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1. 发明申请

WO2011003622A8 METHOD FOR THE PRODUCTION OF VARIABLE DOMAINS 审中-公开
公开(公告)号：WO2011003622A8
公开(公告)日：2011-01-13
申请号：PCT/EP2010/004196
申请日：2010-07-09
申请人： ABLYNX N.V. , STALS, Hilde , DE BRABANDERE, Veronique , SCHOTTE Peter
发明人： STALS, Hilde , DE BRABANDERE, Veronique , SCHOTTE Peter
IPC分类号： C07K16/00 , A61K47/48
摘要： The present invention provides methods for the expression and/or production of variable domains with a C-terminal extension that can be used for coupling of the variable domain to one or more further groups, residues or moieties. In the method of the invention a yield of at least 80% of variable domains with a cysteine containing C-terminal extension is obtained. Also variable domains are provided and polypeptides comprising one or more variable domains obtainable by the methods of the present invention, as well as compounds that comprise such variable domains and/or polypeptides coupled to one or more groups, residues or moieties.

2. 发明授权

EP2451839B1 METHOD FOR THE PRODUCTION OF VARIABLE DOMAINS 有权
公开(公告)号：EP2451839B1
公开(公告)日：2020-04-22
申请号：EP10731480.9
申请日：2010-07-09
申请人： Ablynx N.V.
发明人： STALS, Hilde , DE BRABANDERE, Veronique , SCHOTTE Peter
IPC分类号： C07K16/00 , A61K47/65 , A61K47/60

3. 发明公开

EP2451839A1 METHOD FOR THE PRODUCTION OF VARIABLE DOMAINS 有权
标题翻译： VERFAHREN ZUR ERZEUGUNG VARIABLERDOMÄNEN
公开(公告)号：EP2451839A1
公开(公告)日：2012-05-16
申请号：EP10731480.9
申请日：2010-07-09
申请人： Ablynx N.V.
发明人： STALS, Hilde , DE BRABANDERE, Veronique , SCHOTTE Peter
IPC分类号： C07K16/00 , A61K47/48
摘要： The present invention provides methods for the expression and/or production of variable domains with a C-terminal extension that can be used for coupling of the variable domain to one or more further groups, residues or moieties. In the method of the invention a yield of at least 80% of variable domains with a cysteine containing C-terminal extension is obtained. Also variable domains are provided and polypeptides comprising one or more variable domains obtainable by the methods of the present invention, as well as compounds that comprise such variable domains and/or polypeptides coupled to one or more groups, residues or moieties.
摘要翻译：本发明提供用于表达和/或产生具有C末端延伸的可变结构域的方法，其可用于将可变结构域偶联至一个或多个另外的基团，残基或部分。在本发明的方法中，获得至少80％的含有C末端延伸的半胱氨酸的可变结构域的产率。还提供了可变结构域，以及包含通过本发明的方法可获得的一个或多个可变结构域的多肽，以及包含与一个或多个基团，残基或部分偶联的可变结构域和/或多肽的化合物。

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