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1. 发明申请

WO2007038058A3 AMINO-AZA-ADAMANTANE DERIVATIVES AND METHODS OF USE 审中-公开
标题翻译：氨基亚氨基衍生物及其使用方法
公开(公告)号：WO2007038058A3
公开(公告)日：2007-07-05
申请号：PCT/US2006036360
申请日：2006-09-19
申请人： ABBOTT LAB , SCHRIMPF MICHAEL R , SIPPY KEVIN B , ANDERSON DAVID J , BUNNELLE WILLIAM H , NERSESIAN DIANA L
发明人： SCHRIMPF MICHAEL R , SIPPY KEVIN B , ANDERSON DAVID J , BUNNELLE WILLIAM H , NERSESIAN DIANA L
IPC分类号： C07D471/18 , A61K31/435 , A61P25/00 , C07D487/04 , C07D487/08
CPC分类号： C07D487/04
摘要： The invention relates to amine-substituted aza-adamantane derivatives, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. Radiolabelled compounds useful for evaluating the binding affinity to a7 nicotinic acetylcholine receptors also are described.
摘要翻译：本发明涉及胺取代的氮杂 - 金刚烷衍生物，包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。还描述了可用于评价对α7烟碱乙酰胆碱受体的结合亲和力的放射性标记化合物。

2. 发明申请

WO2008073942A3 PHARMACEUTICAL COMPOSITIONS AND THEIR METHODS OF USE 审中-公开
标题翻译：药物组合物及其使用方法
公开(公告)号：WO2008073942A3
公开(公告)日：2008-12-04
申请号：PCT/US2007087090
申请日：2007-12-12
申请人： ABBOTT LAB , GOPALAKRISHNAN MURALI , HONORE MARIE P , LEE CHIH-HUNG , MALYSZ JOHN , JI JIANGUO , LI TAO , SCHRIMPF MICHAEL R , SIPPY KEVIN B , ANDERSON DAVID J
发明人： GOPALAKRISHNAN MURALI , HONORE MARIE P , LEE CHIH-HUNG , MALYSZ JOHN , JI JIANGUO , LI TAO , SCHRIMPF MICHAEL R , SIPPY KEVIN B , ANDERSON DAVID J
IPC分类号： A61K31/4245 , A61K45/06 , A61P25/28
CPC分类号： A61K31/4439 , A61K31/4245 , A61K31/4427 , A61K31/443 , A61K31/444 , A61K31/4709 , A61K45/06 , C07D413/04 , C07D413/14 , G01N33/944 , G01N2333/70571 , A61K2300/00
摘要： The invention relates to a composition comprising a neuronal nicotinic receptor ligand and an a4ß2 positive allosteric modulator, a method of using the same, and a related article of manufacture.
摘要翻译：本发明涉及包含神经元烟碱受体配体和α4β2正变构调节剂的组合物，使用该组合物的方法和相关的制造物品。

3. 发明申请

WO2009003074A9 CHOLINERGIC/SEROTONINERGIC CHIMERIC RECEPTOR AND USES THEREOF 审中-公开
标题翻译： CHOLINERGIC / SERONONERGIC CHIMERIC RECEPTOR及其用途
公开(公告)号：WO2009003074A9
公开(公告)日：2010-10-28
申请号：PCT/US2008068264
申请日：2008-06-26
申请人： ABBOTT LAB , GOPALAKRISHNAN MURALI , LI JINHE , CASSAR STEVEN C , MALYSZ JOHN , ANDERSON DAVID J , GUBBINS EARL J , BERTRAND DANIEL C
发明人： GOPALAKRISHNAN MURALI , LI JINHE , CASSAR STEVEN C , MALYSZ JOHN , ANDERSON DAVID J , GUBBINS EARL J , BERTRAND DANIEL C
IPC分类号： C07K14/435
CPC分类号： C07K14/723 , C07K14/70571 , G01N33/566 , G01N2500/04
摘要： The present invention describes new cholinergic/serotoninergic chimeric receptors and provides methods and compositions suitable for screening for ligands such as agonists, antagonists and allosteric modulators of a7 nicotinic acetylcholine receptors.
摘要翻译：本发明描述了新的胆碱能/ 5-羟色胺能受体嵌合受体，并且提供适合于筛选配体的方法和组合物，所述配体如α7烟碱乙酰胆碱受体的激动剂，拮抗剂和变构调节剂。

4. 发明申请

WO2009003074A2 CHOLINERGIC/SEROTONINERGIC RECEPTOR AND USES THEREOF 审中-公开
标题翻译：胆碱酯酶/受体受体及其用途
公开(公告)号：WO2009003074A2
公开(公告)日：2008-12-31
申请号：PCT/US2008068264
申请日：2008-06-26
申请人： ABBOTT LAB , GOPALAKRISHNAN MURALI , LI JINHE , CASSAR STEVEN C , MALYSZ JOHN , ANDERSON DAVID J , GUBBINS EARL J , BERTRAND DANIEL C
发明人： GOPALAKRISHNAN MURALI , LI JINHE , CASSAR STEVEN C , MALYSZ JOHN , ANDERSON DAVID J , GUBBINS EARL J , BERTRAND DANIEL C
IPC分类号： C07K14/435
CPC分类号： C07K14/723 , C07K14/70571 , G01N33/566 , G01N2500/04
摘要： The present invention describes new cholinergic/serotoninergic chimeric receptors and provides methods and compositions suitable for screening for ligands such as agonists, antagonists and allosteric modulators of a7 nicotinic acetylcholine receptors.
摘要翻译：本发明描述了新的胆碱能/ 5-羟色胺能受体嵌合受体，并且提供适合于筛选配体的方法和组合物，所述配体如α7烟碱乙酰胆碱受体的激动剂，拮抗剂和变构调节剂。

5. 发明申请

WO2009003074A8 CHOLINERGIC/SEROTONINERGIC RECEPTOR AND USES THEREOF 审中-公开
标题翻译：胆碱酯酶/受体受体及其用途
公开(公告)号：WO2009003074A8
公开(公告)日：2009-07-16
申请号：PCT/US2008068264
申请日：2008-06-26
申请人： ABBOTT LAB , GOPALAKRISHNAN MURALI , LI JINHE , CASSAR STEVEN C , MALYSZ JOHN , ANDERSON DAVID J , GUBBINS EARL J , BERTRAND DANIEL C
发明人： GOPALAKRISHNAN MURALI , LI JINHE , CASSAR STEVEN C , MALYSZ JOHN , ANDERSON DAVID J , GUBBINS EARL J , BERTRAND DANIEL C
IPC分类号： C07K14/435
CPC分类号： C07K14/723 , C07K14/70571 , G01N33/566 , G01N2500/04
摘要： The present invention describes new cholinergic/serotoninergic chimeric receptors and provides methods and compositions suitable for screening for ligands such as agonists, antagonists and allosteric modulators of a7 nicotinic acetylcholine receptors.
摘要翻译：本发明描述了新的胆碱能/ 5-羟色胺能受体嵌合受体，并且提供适合于筛选配体的方法和组合物，所述配体如α7烟碱乙酰胆碱受体的激动剂，拮抗剂和变构调节剂。

6. 发明申请

WO2004106345A3 HETEROARYL-ETHANOLAMINE DERIVATIVES AS ANTIVIRAL AGENTS 审中-公开
标题翻译：异丙醇胺衍生物作为抗病毒剂
公开(公告)号：WO2004106345A3
公开(公告)日：2005-03-03
申请号：PCT/US0324802
申请日：2003-08-27
申请人： UPJOHN CO , SCHNUTE MARK E , CUDAHY MICHELE M , EGGEN MARIJEAN , ANDERSON DAVID J , JUDGE THOMAS M , KIM EUIBONG J , COLLIER SARAH A
发明人： SCHNUTE MARK E , CUDAHY MICHELE M , EGGEN MARIJEAN , ANDERSON DAVID J , JUDGE THOMAS M , KIM EUIBONG J , COLLIER SARAH A
IPC分类号： A61P31/12 , A61P31/18 , C07D495/04 , A61K31/44
CPC分类号： C07D495/04
摘要： The present invention provides a compound of formula (I) as described herein, which are useful as antiviral agents, in particular, as agents against viruses of the herpes family.
摘要翻译：本发明提供了本文所述的式（I）化合物，其可用作抗病毒剂，特别是作为抗疱疹家族病毒的药剂。

7. 发明申请

WO0240540A3 ARTERY SMOOTH MUSCLE- AND VEIN SMOOTH MUSCLE-SPECIFIC PROTEINS AND USES THEREFOR 审中-公开
标题翻译：动物平滑肌肉和丝状肌肉特异性蛋白及其用途
公开(公告)号：WO0240540A3
公开(公告)日：2003-01-16
申请号：PCT/US0142961
申请日：2001-11-20
申请人： CALIFORNIA INST OF TECHN , BRIGHAM & WOMENS HOSPITAL , ANDERSON DAVID J , GARCIA-CARDENA GUILLERMO , GIMBRONE JR MICHAEL A , WANG HAI U
发明人： ANDERSON DAVID J , GARCIA-CARDENA GUILLERMO , GIMBRONE JR MICHAEL A , WANG HAI U
IPC分类号： A01K67/027 , A61K31/436 , A61K31/7088 , A61K35/12 , A61K38/00 , A61K38/22 , A61K38/46 , A61K39/395 , A61K45/00 , A61K45/06 , A61K47/48 , A61K48/00 , A61K49/00 , A61P7/02 , A61P9/00 , A61P17/02 , A61P35/00 , C07K14/52 , C07K14/705 , C12N5/06 , C12N5/10 , C12N15/09 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/533 , G01N33/574 , G01N33/68 , A61K38/17 , A61K38/19
CPC分类号： C07K14/52 , A61K47/64 , A61K49/0006 , C07K14/705 , G01N33/574 , G01N33/6863 , G01N33/6887
摘要： Arterial and venous smooth muscle cells are molecularly distinct from the earliest stages of angiogenesis through to adulthood. This distinction is revelated by expression on arterial cells (e.g., arterial endothelial cells, arterial smooth muscle cells) of a transmembrane ligand, called EphrinB2 whose receptor EphB4 is expressed on venous cells. Targeted disruption of the EphrinB2 genne prevents the remodeling of veins from a capillary plexus into properly branched structures. Moreover, it also disrupts the remodeling of arteries, suggesting that reciprocal interactions between pre-specified arterial and venous cells are necessary for angiogenesis. Expression of EphrinB2 in arterial cells (e.g., arterial endothelial cells, arterial smooth muscle cells) can be used to advantage in methods for targeting agents and/or encoded polypeptides to arterial smooth muscle cells, altering angiogenesis, assessing the effect of agents on arterial smooth muscle cells, identifying arterial smooth muscle cells, isolating arterial smooth muscle cells and production of artificial vessels, for example.
摘要翻译：动脉和静脉平滑肌细胞与血管生成至成年期的最早阶段分子截然不同。通过在受体EphB4在静脉细胞上表达的称为EphrinB2的跨膜配体的动脉细胞（例如动脉内皮细胞，动脉平滑肌细胞）上的表达来揭示这种区别。 EphrinB2Genne的靶向破坏防止了从毛细血管丛将静脉重塑成适当的分支结构。此外，它还破坏动脉重塑，这表明预先规定的动脉和静脉细胞之间的相互作用对血管生成是必需的。 EphrinB2在动脉细胞（例如，动脉内皮细胞，动脉平滑肌细胞）中的表达可用于将动力平滑肌细胞靶向试剂和/或编码的多肽的方法，改变血管发生，评估试剂对动脉平滑的影响肌肉细胞，识别动脉平滑肌细胞，分离动脉平滑肌细胞和生产人造血管。

8. 发明申请

WO9952541A2 ARTERY- AND VEIN-SPECIFIC PROTEINS AND USES THEREFOR 审中-公开
标题翻译：特异性和特异性蛋白质及其用途
公开(公告)号：WO9952541A2
公开(公告)日：1999-10-21
申请号：PCT/US9908098
申请日：1999-04-13
申请人： CALIFORNIA INST OF TECHN , WANG HAI U , CHEN ZHOUFENG , ANDERSON DAVID J
发明人： WANG HAI U , CHEN ZHOUFENG , ANDERSON DAVID J
IPC分类号： A01K67/027 , A01K67/00 , A01K67/033 , A61K35/12 , A61K38/00 , A61K38/17 , A61K38/19 , A61K39/00 , A61K39/395 , A61K45/00 , A61K47/46 , A61K47/48 , A61K49/00 , A61P9/00 , A61P9/10 , A61P35/00 , C07H21/04 , C07K14/00 , C07K14/705 , C07K16/00 , C07K16/28 , C12N5/00 , C12N5/02 , C12N5/071 , C12N5/10 , C12N15/09 , C12N15/85 , C12P21/02 , C12Q1/04 , C12Q1/68 , G01N33/48 , G01N33/50 , G01N33/53 , G01N33/567 , G01N33/574 , C12N5/06 , C12N5/08
CPC分类号： C07K14/705 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0375 , A61K38/00 , A61K38/19 , A61K49/0002 , C07K16/2866 , C12N5/0691 , C12N15/8509 , C12N2503/02 , G01N2333/52
摘要： Arterial and venous endothelial cells are molecularly distinct from the earliest stages of angiogenesis. This distinction is revealed by expression on arterial cells of a transmembrane ligand, called EphrinB2 whose receptor EphB4 is expressed on venous cells. Targeted disruption of the EprhinB2 gene prevents the remodeling of veins from a capillary plexus into properly branched structures. Moreover, it also disrupts the remodeling of arteries, suggesting that reciprocal interactions between pre-specified arterial and venous endothelial cells are necessary for angiogenesis. This distinction can be used to advantage in methods to alter angiogenesis, methods to assess the effect of drugs on artery cells and vein cells, and methods to identify and isolate artery cells nad vein cells, for example.
摘要翻译：动脉和静脉内皮细胞与血管生成的最早阶段分子不同。通过在受体EphB4在静脉细胞上表达的称为EphrinB2的跨膜配体的动脉细胞上的表达来揭示这种区别。 EprhinB2基因的靶向破坏阻止了从毛细血管丛将静脉重塑成适当的支化结构。此外，它还破坏动脉重塑，这表明预先规定的动脉和静脉内皮细胞之间的相互作用对于血管发生是必需的。这种区别可用于改变血管生成的方法，评估药物对动脉细胞和静脉细胞的作用的方法，以及鉴定和分离静脉细胞的动脉细胞的方法。

9. 发明申请

WO2005066674A3 TELECOMMUNICATIONS CONNECTOR PROTECTIVE DEVICE 审中-公开
标题翻译：电信连接器保护装置
公开(公告)号：WO2005066674A3
公开(公告)日：2005-09-15
申请号：PCT/US2004040401
申请日：2004-12-03
申请人： ADC TELECOMMUNICATIONS INC , HOVLAND JEFFREY S , HOLMQUIST MARLON E , POMROY WILLIAM , ANDERSON DAVID J
发明人： HOVLAND JEFFREY S , HOLMQUIST MARLON E , POMROY WILLIAM , ANDERSON DAVID J
IPC分类号： G02B6/38 , G02B6/44
CPC分类号： G02B6/3849 , G02B6/4471
摘要： A fiber optic connector assembly with a fiber optic connector mounted to a fiber optic cable and including a ferrule with an end face terminating the fiber. A plug is configured to fit about and engage the ferrule of the fiber optic connector to the seal the end face from contaminants. An adhesive tape is releasably attached to the connector about the plug, holding the plug to the connector. Further, a cover assembly for a fiber optic connector mounted to an end of and terminating a fiber optic cable. The cover includes an open sided box and a lid sized to engage the open side. The box and the lid define a cavity sized to fit about and receive a fiber optic connector. The cavity has an open end adapted to receive the optical fiber cable. The fiber optic connector is held within the cavity and the cable extends through the open end, with the lid engaging the open side and sealing the cavity from contaminants outside the cavity.
摘要翻译：一种光纤连接器组件，其具有安装到光纤电缆的光纤连接器并且包括具有终止光纤的端面的套圈。插头被配置为使光纤连接器的套圈围绕并接合，以将端面从污染物密封。粘合带围绕插头可释放地附接到连接器，将插头固定到连接器上。此外，用于光纤连接器的盖组件安装到光纤电缆的端部并终止。盖子包括一个敞开的侧面盒和一个尺寸适于接合开放侧面的盖子。盒子和盖子限定了一个尺寸适于围绕和接收光纤连接器的腔体。空腔具有适于容纳光缆的开口端。光纤连接器被保持在空腔内，并且电缆延伸穿过开口端，盖子与开口侧接合，并且将腔体与空腔外的污染物密封。

10. 发明申请

WO9627665A3 Neuron-restrictive silencer factor proteins 审中-公开
标题翻译：神经元限制性沉默因子蛋白
公开(公告)号：WO9627665A3
公开(公告)日：1997-04-24
申请号：PCT/US9602817
申请日：1996-03-01
申请人： CALIFORNIA INST OF TECHN , ANDERSON DAVID J , SCHOENHERR CHRISTOPHER J
发明人： ANDERSON DAVID J , SCHOENHERR CHRISTOPHER J
IPC分类号： C12N15/00 , C07K14/47 , C07K16/18 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12R1/01 , C12R1/91 , C12N5/10
CPC分类号： C07K14/47
摘要： The present invention relates to neuron-restrictive silencer factor proteins, nucleic acids, and antibodies thereto.

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