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1. 发明专利

CA2953755A1 CAPSULE FOR RAPID MOLECULAR QUANTIFICATION OF A FLUID SAMPLE SUCH AS WHOLE BLOOD 未知
公开(公告)号：CA2953755A1
公开(公告)日：2016-01-07
申请号：CA2953755
申请日：2015-06-23
申请人： ABIONIC SA
发明人： MAERKI IWAN , CARRERE LAURIANE , DURAND NICOLAS
IPC分类号： B01L3/00
摘要： A capsule (100) comprising a housing (110) in which are disposed nanofluidic biosensors (120), a fluid connecting element (140), a filter (150) and a cover (160) is described. The capsule (100) allows the analysis of a fluid sample (300) that would be deposited in the capsule system (100) by a pipette (400). The fluid sample (300) is filtered when passing through a filter (150), then transferred by a fluid connecting element (140) to the inlets of one or several nanofluidic biosensors (120). The capsule system (100) is disposed on an external support (200), and finally an optical or an electrical measurement unit (500) is used to measure the molecular interactions in the nanofluidic biosensors.

2. 发明专利

AU2012226463A1 Rapid quantification of biomolecules in a selectively functionalized nanofluidic biosensor and method thereof 未知
公开(公告)号：AU2012226463A1
公开(公告)日：2013-10-10
申请号：AU2012226463
申请日：2012-02-06
申请人： ABIONIC SA
发明人： DURAND NICOLAS , MARKI IWAN , BROILLET STEPHANE , MAYOR ANNICK , LASSER THEO
IPC分类号： G01N21/03 , B01L3/00 , B82Y15/00 , B82Y35/00 , C12Q1/68 , G01N21/05 , G01N21/64
摘要： A method and device for the rapid quantification of biomolecules (320) present in a nanochannel (210) is claimed. In particular, the present invention relates to a novel concept of liquid actuation and selectively functionalized surfaces in a nanochannel that create a concentration gradient of transitory immobilized biomolecules (340) across the nanochannel. The present concept enables the quantification of biomolecular interactions of interest (320).

3. 发明专利

ES2731693T3 Sistema de evacuación de gas para biosensor nanofluídico 未知
公开(公告)号：ES2731693T3
公开(公告)日：2019-11-18
申请号：ES14821282
申请日：2014-11-17
申请人： ABIONIC SA
发明人： DURAND NICOLAS , MÄRKI IWAN , GEISSBÜHLER MATTHIAS
IPC分类号： G01N21/64 , B01L3/00 , G01N21/05
摘要： Un sistema de biosensor nanofluídico (200) que comprende un sustrato inferior (120) y un sustrato superior (110) entre los cuales están definidas una abertura lateral de entrada (210), una nano ranura (230) que contiene al menos un área funcionalizada (231) y una abertura lateral de salida (220) o un depósito interno (221), estando adaptado dicho sistema biosensor (200) para permitir que una solución que contiene biomoléculas (320) entre en la abertura lateral de entrada (210) y pase sucesivamente a través de dicha nano ranura (230) y dicha abertura lateral de salida (220) o depósito interno (221); comprendiendo además dicho sistema biosensor (200) un subsistema de evacuación de gas (150 - 155) que está ubicado entre dicha nano ranura (230) y el entorno externo del biosensor; comprendiendo dicho subsistema de evacuación de gas varios orificios / poros que lo atraviesan (151, 153, 154, 155) que están configurados de forma tal que, cuando la solución está en contacto con el sistema de evacuación de gas, el líquido entra en dichos orificios / poros, con un estado de llenado transitorio, hasta que ha llenado completamente los orificios / poros.

4. 发明专利

ES2702361T3 Método y dispositivo para bioensayos 未知
公开(公告)号：ES2702361T3
公开(公告)日：2019-02-28
申请号：ES14737223
申请日：2014-07-07
申请人： ABIONIC SA
发明人： DURAND NICOLAS , MÄRKI IWAN , MAYOR ANNICK , BROILLET STÉPHANE
IPC分类号： B01L3/00 , B82Y15/00 , B82Y35/00 , G01N21/64 , G01N33/543
摘要： Biosensor (200) para detectar y cuantificar biomoléculas (311-320) marcadas de manera fluorescente, comprendiendo dicho biosensor (200): - un sustrato (220) inferior; - un sustrato (210) superior apilado sobre dicho sustrato (220) inferior; - una nanorendija (223) que es una estructura microfabricada con una dimensión de tamaño nanométrico, 10 formada entre dicho sustrato (220) inferior y dicho sustrato (210) superior, comprendiendo dicha nanorendija (223) una pluralidad de áreas (240-247) estructuradas locales dispuestas a lo largo de dicha nanorendija (223); - una abertura (221) de entrada lateral en contacto directo con dicha nanorendija (223), para permitir que una disolución que contiene biomoléculas entre en dicha nanorendija (223); y - una abertura (222) de salida lateral en contacto directo con dicha nanorendija (223), para conducir dicha disolución a través de dicha nanorendija (223), caracterizado porque la pluralidad de áreas (240-247) estructuradas locales están funcionalizadas cada una mediante diferentes biomarcadores (331-336).

5. 发明专利

AU2015283689A1 Capsule for rapid molecular quantification of a fluid sample such as whole blood 未知
公开(公告)号：AU2015283689A1
公开(公告)日：2017-02-09
申请号：AU2015283689
申请日：2015-06-23
申请人： ABIONIC SA
发明人： MAERKI IWAN , CARRERE LAURIANE , DURAND NICOLAS
IPC分类号： B01L3/00
摘要： A capsule (100) comprising a housing (110) in which are disposed nanofluidic biosensors (120), a fluid connecting element (140), a filter (150) and a cover (160) is described. The capsule (100) allows the analysis of a fluid sample (300) that would be deposited in the capsule system (100) by a pipette (400). The fluid sample (300) is filtered when passing through a filter (150), then transferred by a fluid connecting element (140) to the inlets of one or several nanofluidic biosensors (120). The capsule system (100) is disposed on an external support (200), and finally an optical or an electrical measurement unit (500) is used to measure the molecular interactions in the nanofluidic biosensors.

6. 发明专利

AU2014363071A1 Gas evacuation system for nanofluidic biosensor 未知
公开(公告)号：AU2014363071A1
公开(公告)日：2016-07-07
申请号：AU2014363071
申请日：2014-11-17
申请人： ABIONIC SA
发明人： DURAND NICOLAS , MARKI IWAN , GEISSBUHLER MATTHIAS
IPC分类号： G01N21/64 , B01L3/00 , G01N21/05
摘要： A nanofluidic biosensor system (200) comprising a bottom substrate (120) and a top substrate (110) between which are defined an input lateral aperture (210), a nanoslit (230) which contains at least one functionalized area (231) and an output lateral aperture (220) or an internal reservoir (221), said biosensor system (200) being adapted to let a solution containing biomolecules (320) enter the input lateral aperture (210) and successively pass through said nanoslit (230) and said output lateral aperture (220) or internal reservoir (221); said biosensor system (200) furthermore comprising a gas evacuation subsystem (150-155) which is located between said nanoslit (230) and the biosensor external environment.

7. 发明专利

CA2932577C GAS EVACUATION SYSTEM FOR NANOFLUIDIC BIOSENSOR 未知
公开(公告)号：CA2932577C
公开(公告)日：2022-07-19
申请号：CA2932577
申请日：2014-11-17
申请人： ABIONIC SA
发明人： DURAND NICOLAS , MARKI IWAN , GEISSBUHLER MATTHIAS
IPC分类号： G01N21/64 , B01L3/00 , G01N21/05
摘要： A nanofluidic biosensor system (200) comprising a bottom substrate (120) and a top substrate (110) between which are defined an input lateral aperture (210), a nanoslit (230) which contains at least one functionalized area (231) and an output lateral aperture (220) or an internal reservoir (221), said biosensor system (200) being adapted to let a solution containing biomolecules (320) enter the input lateral aperture (210) and successively pass through said nanoslit (230) and said output lateral aperture (220) or internal reservoir (221); said biosensor system (200) furthermore comprising a gas evacuation subsystem (150-155) which is located between said nanoslit (230) and the biosensor external environment.

8. 发明专利

AU2015283689B2 Capsule for rapid molecular quantification of a fluid sample such as whole blood 未知
公开(公告)号：AU2015283689B2
公开(公告)日：2020-07-16
申请号：AU2015283689
申请日：2015-06-23
申请人： ABIONIC SA
发明人： MAERKI IWAN , CARRERE LAURIANE , DURAND NICOLAS
IPC分类号： B01L3/00
摘要： A capsule (100) comprising a housing (110) in which are disposed nanofluidic biosensors (120), a fluid connecting element (140), a filter (150) and a cover (160) is described. The capsule (100) allows the analysis of a fluid sample (300) that would be deposited in the capsule system (100) by a pipette (400). The fluid sample (300) is filtered when passing through a filter (150), then transferred by a fluid connecting element (140) to the inlets of one or several nanofluidic biosensors (120). The capsule system (100) is disposed on an external support (200), and finally an optical or an electrical measurement unit (500) is used to measure the molecular interactions in the nanofluidic biosensors.

9. 发明专利

ES2767123T3 Cuantificación rápida de biomoléculas en un biosensor nanofluídico selectivamente funcionalizado y método de la misma 未知
公开(公告)号：ES2767123T3
公开(公告)日：2020-06-16
申请号：ES12711449
申请日：2012-02-06
申请人： ABIONIC SA
发明人： DURAND NICOLAS , MÄRKI IWAN , BROILLET STÉPHANE , MAYOR ANNICK , LASSER THEO
IPC分类号： B82Y30/00 , B01L3/00 , B82Y15/00 , B82Y35/00 , G01N21/03 , G01N21/05 , G01N21/64 , G01N33/543
摘要： Un biosensor (200) para detectar y cuantificar biomoléculas marcadas por fluorescencia (320); comprendiendo dicho biosensor (200) un nanocanal (210) definido entre dos sustratos (201, 202) y conteniendo una o más zonas funcionalizadas selectivamente (211) sobre las que están inmovilizados biomarcadores (310), dicho nanocanal definido además por una abertura de entrada lateral (220) y una abertura de salida lateral (230), estando diseñada dicha abertura de entrada (220) para permitir que una solución que contiene biomoléculas (320) entre en dicho nanocanal (210), caracterizado por que dicha abertura de salida (230) contiene o está en contacto con un componente conductor (241, 242) adaptado para absorber dicha solución a través de dicho nanocanal (210) por capilaridad.

10. 发明专利

AU2014363071B2 Gas evacuation system for nanofluidic biosensor 未知
公开(公告)号：AU2014363071B2
公开(公告)日：2019-05-02
申请号：AU2014363071
申请日：2014-11-17
申请人： ABIONIC SA
发明人： DURAND NICOLAS , MARKI IWAN , GEISSBUHLER MATTHIAS
IPC分类号： G01N21/64 , B01L3/00 , G01N21/05
摘要： A nanofluidic biosensor system (200) comprising a bottom substrate (120) and a top substrate (110) between which are defined an input lateral aperture (210), a nanoslit (230) which contains at least one functionalized area (231) and an output lateral aperture (220) or an internal reservoir (221), said biosensor system (200) being adapted to let a solution containing biomolecules (320) enter the input lateral aperture (210) and successively pass through said nanoslit (230) and said output lateral aperture (220) or internal reservoir (221); said biosensor system (200) furthermore comprising a gas evacuation subsystem (150-155) which is located between said nanoslit (230) and the biosensor external environment.

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