专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO03040170A9 ANTIBODIES TO CD40 审中-公开
标题翻译： CD40抗体
公开(公告)号：WO03040170A9
公开(公告)日：2004-06-10
申请号：PCT/US0236107
申请日：2002-11-08
申请人： PFIZER PROD INC , ABGENIX INC , BEDIAN VAHE , GLADUE RONALD P , CORVALAN JOSE , JIA XIAO-CHI , FENG XIAO
发明人： BEDIAN VAHE , GLADUE RONALD P , CORVALAN JOSE , JIA XIAO-CHI , FENG XIAO
IPC分类号： A01H5/00 , A01K67/027 , A61K31/7088 , A61K35/76 , A61K39/395 , A61K48/00 , A61P13/08 , A61P13/10 , A61P35/00 , A61P35/02 , A61P43/00 , C07K20060101 , C07K16/28 , C07K16/40 , C07K16/46 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/06 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12N15/00 , C12N15/11 , C12N15/63
CPC分类号： C07K16/2866 , A01K2217/05 , A61K39/3955 , A61K45/06 , A61K48/00 , A61K2039/505 , A61N5/062 , A61N5/10 , C07K16/2878 , C07K16/40 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/92
摘要： The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to CD40, preferably human CD40, and that function as CD40 agonists. The invention also relates to human anti-CD40 antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-CD40 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-CD40 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-CD40 antibodies. The invention also relates to transgenic animals comprising nucleic acid molecules of the present invention.
摘要翻译：本发明涉及与CD40，优选人CD40特异性结合并且作为CD40激动剂起作用的抗体及其抗原结合部分。本发明还涉及人抗CD40抗体及其抗原结合部分。本发明还涉及嵌合，双特异性，衍生的单链抗体或融合蛋白的部分的抗体。本发明还涉及衍生自人抗CD40抗体的分离的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。本发明还涉及制备人抗CD40抗体的方法，包含这些抗体的组合物和使用抗体和组合物进行诊断和治疗的方法。本发明还提供使用编码包含人抗-CD40抗体的重和/或轻免疫球蛋白分子的核酸分子的基因治疗方法。本发明还涉及包含本发明的核酸分子的转基因动物。

2. 发明申请

WO03040170A2 ANTIBODIES TO CD40 审中-公开
标题翻译：抗CD40抗体
公开(公告)号：WO03040170A2
公开(公告)日：2003-05-15
申请号：PCT/US0236107
申请日：2002-11-08
申请人： PFIZER PROD INC , ABGENIX INC , BEDIAN VAHE , GLADUE RONALD P , CORVALAN JOSE , JIA XIAO-CHI , FENG XIAO
发明人： BEDIAN VAHE , GLADUE RONALD P , CORVALAN JOSE , JIA XIAO-CHI , FENG XIAO
IPC分类号： A01H5/00 , A01K67/027 , A61K31/7088 , A61K35/76 , A61K39/395 , A61K48/00 , A61P13/08 , A61P13/10 , A61P35/00 , A61P35/02 , A61P43/00 , C07K20060101 , C07K16/28 , C07K16/40 , C07K16/46 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/06 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C07K
CPC分类号： C07K16/2866 , A01K2217/05 , A61K39/3955 , A61K45/06 , A61K48/00 , A61K2039/505 , A61N5/062 , A61N5/10 , C07K16/2878 , C07K16/40 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/92
摘要： The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to CD40, preferably human CD40, and that function as CD40 agonists. The invention also relates to human anti-CD40 antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-CD40 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-CD40 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-CD40 antibodies. The invention also relates to transgenic animals comprising nucleic acid molecules of the present invention.
摘要翻译：本发明涉及特异性结合CD40，优选人CD40并且起CD40激动剂作用的抗体及其抗原结合部分。本发明还涉及人抗CD40抗体及其抗原结合部分。本发明还涉及嵌合，双特异性，衍生的单链抗体或融合蛋白部分的抗体。本发明还涉及源自人抗CD40抗体的分离的重链和轻链免疫球蛋白以及编码此类免疫球蛋白的核酸分子。本发明还涉及制备人抗CD40抗体的方法，包含这些抗体的组合物以及使用该抗体和组合物进行诊断和治疗的方法。本发明还提供了使用编码包含人抗CD40抗体的重和/或轻免疫球蛋白分子的核酸分子的基因治疗方法。本发明还涉及包含本发明的核酸分子的转基因动物。

3. 发明公开

EP1660127A4 ANTIBODIES TO C-MET 审中-公开
标题翻译：抗体C-MET
公开(公告)号：EP1660127A4
公开(公告)日：2007-08-01
申请号：EP04780015
申请日：2004-08-03
申请人： PFIZER PROD INC , ABGENIX INC
发明人： MICHAUD NEIL R , KAJIJI SHAMA , BORZILLO GARY , BEDIAN VAHE , COLEMAN KEVIN , GREEN LARRY L , JIA XIAO-CHI
IPC分类号： A61K39/395 , A61P17/00 , A61P35/00 , C07H21/04 , C07K16/00 , C07K16/28 , C07K16/30 , C07K16/44 , C12N15/13 , C12P21/00 , G01N33/574
CPC分类号： A61K39/39558 , A61K2039/505 , C07K16/2863 , C07K16/3076 , C07K2317/21 , C07K2317/73 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92

4. 发明公开

EP1476185A4 ANTIBODIES TO CD40 有权
标题翻译：抗CD40抗体
公开(公告)号：EP1476185A4
公开(公告)日：2007-04-04
申请号：EP02802898
申请日：2002-11-08
申请人： PFIZER PROD INC , ABGENIX INC
发明人： BEDIAN VAHE , GLADUE RONALD P , CORVALAN JOSE , JIA XIAO-CHI , FENG XIAO
IPC分类号： A01H5/00 , A01K67/027 , A61K31/7088 , A61K35/76 , A61K39/395 , A61K48/00 , A61P13/08 , A61P13/10 , A61P35/00 , A61P35/02 , A61P43/00 , C07K20060101 , C07K16/28 , C07K16/40 , C07K16/46 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/06 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12N15/00 , C12N15/11 , C12N15/63
CPC分类号： C07K16/2866 , A01K2217/05 , A61K39/3955 , A61K45/06 , A61K48/00 , A61K2039/505 , A61N5/062 , A61N5/10 , C07K16/2878 , C07K16/40 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/92
摘要： The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to CD40, preferably human CD40, and that function as CD40 agonists. The invention also relates to human anti-CD40 antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-CD40 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-CD40 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-CD40 antibodies. The invention also relates to transgenic animals comprising nucleic acid molecules of the present invention.

5. 发明专利

CA2466128C ANTIBODIES TO CD40 未知
公开(公告)号：CA2466128C
公开(公告)日：2013-10-29
申请号：CA2466128
申请日：2002-11-08
申请人： PFIZER PROD INC , ABGENIX INC
发明人： BEDIAN VAHE , GLADUE RONALD P , CORVALAN JOSE , JIA XIAO-CHI , FENG XIAO
IPC分类号： A01H5/00 , C12N15/13 , A01K67/027 , A61K31/7088 , A61K35/76 , A61K39/395 , A61K48/00 , A61P13/08 , A61P13/10 , A61P35/00 , A61P35/02 , A61P43/00 , C07K20060101 , C07K16/28 , C07K16/40 , C07K16/46 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/06 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/63 , C12P21/02 , C12P21/08
摘要： The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to CD40, preferably human CD40, and that function as CD40 agonists. The invention also relates to human anti-CD40 antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-CD40 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-CD40 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-CD40 antibodies. The invention also relates to transgenic animals comprising nucleic acid molecules of the present invention.

6. 发明专利

AP1918A Antibodies to CD40 未知
公开(公告)号：AP1918A
公开(公告)日：2008-11-13
申请号：AP2004003034
申请日：2002-11-08
申请人： PFIZER PROD INC , AMGEN FREMONT INC , ABGENIX INC
发明人： BEDIAN VAHE , GLADUE RONALD PAUL , CORVALAN JOSE , JIA XIAO-CHI , FENG XIAO
IPC分类号： A01H5/00 , A01K67/027 , A61K31/7088 , A61K35/76 , A61K39/395 , A61K48/00 , A61P13/08 , A61P13/10 , A61P35/00 , A61P35/02 , A61P43/00 , C07K20060101 , C07K16/28 , C07K16/40 , C07K16/46 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/06 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08
摘要： The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to CD40, preferably human CD40, and that function as CD40 agonists. The invention also relates to human anti-CD40 antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-CD40 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-CD40 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-CD40 antibodies. The invention also relates to transgenic animals comprising nucleic acid molecules of the present invention.

7. 发明专利

AU2002356926B2 Antibodies to CD40 未知
公开(公告)号：AU2002356926B2
公开(公告)日：2007-01-04
申请号：AU2002356926
申请日：2002-11-08
申请人： PFIZER PROD INC , ABGENIX INC
发明人： JIA XIAO-CHI , FENG XIAO , BEDIAN VAHE , GLADUE RONALD P , CORVALAN JOSE
IPC分类号： A01H5/00 , A01K67/027 , A61K31/7088 , A61K35/76 , A61K39/395 , A61K48/00 , A61P13/08 , A61P13/10 , A61P35/00 , A61P35/02 , A61P43/00 , C07K20060101 , C07K16/28 , C07K16/40 , C07K16/46 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/06 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08
摘要： The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to CD40, preferably human CD40, and that function as CD40 agonists. The invention also relates to human anti-CD40 antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-CD40 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-CD40 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-CD40 antibodies. The invention also relates to transgenic animals comprising nucleic acid molecules of the present invention.

8. 发明专利

OA12725A Antibodies to CD40. 未知
公开(公告)号：OA12725A
公开(公告)日：2006-06-28
申请号：OA1200400136
申请日：2002-11-08
申请人： ABGENIX INC , PFIZER PROD INC
发明人： BEDIAN VAHE , CORVALAN JOSE , FENG XIAO , GLADUE RONALD P , JIA XIAO-CHI
IPC分类号： A01H5/00 , A01K67/027 , A61K31/7088 , A61K35/76 , A61K39/395 , A61K48/00 , A61P13/08 , A61P13/10 , A61P35/00 , A61P35/02 , A61P43/00 , C07K20060101 , C07K16/28 , C07K16/40 , C07K16/46 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/06 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C07K16/44
摘要： The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to CD40, preferably human CD40, and that function as CD40 agonists. The invention also relates to human anti-CD40 antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-CD40 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-CD40 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-CD40 antibodies. The invention also relates to transgenic animals comprising nucleic acid molecules of the present invention.

9. 发明专利

TNSN04078A1 ANTIBODIES TO CD40 未知
公开(公告)号：TNSN04078A1
公开(公告)日：2006-06-01
申请号：TNSN04078
申请日：2004-05-05
申请人： ABGENIX INC , PFIZER PROD INC
发明人： GLADUE RONALD P , CORVALAN JOSÉ , BEDIAN VAHE , FENG XIAO , JIA XIAO-CHI
IPC分类号： A01H5/00 , C07K16/28 , A01K67/027 , A61K31/7088 , A61K35/76 , A61K39/395 , A61K48/00 , A61P13/08 , A61P13/10 , A61P35/00 , A61P35/02 , A61P43/00 , C07K20060101 , C07K16/40 , C07K16/46 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/06 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08
摘要： LA PRESENTE INVENTION CONCERNE LES ANTICORPS ET LES PARTIES ANTIGENE - LIANTES DE TEL ANTICORPS QUI LIENT SPECIFIQUEMENT A CD40; CD40 DE PREFERENCE HUMAIN; ET QUI FONCTIONNENT COMME DES AGONISTES DE CD40. L' INVENTION SE RELIE EGALEMENT AUX ANTICORPS ANTI- CD40 HUMAINS ET AUX PARTIES ANTIGENE - LIANTES DE CELA. L' INVENTION SE RELIE EGALEMENT AUX ANTICORPS QUI SONT LES ANTICORPS OU LES PARTIES DE PROTEINES DE FUSION CHIMERIQUES; BISPECIFIQUES; DERIVATISES; A CHAINE SEULE. L INVENTION SE RELIE EGALEMENT AUX IMMUNOGLOBULINES A CHAINE LOURDE ET LEGERE ISOLEE DERIVEE DES ANTICORPS ANTI -CD40 HUMAINS ET DES MOLECULES D'ACIDE NUCLEIQUE CODANT ET DE TELLES IMMINOGLOBULINES. LA PRESENTE INVENTION SE RELIE EGALEMENT AUX METHODES DE LA FABRICATION DES ANTICORPS ANTI- CD40 HUMAINS; COMPOSITIONS COMPORTANT CES ANTICORPS ET DES METHODES D' EMPLOYER LES ANTICORPS ET LES COMPOSITIONS POUR LE DIAGNOSTIC ET LE TRAITEMENT. L INVENTION FOURNIT EGALEMENT DES METHODES DE THERAPIE DE GENE EN UTILISANT DES MOLECULES D ACIDE NUCLEIQUE CODANT LES MOLECULES LOURDES ET/ OU LEGERES D' IMMUNOGLOBULINE QUI COMPORTENT LES ANTICORPS ANTI- CD40 HUMAINS. L' INVENTION SE RELIE EGALEMENT AUX ANIMAUX DE TRANSFEREMENT GENIQUE (TRANSGENIQUE) COMPORTANT DES MOLECULES D 'ACIDE NUCLEIQUE DE LA PRESENTE INVENTION .

10. 发明专利

AR047717A1 ANTICUERPOS DIRIGIDOS A C-MET 未知
公开(公告)号：AR047717A1
公开(公告)日：2006-02-15
申请号：ARP040102766
申请日：2004-08-03
申请人： PFIZER PROD INC , ABGENIX INC
发明人： MICHAUD NEIL R , KAJIJI SHAMA , BORZILLO GARY , BEDIAN VAHE , COLEMAN KEVIN , GREEN LARRY , JIA XIAO-CHI
IPC分类号： A61K39/395 , A61P17/00 , A61P35/00 , C07K16/28 , C07K16/30 , C07K16/44 , C12N15/13 , G01N33/574 , A61P17/02 , C12N5/20 , C12N15/85 , C12P21/08
摘要： Anticuerpos que incluyen anticuerpos humanos y porciones que ligan antígeno de los mismos que se ligan específicamente a c-Met, preferentemente a c-Met humano y que funcionan para inhibir c-Met. Anticuerpos anti-c-Met humanos y porciones que ligan antígeno de los mismos. Anticuerpos que son quimérico, bioespecíficos, derivatizados, anticuerpos de cadena simple o porciones de proteínas de fusion. Inmunoglobulinas aisladas de cadena pesada y liviana derivadas de anticuerpos anti-c-Met humanos y a moléculas de ácido nucleico que codifican tales inmunoglobulinas. Métodos para fabricar anticuerpos anti-c-Met humanos, composiciones que comprenden estos anticuerpos y a métodos para usar los anticuerpos y composiciones para diagnostico y tratamiento. También se provee métodos de terapia con genes que usan moléculas de ácido nucleico que codifican las moléculas de inmunoglobulina y/o liviana que comprende los anticuerpos anti-c-Met humanos. También se refiere a animales o plantas transgénicos que comprenden moléculas de ácido nucleico de la presente. Reivindicacion 11: Uso de un anticuerpo o porcion que liga antígeno de acuerdo con cualquiera de las reivindicaciones 1 a 9, caracterizado porque dicho anticuerpo o porcion es un antagonista de c-Met usado en la fabricacion de un medicamento para tratar un trastorno hiperproliferativo de un sujeto que lo necesita. Reivindicacion 12: Uso de un anticuerpo o porcion que liga antígeno de acuerdo con cualquiera de las reivindicaciones 1 a 9, caracterizado porque dicho anticuerpo, porcion que liga antígeno o composicion farmacéutica activa c-Met, y el anticuerpo o porcion que liga antígeno es usado para la fabricacion de un medicamento para promover la curacion de heridas o regeneracion de tejidos en un sujeto que lo necesita. Reivindicacion 13: Una línea celular aislada, caracterizada porque produce el anticuerpo o porcion que liga antígeno de acuerdo con cualquiera de las reivindicaciones 1 a 9 o la cadena pesada o cadena liviana de dicho anticuerpo o dicha porcion. Reivindicacion 15: Un vector, caracterizado porque comprende la molécula de ácido nucleico de acuerdo con la reivindicacion 14 donde el vector comprende opcionalmente una secuencia de control de expresion ligada operativamente a la molécula de ácido nucleico. Reivindicacion 16: Una célula hospedante, caracterizada porque comprende el vector de acuerdo con la reivindicacion 15 o la molécula de ácido nucleico de acuerdo con la reivindicacion 14.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式