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1. 发明申请

WO2009147248A2 AMINO ACID SEQUENCES DIRECTED AGAINST ENVELOPE PROTEINS OF A VIRUS AND POLYPEPTIDES COMPRISING THE SAME FOR THE TREATMENT OF VIRAL DISEASES 审中-公开
标题翻译：针对病毒感染的病毒和包含病毒的多肽的氨基酸序列指导治疗病毒
公开(公告)号：WO2009147248A2
公开(公告)日：2009-12-10
申请号：PCT/EP2009056975
申请日：2009-06-05
申请人： ABLYNX NV , HULTBERG ANNA , MAASSEN BRAM , VANLANDSCHOOT PETER , DEPLA ERIK , STORTELERS CATELIJNE , VERRIPS CORNELIS THEODORUS , VAN GUCHT STEVEN , MELERO JOSE , SAUNDERS MICHAEL JOHN SCOTT , DE HAARD JOHANNES JOSEPH WILHE , WEISS ROBERT ANTHONY , TEMPERTON NIGEL JAMES , SAELENS XAVIER , SCHEPENS BERT , SZYROKI ALEXANDER , HARMSEN MICHAEL MARIE
发明人： HULTBERG ANNA , MAASSEN BRAM , VANLANDSCHOOT PETER , DEPLA ERIK , STORTELERS CATELIJNE , VERRIPS CORNELIS THEODORUS , VAN GUCHT STEVEN , MELERO JOSE , SAUNDERS MICHAEL JOHN SCOTT , DE HAARD JOHANNES JOSEPH WILHELMUS , WEISS ROBERT ANTHONY , TEMPERTON NIGEL JAMES , SAELENS XAVIER , SCHEPENS BERT , SZYROKI ALEXANDER , HARMSEN MICHAEL MARIE
IPC分类号： A61K39/395 , C07K16/08
CPC分类号： C07K16/1027 , A61K2039/505 , A61K2039/507 , C07K16/10 , C07K16/1009 , C07K16/1018 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/565 , C07K2317/569 , C07K2317/622 , C07K2317/64 , C07K2317/76 , C07K2317/92 , C07K2319/00
摘要： The present invention relates in part to amino acid sequences that are directed against and/or that can specifically bind to an envelope protein of a virus, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences.
摘要翻译：本发明部分地涉及针对和/或可以特异性结合病毒的包膜蛋白的氨基酸序列，以及包含或基本上由以下组成的化合物或构建体，特别是蛋白质和多肽的氨基酸序列一个或多个这样的氨基酸序列。

2. 发明申请

WO2010142551A2 AMINO ACID SEQUENCES DIRECTED AGAINST RECEPTORS TO CYTOKINES BELONGING TO THE IL-17 FAMILY 审中-公开
标题翻译：指导针对IL-17家族的细胞因子受体的氨基酸序列
公开(公告)号：WO2010142551A2
公开(公告)日：2010-12-16
申请号：PCT/EP2010057538
申请日：2010-05-31
申请人： ABLYNX NV , HULTBERG ANNA , MAASSEN BRAM , SAUNDERS MICHAEL JOHN SCOTT , DE HAARD JOHANNES JOSEPH WILHELMUS , VANLANDSCHOOT PETER
发明人： HULTBERG ANNA , MAASSEN BRAM , SAUNDERS MICHAEL JOHN SCOTT , DE HAARD JOHANNES JOSEPH WILHELMUS , VANLANDSCHOOT PETER
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , C07K2317/22 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to amino acid sequences that are directed against (as defined herein) the IL-17 receptors, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences (also referred to herein as "amino acid sequences of the invention", "immunoglobulin single variable domain of the invention", '"compounds of the invention'', and ''polypeptides of the invention", respectively).
摘要翻译：本发明涉及针对（如本文所定义）IL-17受体的氨基酸序列以及包含或基本上由一个或多个这样的氨基酸组成的化合物或构建体，特别是蛋白质和多肽的氨基酸序列序列（本文中也分别称为“本发明的氨基酸序列”，“本发明的免疫球蛋白单可变结构域”，“本发明化合物”和“本发明多肽”）。

3. 发明申请

WO2010142551A8 AMINO ACID SEQUENCES DIRECTED AGAINST RECEPTORS TO CYTOKINES BELONGING TO THE IL-17 FAMILY 审中-公开
标题翻译：指导针对IL-17家族的细胞因子受体的氨基酸序列
公开(公告)号：WO2010142551A8
公开(公告)日：2011-04-21
申请号：PCT/EP2010057538
申请日：2010-05-31
申请人： ABLYNX NV , HULTBERG ANNA , MAASSEN BRAM , SAUNDERS MICHAEL JOHN SCOTT , DE HAARD JOHANNES JOSEPH WILHELMUS , VANLANDSCHOOT PETER
发明人： HULTBERG ANNA , MAASSEN BRAM , SAUNDERS MICHAEL JOHN SCOTT , DE HAARD JOHANNES JOSEPH WILHELMUS , VANLANDSCHOOT PETER
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , C07K2317/22 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to amino acid sequences that are directed against (as defined herein) the IL-17 receptors, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences (also referred to herein as "amino acid sequences of the invention", "immunoglobulin single variable domain of the invention", '"compounds of the invention'', and ''polypeptides of the invention", respectively).
摘要翻译：本发明涉及针对（如本文所定义）IL-17受体以及包含或基本上由一个或多个这样的氨基酸组成的化合物或构建体，特别是蛋白质和多肽的氨基酸序列序列（本文中也分别称为“本发明的氨基酸序列”，“本发明的免疫球蛋白单可变结构域”，“本发明化合物”和“本发明的多肽”）。

4. 发明申请

WO2009135953A3 AMINO ACID SEQUENCES DIRECTED AGAINST INTEGRINS AND USES THEREOF 审中-公开
标题翻译：氨基酸序列针对整合体及其用途
公开(公告)号：WO2009135953A3
公开(公告)日：2010-02-04
申请号：PCT/EP2009055679
申请日：2009-05-11
申请人： ABLYNX NV , VANLANDSCHOOT PETER , SAUNDERS MICHAEL JOHN SCOTT , DE HAARD JOHANNES JOSEPH WILHE , BLANCHETOT CHRISTOPH , VERRIPS THEO
发明人： VANLANDSCHOOT PETER , SAUNDERS MICHAEL JOHN SCOTT , DE HAARD JOHANNES JOSEPH WILHELMUS , BLANCHETOT CHRISTOPH , VERRIPS THEO
IPC分类号： C07K16/28
CPC分类号： C07K16/2839 , C07K16/2842 , C07K16/2845 , C07K2317/22 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/76
摘要： Description of amino acid sequences that are directed against (as defined herein) Integrins, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences.
摘要翻译：涉及（如本文所定义）的整合素以及包含或基本上由一个或多个这样的氨基酸序列组成的化合物或构建体，特别是蛋白质和多肽的氨基酸序列的描述。

5. 发明申请

WO2009124931A2 AMINO ACID SEQUENCES DIRECTED AGAINST THE NOTCH PATHWAYS AND USES THEREOF 审中-公开
标题翻译：针对麻雀路径的氨基酸序列及其用途
公开(公告)号：WO2009124931A2
公开(公告)日：2009-10-15
申请号：PCT/EP2009054139
申请日：2009-04-07
申请人： ABLYNX NV , SAUNDERS MICHAEL JOHN SCOTT , DE HAARD JOHANNES JOSEPH WILHE , DOLK EDWARD , DE BRUIN RENEE , VANLANDSCHOOT PETER
发明人： SAUNDERS MICHAEL JOHN SCOTT , DE HAARD JOHANNES JOSEPH WILHELMUS , DOLK EDWARD , DE BRUIN RENEE , VANLANDSCHOOT PETER
IPC分类号： C07K16/28
CPC分类号： C07K16/28 , C07K16/2896 , C07K2317/22 , C07K2317/569 , C07K2317/76
摘要： The present invention relates to amino acid sequences (also referred to herein as "single variable domain(s) of the invention", "Nanobody of the invention" or "Nanobodies of the invention ", ilpolypeptide(s) of the invention") that are directed against (as defined herein) members of the Notch signalling pathway such as the four mammalian members of the Notch Receptors (Notch-1, Notch-2, Notch-3, Notch-4, hereinafter also "Notch Receptors") and the five mammalian members of the Notch Ligands (the Delta-like family with "DLL1", "DLL3", "DLL4" wherein "DLL" stands for Delta-like ligand; the Jagged family with "Jagged-1", "Jagged-2", hereinafter also "Notch Ligands"), as well as to constructs that comprise or essentially consist of one or more such single variable domain(s) (also referred to herein as "construct of the invention " and "constructs of the invention", "Nanobody of the invention " or "Nanobodies of the invention",, respectively). In particular, this invention relates to Notch pathway interfering single variable domains down- or up-regulating Notch signaling (also referred to herein as "Notch-antagonists" or "Notch-agonists").
摘要翻译：本发明涉及氨基酸序列（本文中也称为“本发明的单可变结构域”，“本发明的纳米抗体”或“本发明的纳米抗体”，本发明的多聚肽“），针对（如本文所定义）Notch信号传导途径的成员，例如Notch受体（Notch-1，Notch-2，Notch-3，Notch-4，以下也称为“Notch受体”）的四种哺乳动物成员和 Notch Ligands的五个哺乳动物成员（具有“DLL1”，“DLL3”，“DLL4”的三角形家族，其中“DLL”代表三角形配体;具有“Jagged-1”，“Jagged-2” “，以下也称为”Notch Ligands“），以及包含或基本上由一个或多个这样的单可变结构域（本文中也称为”本发明的构建体“和”本发明的构建体“）构成的构建体，，“本发明的纳米抗体”或“本发明的纳米抗体”），特别涉及Notch 途径干扰单可变区下调或上调Notch信号传导（本文也称为“Notch拮抗剂”或“Notch-激动剂”）。

6. 发明申请

WO2008074867A3 ANTI-FC-RECEPTOR SINGLE DOMAIN ANTIBODIES (NANOBODIES-TM) AND THERAPEUTIC USE 审中-公开
标题翻译：抗FC-受体单个抗体（NANOBODIES TM）和治疗用途
公开(公告)号：WO2008074867A3
公开(公告)日：2009-01-15
申请号：PCT/EP2007064343
申请日：2007-12-20
申请人： ABLYNX NV , DOLK EDWARD , SAUNDERS MICHAEL JOHN SCOTT , DE HAARD JOHANNES JOSEPH WILHE
发明人： DOLK EDWARD , SAUNDERS MICHAEL JOHN SCOTT , DE HAARD JOHANNES JOSEPH WILHELMUS
IPC分类号： C07K16/28 , A61K39/395
CPC分类号： C07K16/283 , A61K38/00 , A61K2039/505 , C07K16/18 , C07K16/2863 , C07K16/2869 , C07K2317/22 , C07K2317/569
摘要： The present invention relates to amino acid sequences that are directed against (as defined herein) receptors for proteins with an immunoglobulin fold (Fc receptors), as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. The invention also relates to nucleic acids encoding such amino acid sequences and polypeptides; to methods for preparing such amino acid sequences and polypeptides; to host cells expressing or capable of expressing such amino acid sequences or polypeptides; to compositions, and in particular to pharmaceutical compositions, that comprise such amino acid sequences, polypeptides, nucleic acids and/or host cells; and to uses of such amino acid sequences or polypeptides, nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic puiposes, such as the prophylactic, therapeutic or diagnostic purposes mentioned herein.
摘要翻译：本发明涉及针对（如本文所定义）的针对具有免疫球蛋白折叠（Fc受体）的蛋白质的受体的氨基酸序列以及包含或基本由以下组成的化合物或构建体，特别是蛋白质和多肽的氨基酸序列一个或多个这样的氨基酸序列。本发明还涉及编码这种氨基酸序列和多肽的核酸; 涉及制备这种氨基酸序列和多肽的方法; 宿主表达或能够表达这种氨基酸序列或多肽的细胞; 包括这样的氨基酸序列，多肽，核酸和/或宿主细胞的组合物，特别是药物组合物; 以及这些氨基酸序列或多肽，核酸，宿主细胞和/或组合物的用途，特别是用于预防，治疗或诊断性胰岛素，例如本文提及的预防，治疗或诊断目的。

7. 发明申请

WO2008077945A3 ANTI-CHEMOKINE (CCL2, CCL3, CCL5, CXCL11, CXCL12) SINGLE-DOMAIN ANTIBODIES 审中-公开
标题翻译：抗体（CCL2，CCL3，CCL5，CXCL11，CXCL12）单抗体
公开(公告)号：WO2008077945A3
公开(公告)日：2008-11-27
申请号：PCT/EP2007064466
申请日：2007-12-21
申请人： ABLYNX NV , BLANCHETOT CHRISTOPHE , SAUNDERS MICHAEL JOHN SCOTT , DE HAARD JOHANNES JOSEPH WILHE
发明人： BLANCHETOT CHRISTOPHE , SAUNDERS MICHAEL JOHN SCOTT , DE HAARD JOHANNES JOSEPH WILHELMUS
IPC分类号： C07K16/24
CPC分类号： C07K16/24 , C07K2317/565 , C07K2317/569 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to amino acid sequences that are directed against chemokines, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. The invention also relates to nucleic acids encoding such amino acid sequences and polypeptides; to methods for preparing such amino acid sequences and polypeptides; to host cells expressing or capable of expressing such amino acid sequences or polypeptides; to compositions, and in particular to pharmaceutical compositions, that comprise such amino acid sequences, polypeptides, nucleic acids and/or host cells; and to uses of such amino acid sequences or polypeptides, nucleic acids, host ceils and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes.
摘要翻译：本发明涉及针对趋化因子的氨基酸序列，以及包含或基本上由一个或多个这样的氨基酸序列组成的化合物或构建体，特别是蛋白质和多肽。本发明还涉及编码这种氨基酸序列和多肽的核酸; 涉及制备这种氨基酸序列和多肽的方法; 宿主表达或能够表达这种氨基酸序列或多肽的细胞; 包括这样的氨基酸序列，多肽，核酸和/或宿主细胞的组合物，特别是药物组合物; 以及这些氨基酸序列或多肽，核酸，宿主细胞和/或组合物的用途，特别是用于预防，治疗或诊断目的。

8. 发明申请

WO2009068627A3 AMINO ACID SEQUENCES DIRECTED AGAINST HETERODIMERIC CYTOKINES AND/OR THEIR RECEPTORS AND POLYPEPTIDES COMPRISING THE SAME 审中-公开
标题翻译：针对非对称细胞因子的氨基酸序列和/或其受体和包含其的多肽
公开(公告)号：WO2009068627A3
公开(公告)日：2009-10-01
申请号：PCT/EP2008066365
申请日：2008-11-27
申请人： ABLYNX NV , SAUNDERS MICHAEL JOHN SCOTT , BLANCHETOT CHRISTOPHE , ROMMELAERE HEIDI , VERCAMMEN JO , DE HAARD JOHANNES JOSEPH WILHE
发明人： SAUNDERS MICHAEL JOHN SCOTT , BLANCHETOT CHRISTOPHE , ROMMELAERE HEIDI , VERCAMMEN JO , DE HAARD JOHANNES JOSEPH WILHELMUS
IPC分类号： C07K16/24 , C07K16/28
CPC分类号： C07K16/468 , C07K16/2863 , C07K16/3007 , C07K16/32 , C07K2317/22 , C07K2317/31 , C07K2317/52 , C07K2317/569 , C07K2317/64 , C07K2319/00
摘要： The present invention relates to amino acid sequences that are directed against (as defined herein) heterodimeric cytokines and/or their receptors, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences (also referred to herein as 'amino acid sequences of the invention', 'compounds of the invention', and 'polypeptides of the invention', respectively). The invention also relates to nucleic acids encoding such amino acid sequences and polypeptides (also referred to herein as 'nucleic acids of the invention' or 'nucleotide sequences of the invention'); to methods for preparing such amino acid sequences and polypeptides; to host cells expressing or capable of expressing such amino acid sequences or polypeptides; to compositions, and in particular to pharmaceutical compositions, that comprise such amino acid sequences, polypeptides, nucleic acids and/or host cells; and to uses of such amino acid sequences or polypeptides, nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes, such as the prophylactic, therapeutic or diagnostic purposes mentioned herein.
摘要翻译：本发明涉及针对（如本文所定义的）异二聚体细胞因子和/或其受体的氨基酸序列，以及包含或基本上由一种或多种这样的蛋白质组成的化合物或构建体，特别是蛋白质和多肽的氨基酸序列氨基酸序列（本文中也分别称为本发明的氨基酸序列，本发明的化合物）和“本发明的多肽”）。本发明还涉及编码这种氨基酸序列和多肽（本文中也称为“本发明的核酸”或“本发明的核苷酸序列”）的核酸; 涉及制备这种氨基酸序列和多肽的方法; 宿主表达或能够表达这种氨基酸序列或多肽的细胞; 包括这样的氨基酸序列，多肽，核酸和/或宿主细胞的组合物，特别是药物组合物; 以及这些氨基酸序列或多肽，核酸，宿主细胞和/或组合物的用途，特别是用于预防，治疗或诊断目的，例如本文提及的预防，治疗或诊断目的。

9. 发明申请

WO2009109572A2 MONOVALENT PHAGE DISPLAY OF SINGLE VARIABLE DOMAINS 审中-公开
标题翻译：单变量单位显示单变量域
公开(公告)号：WO2009109572A2
公开(公告)日：2009-09-11
申请号：PCT/EP2009052499
申请日：2009-03-03
申请人： ABLYNX NV , DE HAARD JOHANNES JOSEPH WILHE , VERHEESEN PETER
发明人： DE HAARD JOHANNES JOSEPH WILHELMUS , VERHEESEN PETER
IPC分类号： C12N15/10 , C07K16/00
CPC分类号： C12N15/1037 , C07K16/005 , C07K2317/22 , C07K2317/569
摘要： The present invention relates to methods of generating single variable domains of high affinity, to libraries or repertoires comprising said single variable domains on phages in a monovalent format and to plasmids, phagemids or phages designed to express said single variable domains in said libraries.
摘要翻译：本发明涉及产生具有高亲和力的单可变结构域的方法，包括在单价形式的噬菌体上包含所述单个可变结构域的文库或库，以及设计用于在所述文库中表达所述单个可变结构域的质粒，噬菌粒或噬菌体。

10. 发明申请

WO2010043650A3 AMINO ACID SEQUENCES TARGETING HUMAN CD4, CXCR4, CCR5, TLR4, ALPHAV INTEGRIN, BETA3- INTEGRIN, BETAL -INTEGRIN, HUMAN ALPHA2- INTEGRIN, CD81, SR-BI, CLAUDIN-I, CLAUDIN-6 AND CLAUDIN-9, RESPECTIVELY, AND NEUTRALIZING VIRAL ENTRY 审中-公开
标题翻译：氨基酸序列靶向人类CD4，CXCR4，CCR5，TLR4，ALPHAV INTEGRIN，BETA3-整合素，BET-INTEGRIN，人ALPHA2- INTEGRIN，CD81，SR-BI，CLAUDIN-1，CLAUDIN-6和CLAUDIN-9，RESPECTIVELY，AND 中和病毒入侵
公开(公告)号：WO2010043650A3
公开(公告)日：2011-01-13
申请号：PCT/EP2009063411
申请日：2009-10-14
申请人： ABLYNX NV , BLANCHETOT CRISTOPH , SMIT MARTINE , LEURS REGORIUS , JAEHNICHEN SVEN , SCHOLS DOMINIQUE , SAUNDERS MICHAEL JOHN SCOTT , DE HAARD JOHANNES JOSEPH WILHELMUS , VANLANDSCHOOT PETER , VERHEESEN PETER
发明人： BLANCHETOT CRISTOPH , SMIT MARTINE , LEURS REGORIUS , JAEHNICHEN SVEN , SCHOLS DOMINIQUE , SAUNDERS MICHAEL JOHN SCOTT , DE HAARD JOHANNES JOSEPH WILHELMUS , VANLANDSCHOOT PETER , VERHEESEN PETER
IPC分类号： C07K16/28 , A61P31/04 , A61P31/12
CPC分类号： C07K16/2866 , A61K39/39533 , A61K2039/505 , C07K16/2812 , C07K2317/21 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/565 , C07K2317/569 , C07K2317/76 , C07K2317/92 , C07K2319/31 , Y10S530/866
摘要： The present invention relates to amino acid sequences that are directed against (as defined herein) human cellular receptors for viruses and/or bacteria such as e.g. Nanobodies specifically recognizing hCD4, hCXCR4, hCCR5. hTLR4, human alphaV integrin, human beta3 integrin, human betal integrin, human alpha2 integrin, hCD81, hSR-Bl, hClaudin-1, hClaudin-6 and hClaudin-9, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. Said amino acid sequences may be used to prevent human cell entry of HIV, HCV, adenoviruses, hantavirus, herpesvirus, echo-virus 1 and others.
摘要翻译：本发明涉及针对（如本文定义的）病毒和/或细菌的人细胞受体的氨基酸序列，例如，纳米抗体专门识别hCD4，hCXCR4，hCCR5。 hTLR4，人αV整联蛋白，人β3整联蛋白，人betal整联蛋白，人α2整联蛋白，hCD81，hSR-B1，hClaudin-1，hClaudin-6和hClaudin-9，以及化合物或构建体，特别是蛋白质和多肽，其包含或基本上由一个或多个这样的氨基酸序列组成。所述氨基酸序列可用于预防HIV，HCV，腺病毒，汉坦病毒，疱疹病毒，回波病毒1等的人细胞进入。

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