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1. 发明申请

WO2012009699A3 PROCESS FOR PREPARING ANTIVIRAL COMPOUNDS 审中-公开
标题翻译：制备抗病毒化合物的方法
公开(公告)号：WO2012009699A3
公开(公告)日：2012-03-15
申请号：PCT/US2011044283
申请日：2011-07-15
申请人： ABBOTT LAB , SHEKHAR SHASHANK , FRANCZYK THADDEUS S , BARNES DAVID M , DUNN TRAVIS B , HAIGHT ANTHONY R , CHAN VINCENT S
发明人： SHEKHAR SHASHANK , FRANCZYK THADDEUS S , BARNES DAVID M , DUNN TRAVIS B , HAIGHT ANTHONY R , CHAN VINCENT S
IPC分类号： C07D239/54 , A61K31/522 , A61P31/14 , B01J31/24
CPC分类号： C07D239/54 , A61K31/513 , A61K31/7056 , A61K38/21 , A61K45/06 , B01J31/2423 , B01J2231/344 , B01J2231/4227 , B01J2231/4283 , B01J2231/4288 , B01J2231/4294 , B01J2531/824 , A61K2300/00
摘要： This disclosure is directed to: (a) processes for preparing a compound and salts thereof that, inter alia, are useful for inhibiting hepatitis C virus (HCV); (b) intermediates useful for the preparation of the compound and salts; (c) pharmaceutical compositions comprising the compound or salts; and (d) methods of use of such compositions.
摘要翻译：本公开涉及：（a）制备其特别是可用于抑制丙型肝炎病毒（HCV）的化合物及其盐的方法; （b）可用于制备化合物和盐的中间体; （c）包含该化合物或其盐的药物组合物; 和（d）使用这种组合物的方法。

2. 发明申请

WO2009073250A3 A PACKET STRUCTURE FOR A MOBILE DISPLAY DIGITAL INTERFACE 审中-公开
标题翻译：移动显示数字接口的分组结构
公开(公告)号：WO2009073250A3
公开(公告)日：2010-04-08
申请号：PCT/US2008063109
申请日：2008-05-08
申请人： QUALCOMM INC , STEELE BRIAN , WILEY GEORGE ALAN , SHEKHAR SHASHANK
发明人： STEELE BRIAN , WILEY GEORGE ALAN , SHEKHAR SHASHANK
IPC分类号： H04L12/56 , H04L29/06 , H04N7/24 , H04W84/18
CPC分类号： H04L69/22 , H04L69/18 , H04W80/02
摘要： A packet structure for a Mobile Display Digital Interface (MDDI) includes a flexible sub-frame length to efficiently transmit large packets. A windowless video stream packet avoids repetitive transmissions of video packets when some parameters are unchanged, saving bandwidth. An enhanced reverse encapsulation packet combines the feature of a separate round trip delay packet with a separate reverse encapsulation packet. A link freeze is used to halt a transmission of a data stream at any point in the transmission and resume the transmission by a host.
摘要翻译：用于移动显示数字接口（MDDI）的分组结构包括有效传输大分组的灵活子帧长度。当一些参数不变时，无窗口视频流数据包避免视频数据包的重复传输，从而节省带宽。增强的反向封装分组将单独的往返延迟分组的特征与单独的反向封装分组相结合。链路冻结用于在传输中的任何点停止数据流的传输，并由主机恢复传输。

3. 发明申请

WO2005018191A3 A SIGNAL INTERFACE FOR HIGHER DATA RATES 审中-公开
标题翻译：用于更高数据速率的信号接口
公开(公告)号：WO2005018191A3
公开(公告)日：2008-01-10
申请号：PCT/US2004026264
申请日：2004-08-12
申请人： QUALCOMM INC , ANDERSON JON JAMES , STEELE BRIAN , WILEY GEORGE ALAN , SHEKHAR SHASHANK
发明人： ANDERSON JON JAMES , STEELE BRIAN , WILEY GEORGE ALAN , SHEKHAR SHASHANK
IPC分类号： H04L29/06 , G06F13/40 , H04L12/56 , H04L29/00 , H04M1/725
CPC分类号： G06F13/4072 , H04L29/06027 , H04L65/607 , H04L69/22 , H04M1/72527 , Y02D70/122 , Y02D70/1262 , Y02D70/144 , Y02D70/26
摘要： A data Interface for transferring digital data between a host and a client over a communication path using packet structures linked together to form a communication protocol for communicating a pre-selected set of digital control and presentation data. The signal protocol is used by link controllers configured to generate, transmit, and receive packets forming the communications protocol, and to form digital data into one or more types of data packets, with at least one residing in the host device and being coupled to the client through the communications path. The interface provides a cost-effective, low power, bi-directional, high-speed data transfer mechanism over a short-range "serial" type data link, which lends itself to implementation with miniature connectors and thin flexible cables which are especially useful in connecting display elements such as wearable micro-displays to portable computers and wireless communication devices.
摘要翻译：一种数据接口，用于通过连接在一起的分组结构通过通信路径在主机和客户端之间传送数字数据，以形成用于传送预先选择的一组数字控制和呈现数据的通信协议。信号协议被配置为生成，发送和接收形成通信协议的分组的链路控制器使用，并且将数字数据形成为一个或多个类型的数据分组，其中至少一个驻留在主机设备中并被耦合到客户端通过通信路径。该接口通过短距离“串行”型数据链路提供了经济高效，低功耗，双向，高速的数据传输机制，可实现微型连接器和薄型柔性电缆，这些电缆特别适用于将可穿戴式微型显示器等显示元件连接到便携式计算机和无线通信装置。

4. 发明申请

WO2004110021A3 GENERATING AND IMPLEMENTING A SIGNAL PROTOCOL AND INTERFACE FOR HIGHER DATA RATES 审中-公开
标题翻译：生成和实施信号协议和接口以实现更高的数据速率
公开(公告)号：WO2004110021A3
公开(公告)日：2005-03-31
申请号：PCT/US2004017579
申请日：2004-06-02
申请人： QUALCOMM INC , ANDERSON JON JAMES , STEELE BRIAN , WILEY GEORGE A , SHEKHAR SHASHANK
发明人： ANDERSON JON JAMES , STEELE BRIAN , WILEY GEORGE A , SHEKHAR SHASHANK
IPC分类号： H04L1/00 , H04L1/24 , H04L7/00 , H04L7/04 , H04L7/10 , H04L29/06 , H04L29/08 , H04M1/725 , H04N7/24 , G06F3/14 , H04L12/64
CPC分类号： H04L65/607 , H04L1/0061 , H04L1/245 , H04L7/0008 , H04L7/048 , H04L7/10 , H04L29/06 , H04L29/06027 , H04L69/03 , H04L69/18 , H04L69/22 , H04L69/24 , H04L69/324 , H04M1/72527 , H04N21/4122 , H04N21/41407 , H04N21/43632 , Y02D70/12 , Y02D70/122 , Y02D70/26
摘要： A data Interface for transferring digital data between a host (100) and a client (104,108) over a communication path (110) using packet structures linked together to form a communication protocol for communicating a pre-selected set of digital control and presentation data. The signal protocol is used by link controllers configured to generate, transmit, and receive packets forming the communications protocol, and to form digital data into one or more types of data packets, with at least one residing in the host device (100) and being coupled to the client (104,108) through the communications path (110). The interface provides a cost-effective, low power, bi-directional, high-speed data transfer mechanism over a short-range "serial" type data link, which lends itself to implementation with miniature connectors and thin flexible cables which are especially useful in connecting display elements such as wearable micro-displays (104) to portable computers (100) and wireless communication devices (102).
摘要翻译：一种数据接口，用于通过链接在一起的分组结构通过通信路径（110）在主机（100）和客户机（104,108）之间传送数字数据，以形成用于传送预先选择的一组数字控制和呈现数据的通信协议。信号协议被配置为生成，发送和接收形成通信协议的分组的链路控制器使用，并且将数字数据形成为一个或多个类型的数据分组，其中至少一个驻留在主机设备（100）中，并且是通过通信路径（110）耦合到客户端（104,108）。该接口通过短距离“串行”型数据链路提供了经济高效，低功耗，双向，高速的数据传输机制，可实现微型连接器和薄型柔性电缆，这些电缆特别适用于将可穿戴微显示器（104）的显示元件连接到便携式计算机（100）和无线通信设备（102）。

5. 发明申请

WO2005053272A9 HIGH DATA RATE INTERFACE WITH IMPROVED LINK SYNCHRONIZATION 审中-公开
标题翻译：具有改进的链路同步的高数据速率接口
公开(公告)号：WO2005053272A9
公开(公告)日：2007-06-21
申请号：PCT/US2004039697
申请日：2004-11-24
申请人： QUALCOMM INC , ANDERSON JON JAMES , STEELE BRIAN , WILEY GEORGE A , SHEKHAR SHASHANK
发明人： ANDERSON JON JAMES , STEELE BRIAN , WILEY GEORGE A , SHEKHAR SHASHANK
IPC分类号： H04L12/28 , H04L12/56 , H04L29/06 , H04M1/725
CPC分类号： H04L67/42 , H04L29/06027 , H04L65/1069 , H04L65/4069 , H04L65/80 , H04L69/18 , H04L69/22 , H04M1/72527 , Y02D70/12 , Y02D70/122 , Y02D70/144 , Y02D70/26
摘要： A data Interface for transferring digital data between a host and a client over a communication path using packet structures linked together to form a communication protocol for communicating a pre-selected set of digital control and presentation data. The signal protocol is used by link controllers configured to generate, transmit, and receive packets forming the communications protocol, and to form digital data into one or more types of data packets, with at least one residing in the host device and being coupled to the client through the communications path. The interface provides a cost-effective, low power, bi-directional, high-speed data transfer mechanism over a short-range "serial" type data link, which lends itself to implementation with miniature connectors and thin flexible cables which are especially useful in connecting display elements such as wearable micro-displays to portable computers and wireless communication devices.
摘要翻译：一种数据接口，用于通过连接在一起的分组结构通过通信路径在主机和客户端之间传送数字数据，以形成用于传送预先选择的一组数字控制和呈现数据的通信协议。信号协议被配置为生成，发送和接收形成通信协议的分组的链路控制器使用，并且将数字数据形成为一个或多个类型的数据分组，其中至少一个驻留在主机设备中并被耦合到客户端通过通信路径。该接口通过短距离“串行”型数据链路提供了经济高效，低功耗，双向，高速的数据传输机制，可实现微型连接器和薄型柔性电缆，这些电缆特别适用于将可穿戴式微型显示器等显示元件连接到便携式计算机和无线通信装置。

6. 发明专利

CA2750125A1 METHODS FOR PREPARING S1P RECEPTOR AGONISTS AND ANTAGONISTS 未知
公开(公告)号：CA2750125A1
公开(公告)日：2010-08-19
申请号：CA2750125
申请日：2010-02-09
申请人： ABBOTT LAB
发明人： SHEKHAR SHASHANK , YU SU , HAIGHT ANTHONY R , CHMURA PRESTON E , KISHORE VIMAL
IPC分类号： A61K31/135
摘要： Disclosed herein are methods of making compounds which are agonists or antagonists of one or more of the individual receptors of the S1P receptor family.

7. 发明专利

CA2727932A1 A PROCESS FOR THE PREPARATION OF THE APOPTOSIS PROMOTER ABT-263 未知
公开(公告)号：CA2727932A1
公开(公告)日：2009-12-23
申请号：CA2727932
申请日：2009-06-18
申请人： ABBOTT LAB
发明人： FRANCZYK THADDEUS S II , HILL DAVID R , HAIGHT ANTHONY R , MCLAUGLIN MAUREEN ANN , SHEKHAR SHASHANK , YU SU , MEI JIANZHANG , WANG LEI
IPC分类号： C07D295/155
摘要： A process for the preparation of the apoptosis promoter N-(4-(4-((2-(4-chlorophenyl)-5,5- dimethyl- 1 -cyclohex- 1 -en- 1 -yl)methyl)piperazin- 1 -yl)benzoyl)-4-((( 1 R)-3-(morpholin-4-yl)- 1-((phenylsulfanyl) methyl)propyl)amino)-3-(trifluoromethyl)sulfonyl)benzenesulfonamide (ABT-263). Formula (I).

8. 发明专利

ES2423668T3 Moduladores de receptores 5-HT y métodos de uso de los mismos 未知
公开(公告)号：ES2423668T3
公开(公告)日：2013-09-23
申请号：ES10720502
申请日：2010-05-20
申请人： ABBOTT LAB , ABBOTT GMBH & CO KG , ABBVIE INC
发明人： WELCH DENNIE S , AKRITOPOULOU-ZANZE IRINI , BRAJE WILFRIED , DJURIC STEVAN W , WILSON NOEL S , TURNER SEAN C , KRUGER ALBERT W , RELO ANA-LUCIA , SHEKHAR SHASHANK , ZHAO HONGYU , GANDARILLA JORGE , GASIECKI ALAN F , LI HUANQIU , THOMPSON CHRISTINA M , ZHANG MIN
IPC分类号： C07D487/04 , A61K31/551 , A61K31/553 , A61K31/554 , A61P25/00 , C07D491/04 , C07D495/04
摘要： Un compuesto de fórmula (I):**Fórmula** o una sal farmacéuticamente aceptable del mismo,donde A está seleccionado entre el grupo que consiste en R1, R3, R4, y R5 están seleccionados independientemente entre el grupo que consiste en hidrógeno, alquenilo, alquilo, haloalquilo, G1, G2, -(CR4aR5a)m-G1, y -(CR4aR5a)m-G2; R4a y R5a, en cada caso, cada uno es independientemente hidrógeno, halógeno, alquilo, o haloalquilo; G1, en cada caso, es independientemente arilo o heteroarilo, donde cada G1 está independientemente sin sustituir osustituido con 1, 2, 3, 4 o 5 sustituyentes seleccionados entre el grupo que consiste en alquilo, alquenilo, alquinilo,halógeno, ciano, -NO2, -OR1b, -OC(O)R1b, -OC(O)N(Rb)(R3b), -SR1b, -S(O)R2b, -S(O)2R2b, -S(O)2N(Rb)(R3b), -C(O)R1b,-C(O)OR1b, -C(O)N(Rb)(R3b), -N(Rb)(R3b), -N(Ra)C(O)R1b, -N(Ra)C(O)O(R1b), -N(Ra)C(O)N(Rb)(R3b), -(CR4bR5b)m-NO2,-N(Rb)S(O)2(R2b), -(CR4bR5b)m-OR1b, -C(OH)[(CR4bR5b)m-R4b]2, -(CR4bR5b)m-OC(O)R1b, -(CR4bR5b)m-OC(O)N(Rb)(R3b), -(CR4bR5b)m-SR1b, -(CR4bR5b)m-S(O)R2b, -(CR4bR5b)m-S(O)2R2b, -(CR4bR5b)m-S(O)2N(Rb)(R3b),-(CR4bR5b)m-C(O)R1b, -(CR4bR5b)m-C(O)OR1b, -(CR4bR5b)m-C(O)N(Rb)(R3b), -(CR4bR5b)m-N(Rb)(R3b), -(CR4bR5b)m-N(Ra)C(O)R1b, -(CR4bR5b)m-N(Ra)C(O)O(R1b), -(CR4bR5b)m-N(Ra)C(O)N(Rb)(R3b), -(CR4bR5b)m-N(Rb)S(O)2(R2b),cianoalquilo, y haloalquilo.

9. 发明专利

ES2409263T3 Un procedimiento para la preparación del promotor de la apoptosis ABT-263 未知
公开(公告)号：ES2409263T3
公开(公告)日：2013-06-26
申请号：ES09767695
申请日：2009-06-18
申请人： ABBOTT LAB
发明人： FRANCZYK THADDEUS , HILL DAVID , HAIGHT ANTHONY , MCLAUGLIN MAUREEN , SHEKHAR SHASHANK , YU SU , MEI JIANZHANG , WANG LEI
IPC分类号： C07D295/13 , C07D295/155
摘要： Un procedimiento para elaborar N-(4-(4-((2-(4-clorofenil)-5,5-dimetil-1-ciclohex-1-en-1-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(morfolin-4-il)-1-((fenilsulfanil)metil)propil)amino)-3-((trifluorometil)sulfonil)bencenosulfonamida,o una de sus sales farmacéuticamente aceptables, que comprende: (e) hacer reaccionar el 2-(4-clorofenil)-5,5-dimetilciclohex-1-eno-1-carbaldehído, 4-piperazin-1-ilbenzoato de etilo yun primer agente reductor y aislar o no aislar el 4-(4-((2-(4-clorofenil)-5,5-dimetilciclohex-1-en-1-il)metil)piperazin-1-il)benzoato de etilo; (f) hacer reaccionar el 4-(4-((2-(4-clorofenil)-5,5-dimetilciclohex-1-en-1-il)metil)piperazin-1-il)benzoato de etilo y unatercera base acuosa, y aislar o no aislar el ácido 4-(4-((2-(4-clorofenil)-5,5-dimetilciclohex-1-en-1-il)metil)piperazin-1-il)benzoico; y (g) hacer reaccionar el ácido 4-(4-((2-(4-clorofenil)-5,5-dimetilciclohex-1-en-1-il)metil)piperazin-1-il)benzoico, 4-(((1R)-3-morfolin-4-il-1-((feniltio)metil)propil)amino)-3-((trifluorometil)sulfonil)bencenosulfonamida y un primer reactivo deacoplamiento con o sin una cuarta base y con o sin un reactivo de acoplamiento auxiliar, y aislar o no aislar la N-(4-(4-((2-(4-clorofenil)-4,5-dimetil-1-ciclohex-1-en-1-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(morfolin-4-il)-1-((fenilsulfanil)metil)propil)amino)-3-((trifluorometil)sulfonil)bencenosulfionamida.

10. 发明专利

NZ589732A A PROCESS FOR THE PREPARATION OF THE APOPTOSIS PROMOTER ABT-263 未知
公开(公告)号：NZ589732A
公开(公告)日：2012-08-31
申请号：NZ58973209
申请日：2009-06-18
申请人： ABBOTT LAB
发明人： FRANCZYK THADDEUS S , HILL DAVID R , HAIGHT ANTHONY R , MCLAUGLIN MAUREEN ANN , SHEKHAR SHASHANK , YU SU , MEI JIANZHANG , WANG LEI
IPC分类号： C07D295/155 , C07D295/023
摘要： Disclosed A process for making ABT-263 (7) an apoptosis promoter having the proper chemical name: N-(4-(4-((2-(4-chlorophenyl)-5,5-dimethyl-1-cyclohex-1-en-1-yl)methyl)piperazin-1-yl)benzoyl)-4-(((1R)-3-(morpholin-4-yl)-((phenylsulfanyl)methyl)propyl)amino)-3-((trifluoromethyl)sulfonyl)benzenesulfonamide, comprising: (a) reacting 4,4-dimethylcyclohexanone, an alkyl formate and a first base to provide (2E)-2-(hydroxymethylene)-4,4-dimethylcyclohexanone and isolating or not isolating the (2E)-2-(hydroxymethylene)-4,4-dimethylcyclohexanone; (b) reacting the (2E)-2-(hydroxymethylene)-4,4-dimethylcyclohexanone, a second base and a first silyl ether protecting group reagent to provide a first protected (2E)-2-(hydroxymethylene)-4,4-dimethylcyclohexanone and isolating or not isolating the first protected (2E)-2-(hydroxymethylene)-4,4-dimethylcyclohexanone; (c) reacting the first protected (2E)-2-(hydroxymethylene)-4,4-dimethylcyclohexanone and 4-chlorophenyl magnesium bromide to provide the first protected (2E)-1-(4-chlorophenyl)-2-(hydroxymethylene)-4,4-dimethylcyclohexanol; and isolating or not isolating the first protected (2E)-1-(4-chlorophenyl)-2-(hydroxymethylene)4,4-dimethylcyclohexanol; and (d) reacting the first protected (2E)-1-(4-chlorophenyl)-2-(hydroxymethylene)-4,4-dimethylcyclohexanol and a first acid to provide 2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-ene-1-carbaldehyde and isolating or not isolating the 2-(4-chlorophenyl)5,5-dimethylcyclohex-1-ene-1-carbaldehyde; (e) reacting 2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-ene-1-carbaldehyde, ethyl 4-piperazin-1-ylbenzoate and a first reducing agent and isolating or not isolating the ethyl 4-(4-((2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-en-1-yl)methyl)piperazin-1-yl)benzoate; (f) reacting ethyl 4-(4-((2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-en-1-yl)methyl)piperazin-1-yl)benzoate and an aqueous third base, and isolating or not isolating the 4-(4-((2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-en-1-yl)methyl)piperazin-1-yl)benzoic acid; and (g) reacting 4-(4-((2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-en-1-yl)methyl)piperazin-1-yl)benzoic acid, 4-(((1R)-3-morpholin-4-yl-1-((phenylthio)methyl)propyl)amino)-3-((trifluoromethyl)sulfonyl)benzenesulfonamide, a first coupling reagent, and, optionally; a first auxiliary coupling reagent and isolating or not isolating the N-(4-(4-((2-(4-chlorophenyl)-5,5-dimethyl-1-cyclohex-1-en-1-yl)methyl)piperazin-1-yl)benzoyl)-4-(((1R)-3-(morpholin-4-yl)-1- ((phenylsulfanyl)methyl)propyl)amino)-3-((trifluoromethyl)sulfonyl)benzenesulfonamide.

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