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1. 发明申请

WO1997008531A2 DETECTION OF HEPATITIS GB VIRUS GENOTYPES 审中-公开
标题翻译：乙型肝炎病毒基因组检测
公开(公告)号：WO1997008531A2
公开(公告)日：1997-03-06
申请号：PCT/US1996013171
申请日：1996-08-14
申请人： ABBOTT LABORATORIES
发明人： ABBOTT LABORATORIES , MUERHOFF, Anthony, S. , SIMONS, John, N. , BIRKENMEYER, Larry , LEARY, Thomas, P. , ERKER, James, C. , DESAI, Suresh, M. , MUSHAHWAR, Isa, K. , CHALMERS, Michelle , DAWSON, George, J.
IPC分类号： G01N00/00
CPC分类号： C12N15/1131 , C07K14/005 , C07K2319/00 , C12N15/86 , C12N2310/315 , C12N2310/3181 , C12N2310/33 , C12N2770/24222 , C12N2840/203 , C12Q1/6813 , C12Q1/707
摘要： HGBV-C oligonucleotides from the 5' end of HGBV-C useful for the detection and genotyping of HGBV-C isolates. Also provided are assays which utilize these oligonucleotides.
摘要翻译：来自HGBV-C的5'端的HGBV-C寡核苷酸可用于HGBV-C分离物的检测和基因分型。还提供了利用这些寡核苷酸的测定法。

2. 发明申请

WO1998029747A1 REAGENTS AND METHODS FOR DETECTING HEPATITIS GB VIRUS ANTIGEN 审中-公开
标题翻译：用于检测乙型肝炎病毒抗原的试剂和方法
公开(公告)号：WO1998029747A1
公开(公告)日：1998-07-09
申请号：PCT/US1997023767
申请日：1997-12-23
申请人： ABBOTT LABORATORIES
发明人： ABBOTT LABORATORIES , DAWSON, George, J. , DILLE, Bruce, J. , GUTIERREZ, Robin, A. , MUSHAHWAR, Isa, K.
IPC分类号： G01N33/569
CPC分类号： C07K14/005 , A61K39/00 , C07K16/109 , C07K2319/00 , C12N2770/24222 , C12Q1/707 , G01N33/576
摘要： Methods for detection of hepatitis GB Virus (HGBV) antigen in test samples. Antibodies to the E2 region of the HGBV are utilized to capture antigen in test samples. Methods include immunoassay and antigen capture polymerase chain reaction. Antibodies are provided which are useful as diagnostic reagents and are provided in test kits.
摘要翻译：检测样本中肝炎病毒（HGBV）抗原的方法。用于HGBV的E2区的抗体用于在测试样品中捕获抗原。方法包括免疫测定和抗原捕获聚合酶链反应。提供了可用作诊断试剂并在试剂盒中提供的抗体。

3. 发明申请

WO1997007224A1 REAGENTS AND METHODS USEFUL FOR CONTROLLING THE TRANSLATION OF HEPATITIS GBV PROTEINS 审中-公开
标题翻译：用于控制乙型肝炎病毒蛋白质翻译的试剂和方法
公开(公告)号：WO1997007224A1
公开(公告)日：1997-02-27
申请号：PCT/US1996013198
申请日：1996-08-14
申请人： ABBOTT LABORATORIES
发明人： ABBOTT LABORATORIES , SIMONS, John, N. , DESAI, Suresh, M. , MUSHAHWAR, Isa, K.
IPC分类号： C12N15/86
CPC分类号： C12N15/1131 , C07K14/005 , C07K2319/00 , C12N15/86 , C12N2310/315 , C12N2310/3181 , C12N2310/33 , C12N2770/24222 , C12N2840/203 , C12N2840/55 , C12Q1/6813 , C12Q1/707
摘要： Reagents and composition for controlling the translation of hepatitis GB virus (HGBV)-A, -B or -C peptides from viral nucleic acid. These reagents and methods comprise control elements of the 5'NTR region of the HGBV-A, -B, or -C viral genome.
摘要翻译：用于控制来自病毒核酸的乙型肝炎病毒（HGBV）-A，-B或-C肽的翻译的试剂和组合物。这些试剂和方法包括HGBV-A，-B或-C病毒基因组的5'NTR区域的控制元件。

4. 发明申请

WO1997007246A1 NUCLEIC ACID DETECTION OF HEPATITIS GB VIRUS 审中-公开
标题翻译：乙型肝炎病毒检测GB病毒
公开(公告)号：WO1997007246A1
公开(公告)日：1997-02-27
申请号：PCT/US1996013199
申请日：1996-08-14
申请人： ABBOTT LABORATORIES
发明人： ABBOTT LABORATORIES , MARSHALL, Ronald, L. , JOU, Cynthia , SIMONS, John, N. , LEARY, Thomas, P. , MUERHOFF, A., Scott , DESAI, Suresh, M. , MUSHAHWAR, Isa, K.
IPC分类号： C12Q01/70
CPC分类号： C12Q1/707 , C12Q1/686 , Y10S435/81
摘要： Nucleic oligomer probes useful for detection of HGBV in test samples. Also provided are assays which utilize these probes and test kits which contain these oligomer probes.
摘要翻译：用于检测样品中HGBV的核寡聚体探针。还提供了利用这些探针和包含这些寡聚体探针的测试试剂盒的测定法。

5. 发明申请

WO1996040996A1 METHOD FOR DETECTING NUCLEIC ACID SEQUENCES USING COMPETITIVE AMPLIFICATION 审中-公开
标题翻译：使用竞争性放大检测核酸序列的方法
公开(公告)号：WO1996040996A1
公开(公告)日：1996-12-19
申请号：PCT/US1996008429
申请日：1996-06-03
申请人： ABBOTT LABORATORIES
发明人： ABBOTT LABORATORIES , BIRKENMEYER, Larry , MUSHAHWAR, Isa, K.
IPC分类号： C12Q01/68
CPC分类号： C12Q1/6851 , C12Q1/6862 , C12Q1/706 , C12Q2545/107 , C12Q2531/137
摘要： The present invention provides a method for quantitatively detecting the amount of a target nucleic acid sequence which may be present in a test sample. A test sample which may contain a target nucleic acid sequence comprising target sequences X and Y is contacted with two primer sets, the first set being specific for target X and the second set being specific for target Y. The test sample also is contacted at the same time with an internal standard sequence IS, which is substantially derived from a combination of the first and second target sequences, and its corresponding oligonucleotide primers. Haptens are associated with the oligonucleotide primer sets in such a way that amplified target sequence products X and Y are detected by capture on a solid phase to which anti-hapten capture reagents are attached. A signal ratio of (X + Y)/S is determined to quantitate the amount of the target nucleic acid sequence contained in the sample.
摘要翻译：本发明提供了定量检测可能存在于测试样品中的靶核酸序列的量的方法。可以含有包含靶序列X和Y的靶核酸序列的测试样品与两个引物组接触，第一组对靶标X是特异性的，第二组对靶标Y是特异性的。测试样品也在同时具有基本上衍生自第一和第二靶序列的组合的内标序列IS及其相应的寡核苷酸引物。半抗原与寡核苷酸引物组相关联，使得扩增的靶序列产物X和Y通过捕获在抗半抗原捕获试剂所连接的固相上而被检测。确定（X + Y）/ S的信号比来定量样品中包含的靶核酸序列的量。

6. 发明公开

EP1247099A2 METHODS AND COMPOSITIONS FOR DETECTING HEPATITIS E VIRUS 审中-公开
标题翻译：方法和组合物戊型肝炎病毒检测
公开(公告)号：EP1247099A2
公开(公告)日：2002-10-09
申请号：EP00986554.4
申请日：2000-12-19
申请人： ABBOTT LABORATORIES
发明人： SCHLAUDER, George, G. , ERKER, James, C. , DESAI, Suresh, M. , DAWSON, George, J. , MUSHAHWAR, Isa, K.
IPC分类号： G01N33/576 , G01N33/577 , C12Q1/70 , C07K14/08 , C07K16/10 , C12N15/51 , C12N5/10 , A61K39/29 , A61K39/42 , A61P31/14
CPC分类号： C07K14/005 , A61K39/00 , C12N2770/28122 , G01N33/5767
摘要： Disclosed herein are methods and compositions for detecting the presence in a sample of a US-type or a US-subtype hepatitis E virus, including naturally occurring variants thereof. In particular, the invention provides nucleic acid sequences corresponding to the genome of the US-type or US-subtype hepatitis E virus, amino acid sequences, including epitope sequences, encoded by the genomes of such viruses, and antibodies that bind specifically to such amino acid sequences. The invention further provides methods and compositions for immunizing individuals against infection by, or for treating individuals already infected with such a virus.

7. 发明授权

EP0832281B1 METHOD FOR DETECTING NUCLEIC ACID SEQUENCES USING COMPETITIVE AMPLIFICATION 失效
标题翻译：采用竞争性扩增检测方法的NUCLEIC序列的
公开(公告)号：EP0832281B1
公开(公告)日：2002-01-09
申请号：EP96917000.0
申请日：1996-06-03
申请人： Abbott Laboratories
发明人： BIRKENMEYER, Larry , MUSHAHWAR, Isa, K.
IPC分类号： C12Q1/68 , C12Q1/70 , C12P19/34 , C07H21/04
CPC分类号： C12Q1/6851 , C12Q1/6862 , C12Q1/706 , C12Q2545/107 , C12Q2531/137
摘要： The present invention provides a method for quantitatively detecting the amount of a target nucleic acid sequence which may be present in a test sample. A test sample which may contain a target nucleic acid sequence comprising target sequences X and Y is contacted with two primer sets, the first set being specific for target X and the second set being specific for target Y. The test sample also is contacted at the same time with an internal standard sequence IS, which is substantially derived from a combination of the first and second target sequences, and its corresponding oligonucleotide primers. Haptens are associated with the oligonucleotide primer sets in such a way that amplified target sequence products X and Y are detected by capture on a solid phase to which anti-hapten capture reagents are attached. A signal ratio of (X + Y)/S is determined to quantitate the amount of the target nucleic acid sequence contained in the sample.

8. 发明公开

EP0845048A1 NUCLEIC ACID DETECTION OF HEPATITIS GB VIRUS 失效
标题翻译：核酸检测肝炎病毒GB的
公开(公告)号：EP0845048A1
公开(公告)日：1998-06-03
申请号：EP96928178.0
申请日：1996-08-14
申请人： ABBOTT LABORATORIES
发明人： MARSHALL, Ronald, L. , JOU, Cynthia , SIMONS, John, N. , LEARY, Thomas, P. , MUERHOFF, A., Scott , DESAI, Suresh, M. , MUSHAHWAR, Isa, K.
IPC分类号： C12N15 , C12Q1 , C12R1
CPC分类号： C12Q1/707 , C12Q1/686 , Y10S435/81
摘要： Nucleic oligomer probes useful for detection of HGBV in test samples. Also provided are assays which utilize these probes and test kits which contain these oligomer probes.

9. 发明公开

EP1023605A1 METHODS AND COMPOSITIONS FOR DETECTING HEPATITIS E VIRUS 审中-公开
标题翻译：方法和组合物用于检测戊型肝炎病毒
公开(公告)号：EP1023605A1
公开(公告)日：2000-08-02
申请号：EP98953643.8
申请日：1998-10-15
申请人： Abbott Laboratories
发明人： SCHLAUDER, George, G. , ERKER, James, C. , DESAI, Suresh, M. , DAWSON, George, J. , MUSHAHWAR, Isa, K.
IPC分类号： G01N33/576 , G01N33/577 , C07K14/08 , C07K16/10 , A61K39/29
CPC分类号： C07K14/005 , A61K39/00 , C12N2770/28122 , G01N33/5767
摘要： Disclosed herein are methods and compositions for detecting the presence in a sample of a US-type or a US-subtype hepatitis E virus, including naturally occurring variants thereof. In particular, the invention provides nucleic acid sequences corresponding to the genome of the US-type or US-subtype hepatitis E virus, amino acid sequences, including epitope sequences, encoded by the genomes of such viruses, and antibodies that bind specifically to such amino acid sequences. The invention further provides methods and compositions for immunizing individuals against infection by, or for treating individuals already infected with such a virus.

10. 发明公开

EP0832281A1 METHOD FOR DETECTING NUCLEIC ACID SEQUENCES USING COMPETITIVE AMPLIFICATION 失效
标题翻译：采用竞争性扩增检测方法的NUCLEIC序列的
公开(公告)号：EP0832281A1
公开(公告)日：1998-04-01
申请号：EP96917000.0
申请日：1996-06-03
申请人： Abbott Laboratories
发明人： BIRKENMEYER, Larry , MUSHAHWAR, Isa, K.
IPC分类号： C12Q1
CPC分类号： C12Q1/6851 , C12Q1/6862 , C12Q1/706 , C12Q2545/107 , C12Q2531/137
摘要： The present invention provides a method for quantitatively detecting the amount of a target nucleic acid sequence which may be present in a test sample. A test sample which may contain a target nucleic acid sequence comprising target sequences X and Y is contacted with two primer sets, the first set being specific for target X and the second set being specific for target Y. The test sample also is contacted at the same time with an internal standard sequence IS, which is substantially derived from a combination of the first and second target sequences, and its corresponding oligonucleotide primers. Haptens are associated with the oligonucleotide primer sets in such a way that amplified target sequence products X and Y are detected by capture on a solid phase to which anti-hapten capture reagents are attached. A signal ratio of (X + Y)/S is determined to quantitate the amount of the target nucleic acid sequence contained in the sample.

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