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1. 发明申请

WO2007140439A3 COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS AND USES THEREOF 审中-公开
标题翻译：化合物作为CANNABINOID受体配体及其用途
公开(公告)号：WO2007140439A3
公开(公告)日：2008-01-24
申请号：PCT/US2007070029
申请日：2007-05-31
申请人： ABBOTT LAB , DART MICHAEL J , CARROLL WILLIAM A , FLORJANCIC ALAN S , FROST JENNIFER M , GALLAGHER MEGAN E , KOLASA TEODOZYJ , LI TONGMEI , NELSON DEREK W , PATEL MEENA V , PEDDI SRIDHAR , PEREZ-MEDRANO ARTURO , RYTHER KEITH B , TIETJE KARIN ROSEMARIE
发明人： DART MICHAEL J , CARROLL WILLIAM A , FLORJANCIC ALAN S , FROST JENNIFER M , GALLAGHER MEGAN E , KOLASA TEODOZYJ , LI TONGMEI , NELSON DEREK W , PATEL MEENA V , PEDDI SRIDHAR , PEREZ-MEDRANO ARTURO , RYTHER KEITH B , TIETJE KARIN ROSEMARIE
IPC分类号： C07D277/46 , A61K31/426 , A61K31/427 , A61K31/428 , A61P29/00 , C07D277/48 , C07D277/82 , C07D417/04 , C07D417/06 , C07D417/12 , C07D493/08
CPC分类号： C07D277/46 , A61K31/429 , C07D277/48 , C07D277/82 , C07D417/04 , C07D417/06 , C07D417/12 , C07D493/08 , C07D513/04
摘要： The present invention relates to compounds of formula (I), or pharmaceutically acceptable salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R 1 , R 2 , R 3 , R 4 , and L 2 , are defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，前体药物，前药盐或其组合，其中R 1，R 2，R 2，在本说明书中定义了含有这些化合物的组合物，以及使用这些化合物治疗病症和障碍的方法，其中，R 3，R 4，和组合物。

2. 发明申请

WO2007140385A2 NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS AND USES THEREOF 审中-公开
标题翻译：新化合物作为CANNABINOID受体配体及其用途
公开(公告)号：WO2007140385A2
公开(公告)日：2007-12-06
申请号：PCT/US2007069921
申请日：2007-05-30
申请人： ABBOTT LAB , DART MICHAEL J , CARROLL WILLIAM A , FLORJANCIC ALAN S , FROST JENNIFER M , GALLAGHER MEGAN E , LI TONGMEI , NELSON DEREK W , PATEL MEENA V , PEDDI SRIDHAR , PEREZ-MEDRANO ARTURO , RYTHER KEITH B , TIETJE KARIN ROSEMARIE , KOLASA TEODOZYJ
发明人： DART MICHAEL J , CARROLL WILLIAM A , FLORJANCIC ALAN S , FROST JENNIFER M , GALLAGHER MEGAN E , LI TONGMEI , NELSON DEREK W , PATEL MEENA V , PEDDI SRIDHAR , PEREZ-MEDRANO ARTURO , RYTHER KEITH B , TIETJE KARIN ROSEMARIE , KOLASA TEODOZYJ
CPC分类号： C07D277/82 , C07D277/46 , C07D277/48 , C07D277/60 , C07D417/06 , C07D417/12 , C07D477/14 , C07D513/04
摘要： The present invention relates to compounds of formula (I), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2 , R3 , R4 , and L1 are defined in the specfication, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. The present invention also relates to compounds of formula (II), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1a, R2a and (Rx)n are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
摘要翻译：本发明涉及式（I）化合物或其药物盐，前体药物，前体药物或其组合的盐，其中R1，R2，R3，R4和L1在具体实施方案中定义，包含这些化合物的组合物和方法使用这些化合物和组合物治疗病症和病症。本发明还涉及式（II）化合物或其药物盐，前药，前体药物或其组合的盐，其中R 1a，R 2a和（R x）n如说明书中所定义，包含这些化合物的组合物和方法使用这些化合物和组合物治疗病症和病症。

3. 发明授权

US3903073A 2-Substituted adenosine-5{40 {0 carboxylates 失效
标题翻译： 2-取代腺苷-5 {40 {0羧酸盐
公开(公告)号：US3903073A
公开(公告)日：1975-09-02
申请号：US42851673
申请日：1973-12-26
申请人： ABBOTT LAB
发明人： PRASAD RAJ NANDAN , STEIN HERMAN HAL , TIETJE KARIN ROSEMARIE
IPC分类号： C07H19/16 , C07H19/18
CPC分类号： C07H19/16
摘要： WHEREIN R is amino, acetamido or hydroxy, R1 is loweralkyl, haloloweralkyl, hydroxyloweralkyl, lowercycloalkyl, loweralkenyl, loweralkynyl, loweralkyl(C3-C6)cycloalkyl or alkoxyalkyl and R2 and R3 each are hydrogen or acyl, or R2 and R3 taken together form an isopropylidene or benzylidene moiety; and the pharmaceutically acceptable acid addition salts thereof. The compounds wherein R2 and R3 are hydrogen or acyl are useful in treating cardiovascular disorders and are particularly useful as anti-anginal agents. Compounds wherein R2 and R3 when taken together form an isopropylidene or benzylidene moiety are intermediates useful in making the final products.
2-Substituted adenosine-5''-carboxylates represented by the formula
摘要翻译：由式WHEREIN R表示的2-取代的腺苷-5'-羧酸盐，乙酰氨基或羟基，R 1是低级烷基，卤代低级烷基，羟基低级烷基，低级环烷基，低级烯基，低级炔基，低级烷基（C 3 -C 6）环烷基或烷氧基烷基，R 2和R 3各自是氢或酰基，或者R 2和R 3一起形成异亚丙基或亚苄基部分; 及其药学上可接受的酸加成盐。其中R2和R3是氢或酰基的化合物可用于治疗心血管疾病，并且特别可用作抗心绞痛剂。其中R2和R3一起形成异亚丙基或亚苄基部分的化合物是可用于制备最终产物的中间体。

4. 发明公开

EP2222165A4 NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS AND USES THEREOF 有权
标题翻译：新的化合物作为大麻素受体配体和用途
公开(公告)号：EP2222165A4
公开(公告)日：2011-01-05
申请号：EP08852528
申请日：2008-11-20
申请人： ABBOTT LAB
发明人： FLORJANCIC ALAN S , DART MICHAEL J , RYTHER KEITH B , PEREZ-MEDRANO ARTURO , CARROLL WILLIAM A , PATEL MEENA V , TIETJE KARIN ROSEMARIE , LI TONGMEI , KOLASA TEODOZYJ , GALLAGHER MEGAN E , PEDDI SRIDHAR , FROST JENNIFER M , NELSON DEREK W
IPC分类号： C07D277/46
CPC分类号： C07D417/12 , C07D277/46 , C07D417/06 , C07D513/04 , C07D513/20

5. 发明专利

MX2010005649A COMPUESTOS NOVEDOSOS COMO LIGANDOS DEL RECEPTOR CANABINOIDE Y SUS USOS. 未知
公开(公告)号：MX2010005649A
公开(公告)日：2010-08-18
申请号：MX2010005649
申请日：2008-11-20
申请人： ABBOTT LAB
发明人： DART MICHAEL J , GALLAGHER MEGAN E , RYTHER KEITH B , LI TONGMEI , CARROLL WILLIAM A , PEREZ-MEDRANO ARTURO , FLORJANCIC ALAN S , NELSON DEREK W , KOLASA TEODOZYJ , PATEL MEENA V , FROST JENNIFER M , PEDDI SRIDHAR , TIETJE KARIN ROSEMARIE
IPC分类号： A01N43/42
摘要： La presente invención se refiere a compuestos de la fórmula (I), o sales farmacéuticas, profármacos, sales de profármaco, o combinaciones de los mismos, fórmula (I), en donde R1, R2, R3, R4, y L1 se definen en la especificación, composiciones que comprenden dichos compuestos, y métodos para el tratamiento de condiciones y trastornos utilizando dichos compuestos y composiciones. La presente invención también se refiere a compuestos de la fórmula (II), o sales farmacéuticas, profármacos, sales de profármacos, o combinaciones de los mismos, fórmula (II), en donde R1a, R2a, Rx, y n son como se define en la especificación, composiciones que comprenden dichos compuestos, y métodos para el tratamiento de condiciones y trastornos utilizando dichos compuestos y composiciones.

6. 发明专利

DE2460553A1 未知
公开(公告)号：DE2460553A1
公开(公告)日：1975-07-10
申请号：DE2460553
申请日：1974-12-20
申请人： ABBOTT LAB
发明人： PRASAD RAJ NANDAN , STEIN HERMAN HAL , TIETJE KARIN ROSEMARIE
IPC分类号： C07H19/16 , C07H19/18
摘要： 2-Substituted adenosine-5'-carboxylates represented by the formula WHEREIN R is amino, acetamido or hydroxy, R1 is loweralkyl, haloloweralkyl, hydroxyloweralkyl, lowercycloalkyl, loweralkenyl, loweralkynyl, loweralkyl(C3-C6)cycloalkyl or alkoxyalkyl and R2 and R3 each are hydrogen or acyl, or R2 and R3 taken together form an isopropylidene or benzylidene moiety; and the pharmaceutically acceptable acid addition salts thereof. The compounds wherein R2 and R3 are hydrogen or acyl are useful in treating cardiovascular disorders and are particularly useful as anti-anginal agents. Compounds wherein R2 and R3 when taken together form an isopropylidene or benzylidene moiety are intermediates useful in making the final products.

7. 发明专利

AU2007266535A1 Thiazole compounds as cannabinoid receptor ligands and uses thereof 未知
公开(公告)号：AU2007266535A1
公开(公告)日：2007-12-06
申请号：AU2007266535
申请日：2007-05-30
申请人： ABBOTT LAB
发明人： NELSON DEREK W , LI TONGMEI , FROST JENNIFER M , RYTHER KEITH B , PEDDI SRIDHAR , TIETJE KARIN ROSEMARIE , PEREZ-MEDRANO ARTURO , KOLASA TEODOZYJ , GALLAGHER MEGAN E , PATEL MEENA V , CARROLL WILLIAM A , FLORJANCIC ALAN S , DART MICHAEL J
IPC分类号： C07D277/46 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/429 , A61P29/00 , C07D277/48 , C07D277/60 , C07D277/82 , C07D417/06 , C07D417/12 , C07D417/14 , C07D513/04
摘要： The present invention relates to compounds of formula (I), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and L1 are defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. The present invention also relates to compounds of formula (II), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1a, R2a and (Rx)n are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

8. 发明专利

NO146432C 未知
公开(公告)号：NO146432C
公开(公告)日：1982-09-29
申请号：NO761216
申请日：1976-04-08
申请人： ABBOTT LAB
发明人： PRASAD RAJ NANDAN , TIETJE KARIN ROSEMARIE , STEIN HERMAN HAL
IPC分类号： C07D215/22 , A61K31/47 , A61P9/06 , A61P9/08 , A61P9/10 , A61P25/02 , C07D215/227 , C07D405/12

9. 发明专利

MX2008015214A COMPUESTOS COMO LIGANDOS DE RECEPTOR CANABINOIDE Y SUS USOS. 未知
公开(公告)号：MX2008015214A
公开(公告)日：2008-12-12
申请号：MX2008015214
申请日：2007-05-31
申请人： ABBOTT LAB
发明人： PEREZ-MEDRANO ARTURO , DART MICHAEL J , GALLAGHER MEGAN E , RYTHER KEITH B , CARROLL WILLIAM A , FLORJANCIC ALAN S , NELSON DEREK W , KOLASA TEODOZYJ , PATEL MEENA V , LI TONGMEI , FROST JENNIFER M , PEDDI SRIDHAR , TIETJE KARIN ROSEMARIE
IPC分类号： C07D277/46 , A61K31/426 , A61K31/427 , A61K31/428 , A61P29/00 , C07D277/48 , C07D277/82 , C07D417/04 , C07D417/06 , C07D417/12 , C07D493/08
摘要： La presente invención se refiere a compuestos de la fórmula (I), o sales farmacéuticamente aceptables, profármacos, sales de profármacos, o combinaciones de los mismos, en donde R1, R2, R3, R4 y L2 se definen en la descripción, composiciones que comprenden dichos compuestos, y métodos para el tratamiento de condiciones y trastornos utilizando dichos compuesto y composiciones. (ver fórmula (I)).

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