ，R _{5 ，R _{6 ，R _{7 ，A _{8 和R _{9 在本文中定义。本文公开的某些式（I）和式（II）化合物是细菌DNA合成和细菌复制的有效和/或选择性抑制剂。本发明还提供了包含一种或多种式（I）或式（II）化合物和一种或多种载体，赋形剂或稀释剂的抗微生物组合物，包括药物组合物。这样的组合物可含有作为唯一活性剂的式（I）或式（II）化合物或可含有式（I）或式（II）化合物与一种或多种其它活性剂的组合。本发明还提供了治疗动物微生物感染的方法。}}}}}}}

3. 发明申请

WO2010068760A3 NEW 4-AMINO-4-OXOBUTANOYL PEPTIDES AS INHIBITORS OF VIRAL REPLICATION 审中-公开
标题翻译：新的4-氨基-4-氧代丁酰基肽作为病毒复制的抑制剂
公开(公告)号：WO2010068760A3
公开(公告)日：2010-10-14
申请号：PCT/US2009067506
申请日：2009-12-10
申请人： ACHILLION PHARMACEUTICALS INC , PHADKE AVINASH , CHEN DAWEI , GADHACHANDA VENKAT , HASHIMOTO AKIHIRO , PAIS GODWIN , WANG XIANGZHU , AGARWAL ATUL , KIM HA YOUNG , LI SHOUMING , LIU CUIXIAN , ZHANG SUOMING , DESHPANDE MILIND
发明人： PHADKE AVINASH , CHEN DAWEI , GADHACHANDA VENKAT , HASHIMOTO AKIHIRO , PAIS GODWIN , WANG XIANGZHU , AGARWAL ATUL , KIM HA YOUNG , LI SHOUMING , LIU CUIXIAN , ZHANG SUOMING , DESHPANDE MILIND
IPC分类号： C07D403/14 , A61K31/437 , A61P31/12 , C07D413/14
CPC分类号： C07D207/16 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/08 , C07D487/08 , C07D487/18 , C07D491/113
摘要： The invention provides 4-amino-4-oxobutanoyl peptides of Formula I and the pharmaceutically salts and hydrates thereof. The variables R, R1, R6-R8, R16, R18, R19, M, n, T, Y, and Z are defined herein. Certain compounds of Formula I are useful as antiviral agents. The 4-amino-4-oxobutanoyl peptides disclosed herein are potent and/ or selective inhibitors of viral replication, particularly Hepatitis C virus replication. The invention also provides pharmaceutical compositions containing one or more 4-amino-4-oxobutanoyl peptides and one or more pharmaceutically acceptable carriers. Such pharmaceutical compositions may contain a 4-amino-4-oxobutanoyl peptides as the only active agent or may contain a combination of a 4-amino-4-oxobutanoyl peptides and one or more other pharmaceutically active agents. The invention also provides methods for treating viral infections, including Hepatitis C infections.
摘要翻译：本发明提供式I的4-氨基-4-氧代丁酰基肽及其药用盐和水合物。变量R，R1，R6-R8，R16，R18，R19，M，n，T，Y和Z在本文中定义。式I的某些化合物可用作抗病毒剂。本文公开的4-氨基-4-氧代丁酰基肽是病毒复制的有效和/或选择性抑制剂，特别是丙型肝炎病毒复制。本发明还提供了含有一种或多种4-氨基-4-氧代丁酰基肽和一种或多种药学上可接受的载体的药物组合物。这种药物组合物可以含有4-氨基-4-氧代丁酰基肽作为唯一的活性剂或可以含有4-氨基-4-氧代丁酰基肽和一种或多种其他药物活性剂的组合。本发明还提供了治疗病毒感染（包括丙型肝炎感染）的方法。

4. 发明申请

WO2010147384A3 INSTRUMENT CONNECTION TYPE UNIT PACK COMBINED CELL CARTRIDGE 审中-公开
标题翻译：仪器连接型单元组合电池盒
公开(公告)号：WO2010147384A3
公开(公告)日：2011-03-31
申请号：PCT/KR2010003872
申请日：2010-06-16
申请人： ICEL SYSTEMS KOREA INC , KANG JEONG WOOK , LEE CHAN GEE , KIM DUK CHUL , JANG YONG HO , KIM HA YOUNG , KIM TAE HOON
发明人： KANG JEONG WOOK , LEE CHAN GEE , KIM DUK CHUL , JANG YONG HO , KIM HA YOUNG , KIM TAE HOON
IPC分类号： H01M10/00
CPC分类号： H01M2/202 , H01M2/1077 , H01M2/206 , H01M10/613 , H01M10/627 , H01M10/643 , H01M10/647 , H01M10/6562
摘要： The present invention relates to an instrument connection type unit pack combined cell cartridge assembled into a compound cell interconnection mesh, and to a combined cartridge electricity storage device assembled into a compound unit interconnection mesh in which a plurality of cell cartridges are electrically interconnected. The unit pack combined cell cartridge of the present invention is configured such that a plurality of cells are interconnected into a unit pack using a suitable device (bus bar), and a plurality of unit packs are interconnected into a unitary cartridge using a suitable device (intermediate conductor plate). The combined cartridge electricity storage device of the present invention is configured such that a plurality of unit pack combined cartridges are accommodated in an outer case and interconnected into a serial or parallel compound interconnection structure to form a unitary system. The present invention interconnects cells, unit packs and cartridges using an easily connectible or separable instrument, to thereby allow for ease of assembly and improve productivity. In addition, the number of cells used in a unit pack, the number of unit packs used in a cartridge, and the number of cartridges used in an electricity storage device can be adjusted and changed to change current capacity and voltage capacity with ease.
摘要翻译：本发明涉及一种装配在复合电池互连网中的仪器连接型单元组合电池盒，以及组装在多个电池盒电互连的复合单元互连网中的组合式盒式蓄电装置。本发明的单元组合式电池盒被配置为使得使用合适的装置（母线）将多个电池互连成单元组，并且使用合适的装置将多个单元组件互连成一体式盒中间导体板）。本发明的组合式磁带蓄电装置被构造为使得多个单元组合的盒被容纳在外壳中并且互连成串联或并联的复合互连结构以形成整体系统。本发明使用易于连接或可分离的仪器来互连电池，单元组件和盒，从而容易组装并提高生产率。此外，可以调节和改变在单元包中使用的单元数量，在盒中使用的单元包的数量以及在蓄电装置中使用的盒的数量，以便容易地改变电流容量和电压容量。

5. 发明公开

EP2364309A4 NEW 4-AMINO-4-OXOBUTANOYL PEPTIDES AS INHIBITORS OF VIRAL REPLICATION 有权
标题翻译：新的4-氨基-4-氧丁肽作为病毒复制抑制剂
公开(公告)号：EP2364309A4
公开(公告)日：2012-08-29
申请号：EP09832541
申请日：2009-12-10
申请人： ACHILLION PHARMACEUTICALS INC
发明人： PHADKE AVINASH , CHEN DAWEI , GADHACHANDA VENKAT , HASHIMOTO AKIHIRO , PAIS GODWIN , WANG XIANGZHU , AGARWAL ATUL , KIM HA YOUNG , LI SHOUMING , LIU CUIXIAN , ZHANG SUOMING , DESHPANDE MILIND
IPC分类号： C07D403/14 , A61K38/05 , C07D403/12 , C07D417/14 , C07K5/06
CPC分类号： C07D207/16 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/08 , C07D487/08 , C07D487/18 , C07D491/113

6. 发明公开

EP2414368A4 HYDROXYTHIENOQUINOLONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS 有权
标题翻译： HYDROXYTHIENCHINOLONE及相关化合物作为抗发炎剂
公开(公告)号：EP2414368A4
公开(公告)日：2012-09-19
申请号：EP10759532
申请日：2010-04-05
申请人： ACHILLION PHARMACEUTICALS INC
发明人： BRADBURY BARTON JAMES , DESHPANDE MILIND , HASHIMOTO AKIHIRO , KIM HA YOUNG , LUCIEN EDLAINE , PAIS GODWIN , PUCCI MICHAEL , WANG QIUPING , WILES JASON ALLAN , PHADKE AVINASH
IPC分类号： C07D495/04 , A61P29/00 , C07D495/14 , C07D495/16
CPC分类号： A61K31/4743 , A61K31/496 , C07D495/04 , C07D498/16 , C07D519/00

7. 发明专利

BRPI0922912A2 peptídeos de 4-amino-4-oxobutanoil como inibidores de replicação viral 未知
公开(公告)号：BRPI0922912A2
公开(公告)日：2016-01-26
申请号：BRPI0922912
申请日：2009-12-10
申请人： ACHILLION PHARMACEUTICALS INC
发明人： HASHIMOTO AKIHIRO , AGARWAL ATUL , PHADKE AVINASH , CHEN DAWEI , PAIS GODWIN , KIM HA YOUNG , DESHPANDE MILIND , LI SHOUMING , GADHACHANDA VENKAT , WANG XIANGZHU
IPC分类号： C07D403/14 , A61K31/437 , A61P31/12 , C07D413/14

8. 发明专利

PL2364309T3 Nowe peptydy 4-amino-4-oksobutanoilowe jako inhibitory wirusowej replikacji 未知
公开(公告)号：PL2364309T3
公开(公告)日：2015-03-31
申请号：PL09832541
申请日：2009-12-10
申请人： ACHILLION PHARMACEUTICALS INC
发明人： PHADKE AVINASH , CHEN DAWEI , GADHACHANDA VENKAT , HASHIMOTO AKIHIRO , PAIS GODWIN , WANG XIANGZHU , AGARWAL ATUL , KIM HA YOUNG , LI SHOUMING , LIU CUIXIAN , ZHANG SUOMING , DESHPANDE MILIND
IPC分类号： C07D403/14 , A61K38/05 , A61P31/12 , C07D403/12 , C07D417/14 , C07K5/06

9. 发明专利

AU2009324643B2 New 4-amino-4-oxobutanoyl peptides as inhibitors of viral replication 未知
公开(公告)号：AU2009324643B2
公开(公告)日：2014-08-28
申请号：AU2009324643
申请日：2009-12-10
申请人： ACHILLION PHARMACEUTICALS INC
发明人： PHADKE AVINASH , CHEN DAWEI , GADHACHANDA VENKAT , HASHIMOTO AKIHIRO , PAIS GODWIN , WANG XIANGZHU , AGARWAL ATUL , KIM HA YOUNG , LI SHOUMING , LIU CUIXIAN , ZHANG SUOMING , DESHPANDE MILIND
IPC分类号： C07D403/14 , A61K31/437 , A61P31/12 , C07D413/14
摘要： The invention provides 4-amino-4-oxobutanoyl peptides of Formula I and the pharmaceutically salts and hydrates thereof. The variables R, R

10. 发明专利

HK1160855A1 HYDROXYTHIENOQUINOLONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS HYDROXYTHIENOQUINOLONES 未知
公开(公告)号：HK1160855A1
公开(公告)日：2012-08-17
申请号：HK12101285
申请日：2012-02-09
申请人： ACHILLION PHARMACEUTICALS INC
发明人： BRADBURY BARTON JAMES , DESHPANDE MILIND , HASHIMOTO AKIHIRO , KIM HA YOUNG , LUCIEN EDLAINE , PAIS GODWIN , PUCCI MICHAEL , WANG QIUPING , WILES JASON ALLAN , PHADKE AVINASH
IPC分类号： C07D20060101 , A61P20060101
摘要： Disclosed herein are hydroxylthienoquinolones and related compounds and their pharmaceutically acceptable salts useful as antiviral agents and having the general formula in which the variables R2, R6, and R7 are defined herein. Certain compounds provided herein possess potent antibacterial, antiprotozoal, or antifungal activity and are particularly efficacious for the treatment of MRSA infections. The invention also provides pharmaceutical compositions, pharmaceutical compositions containing a hydroxylthienoquinolone in combination with one or more other active agent, and methods of treating microbial infections in animals by administering an effective amount of a hydroxylthienoquinolone or related compound to an animal suffering from a microbial infection.

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